Zhang, Baoyue Zhao, Jun Wang, Zhe Guo, Pengfei Liu, Ailin Du, Guanhua
Published in
Frontiers in Pharmacology
Alzheimer’s disease (AD) is a neurodegenerative disease that seriously threatens the health of the elderly. At present, no drugs have been proven to cure or delay the progression of the disease. Due to the multifactorial aetiology of this disease, the multi-target-directed ligand (MTDL) approach provides an innovative and promising idea in search f...
Wang, Xintong Wang, Zixu Cao, Jing Dong, Yulan Chen, Yaoxing
Published in
Frontiers in Pharmacology
Objectives: Memory decline caused by insufficient sleep is a critical public health issues and currently lacks effective treatments. This study objective was to explore alleviative effect of melatonin on sleep deprivation (SD)-induced deficiencies in learning and memory. Materials and Methods: A continuous 72 h SD mouse model, with or without melat...
Li, Shuyuan Zhou, Hongliang Hu, Cheng Yang, Jiabao Ye, Jinfei Zhou, Yuexi Li, Zige Chen, Leilei Zhou, Qishi
Published in
Frontiers in Pharmacology
Wang, Dong Song, Li Shen, Li Zhang, Kaihui Lv, Yuqiang Gao, Min Ma, Jian Wan, Ya Gai, Zhongtao Liu, Yi
...
Published in
Frontiers in Pharmacology
Background: Hereditary spherocytosis (HS), characterized by the presence of spherocytic red cells in peripheral blood, hemolysis, splenomegaly, jaundice, and gallstones, is a common form of inherited hemolytic anemia (HA). To date, five causative genes associated with HS have been identified, including ANK1, SPTB, SPTA1, SLC4A1, and EPB42. Methods:...
Wang, Guyi Deng, Jiayi Li, Jinxiu Wu, Chenfang Dong, Haiyun Wu, Shangjie Zhong, Yanjun
Published in
Frontiers in Pharmacology
The current Coronavirus disease 2019 (COVID-19) pandemic has become a global challenge. Managing a large number of acutely ill patients in a short time, whilst reducing the fatality rate and dealing with complications, brings unique difficulties. The most striking pathophysiological features of patients with severe COVID-19 are dysregulated immune ...
Mosleh, Ghazaleh Badr, Parmis Zaeri, Meysam Mohagheghzadeh, Abdolali
Published in
Frontiers in Pharmacology
Coronavirus disease 2019 is a worldwide pandemic resulting in a severe acute respiratory syndrome. Remdesivir is the only FDA-approved drug for hospitalized patients older than age 12. It shows the necessity of finding new therapeutic strategies. Functional foods (FFs) could have co-therapeutic and protective effects against COVID-19 infection. Tra...
Alhakamy, Nabil A. Ahmed, Osama A. Fahmy, Usama A. Asfour, Hani Z. Alghaith, Adel F. Mahdi, Wael A. Alshehri, Sultan Md, Shadab
Published in
Frontiers in Pharmacology
The therapeutic efficacy of antineoplastic agents possessing a selective target to the nucleus of the cancer cells could be enhanced through novel formulation approaches. Thus, toward the improvement of the anticancer potential of 2-methoxy estradiol (2 ME) on prostate cancer, the drug was entrapped into the hydrophobic micelles core formulated wit...
Li, Gao Du, Xiaowei Wu, Xiaoxiong Wu, Shen Zhang, Yufei Xu, Jing Wang, Hao Chen, Tingsong
Published in
Frontiers in Pharmacology
Background: Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality and heterogeneity. Genetic mutations caused by driver genes are important contributors to the formation of the tumor microenvironment. The purpose of this study is to discuss the expression of cancer driver genes in tumor tissues and their clinical value in p...
Mei, Chenxue Wang, Xiao Meng, Fanxiang Zhang, Xiaoqing Chen, Ling Yan, Siqi Xue, Junxiu Sun, Xun Wang, Yuanyuan
Published in
Frontiers in Pharmacology
Aucuboside is an iridoid glycoside extracted from traditional Chinese medicine such as Rehmannia glutinosa, possessing a wide range of biological activities, including antioxidant, anti-aging, anti-inflammatory, and anti-fibrotic effects. The effects of aucuboside on inflammatory bowel disease (IBD) have not been studied. Therefore, the effects of ...
Yao, Ruyu Heinrich, Michael Wei, Jianhe Xiao, Peigen
Published in
Frontiers in Pharmacology
Ethnobotanical knowledge is indispensable for the conservation of global biological integrity, and could provide irreplaceable clues for bioprospecting aiming at new food crops and medicines. This biocultural diversity requires a comprehensive documentation of such intellectual knowledge at local levels. However, without systematically capturing th...
