Yushchuk, Oleksandr Andreo-Vidal, Andres Marcone, Giorgia Letizia Bibb, Mervyn Marinelli, Flavia Binda, Elisa
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Frontiers in microbiology
Genome sequencing has revealed that Nonomuraea spp. represent a still largely unexplored source of specialized metabolites. Nonomuraea gerenzanensis ATCC 39727 is the most studied representative species since it produces the glycopeptide antibiotic (GPA) A40926 - the precursor of the clinically relevant antibiotic dalbavancin, approved by the FDA i...
Morello, Eric Pérez-Berezo, Teresa Boisseau, Chloé Baranek, Thomas Guillon, Antoine Bréa, Déborah Lanotte, Philippe Carpena, Xavier Pietrancosta, Nicolas Hervé, Virginie
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Frontiers in microbiology
Pseudomonas aeruginosa is an opportunistic bacteria and a major cause of nosocomial pneumonia. P. aeruginosa has many virulence factors contributing to its ability to colonize the host. LoxA is a lipoxygenase enzyme secreted by P. aeruginosa that oxidizes polyunsaturated fatty acids. Based on previous in vitro biochemical studies, several biologica...
Louropoulou, Evangelia Gledhill, Martha Browning, Thomas J Desai, Dhwani K Barraqueta, Jan-Lukas Menzel Tonnard, Manon Sarthou, Géraldine Planquette, Hélène Bowie, Andrew R Schmitz, Ruth A
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Frontiers in microbiology
Heme b is an iron-containing co-factor in hemoproteins. Heme b concentrations are low (0.7 μm) from the North Atlantic Ocean (GEOVIDE cruise - GEOTRACES section GA01), which spanned several biogeochemical regimes. We examined the relationship between heme b abundance and the microbial community composition, and its utility for mapping iron limited ...
Martak, Daniel Valot, Benoît Sauget, Marlène Cholley, Pascal Thouverez, Michelle Bertrand, Xavier Hocquet, Didier
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Frontiers in microbiology
The typing of epidemic bacterial pathogens in hospitals relies on DNA-based, expensive, and time-consuming techniques, that are often limited to retrospective studies. However, the quick identification of epidemic pathogens in the routine of the microbiology laboratories would expedite infection control procedures that limit the contamination of ne...
Gannesen, Andrei V Zdorovenko, Evelina L Botchkova, Ekaterina A Hardouin, Julie Massier, Sebastien Kopitsyn, Dmitry S Gorbachevskii, Maxim V Kadykova, Alexandra A Shashkov, Alexander S Zhurina, Marina V
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Frontiers in microbiology
In skin, Cutibacterium acnes (former Propionibacterium acnes) can behave as an opportunistic pathogen, depending on the strain and environmental conditions. Acneic strains of C. acnes form biofilms inside skin-gland hollows, inducing inflammation and skin disorders. The essential exogenous products of C. acnes accumulate in the extracellular matrix...
Zeaiter, Zahraa Marasco, Ramona Booth, Jenny M Prosdocimi, Erica M Mapelli, Francesca Callegari, Matteo Fusi, Marco Michoud, Grégoire Molinari, Francesco Daffonchio, Daniele
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Frontiers in microbiology
The adaptation of sporeformers to extreme environmental conditions is frequently questioned due to their capacity to produce highly resistant endospores that are considered as resting contaminants, not representing populations adapted to the system. In this work, in order to gain a better understanding of bacterial adaptation to extreme habitats, w...
Zeng, Sheng Constant, Patricia Yang, Dong Baulard, Alain Lefèvre, Philippe Daffé, Mamadou Wattiez, Ruddy Fontaine, Véronique
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Frontiers in microbiology
Biofilm formation is a survival strategy for microorganisms facing a hostile environment. Under biofilm, bacteria are better protected against antibacterial drugs and the immune response, increasing treatment difficulty, as persistent populations recalcitrant to chemotherapy are promoted. Deciphering mechanisms leading to biofilms could, thus, be b...
Mougari, Said Abrahao, Jonatas Oliveira, Graziele P Bou Khalil, Jacques Y La Scola, Bernard
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Frontiers in microbiology
MIMIVIRE is a defense system described in lineage A Mimivirus (Mimiviridae family) that mediates resistance against Zamilon virophage. It is composed of putative helicase and nuclease associated with a gene of unknown function called R349, which contains four 15 bp repeats homologous to the virophage sequence. In a previous study, the silencing of ...
Forlani, Greta Baratella, Marco Tedeschi, Alessandra Pique, Claudine Jacobson, Steve Accolla, Roberto S
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Frontiers in microbiology
Human T cell lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a subset of infected subjects. Two viral proteins, Tax-1 and HTLV-1 basic leucine zipper factor (HBZ), play important roles in the pathogenesis of both diseases. We...
Maya-Martinez, Roberto Alexander, J Andrew N Otten, Christian F Ayala, Isabel Vollmer, Daniela Gray, Joe Bougault, Catherine M Burt, Alister Laguri, Cédric Fonvielle, Matthieu
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Frontiers in microbiology
Peptidoglycan (PG) is an essential component of the cell envelope, maintaining bacterial cell shape and protecting it from bursting due to turgor pressure. The monoderm bacterium Staphylococcus aureus has a highly cross-linked PG, with ~90% of peptide stems participating in DD-cross-links and up to 15 peptide stems connected with each other. These ...
