Pardasani, Meenakshi Marathe, Shruti D Purnapatre, Maitreyee Mandar Dalvi, Urvashi Abraham, Nixon M
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Memorizing pheromonal locations is critical for many mammalian species as it involves finding mates and avoiding competitors. In rodents, pheromonal information is perceived by the main and accessory olfactory systems. However, the role of somatosensation in context-dependent learning and memorizing of pheromone locations remains unexplored. We add...
Armbrust, Fred Bickenbach, Kira Koudelka, Tomas Tholey, Andreas Pietrzik, Claus Becker-Pauly, Christoph
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Meprin β is a zinc-dependent metalloprotease exhibiting a unique cleavage specificity with strong preference for acidic amino acids at the cleavage site. Proteomic studies revealed a diverse substrate pool of meprin β including the interleukin-6 receptor (IL-6R) and the amyloid precursor protein (APP). Dysregulation of meprin β is often associated ...
Nguyen, Huong Koh, Jia Yi Li, Hainan Islas-Robles, Argel Venkata, Sai Pranathi Meda Wang, Jie-Mei Monks, Terrence J.
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Peripheral arterial disease (PAD) is one of the major complications of diabetes due to an impairment in angiogenesis. Since there is currently no drug with satisfactory efficacy to enhance blood vessel formation, discovering therapies to improve angiogenesis is critical. An imidazolinone metabolite of the metformin-methylglyoxal scavenging reaction...
Li, Bin Zhang, Lei Zhu, Lei Cao, Yongqiang Dou, Zhimin Yu, Qin
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
In the current study, we sought to determine the roles of histone deacetylase 5 (HDAC5) on the promotion of intestinal sepsis in a mouse model. Dual luciferase reporter gene assay was used to determine the binding relationship between HDAC5 and Ghrelin. Cecal ligation and puncture (CLP) was used as an animal model of intestinal sepsis. The roles of...
Pospiech, Mateusz Owens, Siân E Miller, David J Austin-Muttitt, Karl Mullins, Jonathan G L Cronin, James G Allemann, Rudolf K Sheldon, I Martin
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Certain species of pathogenic bacteria damage tissues by secreting cholesterol-dependent cytolysins, which form pores in the plasma membranes of animal cells. However, reducing cholesterol protects cells against these cytolysins. As the first committed step of cholesterol biosynthesis is catalyzed by squalene synthase, we explored whether inhibitin...
Ranaei Pirmardan, Ehsan Barakat, Aliaa Zhang, Yuanlin Naseri, Marzieh Hafezi-Moghadam, Ali
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Diabetes is a major risk factor for cataract, the leading cause of blindness worldwide. There is an unmet need for a realistic model of diabetic cataract for mechanistic and longitudinal studies, as existing models do not reflect key aspects of the complex human disease. Here, we introduce and characterize diabetic cataract in the Nile grass rat (N...
Jaswal, Shalini Anand, Vijay Ali, Syed Azmal Jena, Manoj K Kumar, Sudarshan Kaushik, Jai K Mohanty, Ashok K
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
The lactating mammary gland harbours numerous matured alveoli with their lumen surrounded by differentiated mammary epithelial cells (MECs), which are exclusively involved in milk synthesis and secretion. Buffalo (Bubalus bubalis) is the second major milk-producing animal, and its physiology is different from cattle. The complete protein machinery ...
Liu, Ziqiang Lai, Jiacheng Jiang, Heng Ma, Chengyuan Huang, Haiyan
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Extracellular matrix (ECM) plays an important role in the progression of cancer. Collagen is the most abundant component in ECM, and it is involved in the biological formation of cancer. Although type XI collagen is a minor fibrillar collagen, collagen XI alpha 1 chain (COL11A1) has been found to be upregulated in a variety of cancers including ova...
Nemerovsky, Luba Bar-Joseph, Hadas Eldar-Boock, Anat Miller, Irit Ben-Ami, Ido Shalgi, Ruth
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Molecular changes, caused by various environmental factors, affect the quality and developmental potential of oocytes. Oxidative stress (OS) is a major factor involved in various gynecologic disorders and/or in aging. Recent studies suggest that elevated reactive oxygen species (ROS) hamper oocyte quality and future embryonic development. Pigment e...
Anton-Plagaro, Carlos Sanchez, Noelia Valle, Rosario Mulet, Jose Miguel Duncan, Mara C Roncero, Cesar
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Protein sorting at the trans-Golgi network (TGN) usually requires the assistance of cargo adaptors. However, it remains to be examined how the same complex can mediate both the export and retention of different proteins or how sorting complexes interact among themselves. In Saccharomyces cerevisiae, the exomer complex is involved in the polarized t...
