Leflunomide combined with low-dose prednisone inhibits proinflammatory T cells responses in myasthenia gravis patients
Published in Frontiers in Neurology
Leflunomide combined with low-dose prednisone inhibits proinflammatory T cells responses in myasthenia gravis patients
Feasibility and usability of a digital health technology system to monitor mobility and assess medication adherence in m...
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Published in Frontiers in Neurology
Introduction Parkinson's disease (PD) is a neurodegenerative disorder which requires complex medication regimens to mitigate motor symptoms. The use of digital health technology systems (DHTSs) to collect mobility and medication data provides an opportunity to objectively quantify the effect of medication on motor performance during day-to-day acti...
Clinical features and prognosis of pediatric idiopathic sudden sensorineural hearing loss: A bi-center retrospective stu...
Published in Frontiers in Neurology
Objective Limited research has focused on the clinical features of sudden sensorineural hearing loss (SSNHL) in pediatric patients. This study is aimed to investigate the relationship between clinical features and the baseline hearing severity and outcomes of SSNHL in the pediatric population. Method We conducted a bi-center retrospective observati...
Transcriptome analyses of the cortex and white matter of focal cortical dysplasia type II: Insights into pathophysiology...
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Published in Frontiers in Neurology
Introduction Focal cortical dysplasia (FCD) is a common cause of pharmacoresistant epilepsy. According to the 2022 International League Against Epilepsy classification, FCD type II is characterized by dysmorphic neurons (IIa and IIb) and may be associated with balloon cells (IIb). We present a multicentric study to evaluate the transcriptomes of th...
Implications of quantitative susceptibility mapping at 7 Tesla MRI for microbleeds detection in cerebral small vessel di...
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Published in Frontiers in Neurology
Background Cerebral microbleeds (MBs) are a hallmark of cerebral small vessel disease (CSVD) and can be found on T2*-weighted sequences on MRI. Quantitative susceptibility mapping (QSM) is a postprocessing method that also enables MBs identification and furthermore allows to differentiate them from calcifications. Aims We explored the implications ...
Effectiveness and safety of monoclonal antibodies against amyloid-beta vis-à-vis placebo in mild or moderate Alzheimer's...
Published in Frontiers in Neurology
Backgrounds and objectives Currently, no consensus has been reached on the therapeutic implications of monoclonal antibodies against amyloid-beta (Aβ) in Alzheimer's disease (AD). This study aimed to examine the effectiveness and safety of monoclonal antibodies against Aβ as a whole and also to determine the superiority of individual antibodies vis...
Selective brain and heart hypothermia - A path toward targeted organ resuscitation and protection
Published in Frontiers in Neurology
Distinct cortico-muscular coupling between step and stance leg during reactive stepping responses
Published in Frontiers in Neurology
Balance recovery often relies on successful stepping responses, which presumably require precise and rapid interactions between the cerebral cortex and the leg muscles. Yet, little is known about how cortico-muscular coupling (CMC) supports the execution of reactive stepping. We conducted an exploratory analysis investigating time-dependent CMC wit...
Sodium valproate-induced nocturnal enuresis in epilepsy: Three case reports and a review of the literature
Published in Frontiers in Neurology
Background Enuresis is an uncommon adverse effect of sodium valproate therapy that is unknown to most clinicians. This study provides an overview of the literature on enuresis associated with sodium valproate therapy, discussing the clinical manifestations and possible mechanisms of this side effect. Methods We reported three cases of enuresis indu...
Differences in clinical and biological factors between patients with PFO-related stroke and patients with PFO and no cer...
Published in Frontiers in Neurology
Background While stroke is one of the most dissected topics in neurology, the primary prevention of PFO-related stroke in young patients is still an unaddressed subject. We present a study concerning clinical, demographic, and laboratory factors associated with stroke and transient ischemic attack in patients with patent foramen ovale (PFO), as wel...
