García-Rubio, Diana Rodríguez-Varela, Mario Martínez-Vieyra, Ivette de la Mora, M B Méndez-Méndez, Juan Vicente Durán-Álvarez, Juan C Cerecedo, Doris
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Experimental cell research
Arterial hypertension (HTN) can lead to serious organ damage. Several mechanisms have been implicated in the pathogenesis of HTN including constitutive activation of platelets, which increases the risk of aggregation and clot formation. We recently demonstrated the plasma membranes of platelets from patients with HTN exhibit modified structural and...
Li, Yu Zhang, Ru Li, Xuanyi Li, Wei Lu, Yi Dai, Chunfu
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Experimental cell research
The aim of this study is to establish the dexamethasone sodium phosphate multivesicular liposomes thermosensative hydrogel (DEX-MVLs-Gel) drug delivery system and to analyze the pharmacodynamics, pharmacokinetics and safety of DEX-MVLs-Gel as well as to explore whether the prepared DEX-MVLs-Gel can protect the hearing in the guinea pigs following n...
Li, Qianming Cao, Jinghua He, Yajun Liu, Xiaohua Mao, Guanquan Wei, Bo Liao, Shiyan Zhang, Qianqian Li, Jiangchao Zheng, Lingyun
...
Published in
Experimental cell research
Breast cancer (BC) is one of the most common cancers among women in both developed and developing countries with a rising incidence. Using the MMTV-PyMT transgenic mouse model and xenografted breast cancer model, we found that R5, a neutralizing antibody to Robo1, significantly inhibited BC growth and metastasis. Angiogenesis is involved in the gro...
Ogino, Noriyoshi Miyagawa, Koichiro Kusanaga, Masashi Hayashi, Tsuguru Minami, Sota Oe, Shinji Honma, Yuichi Harada, Masaru
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Experimental cell research
Elevated free fatty acids, particularly saturated ones such as palmitic acid, may play an important role in the lipotoxic mechanism of nonalcoholic fatty liver disease (NAFLD). Saturated fatty acids induce autophagy dysfunction and endoplasmic reticulum (ER) stress leading to apoptosis in hepatocytes. However, unsaturated fatty acids, such as oleic...
Ueoka, Ibuki Takai, Akari Yamaguchi, Mizuki Chiyonobu, Tomohiro Yoshida, Hideki Yamaguchi, Masamitsu
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Experimental cell research
The pan-neuron-specific knockdown of dABCA, a Drosophila homologue of the human ATP binding cassette subfamily A member 13 gene, increases social space without affecting climbing ability and induces the early onset of evening activity in adult flies followed by relatively high activity throughout the day. Satellite bouton numbers in the presynaptic...
Zhuang, Mingfeng Song, Mingming Liu, Dadong Huang, Jiamin Sun, Bingwei
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Experimental cell research
Activation of coagulation occurs in sepsis and contributes to the development of thrombosis. Platelet α-granule exocytosis plays an important role in septic coagulation abnormalities. The present study aimed to investigate the effects and the underlying mechanisms of exogenous carbon monoxide, carbon monoxide-releasing molecules II (CORM-2)-liberat...
Huang, Danping Pei, Yuanyuan Dai, Changping Huang, Yun Chen, Han Chen, Xuhong Zhang, Xiaolan Lin, Chun Wang, Hongying Zhang, Rui
...
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Experimental cell research
ADP-ribosylation factor 3 (ARF3) is a member of the KRAS proto-oncogene, GTPase(Ras) super-family of guanine nucleotide-binding proteins that mediates Golgi-related mitosis, but its role in malignant cells is unclear. In the present study, we found that mRNA and protein expression of ARF3 is up-regulated in breast cancer cells. Immunohistochemical ...
Feng, Ying Zheng, Cunjing Zhou, Zongpu Xiong, Huihui Feng, Feng Xie, Fukang Wu, Zhong-Dao
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Experimental cell research
Angiostrongylus cantonensis (A. cantonensis) is a foodborne parasite that can invade the central nervous system (CNS), resulting in eosinophilic meningitis (EM). However, the mechanism by which A. cantonensis causes eosinophilic infiltration into CNS is not well understood. In this study eosinophilic infiltration into the CNS caused by A. cantonens...
Zhang, Chong Qu, Yan Xiao, Haibing Xiao, Wen Liu, Jing Gao, Yunhui Li, Manping Liu, Juntian
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Experimental cell research
LncRNA plays a vital role in many diseases, and abnormal expression of LncRNA has been reported in many types of tumors. In this study, we analyzed the available public TCGA and GEO databases, and found that the expression of SNHG3 was increased in clear cell renal cell carcinoma (ccRCC), which was positively correlated with many clinicopathologica...
Farrell, Kurt Simmers, Phillip Mahajan, Gautam Boytard, Ludovic Camardo, Andrew Joshi, Jyotsna Ramamurthi, Anand Pinet, Florence Kothapalli, Chandrasekhar R
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Experimental cell research
Abdominal aortic aneurysms (AAA) are characterized by matrix remodeling, elastin degradation, absence of nitric oxide (NO) signaling, and inflammation, influencing smooth muscle cell (SMC) phenotype and gene expression. Little is known about the biomolecular release and intrinsic biomechanics of human AAA-SMCs. NO delivery could be an attractive th...
