Neuroinflammation in the interaction between aging and chronic brain injury
Published in Frontiers in Aging Neuroscience
Neuroinflammation in the interaction between aging and chronic brain injury
Linguistic, visuospatial, and kinematic writing characteristics in cognitively impaired patients with beta-amyloid depos...
Published in Frontiers in Aging Neuroscience
Introduction Beta-amyloid (Aβ) deposition, a hallmark of Alzheimer’s disease (AD), begins before dementia and is an important factor in mild cognitive impairment (MCI). Aβ deposition is a recognized risk factor for various cognitive impairments and has been reported to affect motor performance as well. This study aimed to identify the linguistic, v...
Differences in motor inhibition in young and older musicians and non-musicians at rest
Published in Frontiers in Aging Neuroscience
Introduction Older adults experience a decline in motor inhibition. These declines have been implicated in instrumental activities of daily living. However, studies have revealed that older musicians have behavioral and neurophysiological enhancements in various motor domains compared to non-musicians. This suggests that music training may delay th...
BACE1 and SCD1 are associated with neurodegeneration
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Published in Frontiers in Aging Neuroscience
Introduction Proteolytic processing of amyloid protein precursor by β-site secretase enzyme (BACE1) is dependent on the cellular lipid composition and is affected by endomembrane trafficking in dementia and Alzheimer's disease (AD). Stearoyl-CoA desaturase 1 (SCD1) is responsible for the synthesis of fatty acid monounsaturation (MUFAs), whose accum...
Menopausal hormone therapy and risk of dementia: health insurance database in South Korea-based retrospective cohort stu...
Published in Frontiers in Aging Neuroscience
Introduction Menopausal hormone therapy (MHT) is used to alleviate the symptoms associated with menopause, despite the lack of recommendations for MHT in preventing dementia. Recent nationwide studies have explored the association between MHT and dementia risk, but the findings remain limited. This study aims to investigate the association between ...
Epigenetic regulation of Parkinson’s disease risk variant GPNMB cg17274742 methylation by sex and exercise from Taiwan B...
Published in Frontiers in Aging Neuroscience
Background Parkinson’s disease (PD) is a complex neurodegenerative disease with an elusive etiology that involves the interaction between genetic, behavioral, and environmental factors. Recently, epigenetic modifications, particularly DNA methylation, have been recognized to play an important role in the onset of PD. Glycoprotein non-metastatic mel...
Disparity of smell tests in Alzheimer’s disease and other neurodegenerative disorders: a systematic review and meta-anal...
Published in Frontiers in Aging Neuroscience
Background There are discrepancies of olfactory impairment between Alzheimer’s disease (AD) and other neurodegenerative disorders. Olfactory deficits may be a potential marker for early and differential diagnosis of AD. We aimed to assess olfactory functions in patients with AD and other neurodegenerative disorders, to further evaluate the smell te...
The intracerebral injection of Aβ1-42 oligomers does not invariably alter seizure susceptibility in mice
Published in Frontiers in Aging Neuroscience
Objectives Epileptiform activity and seizures are present in patients with Alzheimer’s disease (AD) and genetic animal models of AD. Amyloid beta 1-42 (Aβ1-42) oligomers are thought to be crucial in AD and can cause neuronal hyperexcitability in vitro. However, it is unclear whether these Aβ1-42 oligomers cause the increased seizure susceptibility ...
Can exposure to heat attenuate neurodegeneration in older adults with Parkinson's disease?
Published in Frontiers in Aging Neuroscience
Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s disease
Published in Frontiers in Aging Neuroscience
Alzheimer’s Disease (AD) is an aging-associated neurodegenerative disorder, threatening millions of people worldwide. The onset and progression of AD can be accelerated by environmental risk factors, such as bacterial and viral infections. Human herpesviruses are ubiquitous infectious agents that underpin numerous inflammatory disorders including n...
