COVID-19 screening in a healthcare or community setting: complexity of saliva as a specimen for PCR-based testing.
Published in Future medicinal chemistry
The urgent need for pan-antiviral agents: from multitarget discovery to multiscale design.
Published in Future medicinal chemistry
Synthesis, biochemical evaluation and molecular modeling studies of nonpeptidic nitrile-based fluorinated compounds.
Published in Future medicinal chemistry
Aim: Compounds that block enzyme activity can kill pathogens and help develop effective and safe drugs for Chagas disease and leishmaniasis. Materials & methods: A library of nonpeptidic nitrile-based compounds was synthesized and had their inhibitory affinity tested against cruzain, Leishmania mexicana cysteine protease B and cathepsin L. Isotherm...
N-heterocyclic carbene-metal complexes as bio-organometallic antimicrobial and anticancer drugs, an update (2015-2020).
Published in Future medicinal chemistry
N-heterocyclic carbenes (NHCs) are organic compounds that typically mimic the chemical properties of phosphines. NHCs have made a significant impact on the field of coordination and organometallic chemistry because they are easy to prepare and handle and because of their versatility and stability. Importantly, the physicochemical properties of NHCs...
Novel strategies to eradicate resistant cells in chronic myeloid leukemia.
Published in Future medicinal chemistry
Antimicrobial innovation: a current update and perspective on the antibiotic drug development pipeline.
Published in Future medicinal chemistry
As bacteria continue to develop resistance to our existing treatment options, antibiotic innovation remains overlooked. If current trends continue, then we could face the stark reality of a postantibiotic era, whereby routine bacterial infections could once again become deadly. In light of a warning signaled by the WHO, a number of new initiatives ...
Recent advances in the development of elastase inhibitors.
Published in Future medicinal chemistry
Targeting interleukins in chronic airway diseases using advanced drug delivery.
Published in Future medicinal chemistry
Recent developments in PARP14 research.
Published in Future medicinal chemistry
This review aims to reflect upon the major developments in PARP14 research from late 2017 to early 2020. In doing so, this report will focus on the continual elucidation of PARP14's function including an emerging role in viral replication. This is in addition to other functional developments in cancer and inflammation, along with reflecting upon th...
Proteolysis-targeting chimeras mediate the degradation of bromodomain and extra-terminal domain proteins.
Published in Future medicinal chemistry
Bromodomain and extra-terminal domain (BET) protein family plays an important role in regulating gene transcription preferentially at super-enhancer regions and has been involved with several types of cancers as a candidate. Up to now, there are 16 pan-BET inhibitors in clinical trials, however, most of them have undesirable off-target and side-eff...
