Morris, Jodie L. Letson, Hayley L. Biros, Erik McEwen, Peter C. Dobson, Geoffrey P.
Published in
Frontiers in Medicine
Little is known on the sex-specific healing responses after an anterior cruciate ligament (ACL) rupture. To address this, we compared male and female Sprague-Dawley rats following non-surgical ACL rupture. Hematology, inflammation, joint swelling, range of motion, and pain-sensitivity were analyzed at various times over 31-days. Healing was assesse...
Panagopoulos, Panagiotis K. Goules, Andreas V. Georgakopoulou, Vasiliki E. Kallianos, Anastasios Chatzinikita, Eirini Pezoulas, Vasileios C. Malagari, Katerina Fotiadis, Dimitrios I. Vlachoyiannopoulos, Panayiotis Vassilakopoulos, Theodoros
...
Published in
Frontiers in Medicine
Background A number of studies report small airways involvement in patients with systemic sclerosis (SSc). Furthermore, small airways dysfunction is increasingly recognized in patients with interstitial lung disease (ILD) of idiopathic or autoimmune etiology. The objectives of this study were to evaluate small airways function in SSc patients with ...
Gong, Huankai Chen, Yao Chen, Meiling Li, Jiankang Zhang, Hong Yan, Shijiao Lv, Chuanzhu
Published in
Frontiers in Medicine
The introduction of the Sepsis 3.0 guidelines in 2016 improved our understanding of sepsis diagnosis and therapy. Personalized treatment strategies and nursing methods for sepsis patients are recommended in the “Save Sepsis Campaign” in 2021. However, mortality in sepsis patients remains high. Patients with sepsis-related acute respiratory distress...
Guo, Haiyan Wang, Bian Gao, Hongyuan Zhu, Qianqian
Published in
Frontiers in Medicine
Aim This study aimed to explore the effect of body mass index (BMI) on neonatal outcomes in patients with polycystic ovary syndrome following the frozen embryo transfer (FET). Methods This study included 1,676 singletons born from mothers with polycystic ovary syndrome (PCOS) after FET between 1 Jan 2007 and 31 Dec 2019. BMI was categorized into th...
Muvarak, Nidal Li, Haishan Lahusen, Tyler Galvin, Jeffrey A. Kumar, Princy N. Pauza, C. David Bordon, José
Published in
Frontiers in Medicine
The cell and gene therapy product AGT103-T was designed to restore the Gag-specific CD4+ T cell response in persons with chronic HIV disease who are receiving antiretroviral therapy. This autologous, genetically engineered cell product is under investigation in a Phase 1 clinical trial (NCT03215004). Trial participants were conditioned with cycloph...
Lin, Sheng-Jie Tang, Shang-Ching Joy Lee, Yu-Chia Liu, Ting-Yu Huang, Ting-Chun Yu, Rwei-Ling Tan, Chun-Hsiang
Published in
Frontiers in Medicine
Background Individuals with chronic viral hepatitis are at increased risk of experiencing poor sleep quality and sleep disturbances. However, it remains unclear whether the sleep disorders associated with viral hepatitis are secondary to the comorbidities related to viral hepatitis or the direct effect of hepatitis viruses on sleep. This study inve...
Wang, Lili Guo, Jiamei Wang, Yingying Zhao, Pengcheng Liu, Bin Zhang, Yan Xiong, Yibai Chen, Qing Lin, Lin Li, Li
...
Published in
Frontiers in Medicine
Objectives Influenza is an infectious respiratory disease that can cause severe inflammatory reactions and threaten human life. Chaishi Tuire Granules (CSTRG), a Chinese patent medicine widely used clinically in the treatment of respiratory diseases in China, has a definite anti-inflammatory effect. However, the mechanism of CSTRG in the treatment ...
Radine, Uta Katharina Bumiller-Bini Hoch, Valéria Boldt, Angelica B. Winter Zillikens, Detlef Ludwig, Ralf J. Hammers, Christoph M. Klinger, Matthias Hundt, Jennifer E.
Published in
Frontiers in Medicine
Pemphigus is a chronic autoimmune skin blistering disease, characterized by acantholysis and by the production of autoantibodies directed against the structural desmosomal proteins desmoglein 1 (DSG1) and/or DSG3. Model systems allow the identification and testing of new therapeutic targets. Here, we evaluated ultrastructural desmosomal morphology ...
Eun, Yeonghee Han, Kyungdo Lee, Seung Woo Kim, Kyunga Kang, Seonyoung Lee, Seulkee Cha, Hoon-Suk Koh, Eun-Mi Kim, Hyungjin Lee, Jaejoon
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Published in
Frontiers in Medicine
Background To date, few studies have focused on risk factors for gout in young people, and large-scale studies on the relationship between metabolic syndrome (MetS) and gout are lacking. We aimed to investigate the association between gout and MetS in a large nationwide population-based cohort of young men who participated in national health examin...
Si, Yang Zhang, Jiwei Bao, Shisan Wise, Steven G. Wang, Yuli Zhang, Yanfang Tang, Yuhong
Published in
Frontiers in Medicine
Hepatocellular carcinoma (HCC) remains a major challenge to clinicians due to its unacceptably high mortality and morbidity. The etiology of HCC is multi-faceted, including viral infection, alcoholism and non-alcoholic fatty liver disease. Dysregulated host immunity contributes to tumorigenesis among these susceptible individuals with pre-existing ...
