Garcia, Alfredo J 3rd Dashevskiy, Tatiana Khuu, Maggie A Ramirez, Jan-Marino
Published in
Frontiers in physiology
The preBötzinger complex (preBötC) is a medullary brainstem network crucially involved in the generation of different inspiratory rhythms. In the isolated brainstem slice, the preBötC reconfigures to produce different rhythms that we refer to as "fictive eupnea" under baseline conditions (i.e., carbogen), and "fictive gasping" in hypoxia. We recent...
Trivella, Maria G Capobianco, Enrico L'Abbate, Antonio
Published in
Frontiers in physiology
Shim, Jaemin Hwang, Minki Song, Jun-Seop Lim, Byounghyun Kim, Tae-Hoon Joung, Boyoung Kim, Sung-Hwan Oh, Yong-Seog Nam, Gi-Byung On, Young Keun
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Published in
Frontiers in physiology
Objective: Radiofrequency catheter ablation for persistent atrial fibrillation (PeAF) still has a substantial recurrence rate. This study aims to investigate whether an AF ablation lesion set chosen using in-silico ablation (V-ABL) is clinically feasible and more effective than an empirically chosen ablation lesion set (Em-ABL) in patients with PeA...
Smit, Nicoline W Cócera Ortega, Lucia Végh, Anna M D Meijborg, Veronique M F Smits, Anke M Klerk, Mischa Tijsen, Anke J M Tan, Hanno L Goumans, Marie-José H T Boink, Gerard J J
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Published in
Frontiers in physiology
Background: Cardiomyocyte progenitor cells (CMPCs) are a promising cell source for regenerative cell therapy to improve cardiac function after myocardial infarction. However, it is unknown whether undifferentiated CMPCs have arrhythmogenic risks. We investigate whether undifferentiated, regionally applied, human fetal CMPCs form a pro-arrhythmic su...
Matsoukas, Ianis G
Published in
Frontiers in physiology
Over the past decade, integrated genetic, cellular, proteomic and genomic approaches have begun to unravel the surprisingly crosstalk between photoreceptors and sugar signaling in regulation of floral signal transduction. Although a number of physiological factors in the pathway have been identified, the molecular genetic interactions of some compo...
Gasse, Barbara Prasad, Megana Delgado, Sidney Huckert, Mathilde Kawczynski, Marzena Garret-Bernardin, Annelyse Lopez-Cazaux, Serena Bailleul-Forestier, Isabelle Manière, Marie-Cécile Stoetzel, Corinne
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Published in
Frontiers in physiology
Amelogenesis imperfecta (AI) designates a group of genetic diseases characterized by a large range of enamel disorders causing important social and health problems. These defects can result from mutations in enamel matrix proteins or protease encoding genes. A range of mutations in the enamel cleavage enzyme matrix metalloproteinase-20 gene (MMP20)...
Miles-Chan, Jennifer L Dulloo, Abdul G
Published in
Frontiers in physiology
There is increasing recognition that low-intensity physical activities of daily life play an important role in achieving energy balance and that their societal erosion through substitution with sedentary (mostly sitting) behaviors, whether occupational or for leisure, impact importantly on the obesity epidemic. This has generated considerable inter...
Manconi, Mauro Silvani, Alessandro Ferri, Raffaele
Published in
Frontiers in physiology
Cavalcante-Silva, Luiz H A Lima, Éssia de Almeida Carvalho, Deyse C M de Sales-Neto, José M Alves, Anne K de Abreu Galvão, José G F M da Silva, Juliane S de França Rodrigues-Mascarenhas, Sandra
Published in
Frontiers in physiology
Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described. Ouabain can behave as a stress hormone and adrenal cortex is its main source. Direct effects of ouabain are originated due to the bindin...
Akaishi, Tetsuya
Published in
Frontiers in physiology
Nerve conduction in unmyelinated fibers has long been described based on the equivalent circuit model and cable theory. However, without the change in ionic concentration gradient across the membrane, there would be no generation or propagation of the action potential. Based on this concept, we employ a new conductive model focusing on the distribu...
