Zhuo, Haitao Chen, Yunfei Zhao, Guifang
Published in
Frontiers in Cell and Developmental Biology
Mesenchymal stem cells (MSCs) primarily secrete physiologically functional exosomes via paracrine effects that act on various adjacent and distant cells, thus exerting their therapeutic effects. In recent years, hypoxic preconditioning, as a novel MSC culture mode, has emerged as a research hotspot. Many previous studies have shown the role and und...
Gregersen, Emil Kresse, Jean-Claude Atay, Jasmine Cicek Leifing Boysen, Anders Toftegaard Nejsum, Peter Eijken, Marco Nørregaard, Rikke
Published in
Frontiers in Cell and Developmental Biology
Renal fibrosis, characterized by excessive extracellular matrix accumulation, leads to a progressive decline of renal function and is a common endpoint of chronic kidney disease (CKD). Current treatments primarily focus on managing underlying diseases, offering limited direct intervention for the fibrotic process. This study explores the anti-fibro...
Oh, Hyun-Ji Imam-Aliagan, Abdulhamid B. Kim, Yeo-Bin Kim, Hyun-Jin Izaguirre, Issac A. Sung, Chang K. Yim, Hyungshin
Published in
Frontiers in Cell and Developmental Biology
Despite recent advances in cancer diagnostics and treatment, the mortality associated with lung cancer is still the highest in the world. Late-stage diagnosis, often accompanied by metastasis, is a major contributor to the high mortality rates, emphasizing the urgent need for reliable and readily accessible diagnostic tools that can detect biomarke...
Wu, Xiaojing Chatzigeorgiou, Antonios Shi, Ying Zhu, Liuluan
Published in
Frontiers in Cell and Developmental Biology
Gou, Siqi Wu, Anqi Luo, Zhigang
Published in
Frontiers in Cell and Developmental Biology
Integrins are a class of adhesion receptors on cell membranes, consisting of α and β subunits. By binding to the extracellular matrix, integrins activate intracellular signaling pathways, participating in every step of cancer initiation and progression. Tumor stem cells possess self-renewal and self-differentiation abilities, along with strong tumo...
DeMarco, Andrew G. Dibble, Marcella G. Hall, Mark C.
Published in
Frontiers in Cell and Developmental Biology
Introduction Reversible protein phosphorylation is an abundant post-translational modification dynamically regulated by opposing kinases and phosphatases. Protein phosphorylation has been extensively studied in cell division, where waves of cyclin-dependent kinase activity, peaking in mitosis, drive the sequential stages of the cell cycle. Here we ...
Pintus, Eliana Kotrba, Radim Ros-Santaella, José Luis
Published in
Frontiers in Cell and Developmental Biology
Background: In polygynous species, the development of secondary sexual characters is usually decisive for male reproductive success. However, our understanding about the links between the growth of these traits and reproductive efficiency is still elusive. Most research efforts in this topic have been also focused on adult males, although the devel...
Atkinson-Leadbeater, Karen Bertolesi, Gabriel E. McFarlane, Sarah
Published in
Frontiers in Cell and Developmental Biology
Introduction Developmental processes continue in organisms in which sensory systems have reached functional maturity, however, little research has focused on the influence of sensory input on cell and tissue development. Here, we explored the influence of visual system activity on the development of skin melanophores in Xenopus laevis. Methods Mela...
Anticevic, Ivan Otten, Cecile Popovic, Marta
Published in
Frontiers in Cell and Developmental Biology
DNA-protein crosslinks pose a significant challenge to genome stability and cell viability. Efficient repair of DPCs is crucial for preserving genomic integrity and preventing the accumulation of DNA damage. Despite recent advances in our understanding of DPC repair, many aspects of this process, especially at the organismal level, remain elusive. ...
Sun, Xutao Xiao, Chengpu Wang, Xinyang Wu, Siyu Yang, Zhendong Sui, Bowen Song, Yunjia
Published in
Frontiers in Cell and Developmental Biology
Specific protein 1 (Sp1) is central to regulating transcription factor activity and cell signaling pathways. Sp1 is highly associated with the poor prognosis of various cancers; it is considered a non-oncogene addiction gene. The function of Sp1 is complex and contributes to regulating extensive transcriptional activity, apart from maintaining basa...
