Kouroupis, Dimitrios Correa, Diego
Published in
Frontiers in Bioengineering and Biotechnology
Mesenchymal stem/stromal cell (MSC) exist within their in vivo niches as part of heterogeneous cell populations, exhibiting variable stemness potential and supportive functionalities. Conventional extensive 2D in vitro MSC expansion, aimed at obtaining clinically relevant therapeutic cell numbers, results in detrimental effects on both cellular cha...
Boyd, Derek R. Sharma, Narain D. Loke, Pui L. Carroll, Jonathan G. Stevenson, Paul J. Hoering, Patrick Allen, Christopher C. R.
Published in
Frontiers in Bioengineering and Biotechnology
Molecular docking studies of quinoline and 2-chloroquinoline substrates at the active site of toluene dioxygenase (TDO), were conducted using Autodock Vina, to identify novel edge-to-face interactions and to rationalize the observed stereoselective cis -dihydroxylation of carbocyclic rings and formation of isolable cis -dihydrodiol metabolites. The...
Amos, Sebastian E. Choi, Yu Suk
Published in
Frontiers in Bioengineering and Biotechnology
The metastatic cascade presents a significant challenge to patient survival in the fight against cancer. As metastatic cells disseminate and colonize a secondary site, stepwise exposure to microenvironment-specific mechanical stimuli influences and protects successful metastasis. Following cancerous transformation and associated cell recruitment, t...
Knecht, Raphael S. Bucher, Christian H. Van Linthout, Sophie Tschöpe, Carsten Schmidt-Bleek, Katharina Duda, Georg N.
Published in
Frontiers in Bioengineering and Biotechnology
A misdirected or imbalanced local immune composition is often one of the reasons for unsuccessful regeneration resulting in scarring or fibrosis. Successful healing requires a balanced initiation and a timely down-regulation of the inflammation for the re-establishment of a biologically and mechanically homeostasis. While biomaterial-based approach...
Jareonsin, Surumpa Pumas, Chayakorn
Published in
Frontiers in Bioengineering and Biotechnology
Currently, most commercial recombinant technologies rely on host systems. However, each host has their own benefits and drawbacks, depending on the target products. Prokaryote host is lack of post-transcriptional and post-translational mechanisms, making them unsuitable for eukaryotic productions like phytochemicals. Even there are other eukaryote ...
Zheng, Sherry Bawazir, Marwa Dhall, Atul Kim, Hye-Eun He, Le Heo, Joseph Hwang, Geelsu
Published in
Frontiers in Bioengineering and Biotechnology
Biofilms are structured microbial communities attached to surfaces, which play a significant role in the persistence of biofoulings in both medical and industrial settings. Bacteria in biofilms are mostly embedded in a complex matrix comprised of extracellular polymeric substances that provide mechanical stability and protection against environment...
Ma, Rui Su, Ping Guo, Juan Jin, Baolong Ma, Qing Zhang, Haiyan Chen, Lingli Mao, Liuying Tian, Mei Lai, Changjiangsheng
...
Published in
Frontiers in Bioengineering and Biotechnology
(+)-Borneol is a desirable monoterpenoid with effective anti-inflammatory and analgesic effects that is known as soft gold. (+)-bornyl diphosphate synthase is the key enzyme in the (+)-borneol biosynthesis pathway. Despite several reported (+)-bornyl diphosphate synthase genes, relatively low (+)-borneol production hinders the attempts to synthesiz...
Deng, Shuhao Jiang, Quan Zhang, Yingchun Lu, Xin Shi, Xiurong Zhang, Yuan
Published in
Frontiers in Bioengineering and Biotechnology
With the development of medical technology, medical ultrasound technology is widely used in the diagnosis of human diseases. It has become an indispensable diagnostic method in modern clinical medicine by detecting the internal physiology or tissue structure of the human body by ultrasound and then discovering diseases. Based on this, this paper de...
Zeng, Xuehua Peng, Mengran Liu, Guirong Huang, Yongqing Zhang, Tingting Wen, Jing Lai, Wei Zheng, Yue
Published in
Frontiers in Bioengineering and Biotechnology
Background Patients with systemic internal diseases present high risks for invasive fungal infections, which results in increased morbidity and mortality. Identification of high-risk departments and susceptibility systems could help to reduce the infective rate clinically. Correct selection of sensitive anti-fungal drugs not only could improve the ...
Gosselin, Emily A. Noshin, Maeesha Black, Sheneil K. Jewell, Christopher M.
Published in
Frontiers in Bioengineering and Biotechnology
Therapies for autoimmune diseases such as multiple sclerosis and diabetes are not curative and cause significant challenges for patients. These include frequent, continued treatments required throughout the lifetime of the patient, as well as increased vulnerability to infection due to the non-specific action of therapies. Biomaterials have enabled...
