Toxicological properties of fenugreek (Trigonella foenum graecum)
Published in Food and Chemical Toxicology
Garlic-derived natural polysulfanes as hydrogen sulfide donors: Friend or foe?
Published in Food and Chemical Toxicology
In vitro and in vivo studies reported the anti-cancer potential of organosulfur compounds (OSCs) as they trigger biological effects leading to cell cycle arrest with accumulation of cells in G2/M, alteration of the microtubular network, modulation of Bcl-2 family protein expression patterns and changes of the redox status. Despite these well-descri...
Maternal bisphenol A alters fetal endocrine system: Thyroid adipokine dysfunction.
Because bisphenol A (BPA) has been detected in animals, the aim of this study was to investigate the possible effects of maternal BPA exposure on the fetal endocrine system (thyroid-adipokine axis). BPA (20 or 40 μg/kg body weight) was orally administered to pregnant rats from gestation day (GD) 1-20. In both treated groups, the dams and their fetu...
Exposure assessment of Malondialdehyde, 4-Hydroxy-2-(E)-Nonenal and 4-Hydroxy-2-(E)-Hexenal through specific foods avail...
Published in Food and Chemical Toxicology
The effects of bioactive compounds from plant foods on mitochondrial function: a focus on apoptotic mechanisms
Published in Food and Chemical Toxicology
Mitochondria are essential organelles for cellular integrity and functionality mainteinance and their imparement is implicated in the development of a wide range of diseases, including metabolic, cardiovascular, degenerative and hyperproliferative pathologies. The identification of different compounds able to interact with mitochondria for therapeu...
Immunomodulatory of Selenium Nano-Particles Decorated by Sulfated Ganoderma Lucidum Polysaccharides
Published in Food and Chemical Toxicology
By one-step method, selenium nanoparticles(SeNPs) decorated by the water-soluble derivative of Ganoderma Lucidum polysaccharides (SPS) were successfully prepared. The SeNPs-SPS complexes were stable and the diameter of the SeNPs was homogeneously around 25 nm. This study attempted to investigate the anti-inflammation activity of SeNPs-SPS against m...
Immunomodulatory activity of orphan drug Elmiron® in female B6C3F1/N mice
Published in Food and Chemical Toxicology
Interstitial cystitis (IC) is a chronic disorder characterized by bladder discomfort and urinary urgency in the absence of identifiable infection. Despite the expanding use in treatment of IC and other chronic conditions, the effects of Elmiron® treatment on immune system remain unknown. Therefore, female B6C3F1/N mice were orally administered Elmi...
Terminalia arjuna bark extract inhibits histological alterations by mitigating oxidative stress in lead intoxicated mice...
Published in Oriental Pharmacy and Experimental Medicine
It is well known that plant products are helpful in ameliorating heavy metal toxicity in experimental animals. Here, we investigated the effect of Terminalia arjuna (TA) bark extract (25 and 75 mg/kg p.o.) on lead acetate (LA; 150 mg/kg; i.p.) induced oxidative stress, hepato and nephrotoxicity in male Swiss albino mice. In the present study, morph...
Subchronic toxicity evaluation of γ-aminobutyric acid (GABA) in rats
Published in Food and Chemical Toxicology
γ-Aminobutyric acid (GABA) is an amino acid compound contained in vegetables such as tomatoes and also widely distributed in mammals. GABA acts as an inhibitory neurotransmitter and promotes parasympathetic activity to provide several beneficial effects, for instance, relaxation, anti-stress, and insomnia. GABA, produced via a fermentation process,...
Systemic toxicity induced by paclitaxel in vivo is associated with the solvent cremophor EL through oxidative stress-dri...
Published in Food and Chemical Toxicology
The toxic effects of paclitaxel (PTX) and its solubilizing agent cremophor EL (CREL) have been well established in vitro; however, the in vivo mechanisms underlying this toxicity remain unclear. Thus, the aim of this study was to analyze the in vivo toxicity induced by infusion of PTX and CREL and to investigate the involvement of oxidative stress ...
