Kuncman, Łukasz Pajdziński, Matusz Smółka, Krzysztof Bilski, Mateusz Socha, Joanna Stando, Rafał Peszyńska-Piorun, Magdalena Korab, Katarzyna Jereczek-Fossa, Barbara Alicja Fijuth, Jacek
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Published in
Frontiers in Immunology
Radiation induced lymphopenia (RIL) deteriorate survival and diminishes the benefit of immune checkpoint inhibitors in combined treatment of lung cancer. Given the inconsistent data across various studies on the predictors of RIL, we aim to methodically elucidate these predictors and formulate a practical guide for clinicians.
We conducted obser...
Chen, Zilong Cai, Haoxi Ye, Weiwei Wu, Junming Liu, Jing Xie, Yun Feng, Shiqiang Jin, Yuanpei Lv, Yunxia Ye, Hui
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Published in
Frontiers in Immunology
Background Most head and neck squamous cell carcinoma (HNSCC) patients are diagnosed at an advanced local stage. While immunotherapy has improved survival rates, only a minority of patients respond durably to targeted immunotherapies, posing substantial clinical challenges. We investigated the heterogeneity of the tumor microenvironment in HNSCC co...
Li, Xiaoxuan Luan, Xinchi Zhang, Mengqi Wang, Rui Guo, Jing Lv, Jing Qiu, Wensheng Zhao, Shufen
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Frontiers in Immunology
Transformation from non-small cell lung cancer (NSCLC) to small cell lung cancer (SCLC) is rare and is associated with poor prognosis. However, the standard treatment protocols for patients with SCLC transformation remain unknown. Here, we report the case of a patient with advanced EGFR exon 19 deletion (19del) NSCLC who underwent SCLC transformati...
Song, Ding-ming Shen, Tong Feng, Kun He, Yi-bo Chen, Shi-liang Zhang, Yang Luo, Wen-fei Han, Lu Tong, Ming Jin, Yanyang
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Published in
Frontiers in Immunology
Yu, Bing Kang, Jian Lei, Hong Li, Zhe Yang, Hao Zhang, Meng
Published in
Frontiers in Immunology
Colorectal cancer is the third most common cancer and the second most lethal cancer in the world. The main cause of the disease is due to dietary and behavioral factors. The treatment of this complex disease is mainly based on traditional treatments, including surgery, radiotherapy, and chemotherapy. Due to its high prevalence and high morbidity, m...
Xu, Wenbo Wang, Lihe Shi, Pengbo Liu, Linfeng Zhang, Wenxin
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Frontiers in Immunology
Background Osteonecrosis of the femoral head (ONFH) is a severe complication of systemic lupus erythematosus (SLE) and occurs more frequently in SLE patients than in other autoimmune diseases, which can influence patients’ life quality. The objective of this research was to analyze risk factors for the occurrence of ONFH in female SLE patients, con...
Yao, Min Ullrich, Evelyn Albini, Adriana
Published in
Frontiers in Immunology
Zhang, Jiyu Xia, Xinyi He, Shujie
Published in
Frontiers in Immunology
Background The purpose of this study is to investigate the causal effect and potential mechanisms between telomere length and abdominal aortic aneurysm (AAA). Methods Summary statistics of telomere length and AAA were derived from IEU open genome-wide association studies and FinnGen R9, respectively. Bi-directional Mendelian randomization (MR) anal...
Hansen, Doris K. Lu, Xiaoxiao Puglianini, Omar Castaneda Sorensen, Sonja Usmani, Saad Z. Zhang, Eileen Huo, Stephen Zhang, Yan Qureshi, Zaina P. Jagannath, Sundar
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Published in
Frontiers in Immunology
Introduction Ciltacabtagene autoleucel (cilta-cel) is a chimeric antigen receptor T-cell therapy approved for patients with relapsed/refractory multiple myeloma (RRMM). In the phase 3 trial, CARTITUDE-4 (NCT04181827), cilta-cel demonstrated improved efficacy vs. standard of care (SOC; daratumumab plus pomalidomide and dexamethasone [DPd] or pomalid...
Yuan, Yujing Zhao, Yawen Li, Fan Ling, Chen Wu, Yuan Ma, Wei Wang, Zhaoxia Yuan, Yun Hao, Hongjun Zhang, Wei
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Published in
Frontiers in Immunology
Objectives The aim of this study is to explore the expression of inflammatory cytokines (ICs) in Fabry disease (FD), the correlation between ICs and FD phenotypes, and the impact of enzyme replacement therapy (ERT) on IC expression. Methods We recruited 67 FD patients and 44 healthy controls (HCs) and detected concentrations of the following ICs: i...
