Zaghlol, Louay Y. Beirat, Amir F. Amarin, Justin Z. Hassoun Al Najar, Amro M. Hasan, Yazan Y. Qtaishat, Abdallah Tierney, Michael E. Zaghlol, Raja Y. Zayed, Ayman A.
Published in
Frontiers in Endocrinology
Objective We aimed to investigate the effect of dosage reduction of four hypoglycemic multidrug regimens on the incidences of acute glycemic complications in people with type 2 diabetes who fast during Ramaḍān. Methods We conducted an open-label, parallel-group, randomized controlled trial at a tertiary care center in Amman, Jordan. We recruited ad...
Milesi, María Mercedes Lorenz, Virginia Durando, Milena Rossetti, María Florencia Varayoud, Jorgelina
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Frontiers in Endocrinology
Glyphosate base herbicides (GBHs) are the most widely applied pesticides in the world and are mainly used in association with GBH-tolerant crop varieties. Indiscriminate and negligent use of GBHs has promoted the emergence of glyphosate resistant weeds, and consequently the rise in the use of these herbicides. Glyphosate, the active ingredient of a...
Zhai, Qiangrong Tian, Ci Deng, Zhengzhao Liu, Congrong Ma, Qingbian
Published in
Frontiers in Endocrinology
We present a 30-year old male presented with hemoptysis as a first manifestation and pulmonary CT scan characteristic of diffuse alveolar hemorrhage. Further abdominal examination discovered a left adrenal mass. Elevated catecholamine and metanephrine levels and subsequent adrenalectomy confirmed the diagnosis of pheochromocytoma. Symptoms of pheoc...
Dao, Myriam François, Helene
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Frontiers in Endocrinology
Chronic kidney disease (CKD) concerns millions of individuals worldwide, with few therapeutic strategies available to date. Recent evidence suggests that the endocannabinoid system (ECS) could be a new therapeutic target to prevent CKD. ECS combines receptors, cannabinoid receptor type 1 (CB1R) and type 2 (CB2R), and ligands. The most prominent rec...
Smits, Mark M. Van Raalte, Daniël H.
Published in
Frontiers in Endocrinology
The glucagon-like peptide-1 receptor agonist (GLP-1RA) semaglutide is the most recently approved agent of this drug class, and the only GLP-1RA currently available as both subcutaneous and oral formulation. While GLP-1RAs effectively improve glycemic control and cause weight loss, potential safety concerns have arisen over the years. For semaglutid...
Burgos, Juan Ignacio Vallier, Ludovic Rodríguez-Seguí, Santiago A.
Published in
Frontiers in Endocrinology
The occurrence of diabetes mellitus is characterized by pancreatic β cell loss and chronic hyperglycemia. While Type 1 and Type 2 diabetes are the most common types, rarer forms involve mutations affecting a single gene. This characteristic has made monogenic diabetes an interesting disease group to model in vitro using human pluripotent stem cells...
Obara-Moszynska, Monika Dzialach, Lukasz Rabska-Pietrzak, Barbara Niedziela, Marek Kapczuk, Karina
Published in
Frontiers in Endocrinology
Objective Most girls and women with Turner syndrome (TS) require estrogen replacement therapy (ERT) to initiate or maintain pubertal development. Most likely, the most fundamental effect of ERT in hypogonadism is the promotion of uterine growth. The optimal ERT model is still being discussed. The present study aimed to assess uterine size in girls ...
Li, Ziyi Wang, Yafei Li, Shilun Li, Yukun
Published in
Frontiers in Endocrinology
Bone regeneration is a complex process that requires the coordination of osteogenesis and osteoclastogenesis. The balance between osteogenesis and adipogenesis of bone marrow mesenchymal stem cells (BMSCs) plays a major role in the process of bone formation. Recently, intercellular communication between bone cells and surrounding cells has been gra...
Wang, Xuan Li, Qian Han, Xu Gong, Meirong Yu, Zhi Xu, Bin
Published in
Frontiers in Endocrinology
Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes mellitus (DM) and affects over one-third of all patients. Neuropathic pain and nerve dysfunction induced by DM is related to the increase of advanced glycation end products (AGEs) produced by reactive dicarbonyl compounds in a hyperglycemia environment. AGEs in...
Moser, Othmar Eckstein, Max L. Mueller, Alexander Tripolt, Norbert J. Yildirim, Hakan Abbas, Farah Pferschy, Peter N. Goswami, Nandu Aberer, Felix Obermayer, Anna
...
Published in
Frontiers in Endocrinology
Prolonged fasting has shown beneficial effects in healthy individuals and in people with chronic diseases. In type 1 diabetes, the effect or even the feasibility of fasting is unclear. We aimed to assess the impact and safety of prolonged fasting in adults with type 1 diabetes. Glycemia was assessed during overnight fasting (12 hours) vs. prolonged...
