Wang, Yujiao Fang, Qiyao Zhang, Chaomao Chen, Yongjiang Gou, Tao Cai, Qinglin Yin, Hongyu Gao, Yunxia Feng, Yuliang Qiu, Shuang
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Published in
Experimental eye research
Age-related macular degeneration (AMD) is a leading cause of blindness. Laser-induced nonhuman primate choroidal neovascularization (CNV) is a widely used animal model of neovascular AMD. Subretinal fibrosis (SFb) is the major limiting factor of effective anti-VEGF therapy for neovascular AMD, yet SFb has never been systematically analyzed in the p...
Kang, Tae Kyeom Le, Tam Thi Kim, Kyung-A Kim, Young-Joo Lee, Wook-Bin Jung, Sang Hoon
Published in
Experimental eye research
Lithospermum erythrorhizon (L. erythrorhizon), used in traditional medicine, is a potent wound healing, anti-inflammatory and antioxidant plant. However, the effects of L. erythrorhizon on retinal degenerative diseases remain unknown. Here, we explored the protective effects of L. erythrorhizon in in vitro and in vivo retinal degeneration. We found...
Badia, Anna Salas, Anna Duarri, Anna Ferreira-de-Souza, Bárbara Zapata, Miguel Ángel Fontrodona, Laura García-Arumí, José
Published in
Experimental eye research
Chronic oxidative stress and immune dysregulation are key mechanisms involved in the pathogenesis of most retinal degenerative diseases, including age-related macular degeneration. The Ccl2-/-/Cx3cr1-/-/Crb1rd8/rd8 mouse model develops a progressive degeneration phenotype, with photoreceptor atrophy, drusen-like lesions or pigment alterations at an...
Volatier, Thomas L A Figueiredo, Francisco C Connon, Che J
Published in
Experimental eye research
Current research on healthy corneal stromal cells will typically use primary cells as they are the most representative of in vivo behaviour. Primary cells are normally isolated from the limbus of discarded donor peripheral corneal tissue left over from transplantation (due to its relative abundance). Therefore, the central part of the cornea is les...
Tsuchiya, Shunsuke Higashide, Tomomi Hatake, Sachiyo Sugiyama, Kazuhisa
Published in
Experimental eye research
For research on circadian intraocular pressure (IOP), rebound tonometers are widely used with or without general anesthesia as a non-invasive approach to obtain IOP values. However, whether general anesthesia such as inhalation anesthesia with isoflurane affects the circadian rhythm of IOP and in turn IOP measurements is currently unclear. As such,...
Ash, Neil F Massengill, Michael T Harmer, Lindsey Jafri, Ahmed Lewin, Alfred S
Published in
Experimental eye research
Microglia are immune cells of the central nervous system capable of distinct phenotypic changes and migration in response to injury. These changes most notably include the retraction of fine dendritic structures and adoption of a globular, phagocytic morphology. Due to their characteristic responses, microglia frequently act as histological indicat...
Igarashi, Nozomi Honjo, Megumi Aihara, Makoto
Published in
Experimental eye research
Glaucoma, the second leading cause of blindness worldwide, is characterized by aberrant elevations of intraocular pressure (IOP), which can damage the optic nerve. IOP reduction is the only effective therapy for prevention of visual impairment and blindness in both hypertensive and normotensive individuals, and in some cases, trabeculectomy is a ma...
Shivaji, Sisinthy Jayasudha, Rajagopalaboopathi Chakravarthy, Sama Kalyana SaiAbhilash, Chinthala Reddy Sai Prashanthi, Gumpili Sharma, Savitri Garg, Prashant Murthy, Somasheila I
Published in
Experimental eye research
Microbial keratitis is an infectious disease of the eye, in which the cornea is inflamed. Under severe conditions, keratitis can lead to significant loss of vision and enucleation of the eye. Ocular trauma is the major risk factor causing keratitis and microorganisms viz., bacteria, fungi, viruses are the causative agents. The current study charact...
Li, Jiande Du, Shaobo Shi, Yongpeng Han, Jiangyuan Niu, Zhanyu Wei, Li Yang, Pengfei Chen, Linchi Tian, Huanbing Gao, Lan
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Published in
Experimental eye research
Alkali burn to the cornea is one of the most intractable injuries to the eye due to the opacity resulting from neovascularization (NV) and fibrosis. Numerous studies have focused on studying the effect of drugs on alkali-induced corneal injury in mouse, but fewer on the involvement of alkali-induced DNA methylation and the PI3K/AKT/mTOR signaling p...
Tajiri, Natsumi Kato, Taiki Satoh, Masashi Iizuka, Misao Taniguchi, Masaru Kitaichi, Nobuyoshi Iwabuchi, Kazuya
Published in
Experimental eye research
Experimental autoimmune uveoretinitis (EAU) in mice provides a useful platform to study the pathogenesis and experimental therapeutics of human uveitis. One often used EAU model employs C57BL/6 (B6) mice sensitized with a peptide residue having 1 to 20 amino acids of human interphotoreceptor retinoid binding protein (hIRBP1-20). The model using the...
