Yu, Yang Deschenes, Isabelle Zhao, Ming-Tao
Published in
Expert Reviews in Molecular Medicine
Long QT syndrome (LQTS) is a detrimental arrhythmia syndrome mainly caused by dysregulated expression or aberrant function of ion channels. The major clinical symptoms of ventricular arrhythmia, palpitations and syncope vary among LQTS subtypes. Susceptibility to malignant arrhythmia is a result of delayed repolarisation of the cardiomyocyte action...
Sánchez, Begoña Muñoz-Pinto, Mario F Cano, Mercedes
Published in
Expert reviews in molecular medicine
Ageing is characterised by the accumulation of molecular and cellular damage through time, leading to a decline in physical and mental abilities. Currently, society has experienced a rapid increase in life expectancy, which has led to an increase in age-associated diseases. Therefore, it is crucial to study the process of ageing to guarantee the be...
Li, Jie Yang, Yi Wang, Yanan Li, Qing He, Fan
Published in
Expert Reviews in Molecular Medicine
Immune cells play a key role in maintaining renal dynamic balance and dealing with renal injury. The physiological and pathological functions of immune cells are intricately connected to their metabolic characteristics. However, immunometabolism in chronic kidney disease (CKD) is not fully understood. Pathophysiologically, disruption of kidney immu...
Williams, Sophie T. Wells, Greg Conroy, Samantha Gagg, Hannah Allen, Richard Rominiyi, Ola Helleday, Thomas Hullock, Katie Pennington, Catherine E. W. Rantala, Juha
...
Published in
Expert Reviews in Molecular Medicine
Despite advances in cancer genomics and the increased use of genomic medicine, metastatic cancer is still mostly an incurable and fatal disease. With diminishing returns from traditional drug discovery strategies, and high clinical failure rates, more emphasis is being placed on alternative drug discovery platforms, such as ex vivo approaches. Ex v...
González-Bermúdez, Blanca Abarca-Ortega, Aldo González-Sánchez, Mónica De la Fuente, Mónica Plaza, Gustavo R
Published in
Expert reviews in molecular medicine
Ageing is interrelated with the development of immunosenescence. This article focuses on one of the cell sets of the adaptive immune system, T cells, and provides a review of the known changes in T cells associated with ageing. Such fundamental changes affect both cell molecular content and internal ordering. However, acquiring a complete descripti...
Borbolis, Fivos Palikaras, Konstantinos
Published in
Expert Reviews in Molecular Medicine
The maintenance of a healthy mitochondrial network and the ability to adjust organelle population in response to internal or external stimuli are essential for the function and the survival of eukaryotic cells. Over the last two decades several studies have demonstrated the paramount importance of mitophagy, a selective form of autophagy that remov...
Miller, Carson J. Usdin, Karen
Published in
Expert Reviews in Molecular Medicine
Roughly 3% of the human genome consists of microsatellites or tracts of short tandem repeats (STRs). These STRs are often unstable, undergoing high-frequency expansions (increases) or contractions (decreases) in the number of repeat units. Some microsatellite instability (MSI) is seen at multiple STRs within a single cell and is associated with cer...
Bodas, Manish Subramaniyan, Bharathiraja Karmouty-Quintana, Harry Vitiello, Peter F. Walters, Matthew S.
Published in
Expert Reviews in Molecular Medicine
The mammalian respiratory system or lung is a tree-like branching structure, and the main site of gas exchange with the external environment. Structurally, the lung is broadly classified into the proximal (or conducting) airways and the distal alveolar region, where the gas exchange occurs. In parallel with the respiratory tree, the pulmonary vascu...
Bettiol, Alessandra Galora, Silvia Argento, Flavia Rita Fini, Eleonora Emmi, Giacomo Mattioli, Irene Bagni, Giacomo Fiorillo, Claudia Becatti, Matteo
Published in
Expert Reviews in Molecular Medicine
Thrombosis is a common disorder with a relevant burden of morbidity and mortality worldwide, particularly among elderly patients. Growing evidence demonstrated a direct role of oxidative stress in thrombosis, with various cell types contributing to this process. Among them, erythrocytes produce high quantities of intracellular reactive oxygen speci...
Bankoglu, Ezgi Eyluel Stopper, Helga
Published in
Expert Reviews in Molecular Medicine
The increase in the prevalence of obesity has led to an elevated risk for several associated diseases including cancer. Several studies have investigated the DNA damage in human blood samples and showed a clear trend towards increased DNA damage in obesity. Reduced genomic stability is thus one of the consequences of obesity, which may contribute t...