Chen, Zuhua Yuan, Jiajia Xu, Yingying Zhang, Cheng Li, Zhongwu Gong, Jifang Li, Yanyan Shen, Lin Gao, Jing
Published in
Frontiers in Pharmacology
RC48-ADC is a novel humanized antibody specific for human epidermal growth factor receptor 2 (HER2)in conjugation with a microtubule inhibitor via a cleavable linker. This study was to evaluate the antitumor activity and mechanism of RC48-ADC in gastric cancer (GC) and explore the population that may benefit from RC48-ADC treatment. Four human GC c...
Zou, Yonghui Xu, Yi Chen, Xiaofeng Wu, Yaoqi Fu, Longsheng Lv, Yanni
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Frontiers in Pharmacology
Leucine-rich alpha⁃2 glycoprotein 1 (LRG1) is an important member of the leucine-rich repetitive sequence protein family. LRG1 was mainly involved in normal physiological activities of the nervous system, such as synapse formation, synapse growth, the development of nerve processes, neurotransmitter transfer and release, and cell adhesion molecules...
Wang, Cheng Dai, Shu Gong, Lihong Fu, Ke Ma, Cheng Liu, Yanfang Zhou, Honglin Li, Yunxia
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Frontiers in Pharmacology
Polygonum multiflorum Thunb. (He-shou-wu in Chinese), a Chinese botanical drug with a long history, is widely used to treat a variety of chronic diseases in clinic, and has been given the reputation of “rejuvenating and prolonging life” in many places. 2,3,4′,5-tetrahydroxystilbene-2-O-β-D-glucoside (TSG, C20H22O9) is the main and unique active ing...
Shen, Hao Zhang, Nu Liu, Yuqing Yang, Xuerong He, Yuanyuan Li, Qi Shen, Xiaoyan Zhu, Yulian Yang, Yong
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Frontiers in Pharmacology
COVID-19 is a highly contagious respiratory disease, which mainly affects the lungs. Critically ill patients are easily complicated by cytokine storms, acute respiratory distress syndrome (ARDS), and respiratory failure, which seriously threaten their lives. Pulmonary fibrosis (PF) is a common interstitial lung disease, and its pathogenesis may inv...
Gan, Donghao Cheng, Wenxiang Ke, Liqing Sun, Antonia RuJia Jia, Qingyun Chen, Jianhai Xu, Zhanwang Xu, Juan Zhang, Peng
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Frontiers in Pharmacology
Pirfenidone (PFD), a synthetic arsenic compound, has been found to inhibit angiogenesis at high concentrations. However, the biphasic effects of different PFD concentrations on angiogenesis have not yet been elucidated, and the present study used an in vitro model to explore the mechanisms underlying this biphasic response. The effect of PFD on the...
Borroto-Escuela, Dasiel O. Ferraro, Luca Fuxe, Kjell
Published in
Frontiers in Pharmacology
Wu, Kang Zeng, Jun Shi, Xulian Xie, Jiajia Li, Yuqing Zheng, Haoxiang Peng, Guoyu Zhu, Guanghui Tang, Dongdong Wu, Song
...
Published in
Frontiers in Pharmacology
Bladder cancer is a highly metastatic tumor and one of the most common malignancies originating in the urinary tract. Despite the efficacy of immune checkpoints, including programmed cell death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), the effect of immunotherapy for bladder cancer remains unsatisfactory. Therefore, it is u...
Morren, Marie-Anne Legius, Eric Giuliano, Fabienne Hadj-Rabia, Smail Hohl, Daniel Bodemer, Christine
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Frontiers in Pharmacology
Genodermatoses are rare inherited skin diseases that frequently affect other organs. They often have marked effects on wellbeing and may cause early death. Progress in molecular genetics and translational research has unravelled many underlying pathological mechanisms, and in several disorders with high unmet need, has opened the way for the introd...
Rong, Qingfeng Han, Baosheng Li, Yafeng Yin, Haizhen Li, Jing Hou, Yanjuan
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Frontiers in Pharmacology
Abnormal lipid metabolism in renal tubular epithelial cells contributes to renal lipid accumulation and disturbed mitochondrial bioenergetics which are important in diabetic kidney disease. Berberine, the major active constituent of Rhizoma coptidis and Cortex phellodendri, is involved in regulating glucose and lipid metabolism. The present study a...
Wang, Feng Ning, Shuo Yu, Beiming Wang, Yanfeng
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Frontiers in Pharmacology
Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated with proteasomes and exerts a dual function in regulating protein degradation. USP14 protects protein substrates from degradation by removing ubiquitin chains from proteasome-bound substrates, whereas promotes protein degradation by activating the proteasome. Inc...
