Grabulosa, Caren C Manfredi, Silvia R Canziani, Maria E Quinto, Beata M R Barbosa, Rodrigo B Rebello, Jacqueline F Batista, Marcelo C Cendoroglo, Miguel Dalboni, Maria A
Published in
Experimental cell research
TLR expression in neutrophils and monocytes is associated with increased cytokine synthesis, resulting in increased inflammation. However, the inflammatory pathway related to TLR and cathelicidin expression in these cells from CKD patients is unclear. To evaluate TLR4, cathelicidin, TNF-α, IL-6, IL-10 and MCP-1 expression in neutrophils and monocyt...
Ramasamy, Subbiah Velmurugan, Ganesan Rekha, Balakrishnan Anusha, Sivakumar Shanmugha Rajan, K Shanmugarajan, Suresh Ramprasath, Tharmarajan Gopal, Pandi Tomar, Dhanendra Karthik, Karuppusamy V
...
Published in
Experimental cell research
The results proved Egr-1 mediated regulation of miR-99 family that plays a key role in determining the fate of cardiac hypertrophy by regulating Akt-1 signalling.
Wang, Jingjing Xu, Jian Zhao, Xinyun Xie, Weiping Wang, Hong Kong, Hui
Published in
Experimental cell research
Regulation of leukocyte-endothelial cell interactions and of vascular permeability plays a critical role in the maintenance of functional pulmonary microvascular barriers. Little is yet known about the effect of the Rho-associated protein kinase (ROCK) inhibitor fasudil on leukocyte-endothelial cell interactions or the underlying mechanism. In the ...
Deng, Yanchao Yang, Yang Yao, Bei Ma, Lei Wu, Qipeng Yang, Zhicheng Zhang, Luyong Liu, Bing
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Experimental cell research
High expression of tumoral vascular endothelial growth factor C (VEGF-C) is correlated with clinical non-small cell lung cancer (NSCLC) metastasis and patient survival. Nevertheless, the comprehensive mechanisms accounting for VEGF-C-mediated cancer progression remain largely unclear. The present study found that VEGF-C expression was upregulated i...
Sato, Yoriko Sato, Yusuke Suzuki, Reiko Obeng, Kodwo Yoshizawa, Fumiaki
Published in
Experimental cell research
Mammalian target of rapamycin (mTOR) signaling controls skeletal muscle cell differentiation, growth, and metabolism by sensing the intracellular energy status and nutrients. Recently, leucyl-tRNA synthetase (Lars) was identified as an intracellular sensor of leucine involved in the activation of mTOR signaling. However, there is still no evidence ...
Wang, X Zhang, Y Jiang, B H Zhang, Q Zhou, R P Zhang, L Wang, Chen
Published in
Experimental cell research
Hypertrophic scar (HS) formation is associated with the fibrosis of fibrocytes caused by excessive extracellular matrix (ECM) synthesis and deposition, the initial event of HS formation. Our high throughput screen of miRNA expression profiles identified hsa-miR31-5p, whose transcription level was most differentially in normal skin fibroblasts (NS) ...
Wang, Mei Chen, Bin Sun, Xiao-Xian Zhao, Xiang-Dong Zhao, Yuan-Yuan Sun, Li Xu, Chang-Gen Shen, Bo Su, Zhao-Liang Xu, Wen-Rong
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Published in
Experimental cell research
Gastric cancer tissue-derived mesenchymal stem cells (GC-MSCs) are important resident stromal cells in the tumor microenvironment (TME) and have been shown to play a key role in gastric cancer progression. Whether GC-MSCs exert a tumor-promoting function by affecting anti-tumor immunity is still unclear. In this study, we used GC-MSC conditioned me...
Bai, Minghui Zheng, Youwei Liu, Haichao Su, Baowei Zhan, Yong He, Hua
Published in
Experimental cell research
Despite continued improvement in conventional therapy, pancreatic cancer continues to be one of the deadliest tumors worldwide with abysmal 5-year survival rate. New immunotherapeutic strategies that aim at improving antitumor cytotoxic CD8+ T cell responses are being developed in solid tumors. To assist the development of immunotherapies, we inves...
Li, Zhiwei Jin, Hui Mao, Guozhang Wu, Liuguang Guo, Qingwei
Published in
Experimental cell research
Msi2 has been widely reported to be upregulated and strongly associated with fast progress and poor prognosis in many cancers. However, the expression and role of Msi2 in esophageal squamous cell carcinoma (ESCC) remain unknown. In this study, we found that Msi2 was upregulated in ESCC clinical samples, and was significantly associated with tumor s...
Zhou, Junfei Wang, Fang Xu, Chang Zhou, Zipeng Zhang, Wei
Published in
Experimental cell research
JMJD2A is a JmjC histone demethylase that catalyzes the demethylation of di- and trimethylated Lys9 and Lys36 in histone H3 (H3K9me2/3 and H3K36me2/3). The role of spinal JMJD2A-dependent histone demethylation in nociception hypersensitivity development remains elusive. Here we reported that the JMJD2A responded to neuropathic pain and participated...
