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Effects of sex and estrous cycle on extended-access oxycodone self-administration and cue-induced drug seeking behavior

Published in Frontiers in Behavioral Neuroscience

Introduction Increasing evidence indicates that sex is a factor that impacts the abuse liability and relapse vulnerability of prescription opioids like oxycodone. However, while women are more likely than men to be prescribed and to use these drugs, the impact of sex and ovarian hormones on prescription opioid use and relapse vulnerability remains ...

Role of the dorsolateral prefrontal cortex in processing temporal anomalies retained in working memory

Published in Frontiers in Behavioral Neuroscience

Introduction Time is a crucial abstract construct, allowing us to perceive the duration of events. Working memory (WM) plays an important role in manipulating and storing the different features of environmental stimuli, including temporal features. Different brain structures, including the dorsolateral prefrontal cortex, are involved in time proces...

Supplementation with inulin reverses cognitive flexibility alterations and modulates the gut microbiota in high-fat-fed ...

Published in Frontiers in Behavioral Neuroscience

Introduction Alterations in cognitive performance are associated with inadequate nutritional states and diet composition. Prebiotics, such as inulin, are substances that can modulate the gut microbiome and, consequently, brain function by producing metabolites such as short-chain fatty acids (SCFAs). This study aimed to evaluate the effect of suppl...

A fully automated social interaction chamber for studying social threat learning in mice

Published in Frontiers in Behavioral Neuroscience

Social interactions are fundamental for our survival as a predominately social species. We need and seek positive social interactions to navigate the world. However, when social interactions are negative, and occur in the presence of an aversive event, learning occurs to associate such social interactions as threatening. Gaining insight into the ne...

Reinforcement learning in motor skill acquisition: using the reward positivity to understand the mechanisms underlying s...

Published in Frontiers in Behavioral Neuroscience

Introduction According to reinforcement learning, humans adjust their behavior based on the difference between actual and anticipated outcomes (i.e., prediction error) with the main goal of maximizing rewards through their actions. Despite offering a strong theoretical framework to understand how we acquire motor skills, very few studies have inves...

Mechanical acupuncture at HT7 attenuates alcohol self-administration in rats by modulating neuroinflammation and alterin...

Published in Frontiers in Behavioral Neuroscience

Introduction Alcohol use disorder is a chronic disorder with significant limitations in pharmacological treatments, necessitating the exploration of non-pharmacological interventions. Methods We used a model of alcohol self-administration (10% v/v) to analyze behavioral, neurochemical, and signaling mechanisms. Results Our findings demonstrate that...

Differential regulation of sleep by blue, green, and red light in Drosophila melanogaster

Published in Frontiers in Behavioral Neuroscience

Introduction Exposure to blue-enriched light from electronic devices is an emergent disruptor of human sleep, especially at particular times of day. Further dissection of this phenomenon necessitates modeling in a tractable model organism. Methods Thus, we investigated the effects of light color on sleep in Drosophila melanogaster. We measured slee...

Social contagion of pain and fear results in opposite social behaviors in rodents: meta- analysis of experimental studie...

Published in Frontiers in Behavioral Neuroscience

Introduction The study aimed to explore the key factors influencing emotional valence in rodents, focusing on the critical elements that distinguish the contagion processes of fear and pain. Methods Through a systematic review and meta-analysis, we examined behavioral outcomes of rodents exposed to painful or fearful catastrophes to see whether the...

Generalization and discrimination of inhibitory avoidance differentially engage anterior and posterior retrosplenial sub...

Published in Frontiers in Behavioral Neuroscience

Impaired maturation of resting-state connectivity in anorexia nervosa from adolescence to adulthood: differential mechan...

Published in Frontiers in Behavioral Neuroscience

This functional magnetic resonance imaging (fMRI) study examined resting-state (RS) connectivity in adolescent and adult patients with anorexia nervosa (AN) using symptom provocation paradigms. Differential food reward mechanisms were investigated through separate assessments of responses to food images and low-caloric/high-caloric food consumption...