Becerril-García, Miguel Angel Yam-Puc, Juan Carlos Maqueda-Alfaro, Raúl Beristain-Covarrubias, Nonantzin Heras-Chavarría, Monica Gallegos-Hernández, Isis Amara Calderón-Amador, Juana Munguía-Fuentes, Rosario Donis-Maturano, Luis Flores-Langarica, Adriana
...
Published in
Frontiers in Immunology
Antigen capturing at the periphery is one of the earliest, crucial functions of antigen-presenting cells (APCs) to initiate immune responses. Langerhans cells (LCs), the epidermal APCs migrate to draining lymph nodes (DLNs) upon acquiring antigens. An arsenal of endocytic molecules is available to this end, including lectins and pathogen recognitio...
Cai, Lun Caraballo Galva, Leidy D. Peng, Yibing Luo, Xiaobing Zhu, Wei Yao, Yihong Ji, Yun He, Yukai
Published in
Frontiers in Immunology
Autologous T cells engineered with T receptor genes (TCR) are being studied to treat cancers. We have recently identified a panel of mouse TCRs specific for the HLA-A0201/alpha fetoprotein epitope (AFP158) complex and have shown that human T cells engineered with these TCR genes (TCR-Ts) can eradicate hepatocellular carcinoma (HCC) xenografts in NS...
Callahan, Brianna N. Kammala, Ananth K. Syed, Meesum Yang, Canchai Occhiuto, Christopher J. Nellutla, Rithvik Chumanevich, Alena P. Oskeritzian, Carole A. Das, Rupali Subramanian, Hariharan
...
Published in
Frontiers in Immunology
Mast cells are tissue-resident innate immune cells known for their prominent role in mediating allergic reactions. MAS-related G-protein coupled receptor-X2 (MRGPRX2) is a promiscuous G-protein coupled receptor (GPCR) expressed on mast cells that is activated by several ligands that share cationic and amphipathic properties. Interestingly, MRGPRX2 ...
Han, X. A. Jie, H. Y. Wang, J. H. Zhang, X. M. Wang, Jun Yu, C. X. Zhang, J. L. He, J. Chen, J. Q. Lai, K. F.
...
Published in
Frontiers in Immunology
Neutrophilic inflammation occurs during asthma exacerbation, and especially, in patients with steroid-refractory asthma, but the underlying mechanisms are poorly understood. Recently, a significant accumulation of neutrophil extracellular traps (NETs) in the airways of neutrophilic asthma has been documented, suggesting that NETs may play an import...
Rajarathnam, Krishna Desai, Umesh R.
Published in
Frontiers in Immunology
Proteoglycans (PGs), present in diverse environments, such as the cell membrane surface, extracellular milieu, and intracellular granules, are fundamental to life. Sulfated glycosaminoglycans (GAGs) are covalently attached to the core protein of proteoglycans. PGs are complex structures, and are diverse in terms of amino acid sequence, size, shape,...
Lee, Cheryl Yi-Pin Lin, Raymond T. P. Renia, Laurent Ng, Lisa F. P.
Published in
Frontiers in Immunology
Since December 2019, the novel coronavirus, SARS-CoV-2, has garnered global attention due to its rapid transmission, which has infected more than two million people worldwide. Early detection of SARS-CoV-2 is one of the crucial interventions to control virus spread and dissemination. Molecular assays have been the gold standard to directly detect f...
Qu, Qiu-xia Zhu, Xin-yun Du, Wen-wen Wang, Hong-bin Shen, Yu Zhu, Yi-bei Chen, Cheng
Published in
Frontiers in Immunology
Although the milestone discovery of immune checkpoint blockade (ICB) has been translated into clinical practice, only a fraction of patients can benefit from it with durable responses and subsequent long-term survival. Here, we tested the anti-tumor effect of combining PD-L1 blockade with 4-1BB costimulation in 3LL and 4T1.2 murine tumor models. Du...
Ranganath, Thanmayi Simpson, Laura J. Ferreira, Anne-Maud Seiler, Christof Vendrame, Elena Zhao, Nancy Fontenot, Jason D. Holmes, Susan Blish, Catherine A.
Published in
Frontiers in Immunology
Daclizumab beta is a humanized monoclonal antibody that binds to CD25 and selectively inhibits high-affinity IL-2 receptor signaling. As a former treatment for relapsing forms of multiple sclerosis (RMS), daclizumab beta induces robust expansion of the CD56bright subpopulation of NK cells that is correlated with the drug’s therapeutic effects. As N...
Pulavendran, Sivasami Prasanthi, Maram Ramachandran, Akhilesh Grant, Rezabek Snider, Timothy A. Chow, Vincent T. K. Malayer, Jerry R. Teluguakula, Narasaraju
Published in
Frontiers in Immunology
Francisella tularensis ( Ft ) is a highly virulent, intracellular Gram-negative bacterial pathogen. Acute Ft infection by aerosol route causes pneumonic tularemia, characterized by nodular hemorrhagic lesions, neutrophil-predominant influx, necrotic debris, fibrin deposition, and severe alveolitis. Ft suppresses activity of neutrophils by impairing...
Mi, Yajing Guo, Na Luan, Jing Cheng, Jianghong Hu, Zhifang Jiang, Pengtao Jin, Weilin Gao, Xingchun
Published in
Frontiers in Immunology
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid progenitor and precursor cells at different stages of differentiation, which play an important role in tumor immunosuppression. Glioma is the most common and deadliest primary malignant tumor of the brain, and ample evidence supports key contributions of MDSCs to the immu...
