Su, Bin Brenda Blackmon, Warren Xu, Chun Holt, Christopher Boateng, Nathaniel Wang, Darren Szafron, Vibha Anagnostou, Aikaterini Anvari, Sara Davis, Carla M.
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Frontiers in Allergy
Shrimp allergy, the most common food allergy in the United States, affects up to 2% of the population. Its etiology is multi-factorial with the combination of genetic predisposition and environmental exposures. This review summarizes the latest diagnosis and management strategies for shrimp allergy. Currently, the double-blind, placebo-controlled f...
Hamilton, Matthew J. Greene, Loren W. Madigan, Lauren M. Wang, Sa A. Arana Yi, Cecilia Kuykendall, Andrew George, Tracy I. Castells, Mariana C.
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Frontiers in Allergy
Systemic mastocytosis (SM) is a rare hematologic condition characterized by the proliferation and accumulation in tissue of clonal mast cells in multiple organ systems. The release of mast cell mediators in the indolent disease type and the predominant mast cell infiltration of tissues in advanced disease contribute to the heterogeneous clinical pr...
Elkhalifa, Shuayb Elbashir, Haggar Abuzakouk, Mohamed
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Frontiers in Allergy
Idiopathic anaphylaxis (IA) is a severe allergic reaction without identifiable external triggers, presenting significant challenges in diagnosis and management. However, growing evidence suggests that many cases classified as idiopathic may actually be driven by cofactors such as exercise, hormonal fluctuations, medications, or hidden allergens. Th...
Bizjak, Mojca Košnik, Mitja
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Frontiers in Allergy
Introduction The latest international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for urticaria recommends limited laboratory testing for chronic spontaneous urticaria (CSU) and selective testing for only certain chronic inducible urticaria (CIndU) subtypes, though the rationale for these recommendations is poorly explained. This study aimed to impr...
Feng, Yanhua Xu, Liangyu Zhang, Jinming Bin, Jinlian Pang, Xialing He, Sheng Fang, Lei
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Frontiers in Allergy
Context Type I hypersensitivity affects approximately one-third of the global population. As the pathophysiology underlying the development of type I hypersensitivity (asthma, food allergy, and anaphylactic shock, etc.) is complex and heterogeneous, animal model studies continue to be the key to identifying novel molecular pathways and providing th...
Hagerty, Samantha Pustovyy, Oleg Globa, Ludmila Vodyanoy, Vitaly Singletary, Melissa
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Frontiers in Allergy
It is well understood that odorants interact with specialized G-protein coupled receptors embedded in the ciliary membrane of olfactory sensory neurons (OSN) which initiates a voltage-generating intracellular cascade of signal transduction events that can be recorded at the epithelial level as an electroolfactogram (EOG). While the depolarizing exc...
K, Mamatha Aryan, Manu Kanjoormana Prabhakaran, Prathibha Mulakal, Johannah Natinga Das S, Syam IM, Krishnakumar Parameswara Panicker, Sreejith
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Frontiers in Allergy
Introduction Allergic rhinitis (AR) is an IgE-mediated reaction to inhaled allergens, and is a prominent health concern affecting approximately 400 million people worldwide. A comprehensive understanding of AR's pathophysiology is imperative for developing novel therapies, especially considering its frequent co-morbidity with asthma and conjunctivi...
Donald, Katherine Finlay, B. Brett
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Frontiers in Allergy
The gut houses 70%–80% of the body's immune cells and represents the main point of contact between the immune system and the outside world. Immune maturation occurs largely after birth and is guided by the gut microbiota. In addition to the many human clinical studies that have identified relationships between gut microbiota composition and disease...
Mohamed, Sara Thalappil, Sherin Mohamed Ali, Ramzy
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Frontiers in Allergy
Food-dependent exercise-induced anaphylaxis (FDEIA) is a rare and complex clinical condition in which allergic reactions are triggered by specific foods combined with physical activity, even though the food allergen and exercise are tolerated individually. Wheat is the most common culprit food leading to wheat dependent exercise induced anaphylaxis...
Locatello, Luca Giovanni Lobo, David Saibene, Alberto Maria Pucillo, Carlo
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Frontiers in Allergy