Yao, Xiangyang Zhou, Hui Duan, Chen Wu, Xiaoliang Li, Bo Liu, Haoran Zhang, Yangjun
Published in
Frontiers in Immunology
Background Testicular germ cell tumor (TGCT) is the most common tumor in young men, but molecular signatures, especially the alternative splicing (AS) between its subtypes have not yet been explored. Methods To investigate the differences between TGCT subtypes, we comprehensively analyzed the data of gene expression, alternative splicing (AS), and ...
Zhou, Hui Liao, Xiyan Zeng, Qin Zhang, Haowei Song, Jianfeng Hu, Wanyu Sun, Xiaoxiao Ding, Yujin Wang, Dandan Xiao, Yalun
...
Published in
Frontiers in Immunology
Accumulation and activation of immunocytes in adipose tissues are essential to obesity-induced inflammation and insulin resistance. Chemokines are pivotal for the recruitment of immunocytes in adipose tissue during obesity. Chemokine (C-C motif) ligand 5 (CCL5) plays a vital role in the recruitment of immunocytes to sites of inflammation. CCL5 expr...
Cheng, Nana Liu, Mingzhu Li, Wanting Sun, BingYue Liu, Dandan Wang, Guoqing Shi, Jingwei Li, Lisha
Published in
Frontiers in Immunology
SARS-CoV-2 can cause lung diseases, such as pneumonia and acute respiratory distress syndrome, and multi-system dysfunction. Post-translational modifications (PTMs) related to SARS-CoV-2 are conservative and pathogenic, and the common PTMs are glycosylation, phosphorylation, and acylation. The glycosylation of SARS-CoV-2 mainly occurs on spike (S) ...
Woon, Ee Von Nikolaou, Dimitrios MacLaran, Kate Norman-Taylor, Julian Bhagwat, Priya Cuff, Antonia O. Johnson, Mark R. Male, Victoria
Published in
Frontiers in Immunology
A significant proportion of recurrent miscarriage, recurrent implantation failure and infertility are unexplained, and these conditions have been proposed to have an etiology of immunological dysfunction at the maternal-fetal interface. Uterine Natural Killer cells (uNK) comprise three subsets and are the most numerous immune cells found in the ute...
Ridgley, Laura A. Caron, Jonathan Dalgleish, Angus Bodman-Smith, Mark
Published in
Frontiers in Immunology
Objectives Vγ9Vδ2 T-cells are a subset of T-cells with a crucial role in immunosurveillance which can be activated and expanded by multiple means to stimulate effector responses. Little is known about the expression of checkpoint molecules on this cell population and whether the ligation of these molecules can regulate their activity. The aim of th...
Zhang, Jia Xi Li, Ying Tang, Jun Chun Li, Kai Qing Shen, Juan Juan Liu, Chang Jiang, Yong Hua Zhang, Zi Ping Wang, Yi Lei Zou, Peng Fei
...
Published in
Frontiers in Immunology
As a TIR domain-containing molecular, sterile α-and armadillo motif-containing protein (SARM) acts as an adaptor in Toll-like receptor (TLR) signaling, and also plays important roles in mediating apoptosis and neuronal injury. In the present study, the ortholog of SARM, named as Lc-SARM, was cloned and identified in large yellow croaker (Larimichth...
Katahira, Yasuhiro Murakami, Fumihiro Inoue, Shinya Miyakawa, Satomi Sakamoto, Eri Furusaka, Yuma Watanabe, Aruma Sekine, Ami Kuroda, Masahiko Hasegawa, Hideaki
...
Published in
Frontiers in Immunology
Pressure ulcers (PUs) are increasing with aging worldwide, but there is no effective causal therapy. Although mesenchymal stem cells (MSCs) promote cutaneous wound healing, the effects of the conditioned medium (CM) of MSCs on cutaneous PU formation induced by ischemia-reperfusion injury have been poorly investigated. To address this issue, herein,...
Wang, Yuting Xi, Wenjie Zhang, Xinyi Bi, Xinwen Liu, Boyang Zheng, Xiaoming Chi, Xinjin
Published in
Frontiers in Immunology
Background Acute kidney injury is a common and severe complication of sepsis. Sepsis -induced acute kidney injury(S-AKI) is an independent risk factor for mortality among sepsis patients. However, the mechanisms of S-AKI are complex and poorly understand. Therefore, exploring the underlying mechanisms of S-AKI may lead to the development of therape...
You, Yanwei Chen, Yuquan Fang, Wen Li, Xingtian Wang, Rui Liu, Jianxiu Ma, Xindong
Published in
Frontiers in Immunology
Background Two related lifestyle behaviors associated with sleep disturbance are sedentary behavior and physical exercise participation. We aimed to use a population-based study to disentangle the relationships between sedentary behavior, exercise, and sleep disturbance based on blood-cell-based inflammatory biomarkers. Methods A total of 22,599 pa...
Sun, Libo Lu, Junfeng Li, Kang Zhang, Haitao Zhao, Xiaofei Li, Guangming Li, Ning
Published in
Frontiers in Immunology
Introduction Although we had identified that the methylation of AHNAK was a good diagnostic marker for hepatopathy, here we speculate that there was also another marker, STAP1, whose methylation also involved in the detection of hepatopathy. Methods We investigated the methylation levels of the AHNAK and STAP1 in peripheral blood mononuclear cells ...
