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The paradigm of IL-23-independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases

Published in Frontiers in Immunology

Sepsis: studying the immune system to highlight biomarkers for diagnosis, prognosis and personalized treatments

Published in Frontiers in Immunology

The two-stage molecular scenery of SARS-CoV-2 infection with implications to disease severity: An in-silico quest

Published in Frontiers in Immunology

Introduction The two-stage molecular profile of the progression of SARS-CoV-2 (SCOV2) infection is explored in terms of five key biological/clinical questions: (a) does SCOV2 exhibits a two-stage infection profile? (b) SARS-CoV-1 (SCOV1) vs. SCOV2: do they differ? (c) does and how SCOV2 differs from Influenza/INFL infection? (d) does low viral-load...

Defining discriminatory antibody fingerprints in active and latent tuberculosis

Published in Frontiers in Immunology

Overall avidity declines in TCR repertoires during latent CMV but not EBV infection

Published in Frontiers in Immunology

Introduction The avidity of the T-cell receptor (TCR) for antigenic peptides presented by the MHC (pMHC) on cells is an essential parameter for efficient T cell-mediated immunity. Yet, whether the TCR-ligand avidity can drive the clonal evolution of virus antigen-specific CD8 T cells, and how this process is determined in latent Cytomegalovirus (CM...

A 12-month follow-up of the immune response to SARS-CoV-2 primary vaccination: evidence from a real-world study

Published in Frontiers in Immunology

A real-world population-based longitudinal study, aimed at determining the magnitude and duration of immunity induced by different types of vaccines against COVID-19, started in 2021 by enrolling a cohort of 2,497 individuals at time of their first vaccination. The study cohort included both healthy adults aged ≤65 years and elderly subjects aged >...

A simplified machine learning model utilizing platelet-related genes for predicting poor prognosis in sepsis

Published in Frontiers in Immunology

Background Thrombocytopenia is a known prognostic factor in sepsis, yet the relationship between platelet-related genes and sepsis outcomes remains elusive. We developed a machine learning (ML) model based on platelet-related genes to predict poor prognosis in sepsis. The model underwent rigorous evaluation on six diverse platforms, ensuring reliab...

Identification of omega-3 oxylipins in human milk-derived extracellular vesicles with pro-resolutive actions in gastroin...

Published in Frontiers in Immunology

Introduction Premature infants (PIs) are at risk of suffering necrotizing enterocolitis (NEC), and infants consuming human milk (HM) show a lower incidence than infants receiving formula. The composition of HM has been studied in depth, but the lipid content of HM-derived small extracellular vesicles (HM sEVs) remains unexplored. Identifying these ...

Innate immunity and cross-talk with microflora in the regulation of immune recognition and polarization during immune-re...

Published in Frontiers in Immunology

Helicobacter pylori induces a novel form of innate immune memory via accumulation of NF-кB proteins

Published in Frontiers in Immunology

Helicobacter pylori is a widespread Gram-negative pathogen involved in a variety of gastrointestinal diseases, including gastritis, ulceration, mucosa-associated lymphoid tissue (MALT) lymphoma and gastric cancer. Immune responses aimed at eradication of H. pylori often prove futile, and paradoxically play a crucial role in the degeneration of epit...