Ikeda, Masaki Okamoto, Koichi Suzuki, Keiji Takai, Eriko Kasahara, Hiroo Furuta, Natsumi Furuta, Minori Tashiro, Yuichi Shimizu, Chisato Takatama, Shin
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Published in
Frontiers in Neurology
In Alzheimer's disease, the apolipoprotein E gene (APOE) ε2 allele is a protective genetic factor, whereas the APOE ε4 allele is a genetic risk factor. However, both the APOE ε2 and the APOE ε4 alleles are genetic risk factors for lobar intracerebral hemorrhage. The reasons for the high prevalence of lobar intracerebral hemorrhage and the low preva...
Zhang, Ying Zhou, Junyi Gehl, Carissa R. Long, Jeffrey D. Johnson, Hans Magnotta, Vincent A. Sewell, Daniel Shannon, Kathleen Paulsen, Jane S.
Published in
Frontiers in Neurology
As one of the clinical triad in Huntington's disease (HD), cognitive impairment has not been widely accepted as a disease stage indicator in HD literature. This work aims to study cognitive impairment thoroughly for prodromal HD individuals with the data from a 12-year observational study to determine whether Mild Cognitive Impairment (MCI) in HD g...
Jaramillo-Jimenez, Alberto Giil, Lasse M. Tovar-Rios, Diego A. Borda, Miguel Germán Ferreira, Daniel Brønnick, Kolbjørn Oppedal, Ketil Aarsland, Dag
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Frontiers in Neurology
Introduction: The amygdala is implicated in psychiatric illness. Even as the amygdala undergoes significant atrophy in mild dementia, amygdala volume is underexplored as a risk factor for neuropsychiatric symptoms (NPS). Objective: To analyze the association between baseline amygdala volume and the longitudinal trajectories of NPS and cognitive dec...
Legati, Andrea Giacopuzzi, Edoardo Spinazzi, Marco Lek, Monkol
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Frontiers in Neurology
Custodio, Nilton Montesinos, Rosa Diaz, Monica M. Herrera-Perez, Eder Chavez, Kristhy Alva-Diaz, Carlos Reynoso-Guzman, Willyams Pintado-Caipa, Maritza Cuenca, José Gamboa, Carlos
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Published in
Frontiers in Neurology
Background: The accurate diagnosis of neurocognitive disorders in illiterate Peruvian populations is challenging, largely owing to scarcity of brief cognitive screening tools (BCST) validated in these diverse populations. The Peruvian version of the Rowland Universal Dementia Assessment Scale (RUDAS-PE) is a BCST that relies minimally on educationa...
Piña-Escudero, Stefanie Danielle Aguirre, Gloria Annette Javandel, Shireen Longoria-Ibarrola, Erika Mariana
Published in
Frontiers in Neurology
Latin America is a vast heterogeneous territory where chronic diseases such as mild cognitive impairment or dementia are becoming higher. Frontotemporal dementia (FTD) prevalence in this region is estimated to be around 12–18 cases per thousand persons. However, this prevalence is underestimated given the lack of awareness of FTD even among healthc...
Dzator, Jemima S. A. Howe, Peter R. C. Griffiths, Lyn R. Coupland, Kirsten G. Wong, Rachel H. X.
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Frontiers in Neurology
Background: Migraineurs, particularly young premenopausal women, are at increased risk of cerebrovascular disease; however, there is currently limited evidence as to whether hormonal migraine is associated with poor cerebrovascular function. Objectives: The objectives of this study were to: (1) investigate the potential association of cerebrovascul...
Sechi, Elia Flanagan, Eoin P.
Published in
Frontiers in Neurology
Antibody-mediated disorders of the central nervous system (CNS) are increasingly recognized as neurologic disorders that can be severe and even life-threatening but with the potential for reversibility with appropriate treatment. The expanding spectrum of newly identified autoantibodies targeting glial or neuronal (neural) antigens and associated c...
Fang, Xi Liu, Hong-Yun Wang, Zhi-Yan Yang, Zhao Cheng, Tung-Yang Hu, Chun-Hua Hao, Hong-Wei Meng, Fan-Gang Guan, Yu-Guang Ma, Yan-Shan
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Published in
Frontiers in Neurology
Objective: Vagus nerve stimulation (VNS) is an adjunctive and well-established treatment for patients with drug-resistant epilepsy (DRE). However, it is still difficult to identify patients who may benefit from VNS surgery. Our study aims to propose a VNS outcome prediction model based on machine learning with multidimensional preoperative heart ra...
Magrath Guimet, Nahuel Miller, Bruce L. Allegri, Ricardo F. Rankin, Katherine P.
Published in
Frontiers in Neurology
Behavioral variant frontotemporal dementia, unlike other forms of dementia, is primarily characterized by changes in behavior, personality, and language, with disinhibition being one of its core symptoms. However, because there is no single definition that captures the totality of behavioral symptoms observed in these patients, disinhibition is an ...
