de Kort, Anne R. Joosten, Elbert A. Patijn, Jacob Tibboel, Dick van den Hoogen, Nynke J.
Published in
Frontiers in Pain Research
Neonatal painful procedures causes acute pain and trigger long-term changes in nociceptive processing and anxiety behavior, highlighting the need for adequate analgesia during this critical time. Spinal serotonergic receptors 5-HT1a and 5-HT3 play an important role in modulating incoming nociceptive signals in neonates. The current study aims to at...
Finlay, Katherine A. Madhani, Adam Anil, Krithika Peacock, Sue M.
Published in
Frontiers in Pain Research
Objectives Social support is most positively perceived when there is an optimal match between a patient's need for communication and the purpose of their interaction. Maladaptive communication patterns may inhibit social bonding or mutual support, negatively impacting clinical outcomes. This study aimed to identify how people with chronic pain natu...
Naugle, Kelly M. Blythe, Corinthian Naugle, Keith E. Keith, NiCole Riley, Zachary A.
Published in
Frontiers in Pain Research
Advanced aging is associated with a general decline in physical function and physical activity. The current evidence suggests that pain-related fear of movement (i.e., kinesiophobia) is increased in the general older adult population and impacts physical activity levels in patients with chronic pain. However, whether kinesiophobia could impact phys...
Hartrick, Craig T.
Published in
Frontiers in Pain Research
Wang, Mengya Duong, Thomas L. Rea, Brandon J. Waite, Jayme S. Huebner, Michael W. Flinn, Harold C. Russo, Andrew F. Sowers, Levi P.
Published in
Frontiers in Pain Research
The neuropeptide calcitonin gene-related peptide (CGRP) is a major player in migraine pathophysiology. Previous preclinical studies demonstrated that intracerebroventricular administration of CGRP caused migraine-like behaviors in mice, but the sites of action in the brain remain unidentified. The cerebellum has the most CGRP binding sites in the c...
Harvey, Marie-Philippe Martel, Marylie Houde, Francis Daguet, Inès Riesco, Eléonor Léonard, Guillaume
Published in
Frontiers in Pain Research
Introduction Chronic pain is a significant health problem and is particularly prevalent amongst the elderly. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that has been proposed to reduce chronic pain. The aim of this study was to evaluate and compare the efficacy of active and sham tDCS in reducing pa...
Yang, Xiayin Li, Xuefen Lai, Mengying Wang, Jincui Tan, Shaoying Chan, Henry Ho-lung
Published in
Frontiers in Pain Research
Signs and symptoms of optic neuritis (ON), an autoimmune disorder of the central nervous system (CNS), differ between patients. Pain, which is commonly reported by ON patients, may be the major reason for some patients to visit the clinic. This article reviews the presence of pain related to ON with respect to underlying disorders, including multip...
You, Dokyoung S. Ziadni, Maisa S. Hettie, Gabrielle Darnall, Beth D. Cook, Karon F. Von Korff, Michael R. Mackey, Sean C.
Published in
Frontiers in Pain Research
High impact chronic pain (HICP) is a recently proposed concept for treatment stratifying patients with chronic pain and monitoring their progress. The goal is to reduce the impact of chronic pain on the individual, their family, and society. The US National Pain Strategy defined HICP as the chronic pain associated with substantial restrictions on p...
Tiwari, Siddharth R. Vigotsky, Andrew D. Apkarian, A. Vania
Published in
Frontiers in Pain Research
Previous research reports suggest greater baseline variability is associated with greater pain relief in those who receive a placebo. However, studies that evidence this association do not control for confounding effects from regression to the mean and natural history. In this report, we analyzed data from two randomized clinical trials (Placebo I ...
Kagan, Mackenzie Shea Mongerson, Chandler R. L. Zurakowski, David Bajic, Dusica
Published in
Frontiers in Pain Research
Previously, we reported quantitatively smaller total corpus callosum (CC) and total forebrain size in critically ill term-born and premature patients following complex perioperative critical care for long-gap esophageal atresia (LGEA) that included Foker process repair. We extended our cross-sectional pilot study to determine sub-regional volumes o...
