Qiu, Zhong-Ling Shen, Chen-Tian Sun, Zhen-Kui Song, Hong-Jun Xi, Chuang Zhang, Guo-Qiang Wang, Yang Luo, Quan-Yong
Published in
Frontiers in Endocrinology
Objective The objective of this study was to investigate the clinicopathological characteristics, long-term outcomes, and prognostic factors of elderly patients with distant metastases at initial diagnosis from well-differentiated thyroid cancer (WDTC) during radioactive iodine (131I) treatment and follow-up. Methods A retrospective review of medic...
Oakie, Amanda Nostro, Maria Cristina
Published in
Frontiers in Endocrinology
Restoring the number of glucose-responsive β-cells in patients living with diabetes is critical for achieving normoglycemia since functional β-cells are lost during the progression of both type 1 and 2 diabetes. Stem cell-derived β-cell replacement therapies offer an unprecedented opportunity to replace the lost β-cell mass, yet differentiation eff...
Yang, Haiyan Lin, Jie Li, He Liu, Zhangwei Chen, Xia Chen, Qianqian
Published in
Frontiers in Endocrinology
Background Our study aimed to investigate if serum prolactin (PRL) levels associated with insulin resistance and beta-cell dysfunction in infertile patients with polycystic ovary syndrome (PCOS). Methods This was a retrospective cross-sectional study performed in the reproductive medicine center of the first affiliated hospital of Wenzhou Medical U...
Ishizuka, Bunpei
Published in
Frontiers in Endocrinology
Premature ovarian insufficiency (POI) occurs in at least 1% of all women and causes life-long health problems and psychological stress. Infertility caused by POI used to be considered absolute, with infertility treatment having little or no value. Generally, it has been thought that medicine can provide little service to these patients. The etiolog...
Liu, Ping Luo, Ban Chen, Lang Wang, Qiu-Xia Yuan, Gang Jiang, Gui-hua Zhang, Jing
Published in
Frontiers in Endocrinology
Objective Prediction of therapy response to intravenous methylprednisolone pulses (ivMP) is crucial for thyroid-associated ophthalmopathy (TAO). Image histograms may offer sensitive imaging biomarkers for therapy effect prediction. This study aimed to investigate whether pretherapeutic, multiparametric T2 relaxation time(T2RT) histogram features of...
Lafferty, Ryan A. Tanday, Neil Moffett, R. Charlotte Reimann, Frank Gribble, Fiona M. Flatt, Peter R. Irwin, Nigel
Published in
Frontiers in Endocrinology
Enzymatically stable and specific neuropeptide Y1 receptor (NPYR1) agonists, such as sea lamprey PYY(1-36) (SL-PYY(1-36)), are believed to improve glucose regulation in diabetes by targeting pancreatic islets. In this study, streptozotocin (STZ) diabetic transgenic Glu CreERT2 ; ROSA26-eYFP and Ins1 Cre/+; Rosa26-eYFP mouse models have been used to...
Gomes-Lima, Cristiane J. Shobab, Leila Wu, Di Ylli, Dorina Bikas, Athanasios McCoy, Matthew Feldman, Rebecca Lee, Wen Rao, Sarika N. Jensen, Kirk
...
Published in
Frontiers in Endocrinology
Management of metastatic radioiodine refractory differentiated thyroid cancer (DTC) can be a therapeutic challenge. Generally, little is known about the paired molecular profile of the primary tumor and the metastases and whether they harbor the same genetic abnormalities. The present study compared the molecular profile of paired tumor specimens (...
Pilmark, Nanna Skytt Petersen-Bønding, Christina Holm, Nielse Frederich Rose Johansen, Mette Yun Pedersen, Bente Klarlund Hansen, Katrine Bagge Karstoft, Kristian
Published in
Frontiers in Endocrinology
Introduction In general, patients with type 2 diabetes have lower cardiorespiratory fitness levels and perform exercise at lower intensities compared to healthy controls. Since metformin (MET) has been shown to increase the rate of perceived exertion (RPE) during exercise with a fixed intensity, MET per se may reduce self-selected exercise intensit...
Moin, Abu Saleh Md Sathyapalan, Thozhukat Butler, Alexandra E. Atkin, Stephen L.
Published in
Frontiers in Endocrinology
Background Women with polycystic ovary syndrome (PCOS) often have vitamin D deficiency, a known risk factor for severe COVID-19 disease. Alveolar macrophage-derived cytokines contribute to the inflammation underlying pulmonary disease in COVID-19. We sought to determine if basal macrophage activation, as a risk factor for COVID-19 infection, was pr...
Duez, Hélène Pourcet, Benoit
Published in
Frontiers in Endocrinology
The innate immune system is the first line of defense specialized in the clearing of invaders whether foreign elements like microbes or self-elements that accumulate abnormally including cellular debris. Inflammasomes are master regulators of the innate immune system, especially in macrophages, and are key sensors involved in maintaining cellular h...
