Glossary of phytoconstituents: Can these be repurposed against SARS CoV-2? A quick in silico screening of various phytoc...
Published in Food and Chemical Toxicology
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Nicotinic cholinergic system and COVID-19: In silico identification of interactions between α7 nicotinic acetylcholine r...
Published in Food and Chemical Toxicology
• The nicotinic cholinergic system may be involved in the pathophysiology of COVID19. • SARS-CoV and SARS-CoV-2 Spikes can interact with the human α7 nAChR. • SARS-CoV-2 through nAChRs may dysregulate the cholinergic anti-inflammatory pathway. • Interaction of SARS-CoV-2 Spike with nAChRs is due to a “toxin-like” sequence. • Cholinergic agonists' p...
Immunotoxic role of organophosphates: An unseen risk escalating SARS-CoV-2 pathogenicity
Published in Food and Chemical Toxicology
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Corrigendum to “Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases” [...
...Published in Food and Chemical Toxicology
Inhibition of drug-metabolizing enzymes by Qingfei Paidu decoction: Implication of herb-drug interactions in COVID-19 ph...
...Published in Food and Chemical Toxicology
• Qingfei Paidu decoction (QPD) dose-dependently inhibits CYPs1A, 2A6, 2C8, 2C9, 2C19, 2D6 and 2E1 in a reversible manner. • QPD inhibits CYP3A in a time- and NADPH-dependent manner in liver microsomes from both humans and rats. • QPD significantly increases the plasma exposure and half-life of lopinavir in rats. • Fructus Aurantii Immaturus (Zhish...
Thrombosis and Haemostasis challenges in COVID-19 – Therapeutic perspectives of heparin and tissue-type plasminogen acti...
...Published in Food and Chemical Toxicology
• Anticoagulant therapy is essential in decreasing fibrin deposition and microthrombus formation in the ARDS and in the treatment of pro-thrombotic complications. • Administration of tPA in ARDS patients could provide anti-inflammatory effects. • Heparin and tPA may be useful in these patients minimizing the risk for ARDS complications and/or reduc...
Promising phytochemicals of traditional Indian herbal steam inhalation therapy to combat COVID-19 – An in silico study
Published in Food and Chemical Toxicology
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Exploring the magic bullets to identify Achilles' heel in SARS-CoV-2: Delving deeper into the sea of possible therapeuti...
The symptoms associated with Covid-19 caused by SARS-CoV-2 in severe conditions can cause multiple organ failure and fatality via a plethora of mechanisms, and it is essential to discover the efficacious and safe drug. For this, a successful strategy is to inhibit in different stages of the SARS-CoV-2 life cycle and host cell reactions. The current...
The under-reported role of toxic substance exposures in the COVID-19 pandemic.
Coronavirus disease 2019 (COVID-19) and previous pandemics have been viewed almost exclusively as virology problems, with toxicology problems mostly being ignored. This perspective is not supported by the evolution of COVID-19, where the impact of real-life exposures to multiple toxic stressors degrading the immune system is followed by the SARS-Co...
In silico methods for metabolomic and toxicity prediction of zearalenone, α-zearalenone and β-zearalenone
Published in Food and Chemical Toxicology
• Toxicity and metabolomic profile of ZEA, α-ZEL and β-ZEL was predicted in silico. • MetaTox, SwissADME and PASS online are in silico programs helping to predict toxicity. • O-glucuronidation, S-sulfation and hydrolysis products defined the metabolomic's profile. • In silico studies contribute to 3 R's principle and SDG from Agenda (2030) (WHO).
