Koga, Marianna M. Engel, Adrien Pigni, Matteo Lavanchy, Christine Stevanin, Mathias Laversenne, Vanessa Schneider, Bernard L. Acha-Orbea, Hans
Published in
Frontiers in Immunology
Dendritic cells (DCs) are professional antigen-presenting cells involved in the initiation of immune responses. We generated a tolerogenic DC (tolDC) line that constitutively secretes interleukin-10 (IL10-DCs), expressed lower levels of co-stimulatory and MHCII molecules upon stimulation, and induced antigen-specific proliferation of T cells. Vacci...
Shi, Yong Su, Wantong Zhang, Lei Shi, Chengyu Zhou, Jinren Wang, Peng Wang, Hao Shi, Xiaoli Wei, Song Wang, Qi
...
Published in
Frontiers in Immunology
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease associated with dysregulation of liver metabolism and inflammation. G-protein coupled bile acid receptor 1 (TGR5) is a cell surface receptor that is involved in multiple metabolic pathways. However, the functions of TGR5 in regulating macrophage innate immune activation in NASH remain u...
Husain, Irma Luo, Xunrong
Published in
Frontiers in Immunology
Despite significant advances in prevention and treatment of transplant rejection with immunosuppressive medications, we continue to face challenges of long-term graft survival, detrimental medication side effects to both the recipient and transplanted organ together with risks for opportunistic infections. Transplantation tolerance has so far only ...
Weththasinghe, Pabodha Lagos, Leidy Cortés, Marcos Hansen, Jon Øvrum Øverland, Margareth
Published in
Frontiers in Immunology
The present study investigated effects of dietary inclusion of black soldier fly larvae (BSFL) ( Hermetia illucens ) meal and paste on gut health, plasma biochemical parameters, immune response and skin mucus proteome in pre-smolt Atlantic salmon ( Salmo salar ). The seven-week experiment consisted of seven experimental diets: a control diet based ...
Cinquanta, Luigi Bizzaro, Nicola Pesce, Giampaola
Published in
Frontiers in Immunology
The recent availability of automated computer-assisted diagnosis (CAD) systems for the reading and interpretation of the anti-nuclear antibody (ANA) test performed with the indirect immunofluorescence (IIF) method on HEp-2 cells, has improved the reproducibility of the results and initiated a process of harmonization of this test. Furthermore, CAD ...
Li, Shuping Wang, Xiaohua Zhao, Yuming Yang, Juan Cui, Tianjiao Zhao, Zhizhuang Joe Chen, Yun Zheng, Zhihua
Published in
Frontiers in Immunology
It was previously published that single-nucleotide polymorphism rs2476601 ( PTPN22 [protein tyrosine phosphatase non-receptor type 22]-C1858T) might be related to increased sensibility to Mycobacterium tuberculosis and M. leprae infection. However, the results were inconclusive despite a high degree of similarity between both parameters. Herein, we...
Zhai, Xingyu Zhang, Yunfei Xin, Shuyu Cao, Pengfei Lu, Jianhong
Published in
Frontiers in Immunology
Circular RNAs (circRNAs) are single-stranded, endogenous, non-coding RNA (ncRNA) molecules formed by the backsplicing of messenger RNA (mRNA) precursors and have covalently closed circular structures without 5′-end caps and 3′-end polyadenylation [poly(A)] tails. CircRNAs are characterized by abundant species, stable structures, conserved sequences...
Deng, Feiyan Xu, Gang Cheng, Zhikui Huang, Yu Ma, Caijiao Luo, Chuanjin Yu, Chen Wang, Jun Xu, Xiupeng Liu, Shi
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Published in
Frontiers in Immunology
Chronic hepatitis B is a major health problem worldwide, with more than 250 million chronic carriers. Hepatitis B virus interferes with the host innate immune system so as to evade elimination via almost all of its constituent proteins; nevertheless, the function of HBsAg with respect to immune escape remains unclear. This study aimed to determine ...
Walker, Edith M. Slisarenko, Nadia Gerrets, Giovanni L. Grasperge, Brooke F. Mattison, Julie A. Kissinger, Patricia J. Welsh, David A. Veazey, Ronald S. Jazwinski, S. Michal Rout, Namita
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Published in
Frontiers in Immunology
HIV-associated inflammation has been implicated in the premature aging and increased risk of age-associated comorbidities in cART-treated individuals. However, the immune mechanisms underlying the chronic inflammatory state of cART-suppressed HIV infection remain unclear. Here, we investigated the role of γδT cells, a group of innate IL-17 producin...
Vaahtomeri, Kari Moussion, Christine Hauschild, Robert Sixt, Michael
Published in
Frontiers in Immunology
Gradients of chemokines and growth factors guide migrating cells and morphogenetic processes. Migration of antigen-presenting dendritic cells from the interstitium into the lymphatic system is dependent on chemokine CCL21, which is secreted by endothelial cells of the lymphatic capillary, binds heparan sulfates and forms gradients decaying into the...
