Griffiths, Keren K Wang, Aili Wang, Lifei Tracey, Matthew Kleiner, Giulio Quinzii, Catarina M Sun, Linlin Yang, Guang Perez-Zoghbi, Jose F Licznerski, Pawel
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Fragile X syndrome (FXS) is the leading known inherited intellectual disability and the most common genetic cause of autism. The full mutation results in transcriptional silencing of the Fmr1 gene and loss of fragile X mental retardation protein (FMRP) expression. Defects in neuroenergetic capacity are known to cause a variety of neurodevelopmental...
Canals, Daniel Salamone, Silvia Santacreu, Bruno Jaime Nemeth, Erika Aguilar, Daniel Hernandez-Corbacho, María José Adada, Mohamad Staquicini, Daniela I Arap, Wadih Pasqualini, Renata
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Chemotherapy has been reported to upregulate sphingomylinases and increase cellular ceramide, often linked to the induction to cell death. In this work, we show that sublethal doses of doxorubicin and vorinostat still increased cellular ceramide, which was located predominantly at the plasma membrane. To interrogate possible functions of this speci...
Chiu, Yung Wen Hori, Yukiko Ebinuma, Ihori Sato, Haruaki Hara, Norikazu Ikeuchi, Takeshi Tomita, Taisuke
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
The aberrant metabolism of amyloid β peptide (Aβ) has been implicated in the etiology of Alzheimer disease (AD). Aβ is produced via the sequential cleavage of amyloid precursor protein (APP) by β- and γ-secretases. However, the precise regulatory mechanism of Aβ generation still remains unclear. To gain a better understanding of the molecular mecha...
Kriaa, Aicha Jablaoui, Amin Mkaouar, Héla Akermi, Nizar Maguin, Emmanuelle Rhimi, Moez
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Serine proteases have been long recognized to coordinate many physiological processes and play key roles in regulating the inflammatory response. Accordingly, their dysregulation has been regularly associated with several inflammatory disorders and suggested as a central mechanism in the pathophysiology of digestive inflammation. So far, studies ad...
Wang, Hanzhou Li, Shengxian Dai, Qiuxia Gonzalez, Aaron Tran, Olivia N Sun, Haiyan DeFronzo, Ralph A Dean, David D Yeh, Chih-Ko Chen, Xiao-Dong
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Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Islet transplantation in man is limited by multiple factors including islet availability, islet cell damage caused by collagenase during isolation, maintenance of islet function between isolation and transplantation, and allograft rejection. In this study, we describe a new approach for preparing islets that enhances islet function in vitro and red...
McDonald, Tanya S McCombe, Pamela A Woodruff, Trent M Lee, John D
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron disease without effective treatment. Although the precise mechanisms leading to ALS are yet to be determined, there is now increasing evidence implicating the defective energy metabolism and components of the innate immune complement system in the onset and progress...
Seabright, Alex P. Fine, Nicholas H.F. Barlow, Jonathan P. Lord, Samuel O. Musa, Ibrahim Gray, Alexander Bryant, Jack Banzhaf, Manuel Lavery, Gareth G. Hardie, D. Grahame
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Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Mitophagy is a key process regulating mitochondrial quality control. Several mechanisms have been proposed to regulate mitophagy, but these have mostly been studied using stably expressed non-native proteins in immortalised cell lines. In skeletal muscle, mitophagy and its molecular mechanisms require more thorough investigation. To measure mitopha...
Cheung, Kathleen Barter, Matthew J Falk, Julia Proctor, Carole J Reynard, Louise N Young, David A
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Epigenetic mechanisms are known to regulate gene expression during chondrogenesis. In this study, we have characterized the epigenome during the in vitro differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes. Chromatin immunoprecipitation followed by next-generation sequencing (ChIP-seq) was used to assess a range of N-terminal ...
Castro, Cristina M Corciulo, Carmen Solesio, Maria E Liang, Fengxia Pavlov, Evgeny V Cronstein, Bruce N
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
In OA chondrocytes, there is diminished mitochondrial production of ATP and diminished extracellular adenosine resulting in diminished adenosine A2A receptor (A2AR) stimulation and altered chondrocyte homeostasis which contributes to the pathogenesis of OA. We tested the hypothesis that A2AR stimulation maintains or enhances mitochondrial function ...
Wang, Yingjie Wei, Sumei Song, Honghua Zhang, Xuejie Wang, Wenjuan Du, Nan Song, Tiancheng Liang, Hao Chen, Xiaojun Wang, Yongjun
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Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Macrophages and their initiation of acute inflammation have been defined to be functionally important in tissue repair and regeneration. In injury-induced production of macrophage migration inhibitory factor (MIF), which has been described as a pleiotropic protein that participates in multiple cellular and biologic processes, it is unknown whether ...
