Klocperk, Adam Vcelakova, Jana Vrabcova, Petra Zentsova, Irena Petruzelkova, Lenka Sumnik, Zdenek Pruhova, Stepanka Sediva, Anna Parackova, Zuzana
Published in
Frontiers in Immunology
Type 1 diabetes (T1D) is an autoimmune disorder with unambiguous involvement of both innate and adaptive immune mechanisms in the destruction of pancreatic beta cells. Recent evidence demonstrated that neutrophils infiltrate the pancreas prior to disease onset and therein extrude neutrophil extracellular traps (NETs), web-like structures of DNA and...
Nguyen, Lee S. Salem, Joe-Elie Bories, Marie-Cécile Coutance, Guillaume Amour, Julien Bougle, Adrien Suberbielle, Caroline Kheav, Vissal-David Carmagnat, Maryvonnick Rouvier, Philippe
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Frontiers in Immunology
Background Sensitized patients, i.e. recipients with preformed donor-specific HLA antibodies (pfDSA), are at high-risk of developing antibody-mediated rejections (AMR) and dying after heart transplantation (HTx). Perioperative desensitization procedures are associated with better outcomes but can cause sensitization, which may influence their effic...
Luan, Guangxin Pan, Fan Bu, Lina Wu, Kaixuan Wang, Aizhong Xu, Xiaotao
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Frontiers in Immunology
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is characterized by diffuse inflammation of the lung parenchyma and refractory hypoxemia. Butorphanol is commonly used clinically for perioperative pain relief, but whether butorphanol can regulate LPS-induced alveolar macrophage polarization is unclear. In this study, we observed t...
Sun, Jing Shi, Jiandong Li, Jianfang Wu, Meini Li, Yanhan Jia, Sengquan Ma, Chunli Wang, Xinyi Li, Zhiyuan Hu, Ningzhu
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Frontiers in Immunology
Inducing antigen-specific tolerance is a promising treatment for preventing or reversing Type 1 diabetes (T1D). In contrast to a vaccine that induces immune responses against pathogens, a tolerogenic vaccine can suppress immunity against antigens causing diseases by administrating a mixture of self-antigens with an adjuvant that decreases the stren...
Zheng, Xiangtao Chen, Weiwei Gong, Fangchen Chen, Ying Chen, Erzhen
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Frontiers in Immunology
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Recently was been found that pyroptosis is a unique form of proinflammatory programmed death, that is different from apoptosis. A growing number of studies have investigated pyroptosis and its relationship with sepsis, including the mechanis...
Lassiter, Randi Merchen, Todd D. Fang, Xuexiu Wang, Youli
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Frontiers in Immunology
Renal tubular epithelial cells (TECs) are the primary targets of ischemia–reperfusion injury (IRI) and rejection by the recipient’s immune response in kidney transplantation (KTx). However, the molecular mechanism of rejection and IRI remains to be identified. Our previous study demonstrated that kynurenine 3-monooxygenase (KMO) and kynureninase we...
Uyeda, Molly Javier Freeborn, Robert A. Cieniewicz, Brandon Romano, Rosa Chen, Ping (Pauline) Liu, Jeffrey Mao-Hwa Thomas, Benjamin Lee, Esmond Cepika, Alma-Martina Bacchetta, Rosa
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Frontiers in Immunology
Type 1 regulatory T (Tr1) cells are subset of peripherally induced antigen-specific regulatory T cells. IL-10 signaling has been shown to be indispensable for polarization and function of Tr1 cells. However, the transcriptional machinery underlying human Tr1 cell differentiation and function is not yet elucidated. To this end, we performed RNA sequ...
Michailidou, Despina Schwartz, Daniella Muallem Mustelin, Tomas Hughes, Grant C.
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Frontiers in Immunology
IgG4-related disease (IgG4-RD) is a rare systemic fibroinflammatory disease frequently associated with allergy. The pathogenesis of IgG4-RD is poorly understood, and effective therapies are limited. However, IgG4-RD appears to involve some of the same pathogenic mechanisms observed in allergic disease, such as T helper 2 (Th2) and regulatory T cell...
Redondo, Natalia Zaldívar-López, Sara Garrido, Juan J. Montoya, Maria
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Frontiers in Immunology
There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles during infection are still not completely understood. Here, a review on the current knowledge of SARS-CoV-2 accessory proteins is summarized updating new research that could be...
Chakraborty, Chiranjib Sharma, Ashish Ranjan Bhattacharya, Manojit Lee, Sang-Soo
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Frontiers in Immunology
Recently, mRNA vaccines have become a significant type of therapeutic and have created new fields in the biopharmaceutical industry. mRNA vaccines are promising next-generation vaccines that have introduced a new age in vaccinology. The recent approval of two COVID-19 mRNA vaccines (mRNA-1273 and BNT162b2) has accelerated mRNA vaccine technology an...
