Wu, Xiaodong Zhang, Ting Lyu, Ping Chen, Mengli Ni, Gehui Cheng, Huiling Xu, Guie Li, Xinli Wang, Lijun Shang, Hongcai
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Published in
Frontiers in Cardiovascular Medicine
Background: Diabetic cardiomyopathy is the primary complication associated with diabetes mellitus and also is a major cause of death and disability. Limited pharmacological therapies are available for diabetic cardiomyopathy. Qiliqiangxin (QLQX), a Chinese medication, has been proven to be beneficial for heart failure patients. However, the role an...
Bodini, Antonella Michelucci, Elena Di Giorgi, Nicoletta Caselli, Chiara Signore, Giovanni Neglia, Danilo Smit, Jeff M. Scholte, Arthur J.H.A. Mincarone, Pierpaolo Leo, Carlo G.
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Published in
Frontiers in Cardiovascular Medicine
Background: Lipidomics is emerging for biomarker discovery in cardiovascular disease, and circulating lipids are increasingly incorporated in risk models to predict cardiovascular events. Moreover, specific classes of lipids, such as sphingomyelins, ceramides, and triglycerides, have been related to coronary artery disease (CAD) severity and plaque...
McGinigle, Katharine L. Freeman, Nikki L. B. Marston, William A. Farber, Alik Conte, Michael S. Kosorok, Michael R. Kalbaugh, Corey A.
Published in
Frontiers in Cardiovascular Medicine
Introduction: In cancer, there are survival-based staging systems and tailored, stage-based treatments. There is little personalized treatment in vascular disease. The 2019 Global Vascular Guidelines on the Management of CLTI proposed successful treatment hinges upon Patient risk, Limb severity, and ANatomic complexity (PLAN). We sought to confirm ...
Pei, Junyu Wang, Xiaopu Chen, Pengfei Zheng, Keyang Hu, Xinqun
Published in
Frontiers in Cardiovascular Medicine
Background: Women had worse outcomes after acute myocardial infarction (AMI), and physiologically, women had lower hemoglobin values. We examined whether there were sex-related differences in the relationship between hemoglobin levels and adverse outcomes in patients with acute myocardial infarction. Method: We conducted a post-hoc analysis of data...
Bae, Jiyoung Paltzer, Wyatt G. Mahmoud, Ahmed I.
Published in
Frontiers in Cardiovascular Medicine
Heart failure is the leading cause of death worldwide. The inability of the adult mammalian heart to regenerate following injury results in the development of systolic heart failure. Thus, identifying novel approaches toward regenerating the adult heart has enormous therapeutic potential for adult heart failure. Mitochondrial metabolism is an essen...
Givre, Lucas Crola Da Silva, Claire Swenson, Jon E. Arnemo, Jon M. Gauquelin-Koch, Guillemette Bertile, Fabrice Lefai, Etienne Gomez, Ludovic
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Frontiers in Cardiovascular Medicine
Ischemic heart disease remains one of the leading causes of death worldwide. Despite intensive research on the treatment of acute myocardial infarction, no effective therapy has shown clinical success. Therefore, novel therapeutic strategies are required to protect the heart from reperfusion injury. Interestingly, despite physical inactivity during...
Ayee, Manuela A.A. Levitan, Irena
Published in
Frontiers in Cardiovascular Medicine
Under hypercholesterolemic conditions, exposure of cells to lipoproteins results in a subtle membrane increase in the levels of cholesterol and 7-ketocholesterol, as compared to normal conditions. The effect of these physiologically relevant concentration increases on multicomponent bilayer membranes was investigated using coarse-grained molecular ...
Wang, Shuo Wang, Enmao Chen, Qincong Yang, Yan Xu, Lei Zhang, Xiaolei Wu, Rubing Hu, Xitian Wu, Zhihong
Published in
Frontiers in Cardiovascular Medicine
Background: Morbidity and mortality of heart failure (HF) post-myocardial infarction (MI) remain elevated. The aim of this study was to find potential long non-coding RNAs (lncRNAs) and mRNAs in the progression from acute myocardial infarction (AMI) to myocardial fibrosis (MF) to HF. Methods: Firstly, blood samples from AMI, MF, and HF patients wer...
Dowden, Luke Tucker, David Morgan, Sian Uzun, Orhan Syed, Yasir Ahmed
Published in
Frontiers in Cardiovascular Medicine
Rare pathogenic copy number variants (CNVs) are genetic rearrangements that have been associated with an increased risk for congenital heart disorders (CHDs). However, the association of CNVs with atypical brain development, leading to neurodevelopmental disorders (NDDs), in the presence of CHDs remains unclear. We attempted to explore this associa...
Li, Xiao Zhai, Yajing Zhao, Jiaguo He, Hairong Li, Yuanjie Liu, Yue Feng, Aozi Li, Li Huang, Tao Xu, Anding
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Published in
Frontiers in Cardiovascular Medicine
Background: Patients with metabolic syndrome (MetS) have a higher risk of developing cardiovascular diseases (CVD). However, controversy exists about the impact of MetS on the prognosis of patients with CVD. Methods: Pubmed, Cochrane library, and EMBASE databases were searched. Cohort Studies and randomized controlled trials post hoc analyses that ...
