Hou, Jinli Zhou, Xiang Wang, Ping Zhao, Chunhui Qin, Yuewen Liu, Feng Yu, Liping Xu, Haiyu
Published in
Frontiers in Pharmacology
Portulaca oleracea L. , known as the “vegetable for long life,” is an annual succulent herb that is widely distributed worldwide. Many clinical and experimental studies have demonstrated that purslane seed (MCXZ) can be used as an adjunctive and alternative therapy for the treatment of diabetes mellitus (DM). However, the underlying active constitu...
Wen, Xianghui Lou, Yu Song, Siyue He, Zhixing Chen, Juan Xie, Zhijun Shi, Xiaowei Wen, Chengping Shao, Tiejuan
Published in
Frontiers in Pharmacology
Qu-zhuo-tong-bi decoction (QZTBD) is a traditional Chinese medicine prescription used to treat hyperuricemia and gout with no obvious adverse effects. However, the mechanism by which QZTBD treats gout has not been fully explored. Here, we investigated the effects of QZTBD on gouty arthritis and its therapeutic mechanism from the perspective of the ...
Choida, Varvara Hall-Craggs, Margaret Jebson, Bethany R. Fisher, Corinne Leandro, Maria Wedderburn, Lucy R. Ciurtin, Coziana
Published in
Frontiers in Pharmacology
Background: Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory arthritis of childhood, characterized by various clinical phenotypes associated with variable prognosis. Significant progress has been achieved with the use of biologic treatments, which specifically block pro-inflammatory molecules involved in the disease patho...
Kumar, Ambrish Belhaj, Marwa DiPette, Donald J. Potts, Jay D.
Published in
Frontiers in Pharmacology
Background: α-CGRP (alpha-calcitonin gene related peptide) is a cardioprotective neuropeptide. Our recent study demonstrated that the administration of native α-CGRP, using osmotic mini-pumps, protected against transverse aortic constriction (TAC) pressure-induced heart failure in mice. However, the short half-life of peptides and the non-applicabi...
Kiang, Juliann G. Zhai, Min Lin, Bin Smith, Joan T. Anderson, Marsha N. Jiang, Suping
Published in
Frontiers in Pharmacology
Exposure to ionizing radiation (radiation injury, RI) in nuclear-related episode is evident to be life-threatening. RI occurs at levels of organs, tissues, cytosols, or nucleus. Their mechanisms are still not fully understood. FDA approves pegylated granulocyte colony-stimulating factor (Neulasta™, Peg-G-CSF) for acute hematopoietic syndrome and ha...
Zhou, Yao Gao, Leiping Xia, Ping Zhao, Jing Li, Wei Zhou, Yufeng Wei, Qingxue Wu, Qijing Wu, Qi Sun, Dongdong
...
Published in
Frontiers in Pharmacology
Background and Objective: The incidence of chronic kidney disease (CKD) is steadily increasing. Although renal tubular epithelium injury is closely correlated with the prognosis of CKD, the underlying mechanism is not fully understood and therapeutic strategies are limited. The main bioactive component of the Chinese medicine herb, glycyrrhiza, is ...
Herrera-Zelada, Nicolas Zuñiga-Cuevas, Ursula Ramirez-Reyes, Andres Lavandero, Sergio Riquelme, Jaime A.
Published in
Frontiers in Pharmacology
Despite considerable improvements in the treatment of myocardial infarction, it is still a highly prevalent disease worldwide. Novel therapeutic strategies to limit infarct size are required to protect myocardial function and thus, avoid heart failure progression. Cardioprotection is a research topic with significant achievements in the context of ...
Zhu, Ning Huang, Bingwu Jiang, Wenbing
Published in
Frontiers in Pharmacology
Vitamin C (ascorbic acid) is a nutrient used to treat cardiovascular disease (CVD). However, the pharmacological targets of vitamin C and the mechanisms underlying the therapeutic effects of vitamin C on CVD remain to be elucidated. In this study, we used network pharmacology approach to investigate the pharmacological mechanisms of vitamin C for t...
Yue, Er Yu, Yahan Wang, Xinyao Liu, Bing Bai, Yunlong Yang, Baofeng
Published in
Frontiers in Pharmacology
Diabetic cardiomyopathy (DCM) is one of the major causes of death in diabetic patients. Its pathogenesis involves inflammation and fibrosis that damages the heart tissue and impairs cardiac function. Interleukin (IL)-17, a pro-inflammatory cytokine that plays an important role in a variety of chronic inflammatory processes can serve as an attractiv...
Hossain Saad, Md Zubayer Xiang, Liuruimin Liao, Yan-Shin Reznikov, Leah R. Du, Jianyang
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Frontiers in Pharmacology
Transient receptor potential melastatin 3 channel (TRPM3) is a calcium-permeable nonselective cation channel that plays an important role in modulating glucose homeostasis in the pancreatic beta cells. However, how TRPM3 is regulated under physiological and pathological conditions is poorly understood. In this study, we found that both intracellula...
