Shi, Yueyue Tian, Chongmei Yu, Xinfen Fang, Yuejuan Zhao, Xinyu Zhang, Xiaoxi Xia, Daozong
Published in
Frontiers in Pharmacology
Lead (Pb) is an important environmental pollutant. Oxidative stress and the inflammatory response have been postulated as mechanisms involved in lead-induced renal damage. Smilax glabra Roxb. has been used for treatment of heavy-metal poisoning in China for 500 years. We investigated S. glabra flavonoids extract (SGF) could attenuate lead acetate-i...
Mushtaq, Saima Akhter, Tayyab Saeed Khan, Amjad Sohail, Aamir Khan, Arshad Manzoor, Sobia
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Frontiers in Pharmacology
Background Direct-acting antivirals (DAAs) therapeutic regimens are highly effective against chronic hepatitis C virus (HCV) infection. However, HCV patients with genotype 3 (GT3) respond in a suboptimal way. This study aims to identify which of the DAAs-based therapeutic regimens are the best option for GT3. Methods Multiple governments and privat...
Briottet, Maelle Shum, Mickael Urbach, Valerie
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Frontiers in Pharmacology
Cystic Fibrosis (CF) is a recessive genetic disease due to mutations of the Cystic Fibrosis Transmembrane Conductance Regulator ( CFTR ) gene encoding the CFTR chloride channel. The ion transport abnormalities related to CFTR mutation generate a dehydrated airway surface liquid (ASL) layer, which is responsible for an altered mucociliary clearance,...
Zhang, Jinyu Miller, Zachary Musich, Phillip R. Thomas, Ashlin E. Yao, Zhi Q. Xie, Qian Howe, Philip H. Jiang, Yong
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Frontiers in Pharmacology
Objective Tumor metastasis and resistance to chemotherapy are two critical factors that contribute to the high death rate of colorectal cancer (CRC) patients. Metastasis is facilitated by the epithelial-mesenchymal transition (EMT) of tumor cells, which has emerged not only as a fundamental process during metastasis, but is also a key process leadi...
Zhao, Fan Tao, Weiwei Shang, Zhiyuan Zhang, Weihua Ruan, Jie Zhang, Chenyiyu Zhou, Liping Aiello, Hunter Lai, Hezheng Qu, Rong
...
Published in
Frontiers in Pharmacology
Baicalin isolated from Scutellaria baicalensis possesses antidepressant abilities through its relation to hippocampal neurogenesis. Current research has found that baicalin can promote the proliferation of hippocampal granule cells, however, the detailed mechanism of baicalin on the survival and maturation of hippocampal granule cells has yet to be...
Johnston, Jenessa N. Thacker, Jonathan S. Desjardins, Charissa Kulyk, Brian D. Romay-Tallon, Raquel Kalynchuk, Lisa E. Caruncho, Hector J.
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Frontiers in Pharmacology
Depression is the leading cause of disability worldwide, which necessitates novel therapeutics and biomarkers to approach treatment of this neuropsychiatric disorder. To assess potential mechanisms underlying the fast-acting antidepressant actions of ketamine we used a repeated corticosterone paradigm in adult male rats to assess the effects of ket...
Wang, Wenjun Huang, Lu Thomas, Elizabeth Rosalind Hu, Yingying Zeng, Fancai Li, Xiang
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Frontiers in Pharmacology
Acrylamide (ACR) is a common chemical used in various industries and it said to have chronic neurotoxic effects. It is produced during tobacco smoking and is also generated in high-starch foods during heat processing. Notoginsenoside R1 (NR1) is a traditional Chinese medicine, which is used to improve the blood circulation and clotting. The objecti...
Luo, Chang-yong Li, Yan Li, Xin Liang, Xu Wang, Qian Ma, Yuan-hong Xiong, Cai-hua Zeng, Yan-peng Sun, Wei Wang, Xin
...
Published in
Frontiers in Pharmacology
Background To study the effect of Yiqi Huayu Jiedu Decoction (YQHYJD) on protein expression in the lung tissue of acute respiratory distress syndrome (ARDS) rats and to explore the underlying molecular therapeutic mechanism of YQHYJD. Methods Sprague Dawley rats were administered with YQHYJD by oral gavage for 1 week. The rats were injected with li...
Chen, Xing Li, Yang Xiao, Jie Zhang, Hua Yang, Chuanlei Wei, Zhanjie Chen, Weiqiang Du, Xinling Liu, Jinping
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Frontiers in Pharmacology
The development of abdominal aortic aneurysm (AAA) is attributed to psychological and physical factors. Topiramate, which is an agonist of the GABAA receptor, makes contributions to neuronal disease and is partially involved in immune regulation, may be effective upon abdominal aortic aneurysm progression. We used experimental abdominal aortic aneu...
Schoot, Tessa S. Kerckhoffs, Angèle P. M. Hilbrands, Luuk B. van Marum, Rob J.
Published in
Frontiers in Pharmacology
Background Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is currently unknown whether immunosuppressive drugs are advantageous or detrimental in patients with COVID-19. Immunosuppressive drugs could be harmful in the initial phase of COVID-19. In this phase, the host immune respons...
