Patel, Ami Hissong, Erika Rosado, Lucelina Burkhardt, Robert Cong, Lin Alperstein, Susan A. Siddiqui, Momin T. Park, Hyeon Jin Song, Wei Velu, Priya D.
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Published in
Frontiers in Medicine
Cell-free DNA (cfDNA) extracted from diverse specimen types has emerged as a high quality substrate for molecular tumor profiling. Analytical and pre-analytical challenges in the utilization of cfDNA extracted from pleural effusion supernatant (PES) are herein characterized in patients with metastatic non-small cell lung carcinoma (NSCLC). Pleural ...
Akbar, Mohammad Rizki Pranata, Raymond Wibowo, Arief Irvan, Sihite, Teddy Arnold Martha, Januar Wibawa
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Frontiers in Medicine
Background: This meta-analysis aimed to assess the prognostic value of hyponatremia in patients with COVID-19. Methods: We performed a systematic literature search on PubMed, Scopus, ScienceDirect, and Wiley up until January 26, 2021. The key exposure was hyponatremia, defined as sodium level below the reference level. The outcome of interest was p...
Szymoniak-Lipska, Marta Polańska, Adriana Jenerowicz, Dorota Lipski, Adam Żaba, Ryszard Adamski, Zygmunt Dańczak-Pazdrowska, Aleksandra
Published in
Frontiers in Medicine
Background: The nail unit (NU) is a complex structure that performs a number of functions, including protection, defense, manipulation, and palpation. Non-invasive research methods can facilitate the recognition of NU structure and function. Evaporimetry and HF-USG due to their availability of equipment and low research costs seem to be particularl...
Wiegele, Marion Infanger, Lukas Lacom, Conrad Koch, Stefan Baierl, Andreas Schaden, Eva
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Frontiers in Medicine
Background: To investigate pro- and anticoagulant alterations in uremic critically ill patients prior to and during continuous renal replacement therapy. In addition to the conventional thrombin generation assay (TGA), we performed a thrombomodulin-modified variant to better elucidate procoagulant imbalances. Platelet function was determined via mu...
Ghazanfari, Mona Arastehfar, Amir Davoodi, Lotfollah Yazdani Charati, Jamshid Moazeni, Maryam Abastabar, Mahdi Haghani, Iman Mirzakhani, Roghayeh Mayahi, Sabah Fang, Wenjie
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Published in
Frontiers in Medicine
Background: Recent studies from multiple countries have shown a high prevalence of coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) among severely ill patients. Despite providing valuable insight into the clinical management of CAPA, large-scale prospective studies are limited. Here, we report on one of the largest mult...
Sharif, Sairah Chen, Bohan Brewster, Pamela Chen, Tian Dworkin, Lance Gong, Rujun
Published in
Frontiers in Medicine
Background: Burgeoning pre-clinical evidence suggests that therapeutic targeting of glycogen synthase kinase 3β (GSK3β), a convergence point of multiple cellular protective signaling pathways, confers a beneficial effect on acute kidney injury (AKI) in experimental models. However, it remains unknown if GSK3β inhibition likewise mitigates AKI in hu...
Long, Wei Yang, Jie Li, Zhengwei Li, Jinpeng Chen, Sichao Chen, Danyang Wang, Shipei Li, Qianqian Hu, Di Huang, Jianglong
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Published in
Frontiers in Medicine
Purpose: The coronavirus disease (COVID-19) pandemic poses a global threat, and identification of its prognostic biomarkers could prove invaluable. Fibrinogen (FIB) could be one such indicator as coagulation and fibrinolysis abnormalities are common among COVID-19 patients. We examined the role of FIB levels in the prognosis of COVID-19. Methods: T...
Chan, Kam Wa Chow, Tak Yee Yu, Kam Yan Xu, Yulong Zhang, Nevin Lianwen Wong, Vivian Taam Li, Saimei Tang, Sydney Chi Wai
Published in
Frontiers in Medicine
Background: Previous UK Biobank studies showed that symptoms and physical measurements had excellent prediction on long-term clinical outcomes in general population. Symptoms and signs could intuitively and non-invasively predict and monitor disease progression, especially for telemedicine, but related research is limited in diabetes and renal medi...
Ma, Huijing Ye, Qinghao Ding, Weiping Jiang, Yinghui Wang, Minhao Niu, Zhangming Zhou, Xi Gao, Yuan Wang, Chengjia Menpes-Smith, Wade
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Published in
Frontiers in Medicine
The rapid spread of coronavirus 2019 disease (COVID-19) has manifested a global public health crisis, and chest CT has been proven to be a powerful tool for screening, triage, evaluation and prognosis in COVID-19 patients. However, CT is not only costly but also associated with an increased incidence of cancer, in particular for children. This stud...
Solanich, Xavier Antolí, Arnau Rocamora-Blanch, Gemma Padullés, Núria Fanlo-Maresma, Marta Iriarte, Adriana Mitjavila, Francesca Capdevila, Olga Riera-Mestre, Antoni Bas, Jordi
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Published in
Frontiers in Medicine
Introduction: Severe lung injury is triggered by both the SARS-CoV-2 infection and the subsequent host-immune response in some COVID-19 patients. Methods: We conducted a randomized, single-center, open-label, phase II trial with the aim to evaluate the efficacy and safety of methylprednisolone pulses and tacrolimus plus standard of care (SoC) vs. S...
