Rolli, Sarah Langridge, Chloe A. Sontag, Emily M.
Published in
Frontiers in Molecular Biosciences
Cellular protein homeostasis (proteostasis) plays an essential role in regulating the folding, sequestration, and turnover of misfolded proteins via a network of chaperones and clearance factors. Previous work has shown that misfolded proteins are spatially sequestered into membrane-less compartments in the cell as part of the proteostasis process....
Khurshid, Sana Usmani, Shahabuddin Ali, Raiyan Hamid, Saira Masoodi, Tariq Sadida, Hana Q. Ahmed, Ikhlak Khan, Mohd Shahnawaz Abeer, Inara Albalawi, Ibrahim Altedlawi
...
Published in
Frontiers in Molecular Biosciences
Introduction: Esophageal squamous cell carcinoma (ESCC) accounts for over 90% of all esophageal tumors. However, the molecular mechanism underlying ESCC development and prognosis remains unclear, and there are still no effective molecular biomarkers for diagnosing or predicting the clinical outcome of patients with ESCC. Here, we used bioinformatic...
Liu, Xiaoli Zhang, Xia Shi, Juan Li, Shiqing Zhang, Xiuzhi Wang, Huiling
Published in
Frontiers in Molecular Biosciences
Background Cytokine network disturbances in primary Sjögren’s syndrome (pSS) have been reported in many studies. However, their functions in patients with primary Sjögren’s syndrome and interstitial lung disease (pSS-ILD) is controversial. In this study, we aim to investigate the associations of immunological characteristics and cytokine profiles w...
Liu, Guoqing Liao, Wang Lv, Xiangwen Zhu, Miaomiao Long, Xingqing Xie, Jian
Published in
Frontiers in Molecular Biosciences
Background Hypoxia has been found to cause cellular dysfunction and cell death, which are essential mechanisms in the development of acute myocardial infarction (AMI). However, the impact of hypoxia-related genes (HRGs) on AMI remains uncertain. Methods The training dataset GSE66360, validation dataset GSE48060, and scRNA dataset GSE163956 were dow...
Tilajka, Álmos Kurilla, Anita László, Loretta Lovrics, Anna Novák, Julianna Takács, Tamás Buday, László Vas, Virag
Published in
Frontiers in Molecular Biosciences
Background Colorectal carcinoma (CRC) has emerged as one of the most widespread cancers and was the third leading cause of cancer-related mortality in 2020. The role of the podosomal protein Tks4 in tumor formation and progression is well established, including its involvement in gastric carcinoma and hepatocellular carcinoma; however, exploration ...
Kametani, Yoshie Ito, Ryoji Manabe, Yoshiyuki Kulski, Jerzy K. Seki, Toshiro Ishimoto, Hitoshi Shiina, Takashi
Published in
Frontiers in Molecular Biosciences
Immune-related drug delivery systems (DDSs) in humanized mouse models are at the forefront of cancer research and serve as bridges between preclinical studies and clinical applications. These systems offer unique platforms for exploring new therapies and understanding their interactions with human cells and the immune system. Here, we focus on a DD...
Wang, Feifei Ma, Wenjing Fan, Dongjie Hu, Jing An, Xiaohong Wang, Zuding
Published in
Frontiers in Molecular Biosciences
Melanin is an amino acid derivative produced by melanocyte through a series of enzymatic reactions using tyrosinase as substrate. Human skin and hair color is also closely related to melanin, so understanding the mechanisms and proteins that produce melanin is very important. There are many proteins involved in the process of melanin expression, Fo...
Bhattacharya, Udayan Chauhan, Pooja Goyal, Manish
Published in
Frontiers in Molecular Biosciences
Salina, Elena G. Qiao, Chunhua Chiarelli, Laurent R.
Published in
Frontiers in Molecular Biosciences
Guerrero-Alba, Alexa Bansal, Sandhya Sankpal, Aryan N. Mitra, Geetanjali Rahman, Mohammad Ravichandran, Ranjithkumar Poulson, Christin Fleming, Timothy P. Smith, Michael A. Bremner, Ross M.
...
Published in
Frontiers in Molecular Biosciences
In the realm of biomedical advancement, extracellular vesicles (EVs) are revolutionizing our capacity to diagnose, monitor, and predict disease progression. However, the comprehensive exploration and clinical application of EVs face significant limitations due to the current isolation techniques. The size exclusion chromatography, commercial precip...
