Sun, Lihao Ohashi, Nobuhiko Mori, Takuma Mizuno, Yuka Zang, Weichen Guo, Qi Kouyama-Suzuki, Emi Shirai, Yoshinori Tabuchi, Katsuhiko
Published in
Frontiers in Neural Circuits
Introduction Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social interaction and communication, along with restricted and repetitive behaviors. Both genetic and environmental factors contribute to ASD, with prenatal exposure to valproic acid (VPA) and nicotine being linked to increased risk. Impaired...
Rozov, Andrei Fedulina, Anastasia Krut’, Viktoriya Sokolov, Rostislav Sulimova, Arina Jappy, David
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Frontiers in Neural Circuits
According to the World Health Organization, the number of people suffering from depressive disorders worldwide is approaching 350 million. The consequences of depressive disorders include considerable worsening of the quality of life, which frequently leads to social isolation. One of the key factors which may cause depression in adulthood is early...
Drebitz, Eric Rausch, Lukas-Paul Domingo Gil, Esperanza Kreiter, Andreas K.
Published in
Frontiers in Neural Circuits
Introduction A fundamental property of the neocortex is its columnar organization in many species. Generally, neurons of the same column share stimulus preferences and have strong anatomical connections across layers. These features suggest that neurons within a column operate as one unified network. Other features, like the different patterns of i...
Uchigashima, Motokazu Mikuni, Takayasu
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Frontiers in Neural Circuits
Our brain adapts to the environment by optimizing its function through experience-dependent cortical plasticity. This plasticity is transiently enhanced during a developmental stage, known as the “critical period,” and subsequently maintained at lower levels throughout adulthood. Thus, understanding the mechanism underlying critical period plastici...
Yatomi, Taisuke Tomasi, Dardo Tani, Hideaki Nakajima, Shinichiro Tsugawa, Sakiko Nagai, Nobuhiro Koizumi, Teruki Nakajima, Waki Hatano, Mai Uchida, Hiroyuki
...
Published in
Frontiers in Neural Circuits
Katsuno, Yuki Jitsuki, Susumu Ota, Wataru Yamanoue, Tomomi Abe, Hiroki Takahashi, Takuya
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Frontiers in Neural Circuits
Functional recovery from brain damage, such as stroke, is a plastic process in the brain. The excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) plays a crucial role in neuronal functions, and the synaptic trafficking of AMPAR is a fundamental mechanism underlying synaptic plasticity. We recently identified ...
Nakagawa, Naoki
Published in
Frontiers in Neural Circuits
The Golgi apparatus is a central hub in the intracellular secretory pathway. By positioning in the specific intracellular region and transporting materials to spatially restricted compartments, the Golgi apparatus contributes to the cell polarity establishment and morphological specification in diverse cell types. In neurons, the Golgi apparatus me...
Lipari, Natalie Galfano, Ashley Venkatesh, Shruti Grezenko, Han Sandoval, Ivette M. Manfredsson, Fredric P. Bishop, Christopher
Published in
Frontiers in Neural Circuits
Introduction Parkinson’s disease (PD) is commonly characterized by severe dopamine (DA) depletion within the substantia nigra (SN) leading to a myriad of motor and non-motor symptoms. One underappreciated and prevalent non-motor symptom, Parkinson’s disease-associated psychosis (PDAP), significantly erodes patient and caregiver quality of life yet ...
Brosse, Sarah Tremblay, Cécilia Mérida, Inés Frasnelli, Johannes
Published in
Frontiers in Neural Circuits
Context Olfactory dysfunction (OD) is a common early symptom of Parkinson’s disease (PD). However, OD is not specific to PD, as approximatively 20% of the general population exhibit different forms of OD. To use olfactory measures for early Parkinson screening, it is crucial to distinguish PD-related OD from Non-Parkinsonian OD (NPOD). Objectives a...
Podder, Sajib Murata, Yoshihiro Taniguchi, Mutsuo Shimizu, Shogo Yamaguchi, Masahiro
Published in
Frontiers in Neural Circuits
Olfactory behavior is highly plastic, and the olfactory tubercle (OT), a component of the olfactory cortex and ventral striatum, includes anteromedial (amOT) and lateral (lOT) domains with roles in attractive and aversive olfactory behavioral learning, respectively. However, the underlying properties of synaptic plasticity in these domains are inco...
