Del Rio, Rodrigo Jr. Serrano, Rosa G. Gomez, Eric Martinez, Joshua C. Edward, Marina A. Santos, Rommel A. Diaz, Kenneth S. Cohen-Cory, Susana
Published in
Frontiers in Synaptic Neuroscience
Cannabis exposure during gestation evokes significant molecular modifications to neurodevelopmental programs leading to neurophysiological and behavioral abnormalities in humans. The main neuronal receptor for Δ9-tetrahydrocannabinol (THC) is the type-1 cannabinoid receptor CB1R, one of the most abundant G-protein-coupled receptors in the nervous s...
Lin, Jianwen Liu, Wenxin Guan, Jing Cui, Jianing Shi, Ruolin Wang, Lu Chen, Dong Liu, Yi
Published in
Frontiers in Synaptic Neuroscience
Psychiatric disorders are among the leading causes of global health burden, with depression and anxiety being the most disabling subtypes. The two common disorders, depression and anxiety, usually coexist and are pathologically polygenic with complicated etiologies. Current drug-based therapies include selective serotonin reuptake inhibitors, serot...
Liu, Ting-Ting Qiu, Chun-Yu Hu, Wang-Ping
Published in
Frontiers in Synaptic Neuroscience
Introduction Cancer patients treated with paclitaxel often develop chemotherapy-induced peripheral neuropathy, which has not been effectively treated with drugs. The anti-diabetic drug metformin is effective in the treatment of neuropathic pain. The aim of this study was to elucidate effect of metformin on paclitaxel-induced neuropathic pain and sp...
Nugent, Fereshteh S. Li, Ka Wan Chen, Lu
Published in
Frontiers in Synaptic Neuroscience
Hao, Shun Shi, Wantong Liu, Weiqi Chen, Qi-Yu Zhuo, Min
Published in
Frontiers in Synaptic Neuroscience
Chronic pain is long-lasting pain that often persists during chronic diseases or after recovery from disease or injury. It often causes serious side effects, such as insomnia, anxiety, or depression which negatively impacts the patient’s overall quality of life. Serotonin (5-HT) in the central nervous system (CNS) has been recognized as an importan...
Jung, Jae Hoon Chen, Xiaobing Reese, Thomas S.
Published in
Frontiers in Synaptic Neuroscience
Postsynaptic densities (PSDs) are large protein complexes associated with the postsynaptic membrane of excitatory synapses important for synaptic function including plasticity. Conventional electron microscopy (EM) typically depicts PSDs as compact disk-like structures of hundreds of nanometers in size. Biochemically isolated PSDs were also similar...
Chen, Yuh-Tarng Arano, Rachel Guo, Jun Saleem, Uzair Li, Ying Xu, Wei
Published in
Frontiers in Synaptic Neuroscience
Although the hippocampus is generally considered a cognitive center for spatial representation, learning, and memory, increasing evidence supports its roles in regulating locomotion. However, the neuronal mechanisms of the hippocampal regulation of locomotion and exploratory behavior remain unclear. In this study, we found that the inhibitory hippo...
de Carvalho, Gregory Khoja, Sheraz Haile, Mulatwa T. Chen, Lulu Y.
Published in
Frontiers in Synaptic Neuroscience
Early life adversity (ELA) is a major health burden in the United States, with 62% of adults reporting at least one adverse childhood experience. These experiences during critical stages of brain development can perturb the development of neural circuits that mediate sensory cue processing and behavioral regulation. Recent studies have reported tha...
Smith, Joscelin E. G. Ashton, Jesse L. Argent, Liam P. Cheyne, Juliette E. Montgomery, Johanna M.
Published in
Frontiers in Synaptic Neuroscience
The intrinsic cardiac nervous system (ICNS) is composed of interconnected clusters of neurons called ganglionated plexi (GP) which play a major role in controlling heart rate and rhythm. The function of these neurons is particularly important due to their involvement in cardiac arrhythmias such as atrial fibrillation (AF), and previous work has sho...
Uzay, Burak Kavalali, Ege T.
Published in
Frontiers in Synaptic Neuroscience
Synaptic neurotransmitter release is an evolutionarily conserved process that mediates rapid information transfer between neurons as well as several peripheral tissues. Release of neurotransmitters are ensured by successive events such as synaptic vesicle docking and priming that prepare synaptic vesicles for rapid fusion. These events are orchestr...
