Sprenger, Marcel Brunke, Sascha Hube, Bernhard Kasper, Lydia
Published in
FEMS yeast research
Although less prevalent than its relative Candida albicans, the yeast Candida glabrata is a successful pathogen of humans which causes life-threatening candidiasis. It is thus vital to understand the pathogenicity mechanisms and contributing genes in C. glabrata. However, gene complementation as a tool for restoring the function of a previously del...
Fauzee, Yasmin Nabilah Binti Mohd Taniguchi, Naoki Ishiwata-Kimata, Yuki Takagi, Hiroshi Kimata, Yukio
Published in
FEMS yeast research
Dysfunction or capacity shortage of the endoplasmic reticulum (ER) is cumulatively called ER stress and provokes the unfolded protein response (UPR). In various yeast species, the ER-located transmembrane protein Ire1 is activated upon ER stress and performs the splicing reaction of HAC1 mRNA, the mature form of which is translated into a transcrip...
Onetto, Cristobal A Schmidt, Simon A Roach, Michael J Borneman, Anthony R
Published in
FEMS yeast research
Aureobasidium pullulans is the most abundant and ubiquitous species within the genus and is also considered a core component of the grape juice microflora. So far, a small number of other Aureobasidium species have been reported, that in contrast to A. pullulans, appear far more constrained to specific habitats. It is unknown whether grape juice is...
Duran, Lisset López, José Montaño Avalos, José L
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FEMS yeast research
The mitochondria, often referred to as the powerhouse of the cell, offer a unique physicochemical environment enriched with a distinct set of enzymes, metabolites and cofactors ready to be exploited for metabolic engineering. In this review, we discuss how the mitochondrion has been engineered in the traditional sense of metabolic engineering or co...
Libkind, D Čadež, N Opulente, D A Langdon, Q K Rosa, C A Sampaio, J P Gonçalves, P Hittinger, C T Lachance, M A
Published in
FEMS yeast research
In recent years, 'multi-omic' sciences have affected all aspects of fundamental and applied biological research. Yeast taxonomists, though somewhat timidly, have begun to incorporate complete genomic sequences into the description of novel taxa, taking advantage of these powerful data to calculate more reliable genetic distances, construct more rob...
Zhu, Hangqi Zhu, Nali Peng, Liping Zhang, Bing Yu, Qilin Li, Mingchun
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FEMS yeast research
Inositol polyphosphates (IPs) is an important family of signaling molecules that regulate multiple cellular processes, such as chromatin remodeling, transcription and mRNA export. Inositol polyphosphate kinases, as the critical enzymes for production and transformation of IPs, directly determine the intracellular levels of IPs and therefore are inv...
Renne, Mike F Bao, Xue de Kroon, Anton I P M
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FEMS yeast research
The presence of the water soluble glycerophospholipid precursors choline and inositol in culture media highly affects lipid biosynthesis and regulation thereof. We report that widely used media ingredients contain trace amounts of choline and inositol that are not mentioned on the product label, influencing experimental outcome. © FEMS 2020.
Toplis, Barbra Bosch, Caylin Schwartz, Ilan S Kenyon, Chris Boekhout, Teun Perfect, John R Botha, Alfred
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FEMS yeast research
Cryptococcal urease is believed to be important for the degradation of exogenous urea that the yeast encounters both in its natural environment and within the human host. Endogenous urea produced by the yeast's own metabolic reactions, however, may also serve as a substrate for the urease enzyme. Using wild-type, urease-deletion mutant and urease-r...
Agus, Hizlan Hincal Kok, Gizem Derinoz, Ezgi Oncel, Didem Yilmaz, Sedanur
Published in
FEMS yeast research
Alpha-thujone, widely used in beverages (1-5 mg/kg), is known to have cytotoxic effects, but the mode of action and the role of potential apoptotic proteins in yeast cell death should be unraveled. In this study, we used Schizosaccharomyces pombe, which is a promising unicellular model organism in mechanistic toxicology and cell biology, to investi...
Ren, Tongtong Zhu, Hangqi Tian, Lei Yu, Qilin Li, Mingchun
Published in
FEMS yeast research
Candida albicans is a common pathogenic fungus with high mortality in immunocompromised patients. However, the mechanism by which C. albicans invades host epithelial cells and causes serious tissue damage remains to be further investigated. In this study, we established the C. albicans-293T renal epithelial cell interaction model to investigate the...
