Shi, Xin Zhang, Li Li, Yi Xue, Jieyuan Liang, Feng Ni, Han-wen Wang, Xia Cai, Zhaohua Shen, Ling-hong Huang, Tao
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Published in
Frontiers in Bioengineering and Biotechnology
Owing to the high mortality rates of heart failure (HF), a more detailed description of the HF becomes extremely urgent. Since the pathogenesis of HF remain elusive, a thorough identification of the genetic factors will provide novel insights into the molecular basis of this cardiac dysfunction. In our research, we performed publicly available tran...
Zhou, Hailing Zhang, Wei Tan, Zhiqiang Zhou, Ziqing Li, Ying Zhang, Shaojuan Zhang, Lingling Gan, Jiefeng Wu, Huanhua Tang, Yongjin
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Published in
Frontiers in Bioengineering and Biotechnology
Patients with refractory epilepsy are not only free of seizures after resecting epileptic foci, but also experience significantly improved quality of life. Fluorine-18-fluorodeoxyglucose positron-emission tomography (18F-FDG PET) is a promising avenue for detecting epileptic foci in patients with magnetic resonance imaging (MRI)-negative refractory...
Ghamrawi, Ranine Velickovic, Igor Milicevic, Ognjen White, Wendy M. Thistlethwaite, Lillian Rosa Cunningham, Julie M. Milosavljevic, Aleksandar Milic, Natasa M. Garovic, Vesna D.
Published in
Frontiers in Bioengineering and Biotechnology
Background: We aimed to assess the extent to which the buffy coat DNA methylome is representative of methylation patterns in constitutive white blood cell (WBC) types in normal pregnancy. Methods: A comparison of differential methylation of buffy coat DNA vs DNA isolated from polymorphonuclear (PMN) and lymphocytic fractions was performed for each ...
Tan, Quan-Chang Huang, Jin-Feng Bai, Hao Liu, Zi-Xuan Huang, Xin-Yi Zhao, Xiong Yang, Zhao Du, Cheng-Fei Lei, Wei Wu, Zi-Xiang
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Published in
Frontiers in Bioengineering and Biotechnology
Revision surgery (RS) is a necessary surgical intervention in clinical practice to treat spinal instrumentation–related symptomatic complications. Three constructs with different configurations have been applied in RS. One distinguishing characteristic of these configurations is that the revision rods connecting previous segments and revision segme...
Dwijayanti, Ari Zhang, Congqiang Poh, Chueh Loo Lautier, Thomas
Published in
Frontiers in Bioengineering and Biotechnology
Owing to its ubiquity and easy availability in nature, light has been widely employed to control complex cellular behaviors. Light-sensitive proteins are the foundation to such diverse and multilevel adaptive regulations in a large range of organisms. Due to their remarkable properties and potential applications in engineered systems, exploration a...
Chen, Jiaci Li, Peilong Zhang, Taiyi Xu, Zhipeng Huang, Xiaowen Wang, Ruiming Du, Lutao
Published in
Frontiers in Bioengineering and Biotechnology
Exosomes, a nano-sized subtype of extracellular vesicles secreted from almost all living cells, are capable of transferring cell-specific constituents of the source cell to the recipient cell. Cumulative evidence has revealed exosomes play an irreplaceable role in prognostic, diagnostic, and even therapeutic aspects. A method that can efficiently p...
Zhang, Xu Liu, Xin-Yi Yang, Hao Chen, Jiang-Nan Lin, Ying Han, Shuang-Yan Cao, Qian Zeng, Han-Shi Ye, Jian-Wen
Published in
Frontiers in Bioengineering and Biotechnology
Bioactive substances (BAS), such as small molecule drugs, proteins, RNA, cells, etc., play a vital role in many therapeutic applications, especially in tissue repair and regeneration. However, the therapeutic effect is still a challenge due to the uncontrollable release and instable physico-chemical properties of bioactive components. To address th...
Liu, Kun Luo, Xin Lv, Zhao-Yong Zhang, Yu-Jue Meng, Zhen Li, Jun Meng, Chun-Xiu Qiang, Hui-Fen Hou, Cai-Yao Hou, Lei
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Published in
Frontiers in Bioengineering and Biotechnology
The effective healing of a bone defect is dependent on the careful coordination of inflammatory and bone-forming cells. In the current work, pro-inflammatory M1 and anti-inflammatory M2 macrophages were co-cultured with primary murine bone mesenchymal stem cells (BMSCs), in vitro, to establish the cross-talk among polarized macrophages and BMSCs, a...
Cheng, Xianfu Guo, Zhihu Ma, Xiaotian Yuan, Tian
Published in
Frontiers in Bioengineering and Biotechnology
Modular design is a widely used strategy that meets diverse customer requirements. Close relationships exist between parts inside a module and loose linkages between modules in the modular products. A change of one part or module may cause changes of other parts or modules, which in turn propagate through a product. This paper aims to present an ap...
Tong, Feifei Qin, Zongmin Wang, Hongyue Jiang, Yingying Li, Junkuan Ming, Hui Qu, Ge Xiao, Yazhong Sun, Zhoutong
Published in
Frontiers in Bioengineering and Biotechnology
Chiral amino alcohols are prevalent synthons in pharmaceuticals and synthetic bioactive compounds. The efficient synthesis of chiral amino alcohols using ammonia as the sole amino donor under mild conditions is highly desired and challenging in organic chemistry and biotechnology. Our previous work explored a panel of engineered amine dehydrogenase...
