Functional Characterization of ABCC Proteins from Trypanosoma cruzi and Their Involvement with Thiol Transport
Published in Frontiers in Microbiology
Microbially-accelerated consolidation of oil sands tailings. Pathway II: solid phase biogeochemistry.
Published in Frontiers in Microbiology
Consolidation of clay particles in aqueous tailings suspensions is a major obstacle to effective management of oil sands tailings ponds in northern Alberta, Canada. We have observed that microorganisms indigenous to the tailings ponds accelerate consolidation of mature fine tailings (MFT) during active metabolism by using two biogeochemical pathway...
Novel pili-like surface structures of Halobacterium salinarum strain R1 are crucial for surface adhesion.
Published in Frontiers in Microbiology
It was recently shown that haloarchaeal strains of different genera are able to adhere to surfaces and form surface-attached biofilms. However, the surface structures mediating the adhesion were still unknown. We have identified a novel surface structure with Halobacterium salinarum strain R1, crucial for surface adhesion. Electron microscopic stud...
Impact of floral sources and processing on the antimicrobial activities of different unifloral honeys
Published in Asian Pacific Journal of Tropical Disease
ObjectiveTo study in vitro antibacterial activity and physicochemical properties of three unifloral honeys (citrus, clover and cotton honeys), and to study the impacts of storage, dilution with water (33%, w/v) and autoclaving (121 °C for 15 min) on honeys characteristics. MethodsHoney samples from monofloral sources including citrus (Citrus spp.),...
Comparative genomic and transcriptional analyses of CRISPR systems across the genus Pyrobaculum.
Published in Frontiers in microbiology
Within the domain Archaea, the CRISPR immune system appears to be nearly ubiquitous based on computational genome analyses. Initial studies in bacteria demonstrated that the CRISPR system targets invading plasmid and viral DNA. Recent experiments in the model archaeon Pyrococcus furiosus have uncovered a novel RNA-targeting variant of the CRISPR sy...
Manipulating Immune Tolerance with Micro-RNA Regulated Gene Therapy.
Published in Frontiers in microbiology
The success of in vivo gene therapy greatly depends on the ability to control the immune response toward the therapeutic transgene. Over the last decade several vector-based and pharmacological approaches have been explored to control the immune-mediated clearance of transgene-expressing cells after viral delivery. One important outcome from these ...
Autotransporters and Their Role in the Virulence of Burkholderia pseudomallei and Burkholderia mallei.
Published in Frontiers in microbiology
Burkholderia pseudomallei and Burkholderia mallei are closely related Gram-negative bacteria responsible for the infectious diseases melioidosis and glanders, respectively. Autotransporters (ATs) comprise a large and diverse family of secreted and outer membrane proteins that includes virulence-associated invasins, adhesins, proteases, and actin-nu...
Community Structure and Function of High-Temperature Chlorophototrophic Microbial Mats Inhabiting Diverse Geothermal Env...
...Published in Frontiers in Microbiology
Six phototrophic microbial mat communities from different geothermal springs (YNP) were studied using metagenome sequencing and geochemical analyses. The primary goals of this work were to determine differences in community composition of high-temperature phototrophic mats distributed across the Yellowstone geothermal ecosystem, and to identify met...
Post-Translational Modifications of Kaposi s Sarcoma-Associated Herpesvirus Regulatory Proteins - SUMO and KSHV.
Published in Frontiers in Microbiology
KSHV latency can be envisioned as an outcome that is balanced between factors that promote viral gene expression and lytic replication against those that facilitate gene silencing and establish or maintain latency. A large body of work has focused on the activities of the key viral regulatory proteins involved in KSHV latent or lytic states. Moreov...
Diversity of Antisense and Other Non-Coding RNAs in Archaea Revealed by Comparative Small RNA Sequencing in Four Pyrobac...
Published in Frontiers in Microbiology
A great diversity of small, non-coding RNA (ncRNA) molecules with roles in gene regulation and RNA processing have been intensely studied in eukaryotic and bacterial model organisms, yet our knowledge of possible parallel roles for small RNAs (sRNA) in archaea is limited. We employed RNA-seq to identify novel sRNA across multiple species of the hyp...
