Methods, techniques, and applications involving the use of high resolution microscopy to study cell structures
Published in Frontiers in Cell and Developmental Biology
Methods, techniques, and applications involving the use of high resolution microscopy to study cell structures
Relation between learning process and morphology of transport tube network in plasmodium of Physarum polycephalum
Published in Frontiers in Cell and Developmental Biology
The question of whether a single-celled organism without a brain could have functions such as learning and memory has been the subject of much debate in recent years. The plasmodium of the true slime mold, Physarum polycephalum, is an ideal model organism for such a question. The plasmodium exhibits behaviors that resemble intelligence, including s...
Single-cell RNA sequencing reveals cancer stem-like cells and dynamics in tumor microenvironment during cholangiocarcino...
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Published in Frontiers in Cell and Developmental Biology
Cholangiocarcinoma is a malignancy of the bile ducts that is driven by activities of cancer stem-like cells and characterized by a heterogeneous tumor microenvironment. To better understand the transcriptional profiles of cancer stem-like cells and dynamics in the tumor microenvironment during the progression of cholangiocarcinoma, we performed sin...
m6A demethylase FTO and osteoporosis: potential therapeutic interventions
Published in Frontiers in Cell and Developmental Biology
Osteoporosis is a common bone disease, characterized by a descent in bone mass due to the dysregulation of bone homeostasis. Although different studies have identified an association between osteoporosis and epigenetic alterations in osteogenic genes, the mechanisms of osteoporosis remain unclear. N6-methyladenosine (m6A) modification is a methylat...
Causal association of physical activity with low back pain, intervertebral disc degeneration and sciatica: a two-sample ...
Published in Frontiers in Cell and Developmental Biology
Objective: Previous studies are insufficient to confirm a causal association between physical activity (PA) and low back pain (LBP), intervertebral disc degeneration (IDD), and sciatica. The present study used a two-sample Mendelian randomization (MR) analysis method to demonstrate whether or not there was a causal connection. Methods: First, four ...
Lipid rafts mediate multilineage differentiation of human dental pulp-derived stem cells (DPSCs)
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Published in Frontiers in Cell and Developmental Biology
Cell outer membranes contain glycosphingolipids and protein receptors, which are integrated into glycoprotein domains, known as lipid rafts, which are involved in a variety of cellular processes, including receptor-mediated signal transduction and cellular differentiation process. In this study, we analyzed the lipidic composition of human Dental P...
A complex interplay between H2A.Z and HP1 isoforms regulates pericentric heterochromatin
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Published in Frontiers in Cell and Developmental Biology
Pericentric heterochromatin (PCH) plays an essential role in the maintenance of genome integrity and alterations in PCH have been linked to cancer and aging. HP1 α, β, and γ, are hallmarks of constitutive heterochromatin that are thought to promote PCH structure through binding to heterochromatin-specific histone modifications and interaction with ...
Protein kinase B/AKT phosphorylates hypoxia-inducible factor-3α1 in response to insulin, promoting cell growth and migra...
Published in Frontiers in Cell and Developmental Biology
Hypoxia-inducible factors (HIFs) are best known for their roles in the adaptation to low oxygen environments. Besides hypoxia, HIF-1/2 α-subunits are also regulated by various non-hypoxic stimuli including insulin which can act via the PI3K/protein kinase B (PKB) signaling pathway. However, with respect to insulin little is known about HIF-3α. We a...
Peptidomic analysis of follicular fluid in patients with polycystic ovarian syndrome
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Published in Frontiers in Cell and Developmental Biology
Objective: The aim of this study was to analyze and compare the differential expression of peptides within the follicular fluid of polycystic ovary syndrome (PCOS) patients versus normal women by using peptidomics techniques. The underlying mechanisms involved in PCOS pathogenesis will be explored, together with screening and identification of pote...
Editorial: Evolution, emerging functions and structure of actin‐binding proteins, Volume II
Published in Frontiers in Cell and Developmental Biology
