Zhang, Xiuying Chen, Qilei Zhao, Jia Zhao, Wei Fan, Ni Wang, Yu Chen, Hubiao Rong, Jianhui
Published in
Frontiers in Pharmacology
Myocardial infarction (MI) is a highly prevalent and lethal disease worldwide. Prevention and timely recovery are critical for the control of the recurrence and heart failure in MI survivors. The present study was designed to investigate the cardioprotective activity of the herbal medicine formula Baoyuan Decoction (BYD) and identify the active com...
Zhang, Xiaoli Ma, Yiming Lv, Guoqing Wang, Hongying
Published in
Frontiers in Pharmacology
Ferroptosis is an iron-dependent programmed cell death characterized by reactive oxygen species-induced lipid peroxidation and resultant membrane damage. Recent research has elucidated the mechanism of ferroptosis and investigated the relationship between ferroptosis and various diseases, including degenerative diseases, cancer, and inflammation. F...
Shao, Ruifei Li, Wei Chen, Rui Li, Kunlin Cao, Yu Chen, Guobing Jiang, Lihong
Published in
Frontiers in Pharmacology
Sepsis-induced cardiomyopathy (SIC) is an important manifestation of sepsis, and abnormal cardiac function affects the development of sepsis. Notoginsenoside R1 (NG-R1) is a unique bioactive component of Panax notoginseng with anti-inflammatory and antioxidant effects. However, the effects and possible mechanisms of NG-R1 on SIC are not clear. The ...
Xu, Chunmei Miao, Huikai Chen, Xiaoxuan Zhang, Haiqing
Published in
Frontiers in Pharmacology
Background: Diabetic kidney disease (DKD) becomes the leading cause of death for end-stage renal disease, whereas the potential mechanism is unclear and effective therapy is still rare. Our study was designed to investigate the cellular mechanism of Forsythiaside against DKD. Materials and Methods: The targets of Forsythiaside and the DKD-related t...
Yao, Guangzhe Miao, Xinxin Wu, Mengxuan Lv, Zhenguo Bai, Yu Chang, Yanxu Ouyang, Huizi He, Jun
Published in
Frontiers in Pharmacology
Terminalia chebula Retz. (TC) is a well-known Chinese herbal medicine and rich in chemical components with multiple pharmacological effects. In this study, an ultra-performance liquid chromatography-tandem mass spectroscopy (UPLC-MS/MS) method was developed and used to determine the blood concentrations of nine active compounds (chebulic acid, gall...
Liao, Yanfang Wang, Xue Huang, Liting Qian, Hu Liu, Wei
Published in
Frontiers in Pharmacology
Neurodegenerative diseases (NDs) are disorders characterized by degenerative degeneration of neurons and loss of their function. NDs have a complicated pathophysiology, of which neuroinflammation and neuronal death are significant factors. The inflammatory process known as pyroptosis (“fiery death”) is caused by a family of pore-forming proteins ca...
Li, Lili Qu, Jianye Song, Ming Zhao, Qun Yang, Yonghua Tan, Xi Hu, Yanyan Li, Jing Lin, Yunfei Feng, Hui
...
Published in
Frontiers in Pharmacology
Introduction: Flat dosing regimen has recently been approved for programmed death receptor-1 (PD-1) inhibitors including toripalimab, nivolumab and pembrolizumab. The objective of this study is to provide pharmacological evidence for a flat dosing regimen of toripalimab by assessing the efficacy and safety profile of a 240 mg Q3W flat dose relative...
Hughes, Tessa Dijkstra, Krijn K. Rawlins, Emma L. Hynds, Robert E.
Published in
Frontiers in Pharmacology
Organoids have become a prominent model system in pulmonary research. The ability to establish organoid cultures directly from patient tissue has expanded the repertoire of physiologically relevant preclinical model systems. In addition to their derivation from adult lung stem/progenitor cells, lung organoids can be derived from fetal tissue or ind...
Qin, Manman Qian, Yuqing Huang, Lu Zhong, Chao Li, Mingdong Yu, Jun Chen, Huanwen
Published in
Frontiers in Pharmacology
Extraction electrospray ionization mass spectrometry (EESI-MS), due to the unique configuration of its ionization module, enables the effective ionization of trace molecules of interest in samples containing complex matrices with high sensitivity, high selectivity and high responding speed without requiring sample pretreatment, and allows high-ener...
Li, Ruichen Yan, Li Tian, Shu Zhao, Yang Zhu, Yi Wang, Xiaoshen
Published in
Frontiers in Pharmacology
Background: There is an urgent need to identify which patients would benefit from TPF chemotherapy in hypopharyngeal squamous cell carcinoma (HPSCC) and to explore new combinations to improve the treatment effect. Materials and methods: Gene-expression profiles in 15 TPF-sensitive patients were compared to 13 resistant patients. Immunohistochemistr...
