García-Cosío, María Dolores González-Vilchez, Francisco López-Vilella, Raquel Barge-Caballero, Eduardo Gómez Bueno, Manuel Martínez-Selles, Manuel María Arizón, Jose Rangel Sousa, Diego González-Costello, José Mirabet, Sonia
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Published in
Frontiers in Cardiovascular Medicine
Biological differences between males and females change the course of different diseases and affect therapeutic measures' responses. Heart failure is not an exception to these differences. Women account for a minority of patients on the waiting list for heart transplantation or other advanced heart failure therapies. The reason for this under-repre...
Finke, Daniel Heckmann, Markus B. Herpel, Esther Katus, Hugo A. Haberkorn, Uwe Leuschner, Florian Lehmann, Lorenz H.
Published in
Frontiers in Cardiovascular Medicine
Objective: Checkpoint inhibitors (ICIs) have gained importance in recent years regarding the treatment of a variety of oncologic diseases. The possibilities of diagnosing cardiac adverse autoimmune effects of ICIs are still limited. We aimed to implement FAPI PET/CT imaging in detecting ICI-associated myocarditis. Methods: In a retrospective study,...
Kim, Peter Masha, Luke Olson, Amanda Iliescu, Cezar Karimzad, Kaveh Hassan, Saamir Palaskas, Nicolas Durand, Jean-Bernard Leung, Cheuk Hong Lopez-Mattei, Juan
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Published in
Frontiers in Cardiovascular Medicine
Background: QT prolongation and torsades de pointes pose a major concern for cardiologists and oncologists. Although cancer patients are suspected to have prolonged QT intervals, this has not been investigated in a large population. The purpose of this study was to analyze the QT interval distribution in a cancer population and compare it to a non-...
Pichler Sekulic, Simona Sekulic, Miroslav
Published in
Frontiers in Cardiovascular Medicine
Cardiac valve inflammation is seen in the setting of autoimmune or infectious processes, and rarely is valvulitis characterized by granulomatous inflammation. We present two patients who underwent surgical repair of prolapsing/regurgitating mitral valves. Excised valve tissue in both cases revealed commonly encountered nodular fibrosis and calcific...
Tokodi, Márton Behon, Anett Merkel, Eperke Dóra Kovács, Attila Tősér, Zoltán Sárkány, András Csákvári, Máté Lakatos, Bálint Károly Schwertner, Walter Richard Kosztin, Annamária
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Published in
Frontiers in Cardiovascular Medicine
Background: The relative importance of variables explaining sex-related differences in outcomes is scarcely explored in patients undergoing cardiac resynchronization therapy (CRT). We sought to implement and evaluate machine learning (ML) algorithms for the prediction of 1- and 3-year all-cause mortality in CRT patients. We also aimed to assess the...
Cui, Jing Liu, Yanfei Li, Yiwen Xu, Fengqin Liu, Yue
Published in
Frontiers in Cardiovascular Medicine
Type 2 diabetes mellitus (T2DM) and its complications are seriously affecting public health worldwide. Myocardial infarction (MI) is the primary cause of death in patients with T2DM. T2DM patients without a history of coronary artery disease (CAD) have the same risk of major coronary events as those with CAD; T2DM patients with a history of MI have...
Li, Jiannan Tan, Yu Zhou, Peng Liu, Chen Zhao, Hanjun Song, Li Zhou, Jinying Chen, Runzhen Wang, Ying Zhao, Xiaoxiao
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Published in
Frontiers in Cardiovascular Medicine
The presence of calcified plaques is one of the pathological phenotypes of acute coronary syndrome (ACS) and can be frequently found in culprit lesion segments. Trimethylamine N-oxide (TMAO) is reported to be involved in vascular calcification and plaque instability. This study investigated the relationship between plasma TMAO levels and calcified ...
Fosse, Johanna Hol Haraldsen, Guttorm Falk, Knut Edelmann, Reidunn
Published in
Frontiers in Cardiovascular Medicine
There are several reasons to consider the role of endothelial cells in COVID-19 and other emerging viral infections. First, severe cases of COVID-19 show a common breakdown of central vascular functions. Second, SARS-CoV-2 replicates in endothelial cells. Third, prior deterioration of vascular function exacerbates disease, as the most common comorb...
Nassir, Che Mohd Nasril Che Mohd Ghazali, Mazira Mohamad Hashim, Sabarisah Idris, Nur Suhaila Yuen, Lee Si Hui, Wong Jia Norman, Haziq Hazman Gau, Chuang Huei Jayabalan, Nanthini Na, Yuri
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Published in
Frontiers in Cardiovascular Medicine
Cerebral small vessel disease (CSVD) represents a spectrum of pathological processes of various etiologies affecting the brain microcirculation that can trigger neuroinflammation and the subsequent neurodegenerative cascade. Prevalent with aging, CSVD is a recognized risk factor for stroke, vascular dementia, Alzheimer disease, and Parkinson diseas...
Chen, Mi Sun, Lizhong
Published in
Frontiers in Cardiovascular Medicine
In the evolving scenario of the transcatheter mitral valve repair (TMVr), TMVr devices constitute a rapidly expanding field. The standard classification includes edge-to-edge repair, direct annuloplasty, indirect annuloplasty, chordal/papillary muscular repair, and the others. However, the unknowns and uncertainties to innovate a high-performing de...
