Zheng, Jiayu Ding, Jiaxing Liao, Mengyang Qiu, Zhihua Yuan, Qingchen Mai, Wuqian Dai, Yong Zhang, Hongrong Wu, Hailang Wang, Yingxuan
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
The angiotensin II type 1 receptor (AT1R) signaling pathway is reported to modulate glucose metabolism. Targeting AT1R, our group invented ATRQβ-001 vaccine, a novel immunotherapeutic strategy to block the activation of AT1R. Here, we evaluated the therapeutic efficacy of ATRQβ-001 vaccine in insulin resistance, and investigated the mechanism. Our ...
Li, Bo Zhou, Yue Chen, Jing Wang, Tingting Li, Zhijuan Fu, Yili Zhai, Aixia Bi, Changlong
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Aberrant expression of long noncoding RNA (lncRNA) H19 and microRNA (miR)-29b has been implicated in the complications of diabetes mellitus (DM). As a common and important complication of DM, diabetic foot ulcer (DFU) is characterized by high incidence and poor prognosis. Herein, we explored the role of lncRNA H19 in wound healing of DFU. Different...
Yan, Shaomin Wu, Guang
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
SARS-CoV and SARS-CoV-2 encode four structural and accessory proteins (spike, envelope, membrane and nucleocapsid proteins) and two polyproteins (pp1a and pp1ab). The polyproteins are further cleaved by 3C-like cysteine protease (3CLpro ) and papain-like protease (PLpro ) into 16 nonstructural proteins (nsps). PLpro is released from nsp3 through au...
Zhou, Haoyang Simion, Viorel Pierce, Jacob B Haemmig, Stefan Chen, Alex F Feinberg, Mark W
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Chronic vascular inflammation plays a key role in the pathogenesis of atherosclerosis. Long non-coding RNAs (lncRNAs) have emerged as essential inflammation regulators. We identify a novel lncRNA termed lncRNA-MAP3K4 that is enriched in the vessel wall and regulates vascular inflammation. In the aortic intima, lncRNA-MAP3K4 expression was reduced b...
Rovini, Amandine Heslop, Kareem Hunt, Elizabeth G Morris, Morgan E Fang, Diana Gooz, Monika Gerencser, Akos A Maldonado, Eduardo N
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Mitochondrial membrane potential (ΔΨm) is a global indicator of mitochondrial function. Previous reports on heterogeneity of ΔΨm were qualitative or semiquantitative. Here, we quantified intercellular differences in ΔΨm in unsynchronized human cancer cells, cells synchronized in G1, S, and G2, and human fibroblasts. We assessed ΔΨm using a two-pron...
Wu, Xianqiu Liu, Yang Mo, Song Wei, Wuli Ye, Ziliang Su, Qiang
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
The aberrant expression of long noncoding RNA (lncRNA) taurine-upregulated gene 1 (TUG1) has been previously associated with myocardial ischemia-reperfusion injury (MIRI), but the underlying molecular mechanisms remain elusive. The current study aimed to clarify the functional role of TUG1/microRNA (miR)-340/histone deacetylase 4 (HDAC4)/β-catenin/...
Guo, Yao Wang, Qiang-Jun Zhang, Ke-Hao Yao, Chun-Yan Huang, Jie Li, Qin Liu, Zhong-Ying Zhang, Yu Shan, Chun-Hua Liu, Peng
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
An unfavorable lifestyle disrupts the circadian rhythm, leading to metabolic dysfunction in adult humans and animals. Increasing evidence suggests that night-restricted feeding (NRF) can effectively prevent ectopic fat deposition caused by circadian rhythm disruption, and reduce the risk of metabolic diseases. However, previous studies have mainly ...
Gomez-Perosanz, Marta Sanchez-Trincado, Jose L Fernandez-Arquero, Miguel Sidney, John Sette, Alessandro Lafuente, Esther M Reche, Pedro A
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Human Rhinovirus (HRV) is a major cause of common cold, bronchiolitis, and exacerbations of chronic pulmonary diseases such as asthma. CD8 T cell responses likely play an important role in the control of HRV infection but, surprisingly, HRV-specific CD8 T cell epitopes remain yet to be identified. Here, we approached the discovery and characterizat...
Wang, Lijun Moore, Douglas C Huang, Jiahui Wang, Yuhong Zhao, Hu D-H Yue, Jerry Jackson, Cynthia L Quesenberry, Peter J Cao, Weibiao Yang, Wentian
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
The protein tyrosine phosphatase SHP2, encoded by PTPN11, is ubiquitously expressed and essential for the development and/or maintenance of multiple tissues and organs. SHP2 is involved in gastrointestinal (GI) epithelium development and homeostasis, but the underlying mechanisms remain elusive. While studying SHP2's role in skeletal development, w...
Wang, Xuetong Li, Xinle Li, Jie Zhai, Lidong Liu, Daquan Abdurahman, Abdusami Zhang, Yifan Yokota, Hiroki Zhang, Ping
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Exosomes are important transporters of miRNAs, which play varying roles in the healing of the bone fracture. Angiogenesis is one of such critical events in bone healing, and we previously reported the stimulatory effect of mechanical loading in vessel remodeling. Focusing on type H vessels and exosomal miR-214-3p, this study examined the mechanism ...
