Casotti, Chiara Hattinger, Claudia Maria Patrizio, Maria Pia Luppi, Silvia Fantoni, Leonardo Pasello, Michela Scotlandi, Katia Ibrahim, Toni Serra, Massimo
Published in
Frontiers in Pharmacology
Introduction: Methotrexate (MTX) is one of the most important drugs included in the first-line protocols to treat high-grade osteosarcoma (HGOS). Although several polymorphisms have been reported to be associated with drug response or MTX-related toxicity in pharmacogenetic studies, their role in the development of MTX resistance in HGOS is still u...
Zhong, Fangmin Jiang, Junyao Yao, Fang-Yi Liu, Jing Shuai, Xu Wang, Xin-Lu Huang, Bo Wang, Xiaozhong
Published in
Frontiers in Pharmacology
Background: Disulfidptosis is a metabolically relevant mode of cell death, and its relationship with acute myeloid leukemia (AML) has not been clarified. In this study, disulfidptosis scores were computed to examine the potential biological mechanisms. Methods: Consensus clustering was applied to detect disulfidptosis-related molecular subtypes. Th...
Chang, Wenguang Li, Wei Li, Peifeng
Published in
Frontiers in Pharmacology
Type 2 diabetes (T2D) is a metabolic disease with complex etiology and mechanisms. Long non-coding ribonucleic acid (LncRNA) is a novel class of functional long RNA molecules that regulate multiple biological functions through various mechanisms. Studies in the past decade have shown that lncRNAs may play an important role in regulating insulin res...
Puthanveetil, Prasanth Al-Nakkash, Layla Lampejo, Arinola O. Murfee, Walter L.
Published in
Frontiers in Pharmacology
Xia, Wanru Li, Shuqian Li, LinZehao Zhang, Shibo Wang, Xiaolei Ding, Wenyu Ding, Lina Zhang, Xiandang Wang, Zhibin
Published in
Frontiers in Pharmacology
Fendt, Rebekka Ghallab, Ahmed Myllys, Maiju Hofmann, Ute Hassan, Reham Hobloss, Zaynab González, Daniela Brackhagen, Lisa Marchan, Rosemarie Edlund, Karolina
...
Published in
Frontiers in Pharmacology
Rationale: Liver cirrhosis is known to affect drug pharmacokinetics, but the functional assessment of the underlying pathophysiological alterations in drug metabolism is difficult. Methods: Cirrhosis in mice was induced by repeated treatment with carbon tetrachloride for 12 months. A cocktail of six drugs was administered, and parent compounds as w...
Wang, Chengcheng He, Zheng
Published in
Frontiers in Pharmacology
Objective: Epithelial-mesenchymal transition (EMT) is a tightly regulated and dynamic process occurring in both embryonic development and tumor progression. Our study aimed to comprehensively explore the molecular subtypes, immune landscape, and prognostic signature based on EMT-related genes in low-grade gliomas (LGG) in order to facilitate treatm...
Li, Jun Peng, Sisi Yan, Ying Yan, Shan Cao, Xin Li, Yong Zhu, Luying Xu, Jie
Published in
Frontiers in Pharmacology
Background: The temporomandibular joint is often afflicted by osteoarthritis (TMJOA), causing pain and dysfunction, which is particularly prevalent in the elderly population. IL-37 is effective in avoiding excessive inflammatory damage to the organism. This article investigates the role and mechanism of intracellular IL-37 in TMJOA. Methods: Enzyme...
Silva, Joana Alvariño, Rebeca Goettert, Márcia I. Caruncho, Hector J. Alves, Celso
Published in
Frontiers in Pharmacology
Hader, Helena Hering, Nina A. Schulzke, Jörg-Dieter Bücker, Roland Rosenthal, Rita
Published in
Frontiers in Pharmacology
The oleoresin myrrh has been used for centuries as an anti-inflammatory remedy for a variety of diseases and is said to have a protective effect on the intestinal epithelium. An intact epithelial barrier function is the prerequisite for a healthy gut. Inflammatory and infectious diseases of the intestine, in particular, lead to barrier impairment r...
