Hitrec, Timna Squarcio, Fabio Cerri, Matteo Martelli, Davide Occhinegro, Alessandra Piscitiello, Emiliana Tupone, Domenico Amici, Roberto Luppi, Marco
Published in
Frontiers in Neuroanatomy
Tau is a key protein in neurons, where it affects the dynamics of the microtubule system. The hyperphosphorylation of Tau (PP-Tau) commonly leads to the formation of neurofibrillary tangles, as it occurs in tauopathies, a group of neurodegenerative diseases, including Alzheimer's. Hypothermia-related accumulation of PP-Tau has been described in hib...
Ponte, Giovanna Taite, Morag Borrelli, Luciana Tarallo, Andrea Allcock, A. Louise Fiorito, Graziano
Published in
Frontiers in Neuroanatomy
Here we analyze existing quantitative data available for cephalopod brains based on classical contributions by J.Z. Young and colleagues, to cite some. We relate the relative brain size of selected regions (area and/or lobe), with behavior, life history, ecology and distribution of several cephalopod species here considered. After hierarchical clus...
Latini, Francesco Trevisi, Gianluca Fahlström, Markus Jemstedt, Malin Alberius Munkhammar, Åsa Zetterling, Maria Hesselager, Göran Ryttlefors, Mats
Published in
Frontiers in Neuroanatomy
The middle longitudinal fascicle (MdLF) is a long, associative white matter tract connecting the superior temporal gyrus (STG) with the parietal and occipital lobe. Previous studies show different cortical terminations, and a possible segmentation pattern of the tract. In this study, we performed a post-mortem white matter dissection of 12 human he...
Reissig, Lukas F. Seyedian Moghaddam, Atieh Prin, Fabrice Wilson, Robert Galli, Antonella Tudor, Catherine White, Jaqueline K. Geyer, Stefan H. Mohun, Timothy J. Weninger, Wolfgang J.
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Published in
Frontiers in Neuroanatomy
An essential step in researching human central nervous system (CNS) disorders is the search for appropriate mouse models that can be used to investigate both genetic and environmental factors underlying the etiology of such conditions. Identification of murine models relies upon detailed pre- and post-natal phenotyping since profound defects are no...
Hu, Tianyu Xu, Xiaofeng Chen, Shangbin Liu, Qian
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Frontiers in Neuroanatomy
Neuronal soma segmentation is a crucial step for the quantitative analysis of neuronal morphology. Automated neuronal soma segmentation methods have opened up the opportunity to improve the time-consuming manual labeling required during the neuronal soma morphology reconstruction for large-scale images. However, the presence of touching neuronal so...
Pan, Huijun Zhang, Shen Pan, Deng Ye, Zheng Yu, Hao Ding, Jian Wang, Qin Sun, Qingyan Hua, Tianmiao
Published in
Frontiers in Neuroanatomy
Previous studies indicate that top-down influence plays a critical role in visual information processing and perceptual detection. However, the substrate that carries top-down influence remains poorly understood. Using a combined technique of retrograde neuronal tracing and immunofluorescent double labeling, we characterized the distribution and ce...
Bitschi, Maya-Lena Bagó, Zoltán Rosati, Marco Reese, Sven Goehring, Lutz S. Matiasek, Kaspar
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Frontiers in Neuroanatomy
Introduction of new imaging modalities for the equine brain have refocused attention on the horse as a natural model for ethological, neuroanatomical, and neuroscientific investigations. As opposed to imaging studies, strategies for equine neurodissection still lack a structured approach, standardization and reproducibility. In contrast to other sp...
Tsai, Shin-Hwa Tsao, Chih-Yu Lee, Li-Jen
Published in
Frontiers in Neuroanatomy
Increased white matter neuron density has been associated with neuropsychiatric disorders including schizophrenia. However, the pathogenic features of these neurons are still largely unknown. Subplate neurons, the earliest generated neurons in the developing cortex have also been associated with schizophrenia and autism. The link between these neur...
Tomasi, Santino Ottavio Umana, Giuseppe Emmanuele Scalia, Gianluca Rubio-Rodriguez, Roberto Luis Cappai, Pier Francesco Capone, Crescenzo Raudino, Giuseppe Chaurasia, Bipin Salvati, Maurizio Jorden, Nicolas
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Published in
Frontiers in Neuroanatomy
Modern neurosurgery uses preoperative imaging daily. Three-dimensional reconstruction of the cortical anatomy and of the superficial veins helps the surgeons plan and perform neurosurgical procedures much more safely. The target is always to give the patient maximum benefit in terms of outcome and minimize intraoperative and postoperative complicat...
Morigaki, Ryoma Lee, Jannifer H. Yoshida, Tomoko Wüthrich, Christian Hu, Dan Crittenden, Jill R. Friedman, Alexander Kubota, Yasuo Graybiel, Ann M.
Published in
Frontiers in Neuroanatomy
The striatum of humans and other mammals is divided into macroscopic compartments made up of a labyrinthine striosome compartment embedded in a much larger surrounding matrix compartment. Anatomical and snRNA-Seq studies of the Huntington’s disease (HD) postmortem striatum suggest a preferential decline of some striosomal markers, and mRNAs studies...