Neto, Alexandre Fernandes, Adelaide Barateiro, Andreia
Published in
Frontiers in Cellular Neuroscience
Obesity is a global epidemic, affecting roughly 30% of the world’s population and predicted to rise. This disease results from genetic, behavioral, societal, and environmental factors, leading to excessive fat accumulation, due to insufficient energy expenditure. The adipose tissue, once seen as a simple storage depot, is now recognized as a comple...
Morisaki, Yuta Ohshima, Motoki Suzuki, Hikaru Misawa, Hidemi
Published in
Frontiers in Cellular Neuroscience
Microglia are resident innate immune cells in the central nervous system (CNS) and play important roles in the development of CNS homeostasis. Excessive activation and neurotoxicity of microglia are observed in several CNS disorders, but the mechanisms regulating their activation remain unclear. Immune checkpoint molecules are expressed on activate...
Zhang, Yuejin Chu, Guangpin Leng, Yangming Lin, Xueling Zhou, Hong Lu, Yisheng Liu, Bo
Published in
Frontiers in Cellular Neuroscience
Background The commissural inhibitory system between the bilateral medial vestibular nucleus (MVN) plays a key role in vestibular compensation. Calcium-binding protein parvalbumin (PV) is expressed in MVN GABAergic neurons. Whether these neurons are involved in vestibular compensation is still unknown. Methods After unilateral labyrinthectomy (UL),...
Donison, Neil Hintermayer, Matthew Subramaniam, Maegha Santandrea, Erin Volkening, Kathryn Strong, Michael J.
Published in
Frontiers in Cellular Neuroscience
Phosphorylated microtubule-associated protein tau (tau) aggregates are a pathological hallmark of various neurodegenerative diseases, including chronic traumatic encephalopathy and amyotrophic lateral sclerosis with cognitive impairment. While there are many residues phosphorylated on tau, phosphorylation of threonine 175 (pThr175 tau) has been sho...
Cording, Katherine R. Bateup, Helen S.
Published in
Frontiers in Cellular Neuroscience
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with increasing prevalence. Over 1,000 risk genes have now been implicated in ASD, suggesting diverse etiology. However, the diagnostic criteria for the disorder still comprise two major behavioral domains - deficits in social communication and interaction, and the presence of ...
Karatas, Hulya
Published in
Frontiers in Cellular Neuroscience
Gierke, Kaspar Lux, Uwe Thorsten Regus-Leidig, Hanna Brandstätter, Johann Helmut
Published in
Frontiers in Cellular Neuroscience
Vision is our primary sense, and maintaining it throughout our lifespan is crucial for our well-being. However, the retina, which initiates vision, suffers from an age-related, irreversible functional decline. What causes this functional decline, and how it might be treated, is still unclear. Synapses are the functional hub for signal transmission ...
Guangming, Gan Mei, Chen Qinfeng, Yu Xiang, Gao Chenchen, Zhang Qingyuan, Sheng Wei, Xie Junhua, Geng
Published in
Frontiers in Cellular Neuroscience
The Drosophila larval neuromuscular junction (NMJ) is a well-known model system and is often used to study synapse development. Here, we show synaptic degeneration at NMJ boutons, primarily based on transmission electron microscopy (TEM) studies. When degeneration starts, the subsynaptic reticulum (SSR) swells, retracts and folds inward, and the re...
Mohamed, Doaa I. Abo Nahas, Hebatallah H. Elshaer, Asmaa M. El-Waseef, Dalia Alaa El-Din Aly El-Kharashi, Omnyah A. Mohamed, Soha M. Y. Sabry, Yasmine Gamal Almaimani, Riyad A. Almasmoum, Hussain A. Altamimi, Abdulmalik S.
...
Published in
Frontiers in Cellular Neuroscience
Autism spectrum disorders (ASD) represent a diverse group of neuropsychiatric conditions, and recent evidence has suggested a connection between ASD and microbial dysbiosis. Immune and gastrointestinal dysfunction are associated with dysbiosis, and there are indications that modulating the microbiota could improve ASD-related behaviors. Additionall...
Yoshida, Kenji Kato, Daisuke Sugio, Shouta Takeda, Ikuko Wake, Hiroaki
Published in
Frontiers in Cellular Neuroscience
Oligodendrocytes (OCs) form myelin around axons, which is dependent on neuronal activity. This activity-dependent myelination plays a crucial role in training and learning. Previous studies have suggested that neuronal activity regulates proliferation and differentiation of oligodendrocyte precursor cells (OPCs) and myelination. In addition, defici...
