Over and under the skin: how our habits can influence cutaneous toxicity
Published in Frontiers in Toxicology
Effect of altered production and storage of dopamine on development and behavior in C. elegans
Published in Frontiers in Toxicology
Introduction The nematode, Caenorhabditis elegans (C. elegans), is an advantageous model for studying developmental toxicology due to its well-defined developmental stages and homology to humans. It has been established that across species, dopaminergic neurons are highly vulnerable to neurotoxicant exposure, resulting in developmental neuronal dys...
The heart of plastic: utilizing the Drosophila model to investigate the effects of micro/nanoplastics on heart function
Published in Frontiers in Toxicology
Microplastics (MPs) and nanoplastics (NPs) have increasingly been found in the environment. Until recently, most MPs/NPs toxicological research has been done in aquatic systems resulting in a gap in knowledge regarding terrestrial systems. Plastics have been shown to enter the circulatory system of humans, and can accumulate within organs, little i...
Science evolves but outdated testing and static risk management in the US delay protection to human health
Published in Frontiers in Toxicology
The safety of magnetic resonance imaging contrast agents
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Published in Frontiers in Toxicology
Gadolinium-based contrast agents are increasingly used in clinical practice. While these pharmaceuticals are verified causal agents in nephrogenic systemic fibrosis, there is a growing body of literature supporting their role as causal agents in symptoms associated with gadolinium exposure after intravenous use and encephalopathy following intrathe...
European partnership on the assessment of risks from chemicals (PARC): focus on new approach methodologies (NAMs) in ris...
Published in Frontiers in Toxicology
Decreased activity in zebrafish larvae exposed to glyphosate-based herbicides during development—potential mediation by ...
Published in Frontiers in Toxicology
Glyphosate-based herbicides (GBH) are a widely used group of pesticides that have glyphosate (GLY) as main active compound and are used to control a wide range of weeds. Experimental and epidemiological studies point to neurotoxicity and endocrine disruption as main toxic effects. The aim of this study was to investigate the effects of developmenta...
Hypoactivity and neurochemical alterations in the basal ganglia of female Sprague-Dawley rats after repeated exposure to...
Published in Frontiers in Toxicology
The herbicide atrazine (ATR) has been one of the most widely used herbicides worldwide. However, due to its indiscriminate use, it has been considered an environmental contaminant. Several studies have classified ATR as an endocrine disruptor, and it has been found to have neurotoxic effects on behavior, along with alterations in the dopaminergic, ...
Chemical respiratory sensitization—Current status of mechanistic understanding, knowledge gaps and possible identificati...
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Published in Frontiers in Toxicology
Respiratory sensitization is a complex immunological process eventually leading to hypersensitivity following re-exposure to the chemical. A frequent consequence is occupational asthma, which may occur after long latency periods. Although chemical-induced respiratory hypersensitivity has been known for decades, there are currently no comprehensive ...
Near-cure in patients with Gadolinium deposition disease undergoing intravenous DTPA chelation
Published in Frontiers in Toxicology
Purpose To demonstrate and evaluate factors contributing to near-cures in patients with Gadolinium Deposition Disease (GDD) undergoing intravenous (IV) DTPA chelation. Methods Patients who had undergone or are currently undergoing DTPA chelation for GDD were included in this report based on their medical records that showed their perceived improvem...
