Higgins, Guy A. Silenieks, Leo B. MacMillan, Cam Thevarkunnel, Sandy Parachikova, Anna I. Mombereau, Cedric Lindgren, Hanna Bastlund, Jesper F.
Published in
Frontiers in Pharmacology
Amphetamine (AMP), methylphenidate (MPH), and atomoxetine (ATX) are approved treatments for ADHD, and together with nicotine (NIC), represent pharmacological agents widely studied on cognitive domains including attention and impulsive action in humans. These agents thus represent opportunities for clinical observation to be reinvestigated in the pr...
Xu, Fan Lv, Chun Deng, Yan Liu, Yuangui Gong, Qihai Shi, Jingshan Gao, Jianmei
Published in
Frontiers in Pharmacology
Background Ischemic stroke remains the leading cause of death and adult disability. Cerebral ischemic/reperfusion (I/R) injury is caused by ischemic stroke thereafter aggravates overwhelming neuronal apoptosis and even the death of neurons. Of note, hippocampus is more susceptive to cerebral I/R injury than the other brain region. This study was de...
Shen, Xi Hui, Rongji Luo, Yixiao Yu, Hailei Feng, Suiyuan Xie, Bing Bi, Haitao Galaj, Ewa Cong, Bin Ma, Chunling
...
Published in
Frontiers in Pharmacology
A high rate of relapse is a major clinical problem among drug-addicted individuals. Persistent traces of drug-associated reward memories contribute to intense craving and often trigger relapse. A number of interventions on drug-associated memories have shown significant benefits in relapse prevention. Among them are pre- or post-extinction pharmaco...
Chen, Guiling Ye, Yang Cheng, Ming Tao, Yi Zhang, Kejun Huang, Qiong Deng, Jingwen Yao, Danni Lu, Chuanjian Huang, Yu
...
Published in
Frontiers in Pharmacology
The beneficial effect of quercetin in rheumatic diseases is unclear. Studies have already confirmed that human umbilical cord mesenchymal stem cells (hUCMSCs) alleviate some symptoms of rheumatoid arthritis (RA) by their immunosuppressive capacities. This study explored whether there are additive effects of quercetin and hUCMSCs on peripheral blood...
Padhan, Bandana Panda, Debabrata
Published in
Frontiers in Pharmacology
Food and nutritional security are the major concerns in many countries of the world and may have potential to contribute to sustainable food systems under climate change. To address the food and nutritional insecurity, it has become extremely important to diversify the present-day agricultural system as well as to search for alternative food and fe...
Díaz-Castro, Francisco Monsalves-Álvarez, Matías Rojo, Leonel E. del Campo, Andrea Troncoso, Rodrigo
Published in
Frontiers in Pharmacology
A growing body of research indicates that cortisol, the glucocorticoid product of the activation of the hypothalamic-pituitary-adrenal axis, plays a role in the pathophysiology of metabolic syndrome. In this regard, chronic exposure to cortisol is associated with risk factors related to metabolic syndrome like weight gain, type 2 diabetes, hyperten...
Yuan, Zi-Qing-Yun Qiao, Chun Yang, Zhi-Cheng Yu, Lei Sun, Lu-Ning Qian, Yi Zhang, Xue-Hui Meng, Ling Zhang, Xiao-Yan Wang, Yong-Qing
...
Published in
Frontiers in Pharmacology
This study investigated voriconazole (VRC) unbound plasma concentration and its relationship with adverse drug reactions (ADRs) in patients with malignant hematologic disease. Plasma samples were collected from patients or spiked in vitro . A time-saving rapid equilibrium dialysis assay was used for the separation of unbound and bound VRC, followin...
Cao, Sisi Han, Yaoyao Li, Qiaofeng Chen, Yanjiang Zhu, Dan Su, Zhiheng Guo, Hongwei
Published in
Frontiers in Pharmacology
Considerable pharmacological studies have demonstrated that the extracts and ingredients from different parts (seeds, peels, pulps, and flowers) of Litchi exhibited anticancer effects by affecting the proliferation, apoptosis, autophagy, metastasis, chemotherapy and radiotherapy sensitivity, stemness, metabolism, angiogenesis, and immunity via mult...
Wei, Cheng-Yu Tzeng, I-Shiang Lin, Mei-Chen Yeh, Yung-Hsiang Hsu, Chung Y. Kung, Woon-Man
Published in
Frontiers in Pharmacology
Background Sulpiride is a highly selective dopamine D2 receptor antagonist and is commonly used in psychiatric disorders, Tourette syndrome, peptic ulcer disease (PUD), and gastroesophageal reflux disease (GERD). However, sulpiride has been recognized as a potential cause of drug-induced parkinsonism (DIP) for a long time. In this study, we aimed t...
Udawatte, Nadeeka S. Kang, Sung Wook Wang, Yue Arumugam, Thiruma V. Seneviratne, Chaminda J.
Published in
Frontiers in Pharmacology
Background and Purpose Candida albicans is the major fungal species associated with superficial mucosal infections such as oral candidiasis as well as systemic mycoses with high morbidity and mortality. On top of the rising drug resistance, currently available antifungal agents have significant adverse effects. Nephrotoxicity is the major treatment...
