Hao, Yun Zhao, Yan Wang, Ping Du, Kun Li, Ying Yang, Zhen Wang, Xiangdong Zhang, Luo
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Frontiers in Genetics
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic sinonasal inflammatory disease with limited treatment options of corticosteroids, sinus surgery, or both. CRSwNP is frequently associated with allergic rhinitis and asthma, but the molecular mechanisms underlying CRSwNP inflammation are not completely understood. We obtained four gene e...
Wang, Weina Shui, Liyan Liu, Yanning Zheng, Min
Published in
Frontiers in Genetics
Previous studies have reported an important role of c-kit in embryogenesis and adulthood. Activation of the SCF/KIT signal transduction pathway is customarily linked to cell proliferation, migration and survival thus influence hematopoiesis, pigmentation, and spermatogenesis. The role of c-kit in the liver is controversial, it is however argued tha...
Gálvez, Sergio Agostini, Federico Caselli, Javier Hernandez, Pilar Dorado, Gabriel
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Frontiers in Genetics
New High-Performance Computing architectures have been recently developed for commercial central processing unit (CPU). Yet, that has not improved the execution time of widely used bioinformatics applications, like BLAST+. This is due to a lack of optimization between the bases of the existing algorithms and the internals of the hardware that allow...
Fan, Jianglin Wang, Yanli Chen, Y. Eugene
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Frontiers in Genetics
Rabbits are one of the most used experimental animals for investigating the mechanisms of human cardiovascular disease and lipid metabolism because they are phylogenetically closer to human than rodents (mice and rats). Cholesterol-fed wild-type rabbits were first used to study human atherosclerosis more than 100 years ago and are still playing an ...
Li, Dan Jin, Wen Sun, Li Wu, Jiawei Hu, Hao Ma, Likun
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Frontiers in Genetics
Background Atherosclerosis is a risk factor for cardiovascular diseases. However, the roles of Circular RNAs (circRNAs) in atherosclerosis is unknown. Our study aimed to explore the effects of circ_0065149 in the pathogenesis of atherosclerosis. Methods The expression of circ_0065149 ox-LDL-induced in human umbilical vein endothelial cells (HUVECs)...
Vieira, Igor Araujo Andreis, Tiago Finger Fernandes, Bruna Vieira Achatz, Maria Isabel Macedo, Gabriel S. Schramek, Daniel Ashton-Prolla, Patricia
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Frontiers in Genetics
In Southern and Southeastern Brazil, there is a germline pathogenic variant with incomplete penetrance located in the oligomerization domain of TP53 , c.1010G>A (p.Arg337His). Due to a founder effect, the variant is present in 0.3% of the general population of the region. Recently, this variant was identified in 4.4 and 8.9% of two apparently unsel...
Zhao, Zhifeng Zou, Xian Lu, Tingting Deng, Ming Li, Yaokun Guo, Yongqing Sun, Baoli Liu, Guangbin Liu, Dewu
Published in
Frontiers in Genetics
Wei, Xiangzhen Cai, Menghua Jin, Lifang
Published in
Frontiers in Genetics
Parkinson’s means Parkinson’s disease, a chronic degenerative disease of central nervous system. The main area which is affected by this disease is motor system. Since it firstly founded by James Parkinson in his 1817 publication, nowadays, people still have lots of questions about this disease. This review mainly summarizes the epigenetics of Park...
Chen, Guanzhong Liu, Liwei Li, Huanqiang Lun, Zhubin Mai, Ziling Lai, Wenguang Chen, Enzhao Zhou, Chunyun Yu, Sijia Yang, Junqing
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Published in
Frontiers in Genetics
Background Acute myocardial infarction (AMI), characterized by an event of myocardial necrosis, is a common cardiac emergency worldwide. However, the genetic mechanisms of AMI remain largely elusive. Methods A genome-wide association study dataset of AMI was obtained from the CARDIoGRAMplusC4D project. A transcriptome-wide association study (TWAS) ...
Guo, Jiani Yang, Yu Ji, Zhuqing Yao, Mengchu Xia, Xiaotian Sha, Xiaofeng Huang, Mingde
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Frontiers in Genetics
A 78 years old Chinese woman with five different cancer types and a family history of malignancy was the subject of this study. Pancreatic adenocarcinoma and gingival squamous cell carcinoma tissues were obtained from the patient and sequenced using Whole Exome Sequencing. Whole exome sequencing identified 20 mutation sites in six candidate genes. ...