Published in Food and Chemical Toxicology
● Network-based framework identifies the potential side effects of current COVID-19 drugs ● Network proximity and gene-set enrichment analysis (GSEA) approaches predict the associations between COVID-19 drugs and human tissues ● Pharmacovigilance analysis validates several drug-tissue toxicities via data mining adverse event reporting data ● Severa...
Published in Food and Chemical Toxicology
• α-glucosidase inhibitors delay glucose absorption in small intestine. • Various α-glucosidase inhibitors from dietary and non-dietary sources have been reported. • α-glucosidase inhibitors control postprandial hyperglycemia. • 4. AGIs delay polysaccharide digestion to activate GLP1 which stimulates insulin secretion. • AGIs exhibit competitive in...
Published in Food and Chemical Toxicology
• Nontoxic-dose DON aggravates LPS-induced cellular inflammatory response in IPEC-J2 cell monolayers. • Nontoxic-dose DON aggravates LPS-induced decrease and distribution disorder of tight junction in IPEC-J2 cell monolayers. • Nontoxic-dose DON aggravates LPS-induced inflammatory response and tight junction disorder by activating NF-κB and LC3B.
Our surrounding environment, especially often-touched contaminated surfaces, plays an important role in the transmission of pathogens in society. The shortage of effective sanitizing fluids, however, became a global challenge quickly after the coronavirus disease-19 (COVID-19) outbreak in December 2019. In this study, we present the effect of surfa...
Obesity and its related metabolic disorders, as well as infectious diseases like covid-19, are important health risks nowadays. It was recently documented that long-term fasting improves metabolic health and enhanced the total antioxidant capacity. The present study investigated the influence of a 10-day fasting on markers of the redox status in 10...
We investigated the effects of tocilizumab on endothelial glycocalyx, a determinant of vascular permeability, and myocardial function in rheumatoid arthritis (RA). Eighty RA patients were randomized to tocilizumab (n = 40) or conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and glucocorticoids (GC) (n = 40) for 3 months. Fort...
Coronavirus disease 2019 (COVID-19) and previous pandemics have been viewed almost exclusively as virology problems, with toxicology problems mostly being ignored. This perspective is not supported by the evolution of COVID-19, where the impact of real-life exposures to multiple toxic stressors degrading the immune system is followed by the SARS-Co...
Published in Food and Chemical Toxicology
• Combinations of medications in COVID-19 treatment could present a safety risk. • Remdesivir can cause reversible increase in ALT and AST levels. • Azithromycin and hydroxychloroquine constitute low risk of a prolonged QT interval. • Screening for retinotoxicity in patients taking (hydroxy)chloroquine is recommended. • The most reported toxic effe...
Published in Food and Chemical Toxicology
• VD3 was not toxic, mutagenic neither carcinogenic to Drosophila melanogaster. • VD3 has modulatory effects on the mutagenicity and carcinogenicity induced by DXR in Drosophila. • VD3 revealed a modulatory effect without altering the recombinogenic activity of DXR. • VD3 showed satisfactory interactions with the Ecdysone Receptor (EcR).
Published in Food and Chemical Toxicology
• Inflammatory cues contribute to chronic and acute disease. • Nutraceuticals are important in prevention and treatment of inflammation. • Omega-3 polyunsaturated fatty acids have beneficial effects in chronic disease. • Polyphenols inhibit the inflammatory processes through multiple pathways. • Carbohydrate restriction and Mediterranean diet gener...
