Jodeiri Farshbaf, Mohammad Matos, Taelor A. Niblo, Kristi Alokam, Yacoub Ables, Jessica L.
Published in
Frontiers in Cellular Neuroscience
Introduction Diabetes is a metabolic disorder of glucose homeostasis that is a significant risk factor for neurodegenerative diseases, such as Alzheimer’s disease, as well as mood disorders, which often precede neurodegenerative conditions. We examined the medial habenulainterpeduncular nucleus (MHb-IPN), as this circuit plays crucial roles in mood...
Cupolillo, Dario Regio, Vincenzo Barberis, Andrea
Published in
Frontiers in Cellular Neuroscience
Di Marco, Irene Sansevero, Gabriele Berardi, Nicoletta Sale, Alessandro
Published in
Frontiers in Cellular Neuroscience
Abnormal visual experience during development resulting from an imbalance in the activity of the two eyes can lead to permanent severe visual deficits, a pathology called amblyopia (lazy eye). While this condition is extremely difficult to treat in adults, current interventions can elicit significant amounts of visual recovery when performed in juv...
Simões-Abade, Madalena B. C. Patterer, Marlene Nicaise, Alexandra M. Pluchino, Stefano
Published in
Frontiers in Cellular Neuroscience
Multiple sclerosis (MS), a debilitating autoimmune disorder targeting the central nervous system (CNS), is marked by relentless demyelination and inflammation. Clinically, it presents in three distinct forms: relapsing–remitting MS (RRMS), primary progressive MS (PPMS), and secondary progressive MS (SPMS). While disease-modifying therapies (DMTs) o...
Menezes, Filipe Palmeira, Julys da Fonseca Oliveira, Juliana dos Santos Argañaraz, Gustavo Adolfo Soares, Carlos Roberto Jorge Nóbrega, Otávio Toledo Ribeiro, Bergmann Morais Argañaraz, Enrique Roberto
Published in
Frontiers in Cellular Neuroscience
The persistence or emergence of long-term symptoms following resolution of primary SARS-CoV-2 infection is referred to as long COVID or post-acute sequelae of COVID-19 (PASC). PASC predominantly affects the cardiovascular, neurological, respiratory, gastrointestinal, reproductive, and immune systems. Among these, the central nervous system (CNS) is...
Meng, Lingda Gu, Tianxiang Yu, Peng Zhang, Zhiwei Wei, Zhijing
Published in
Frontiers in Cellular Neuroscience
Cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) are indispensable core techniques in cardiac surgery. Numerous studies have shown that cardiopulmonary bypass and deep hypothermic circulatory arrest are associated with the occurrence of neuroinflammation, accompanied by the activation of microglia. Microglia, as macrophag...
Evans, Megan A. Chavkin, Nicholas W. Sano, Soichi Sun, Hanna Sardana, Taneesha Ravi, Ramya Doviak, Heather Wang, Ying Yura, Yoshimitsu Polizio, Ariel H.
...
Published in
Frontiers in Cellular Neuroscience
Introduction Recent work has revealed that clonal hematopoiesis (CH) is associated with a higher risk of numerous age-related diseases, including ischemic stroke, however little is known about whether it influences stroke outcome independent of its widespread effects on cardiovascular disease. Studies suggest that leukocytes carrying CH driver muta...
Orsini, Franca Pascente, Rosaria Martucci, Annacarla Palacino, Sara Fraser, Paul Arancio, Ottavio Fioriti, Luana
Published in
Frontiers in Cellular Neuroscience
Introduction Abnormal intracellular accumulation of Tau aggregates is a hallmark of Alzheimer’s disease (AD) and other Tauopathies, such as Frontotemporal dementia (FTD). Tau deposits primarily affect neurons, but evidence indicates that glial cells may also be affected and contribute distinctively to disease progression. Cells can respond to toxic...
Knopper, Rasmus West Skoven, Christian Stald Eskildsen, Simon Fristed Østergaard, Leif Hansen, Brian
Published in
Frontiers in Cellular Neuroscience
The locus coeruleus (LC) produces most of the brain’s noradrenaline (NA). Among its many roles, NA is often said to be neuroprotective and important for brain upkeep. For this reason, loss of LC integrity is thought to impact brain volume and microstructure as well as plasticity broadly. LC dysfunction is also a suspected driver in the development ...
Müller, Ludmila Di Benedetto, Svetlana
Published in
Frontiers in Cellular Neuroscience
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global health, affecting not only the immediate morbidity and mortality rates but also long-term health outcomes across various populations. Although the acute effects of COVID-19 on the respiratory system have initially been the primary focus, it is increasi...
