Hamanaka, Teruhiko Chin, Shinki Shinmei, Yasuhiro Sakurai, Tetsuro Tanito, Masaki Kijima, Riki Tsutsui, Aika Ueno, Yuta Ishida, Nobuo Ueda, Toshihiko
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Published in
Experimental eye research
The primary aim of trabeculotomy (TLO) and/or minimally invasive glaucoma surgery (MIGS) is to produce a direct communication between the anterior chamber (AC) and collector channels (CC), which is believed to be the process by which intraocular pressure (IOP) is normalized. However, we previously reported our finding of the large opening of the Sc...
Pal, Spandita Vani, Gorati Shivaji, Sisinthy Donthineni, Pragnya Rao Basu, Sayan Arunasri, Kotakonda
Published in
Experimental eye research
Conjunctival swabs (CS) are the major source of sampling for ocular microbiome studies, however collecting CS from the diseased eyes is difficult and painful. In this study, as an alternative to CS, a less invasive approach of tear collection was used to establish the bacterial microbiome in healthy eyes. Tear bacterial microbiome was generated fro...
Yan, Jiangbo Li, Yunzepeng Zhang, Tianlu Shen, Yin
Published in
Experimental eye research
Numb is expressed in the progenitor and mature neurons throughout the development progress of the retina. We attempted to investigate the role of Numb in the retina and visual system, and the effects of Numb deficiency on retinal structure and visual function. Conditional Numb/Nbl double-knockout mice were generated to observe the retinal damage in...
Grinage, Earon Shukla, Deepak
Published in
Experimental eye research
Herpes Simplex Virus-1 (HSV-1) is a neurotropic virus that can infect humans in the eye and travel to the trigeminal ganglion to establish latency. HSV-1 causes various disease states in both the primary and secondary sites of infection including the eye and the nervous system. This DNA virus exploits various adaptive measures to infect host cells,...
Acera, Arantxa Abad, Beatriz Pereiro, Xandra Rodríguez, Francisco David Ruzafa, Noelia Duran, Juan Antonio Vecino, Elena
Published in
Experimental eye research
The Tear Film Lipid Layer (TFLL) acts primarily as an interface between the aqueous layer and air. Tear film lipid is composed of a thin layer of polar lipids that interact with the secretory layer of the underlying mucosa and a thicker layer of non-polar lipids at the air interface. The tear film has a complex structure and composition that protec...
Tedesco, Laura Rossi, Fabio Ruocco, Chiara Ragni, Maurizio Carruba, Michele O Valerio, Alessandra Nisoli, Enzo
Published in
Experimental eye research
Corneal disorders are frequent, involving most diabetic patients; among its manifestations, they include delayed wound healing. Since maintenance of mitochondrial homeostasis is fundamental for the cell, stimulation of mitochondrial biogenesis represents a unique therapeutic tool for preventing and treating disorders with a deficit in energy metabo...
Akhtar, Saeed Smedowski, Adrian Masmali, Ali Alkanaan, Aljoharah Khan, Adnan Ali Almutleb, Essam Mofty, Hanan Khalid Al-Debasi, Hind I Samivel, Ramachandran Almubrad, Turki
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Published in
Experimental eye research
Corneal collagen cross-linking (CXL) is a treatment that is widely applied to halt the progression of ectatic diseases such as keratoconus by creating biomechanical strength in the cornea. Most of the studies assessed the effect of the CXL on the cornea without any differentiation of its effect between periphery and the center of the untreated cont...
Dörschmann, Philipp Böser, Sebastian Isik, David Arndt, Christine Roider, Johann Selhuber-Unkel, Christine Klettner, Alexa
Published in
Experimental eye research
Properties of retinal pigment epithelium (RPE) are relevant for the development of cell culture models concerning an exact reproduction of the ocular cell biology. Here, we want to investigate how different carrier materials and coatings influence proliferation, differentiation and functions of RPE in regard to development of a three-dimensional ce...
Monteiro de Barros, Maithê Rocha Chakravarti, Shukti
Published in
Experimental eye research
Keratoconus (KC) is a degenerative disease associated with cell and extracellular matrix (ECM) loss that causes gradual thinning and steepening of the cornea and loss of vision. Collagen cross linking with ultraviolet light treatment can strengthen the ECM and delay weakening of the cornea, but severe cases require corneal transplantation. KC is mu...
Peral, Assumpta Mateo, Jesús Domínguez-Godínez, Carmen O Carracedo, Gonzalo Gómez, Jose Antonio Crooke, Almudena Pintor, Jesús
Published in
Experimental eye research
Given the implications of the problem of neovascularization on ocular health, as well as the growth in the number of cases, the purpose of the present study has been testing the efficacy of siRNAs (small interfering RNA) designed to silence Hypoxia Inducible Factor -1α (HIF-1α) and to demonstrate that their use stops neovascularization in a model o...
