Kobayashi, Yutaka Tanaka, Tomoyuki Mulati, Mieradilli Ochi, Hiroki Sato, Shingo Kaldis, Philipp Yoshii, Toshitaka Okawa, Atsushi Inose, Hiroyuki
Published in
Frontiers in Cell and Developmental Biology
Satellite cell proliferation is an essential step in proper skeletal muscle development and muscle regeneration. However, the mechanisms regulating satellite cell proliferation are relatively unknown compared to the knowledge associated with the differentiation of satellite cells. Moreover, it is still unclear whether overload muscle fiber hypertro...
Ceder, Mikaela M. Aggarwal, Tanya Hosseini, Kimia Maturi, Varun Patil, Sourabh Perland, Emelie Williams, Michael J. Fredriksson, Robert
The number of transporter proteins that are not fully characterized is immense. Here, we used Drosophila melanogaster and human cell lines to perform a first in-depth characterization of CG4928, an ortholog to the human UNC93A, of which little is known. Solute carriers regulate and maintain biochemical pathways important for the body, and malfuncti...
Castellano, José M. Espinosa, Juan M. Perona, Javier S.
Published in
Frontiers in Cell and Developmental Biology
Small lipophilic molecules present in foods of plant origin have relevant biological activities at rather low concentrations. Evidence suggests that phytosterols, carotenoids, terpenoids, and tocopherols can interact with different metabolic pathways, exerting beneficial effects against a number of metabolic diseases. These small molecules can modu...
Abe, Yuichi Nishimura, Yoshiki Nakamura, Kaori Tamura, Shigehiko Honsho, Masanori Udo, Hiroshi Yamashita, Toshihide Fujiki, Yukio
Published in
Frontiers in Cell and Developmental Biology
Peroxisome is an intracellular organelle that functions in essential metabolic pathways including β-oxidation of very-long-chain fatty acids and biosynthesis of plasmalogens. Peroxisome biogenesis disorders (PBDs) manifest severe dysfunction in multiple organs including central nervous system (CNS), whilst the pathogenic mechanisms are largely unkn...
Bonilha, Vera L. Bell, Brent A. DeBenedictis, Meghan J. Hagstrom, Stephanie A. Fishman, Gerald A. Hollyfield, Joe G.
Published in
Frontiers in Cell and Developmental Biology
Best disease (BD), also known as vitelliform macular dystrophy, is an inherited disease of the central retina caused by more than 300 pathogenic variants in the BEST1 gene. The phenotype of BD is variable, and there are just a few reports on the histopathology of eyes from donors with BD. Here, we describe the histopathological comparison of donor’...
Kuroda, Junpei Itabashi, Takeshi Iwane, Atsuko H. Aramaki, Toshihiro Kondo, Shigeru
Published in
Frontiers in Cell and Developmental Biology
Fibrous collagen imparts physical strength and flexibility to tissues by forming huge complexes. The density and orientation of collagen fibers must be correctly specified for the optimal physical property of the collagen complex. However, little is known about its underlying cellular mechanisms. Actinotrichia are collagen fibers aligned at the fin...
Huo, Xiao Sun, Hengzi Qian, Qiuhong Ma, Xiangwen Peng, Peng Yu, Mei Zhang, Ying Yang, Jiaxin Cao, Dongyan Gui, Ting
...
Published in
Frontiers in Cell and Developmental Biology
Background Ovarian cancer has the highest mortality rate among gynecologic cancers, and most patients are diagnosed in advanced stages. Enhancer of zeste homolog 2 (EZH2) is a major tumor marker and an effective therapeutic target for ovarian cancer, but the underlying molecular mechanism remains unclear. The present study investigated the biologic...
Lu, Yan Hou, Kaiqing Li, Mengsen Wu, Xiaobin Yuan, Shaochun
Published in
Frontiers in Cell and Developmental Biology
Gastric cancer is the third leading cause of cancer-related deaths worldwide and is characterized by poor survival and high recurrence rates. Long non-coding RNAs (lncRNAs) have gained considerable attention in recent years as prognostic markers and gene regulators in various cancers. Here, we found that lncHEIH was upregulated in gastric cancer ti...
Zhao, Linlin Fu, Qingshan Pan, Liqiang Piai, Alessandro Chou, James J.
Published in
Frontiers in Cell and Developmental Biology
Receptors in the tumor necrosis factor receptor superfamily (TNFRSF) regulate proliferation of immune cells or induce programmed cell death, and many of them are candidates for antibody-based immunotherapy. Previous studies on several death receptors in the TNFRSF including Fas, p75NTR, and DR5 showed that the transmembrane helix (TMH) of these rec...
Baldassari, Simona Musante, Ilaria Iacomino, Michele Zara, Federico Salpietro, Vincenzo Scudieri, Paolo
Published in
Frontiers in Cell and Developmental Biology
Neurodevelopmental disorders (NDDs) are a group of disorders in which the development of the central nervous system (CNS) is disturbed, resulting in different neurological and neuropsychiatric features, such as impaired motor function, learning, language or non-verbal communication. Frequent comorbidities include epilepsy and movement disorders. Ad...
