Vidal, Benjamin Droguerre, Marine Valdebenito, Marco Zimmer, Luc Hamon, Michel Mouthon, Franck Charvériat, Mathieu
Published in
Frontiers in neuroscience
Donepezil is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate cognitive symptoms in Alzheimer's disease (AD). Beyond the widely described neuronal impact of donepezil, it was recently shown that targeting connexins, the proteins involved in astrocyte network organization, potentiates donepezil efficacy profile using beha...
Rodrigues, Belina Coelho, Ana Portugal-Nunes, Carlos Magalhães, Ricardo Moreira, Pedro Silva Castanho, Teresa Costa Amorim, Liliana Marques, Paulo Soares, José Miguel Sousa, Nuno
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Published in
Frontiers in neuroscience
The Mediterranean diet (MedDiet) has been associated with cognitive performance. Yet, controlled trials have yielded contradictory results. To tackle this controversy, a comprehensive multimodal analysis of the association of the MedDiet with cognitive performance and brain structure in normative aging is still necessary. Here, community dwellers ≥...
Le, Jiao Kou, Juan Zhao, Weihua Fu, Meina Zhang, Yingying Becker, Benjamin Kendrick, Keith M
Published in
Frontiers in neuroscience
One of the most robust effects of intranasal oxytocin treatment is its enhancement of emotional empathy responses across cultures to individuals displaying emotions in realistic contexts in the Multifaceted Empathy Task (MET). However, it is not established if this effect of oxytocin on emotional empathy is due to altered visual attention toward di...
Seki, Tatsunori
Published in
Frontiers in neuroscience
The concept of adult hippocampal neurogenesis (AHN) has been widely accepted, and a large number of studies have been performed in rodents using modern experimental techniques, which have clarified the nature and developmental processes of adult neural stem/progenitor cells, the functions of AHN, such as memory and learning, and its association wit...
Kessler, Mariella Schierholz, Irina Mamach, Martin Wilke, Florian Hahne, Anja Büchner, Andreas Geworski, Lilli Bengel, Frank M Sandmann, Pascale Berding, Georg
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Published in
Frontiers in neuroscience
Cochlear implantation constitutes a successful therapy of inner ear deafness, with the majority of patients showing good outcomes. There is, however, still some unexplained variability in outcomes with a number of cochlear-implant (CI) users, showing major limitations in speech comprehension. The current study used a multimodal diagnostic approach ...
Pilkar, Rakesh Karunakaran, Kiran K Veerubhotla, Akhila Ehrenberg, Naphtaly Ibironke, Oluwaseun Nolan, Karen J
Published in
Frontiers in neuroscience
There is limited research on sensory acuity i.e., ability to perceive external perturbations via body-sway during standing in individuals with a traumatic brain injury (TBI). It is unclear whether sensory acuity diminishes after a TBI and if it is a contributing factor to balance dysfunction. The objective of this investigation is to first objectiv...
Maugeri, Grazia D'Amico, Agata Grazia Morello, Giovanna Reglodi, Dora Cavallaro, Sebastiano D'Agata, Velia
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Frontiers in neuroscience
Amyotrophic lateral sclerosis (ALS) is a progressive multifactorial disease characterized by the loss of motor neurons (MNs). Not all MNs undergo degeneration: neurons of the oculomotor nucleus, which regulate eye movements, are less vulnerable compared to hypoglossal nucleus MNs. Several molecular studies have been performed to understand the diff...
Lazarus, Michael Hayashi, Yu Honjoh, Sakiko Vogt, Kaspar E Eban-Rothschild, Ada Liu, Qinghua Sakurai, Takeshi
Published in
Frontiers in neuroscience
Zivi, Pierpaolo De Gennaro, Luigi Ferlazzo, Fabio
Published in
Frontiers in neuroscience
The recently renewed focus on the human exploration of outer space has boosted the interest toward a variety of questions regarding health of astronauts and cosmonauts. Among the others, sleep has traditionally been considered a central issue. To extend the research chances, human sleep alterations have been investigated in several analog environme...
Li, Chang Zuo, Zhiwei Liu, Daihong Jiang, Rui Li, Yang Li, Haitao Yin, Xuntao Lai, Yuqi Wang, Jian Xiong, Kunlin
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Published in
Frontiers in neuroscience
The precise physiopathological association between the courses of neurodegeneration and cognitive decline in type 2 diabetes mellitus (T2DM) remains unclear. This study sought to comprehensively investigate the distribution characteristics of gray matter atrophy in middle-aged T2DM patients with newly diagnosed mild cognitive impairment (MCI). Four...
