Toma, Maddalena Felisi, Mariagrazia Bonifazi, Donato Bonifazi, Fedele Giannuzzi, Viviana Reggiardo, Giorgio de Wildt, Saskia Ceci, Adriana
Published in
Frontiers in Medicine
Objectives: In this paper, we investigated the effects of the European Paediatric Regulation (EC) N° 1901/2006 with respect to satisfying the paediatric therapeutic needs, assessed in terms of the increased number of paediatric medicinal products, new therapeutic indications in specific high-need conditions (neonates, oncology, rare disease, etc.) ...
Liu, Weiping Li, Yufu Wang, Quanshun Su, Hang Ding, Kaiyang Shuang, Yuerong Gao, Sujun Zou, Dehui Jing, Hongmei Chai, Ye
...
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Frontiers in Medicine
Background: YF-H-2015005, a novel CXCR4 antagonist, has been proven to increase the quantities of circulating hematopoietic stem cells (HSCs), which results in an adequate collection of HSCs in non-Hodgkin lymphoma (NHL) patients. Methods: This was a multicenter, double-blind, randomized (1:1), placebo-controlled phase III clinical trial. All patie...
Peng, Chen Xu, Xin Chen, Wenjuan Li, Xingzi Yi, Xuemei Ding, Yangfeng Yu, Ning Lu, Jiajing
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Frontiers in Medicine
Background: Although there have been many epidemiological studies, research focusing on psoriasis' health burden on a global scale is still lacking. Trends and variations in the global health burden of psoriasis are evaluated by time, age, gender, geographical location, and socioeconomic status, using disability-adjusted life years (DALYs) from the...
Zhou, Feng Chu, Linyang Liu, Xuqiang He, Zihao Han, Xuequan Yan, Mengning Qu, Xinhua Li, Xiaofeng Yu, Zhifeng
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Frontiers in Medicine
Osteoporotic osteoarthritis (OP-OA) is a specific type of OA. In this study, we aimed to assess the subchondral plate and rod microstructural differences between OA and OP-OA patients by using an individual trabeculae segmentation (ITS) system and to analyze the relationships between subchondral microstructures and cartilage damage in OA and OP-OA ...
Shao, Mingxi Li, Yingzhu Teng, Jisen Li, Shengjie Cao, Wenjun
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Frontiers in Medicine
Objective: To evaluate the serum lipid levels of patients with primary angle-closure glaucoma (PACG) and to investigate the relationship between serum lipid levels and PACG. Methods: In this cross-sectional, case–control study, a total of 320 PACG subjects and 242 age- and sex-matched control subjects were recruited. Serum high-density lipoprotein ...
Liu, Weixi Yang, Zhicheng Chen, Yan Yang, Haoyu Wan, Xiaoxian Zhou, Xindie Liu, Ruiping Zhang, Yunkun
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Frontiers in Medicine
Background: Rheumatoid arthritis (RA) is related to several pivotal susceptibility genes, including cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes. Although the connection between polymorphisms of CTLA-4 and CD86 genes in different populations of RA have been studied extensively, the results are co...
Medipally, Ajay K. Xiao, Min Qaisar, Shahzeb Satoskar, Anjali A. Ivanov, Iouri Rovin, Brad Brodsky, Sergey V.
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Frontiers in Medicine
Anticoagulant-related nephropathy (ARN) may develop in patients that are on anticoagulation therapy. Rats with 5/6 nephrectomy treated with different anticoagulants showed acute kidney injury (AKI) and red blood cell (RBC) casts in the tubules similar to ARN in humans. The aim of the current study was to investigate the feasibility of inducing ARN ...
Ständer, Sascha Ständer, Sonja
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Frontiers in Medicine
Scabies is a common parasitic skin infestation characterized by severe itch and a heterogenous clinical presentation. Itch, as the cardinal symptom of scabies, is imposing a high burden on affected patients and is often difficult to manage. Decreased life quality and secondary complications, caused by an itch-related disruption of the epidermal bar...
Nakamura, Koichiro Tsunemi, Yuichiro Kaneko, Fumio Alpsoy, Erkan
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Frontiers in Medicine
Behçet's disease (BD) is a chronic, relapsing, systemic inflammatory disease with clinical features showing mucocutaneous lesions involving the ocular, articular, and further miscellaneous organs. Mucocutaneous manifestations, one of the most characteristic signs of BD, have been most commonly observed upon onset or at any disease stage and are exc...
Sciascia, Savino Radin, Massimo Cecchi, Irene Rubini, Elena Foddai, Silvia Grazietta Barinotti, Alice Vaccarino, Antonella Rossi, Daniela Roccatello, Dario
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Frontiers in Medicine
Objective: This study aimed to prospectively investigate the incidence of first thromboembolic events (TEs) in a cohort of systemic lupus erythematosus (SLE) patients. The patients were positive for anti-phosphatidylserine/prothrombin (aPS/PT) antibodies and tested negative for anticardiolipin (aCL) and anti-β2–glycoprotein I (aβ2GPI) antibodies [r...