Liao, Dingying Zhou, Zixia Wang, Fei Zhang, Bin Wang, Yanfen Zheng, Yuping Li, Jinying
Published in
Frontiers in Medicine
Purpose To investigate changes in foveal avascular area (FAZ) and retinal vein diameter in patients with retinal vein occlusion (RVO) after intravitreal ranibizumab, and to analyze the correlation between ranibizumab therapy and visual gain. Methods This retrospective study enrolled 95 eyes of 95 patients who had accepted three consecutive monthly ...
Jiao, Tiantian Wang, Yuanqi Lin, Xueqi Song, Wei Wang, Liang Rahman, Tapu Md Sakibur Xu, Linghao Nie, Lindong Zhang, Qi Li, Jiming
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Published in
Frontiers in Medicine
Background There are no specific clinical medications that target cardiac fibrosis in heart failure (HF). Recent studies have shown that tyrosine kinase inhibitors (TKIs) may benefit fibrosis in various organs. However, there is limited research on their application in cardiac fibrosis. Axitinib, an FDA-approved tyrosine kinase inhibitor, was used ...
Zhang, Songyang Wang, Yidi Mao, Dezhi Wang, Yue Zhang, Hong Pan, Yihan Wang, Yuezeng Teng, Shuzhi Huang, Ping
Published in
Frontiers in Medicine
The CRISPR/Cas9 system is a powerful genome editing tool that has made enormous impacts on next-generation molecular diagnostics and therapeutics, especially for genetic disorders that traditional therapies cannot cure. Currently, CRISPR-based gene editing is widely applied in basic, preclinical, and clinical studies. In this review, we attempt to ...
Chen, Jie Han, Yehong
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Frontiers in Medicine
Background Gallbladder cancer is the most common malignant tumor of the biliary system, most of which is adenocarcinoma. Our study explored developing and validating a nomogram to predict overall and cancer-specific survival probabilities internally and externally for incidental gallbladder adenocarcinoma patients without distant metastasis after s...
Puetz, John
Published in
Frontiers in Medicine
After decades of investigation, gene therapy has received regulatory approval to treat hemophilia. However, since gene therapy investigations were initially conceived, other avenues of treatment have revolutionized the care of hemophilia. Emergent data is showing that gene therapy may not be as beneficial as hoped and more toxic than planned. At a ...
Jordakieva, Galateja Nowak, Dennis
Published in
Frontiers in Medicine
Pankow, Anne Sinno, Sena Derlin, Thorsten Hiss, Marcus Wagner, Annette D.
Published in
Frontiers in Medicine
Introduction Giant cell arteritis (GCA) is a systemic granulomatous vasculitis affecting the large arteries. Abnormal lymphocyte function has been noted as a pathogenic factor in GCA. Mycophenolate mofetil (MMF) inhibits inosine monophosphate dehydrogenase and is therefore a highly lymphocyte-specific immunosuppressive therapy. We aimed to assess t...
Abedalthagafi, Malak Bawazeer, Shahad Fawaz, Romy I. Heritage, A. Merrihew Alajaji, Nouf M. Faqeih, Eissa
Published in
Frontiers in Medicine
Non-invasive prenatal testing (NIPT) is a pioneering technique that has consistently advanced the field of prenatal testing to detect genetic abnormalities and conditions with the aim of decreasing the incidence and prevalence of inherited conditions. NIPT remains a method of choice for common autosomal aneuploidies, mostly trisomy 21, and several ...
Phatak, Sanat Chakraborty, Somashree Goel, Pranay
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Frontiers in Medicine
Introduction Computer vision extracts meaning from pixelated images and holds promise in automating various clinical tasks. Convolutional neural networks (CNNs), a deep learning network used therein, have shown promise in analyzing X-ray images and joint photographs. We studied the performance of a CNN on standardized smartphone photographs in dete...
Sun, Wenwu Zhao, Bing Li, Jiaoyan Wang, Yihui Qi, Xing Ning, Ning Sun, Silei Li, Mengjiao Yao, Yi Ni, Tongtian
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Published in
Frontiers in Medicine
Introduction Acute pancreatitis is a common gastrointestinal disease. The mortality of patients affected by severe acute pancreatitis (SAP) remains high. It is unclear whether high-dose intravenous vitamin C (HDIVC) therapy could improve the prognosis of these patients. The current prospective, randomized, double-blinded, placebo-controlled study w...
