Zhang, Haifeng Yang, Xiaobei Zhu, Lili Li, Zhihui Zuo, Peipei Wang, Peng Feng, Jingyu Mi, Yang Zhang, Chengjuan Xu, Yan
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FEBS open bio
Hepatocellular carcinoma (HCC) is one of the most fatal cancers worldwide. In this article, we show that expression of abnormal spindle-like microcephaly-associated protein (ASPM) is up-regulated in liver cancer samples, and this up-regulation is significantly associated with tumor aggressiveness and reduced survival times of patients. Down-regulat...
Ito-Harashima, Sayoko Matsuura, Mai Takada, Eiji Kawanishi, Masanobu Nakagawa, Yoshiaki Yagi, Takashi
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FEBS open bio
Juvenile hormones (JHs) are sesquiterpenoids that play important roles in the regulation of growth, metamorphosis and reproduction in insects. Synthetic JH agonists (JHAs) have been used as insecticides and are categorized as a class of insect growth regulators (IGRs). Natural JHs and synthetic JHAs bind to the JH receptor methoprene-tolerant (Met)...
Liu, Xiu-Juan Lv, Yan-Fei Cui, Wen-Zhu Li, Yan Liu, Yang Xue, Yi-Tao Dong, Feng
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FEBS open bio
Myocardial infarction (MI) is caused by the formation of plaques in the arterial walls, leading to a decrease of blood flow to the heart and myocardium injury due to hypoxia. Ferroptosis is a crucial event in myocardial injury, and icariin (ICA) exerts protective effects against myocardial injury. Here, we investigated the protective mechanism of I...
Li, Zuyin Shen, Weixing Wu, Gang Qin, Changjiang Zhang, Yijie Wang, Yupeng Song, Guohe Xiao, Chao Zhang, Xin Deng, Guilong
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FEBS open bio
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation. SAMM50 encodes Sam50, a mitochondrial outer membrane protein involved in the removal of reactive oxygen species, mitochondrial morphology and regulation of mitophagy. Certain single nucleotide polymorphisms of SAMM50 have been reported to be correlated with NA...
Wu, Yu Zheng Chan, Kathy Yuen Yee Leung, Kam Tong Lam, Hugh Simon Tam, Yuk Him Lee, Kim Hung Li, Karen Ng, Pak Cheung
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FEBS open bio
We previously demonstrated that microRNA(miR)-223 is overexpressed in intestinal tissue of infants with necrotizing enterocolitis (NEC). The objective of the current study was to identify the target gene of miR-223 and to investigate the role of the miR-223/nuclear factor I-A (NFIA) axis in cellular functions that underpin the pathophysiology of NE...
Kang, Jianshu Li, Yunqin Zhao, Zhijian Zhang, Hong
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FEBS open bio
Graves' ophthalmopathy, also known as thyroid-associated orbitopathy (TAO), is the most common inflammatory eye disease in adults. The most common etiology for TAO is Graves' disease (GD); however, proteomic research focusing on differences between GD and TAO is limited. This study aimed to identify differentially expressed proteins between thyroid...
Genchev, Georgi Z Kobayashi, Minae Kobayashi, Tomoyoshi Lu, Hui
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FEBS open bio
Understanding the regulation of cardiac muscle contraction at a molecular level is crucial for the development of therapeutics for heart conditions. Despite the availability of atomic structures of the protein components of cardiac muscle thin filaments, detailed insights into their dynamics and response to calcium are yet to be fully depicted. In ...
Lina, Shao
Published in
FEBS open bio
Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most common cancer among systemic malignant tumors, with 600 000 new cases occurring every year worldwide. Since HNSCC has high heterogeneity and complex pathogenesis, no effective prognostic indicator has yet been identified. Here, we aimed to identify a lncRNA signature associated w...
Ye, Jinjun Xin, Le Liu, Jidong Tang, Tao Bao, Xing Yan, Yukuang
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FEBS open bio
Dickkopf-1 (Dkk1) is an inhibitor of Wnt signaling involved in cancer cell proliferation, apoptosis, and migration and angiogenesis. It was previously reported that B cell-specific Moloney mouse leukemia virus integration site 1 (Bmi1) activates the Wnt pathway by inhibiting the expression of DKK1 in breast cancer cell lines and 293T cells. Bmi1 an...
Pandey, Rajan Gupta, Priya Mohmmed, Asif Malhotra, Pawan Gupta, Dinesh
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FEBS open bio
Post-translational modifications, especially reversible phosphorylation, are among the most common mechanisms that regulate protein function and biological processes in Plasmodium species. Of the Plasmodium phosphatases, phosphatase of regenerating liver (PfPRL) is secreted and is an essential phosphatase. Here, we expressed PfPRL in a heterologous...
