del Giudice, Giusy Migliaccio, Giorgia D’Alessandro, Nicoletta Saarimäki, Laura Aliisa Torres Maia, Marcella Annala, Maria Emilia Leppänen, Jenni Mӧbus, Lena Pavel, Alisa Vaani, Maaret
...
Published in
Frontiers in Toxicology
Assessing chemical safety is essential to evaluate the potential risks of chemical exposure to human health and the environment. Traditional methods relying on animal testing are being replaced by 3R (reduction, refinement, and replacement) principle-based alternatives, mainly depending on in vitro test methods and the Adverse Outcome Pathway frame...
Alarape, Selim Adewale Fagbohun, Adekemi Florence Ipadeola, Oladeni Adegoke Adeigbo, Anthony Ayodeji Adesola, Ridwan Olamilekan Adeyemo, Olanike Kudirat
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Frontiers in Toxicology
Introduction: Glyphosate is a non-targeted organophosphate insecticide whose solubility and mobility in hydrophilic solvents enable its rapid leaching into the soil and subsequent contamination of ground and surface water and possible build-up in the aquatic food chain. Based on the public health importance of glyphosate in fish through consumption...
Menke, Bryant A. Ryu, Christine Justin, Grant A. Chundury, Rao V. Hayek, Brent R. Debiec, Matthew R. Yeh, Steven
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Frontiers in Toxicology
Chemical agents have been utilized for centuries in warfare and pose a health threat to civilians and military personnel during armed conflict. Despite treaties and regulations against their use, chemical agent exposure remains a threat and measures to understand their effects and countermeasures for systemic and organ-specific health are needed. M...
Kincaid, Breanne Piechota, Przemyslaw Golden, Emily Maertens, Mikhail Hartung, Thomas Maertens, Alexandra
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Frontiers in Toxicology
Introduction: The positive identification of xenobiotics and their metabolites in human biosamples is an integral aspect of exposomics research, yet challenges in compound annotation and identification continue to limit the feasibility of comprehensive identification of total chemical exposure. Nonetheless, the adoption of in silico tools such as m...
Scieszka, David Bolt, Alicia M. McCormick, Mark A. Brigman, Jonathan L. Campen, Matthew J.
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Frontiers in Toxicology
Aging is a complex biological process involving multiple interacting mechanisms and is being increasingly linked to environmental exposures such as wildfire smoke. In this review, we detail the hallmarks of aging, emphasizing the role of telomere attrition, cellular senescence, epigenetic alterations, proteostasis, genomic instability, and mitochon...
Salminen, Alec T. Manga, Prashiela Camacho, Luísa
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Frontiers in Toxicology
A functional human skin barrier is critical in limiting harmful exposure to environmental agents and regulating the absorption of intentionally applied topical drug and cosmetic products. Inherent differences in the skin barrier between consumers due to extrinsic and intrinsic factors are an important consideration in the safety assessment of derma...
Bouchard, Katherine Virginia Costin, Gertrude-Emilia
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Frontiers in Toxicology
Aging is one of the most dynamic biological processes in the human body and is known to carry significant impacts on individuals’ self-esteem. Skin pigmentation is a highly heritable trait made possible by complex, strictly controlled cellular and molecular mechanisms. Genetic, environmental and endocrine factors contribute to the modulation of mel...
Abarikwu, Sunny O. Ezim, Ogechukwu E. Ikeji, Cynthia N. Farombi, Ebenezer O.
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Frontiers in Toxicology
Atrazine (ATZ) is an environmental pollutant that interferes with several aspects of mammalian cellular processes including germ cell development, immunological, reproductive and neurological functions. At the level of human exposure, ATZ reduces sperm count and contribute to infertility in men. ATZ also induces morphological changes similar to apo...
Rojo, Macarena Gisele Cristos, Diego Carriquiriborde, Pedro
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Frontiers in Toxicology
Sewage effluents are the main source of entry of Human Pharmaceutical Active Ingredients (HPAIs) to surface water bodies. Carbamazepine (CBZ), psychiatric drug, enalapril (ENA) antihypertensive, and sildenafil (SIL), to treat erectile dysfunction, have been frequently detected in receiving wastewater and in wild fish species from Argentina. This st...
Hall, Alina Mattison, Donald Singh, Narendra Chatzistamou, Ioulia Zhang, Jiajia Nagarkatti, Mitzi Nagarkatti, Prakash
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Frontiers in Toxicology
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant found widely across the world. While animal and human studies have shown that exposure to TCDD may cause significant alterations in the reproductive tract, the effect of TCDD on the expression of miRNA in the reproductive organs has not been previously tested. In the current...
