Liu, YuChen Zhang, Jun Han, Bing Du, LiJuan Shi, ZhaoYang Wang, ChunCheng Xu, Min Luo, YongGang
Published in
Frontiers in Medicine
mNGS(metagenomics Next Generation Sequencing), as a novel culture-independent approach, demonstrated the capability of rapid, sensitive, and accurate pathogen identification. At present, there have been many case reports about the use of mNGS to assist in the diagnosis of bacterial, fungal, viral and parasitic infections and to guide clinicians to ...
Namuganga, Anna Ritah Chegou, Novel N. Mayanja-Kizza, Harriet
Published in
Frontiers in Medicine
Tuberculosis disease continues to contribute to the mortality burden globally. Due to the several shortcomings of the available diagnostic methods, tuberculosis disease continues to spread. The difficulty to obtain sputum among the very ill patients and the children also affects the quick diagnosis of tuberculosis disease. These challenges warrant ...
Aoyagi, Tetsuji Sato, Yukio Baba, Hiroaki Shiga, Takuya Seike, Issei Niitsuma Sugaya, Ikumi Takei, Kentarou Iwasaki, Yudai Oshima, Kengo Kanamori, Hajime
...
Published in
Frontiers in Medicine
Acute respiratory distress syndrome (ARDS) is the leading cause of mortality in hospitalized patients with coronavirus disease 2019 (COVID-19) because of limited effective therapies. During infection, the accumulation and activation of macrophages and monocytes in the lungs induce inflammatory mediators and contribute to tissue injury, leading to A...
Kolanko, Emanuel Grajoszek, Aniela Czekaj, Piotr
Published in
Frontiers in Medicine
Isolated human amniotic cells (hAC) could be used as a source of immunomodulatory factors in regenerative medicine and transplantation. However, in previous experimental studies, native hAC administered to skin graft recipients did not induce graft immunotolerance. To strengthen the immunomodulatory properties of hAC prior to administration to the ...
Liu, Yuanyuan Yang, Tiantian Yu, Jinguo Li, Mengxuan Li, Jianan Yan, Hua
Published in
Frontiers in Medicine
To establish a rabbit animal model of closed globe blast injury with an application of self-developed explosive injury equipment, we tend to explore the anatomic and pathological changes of eyes under different gas pressure. The device comprises of high-pressure air source compression pump, air channel, and gas shock. There were 36 healthy bluish b...
Sobotta, Michael Moerer, Onnen Gross, Oliver
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Frontiers in Medicine
Introduction: Goodpasture's syndrome is a life-threatening autoimmune type IV collagen disease characterized by the presence anti–glomerular basement membrane antibodies, rapid progressive glomerulonephritis and/or pulmonary hemorrhage. Methods: Here, we describe new therapeutic options, which take recent advances in unraveling Goodpasture's pathog...
Hashimoto, Shoji Yoshizaki, Kazuyuki Uno, Kazuko Kitajima, Heita Arai, Tsuyoshi Tamura, Yoshitaka Morishita, Hiroshi Matsuoka, Hiroto Han, Yuki Minamoto, Seijiro
...
Published in
Frontiers in Medicine
Background and Aim: Tocilizumab, a humanized anti-IL-6 receptor antibody, has been used to treat severely to critically ill patients with COVID-19. A living systematic review with meta-analysis of recent RCTs indicates that the combination therapy of corticosteroids and tocilizumab produce better outcomes, while previous observational studies sugge...
Lo Nigro, Antonio Gallo, Alessia Bulati, Matteo Vitale, Giampiero Paini, Diego Sebastian Pampalone, Mariangela Galvagno, Daniele Conaldi, Pier Giulio Miceli, Vitale
Published in
Frontiers in Medicine
The prevalence of end-stage liver diseases has reached very high levels globally. The election treatment for affected patients is orthotopic liver transplantation, which is a very complex procedure, and due to the limited number of suitable organ donors, considerable research is being done on alternative therapeutic options. For instance, the use o...
Haddadi, Sara Mirsaeidi, Mehdi
Published in
Frontiers in Medicine
Qi, Jiao He, Wenwen Meng, Jiaqi Wei, Ling Qian, Dongjin Lu, Yi Zhu, Xiangjia
Published in
Frontiers in Medicine
Purpose: To investigate the distributions of the ocular anterior and posterior segment lengths among a cataract surgical population in Shanghai. Design: Cross-sectional study. Methods: Ocular biometric parameters of 23,462 eyes of 23,462 cataract surgery candidates were reviewed. Axial length (AL), anterior chamber depth (ACD), and lens thickness (...
