Suceveanu, Andra-Iulia Micu, Ioan Sergiu Baltatescu, Gabriela-Izabela Petcu, Lucian Cristian Dobrin, Nicolae Brinzan, Costel Nitipir, Cornelia Mazilu, Laura Botea, Florin Herlea, Vlad
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Published in
Experimental and Therapeutic Medicine
Epidemiological data regarding hepatocellular carcinoma (HCC) report unsatisfactory morbimortality rates despite the global efforts to decrease the incidence and prolong patient survival. Current guidelines lack diagnostic biomarkers to better characterize patients with HCC. We aimed to validate the overexpression of Survivin-1, tumor-associated gl...
Gavriș, Claudia Mihaela Nedelcu, Laurențiu Dănuț Pascu, Alina Mihaela
Published in
Experimental and Therapeutic Medicine
Thirty-five years after it was first described, antiphospholipid syndrome (APS) is unanimously recognized as a systemic autoimmune disease, a major acquired thrombophilia, which can affect any arterial or venous vascular territory, explaining the great diversity of clinical manifestations. The current classification criteria updated in the Internat...
Dascalu, Ana Maria Stana, Daniela Nicolae, Vanesa Andrada Cirstoveanu, Catalin Vancea, Geta Serban, Dragos Socea, Bogdan
Published in
Experimental and Therapeutic Medicine
Glaucoma, one of the significant causes of blindness worldwide, is a chronic optic neuropathy, characterized by progressive loss of retinal ganglion cells and specific perimetric defects. This study aimed to assess the association between the risk of glaucoma progression and different systemic vascular abnormalities. A 4-year prospective study was ...
Timofte, Delia Tanasescu, Maria-Daniela Balan, Daniela Gabriela Tulin, Adrian Stiru, Ovidiu Vacaroiu, Ileana Adela Mihai, Andrada Popa, Cristian Constantin Cosconel, Cristina-Ileana Enyedi, Mihaly
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Published in
Experimental and Therapeutic Medicine
An increasing number of patients require renal replacement therapy through dialysis and renal transplantation. Chronic kidney disease (CKD) affects a large percentage of the world's population and has evolved into a major public health concern. Diabetes mellitus, high blood pressure and a family history of kidney failure are all major risk factors ...
Barac, Ileana Ramona Balta, George Zemba, Mihail Branduse, Lacramioara Mehedintu, Claudia Burcea, Marian Barac, Diana Andreea Branisteanu, Daniel Constantin Balta, Florian
Published in
Experimental and Therapeutic Medicine
Infectious keratitis represents a serious concern for ophthalmologists, with a progressively growing incidence in the last few years. In this prospective comparative study, we evaluated two groups of patients with infectious keratitis or corneal ulcer resistant to antimicrobial and antifungal therapy, treated respectively with conventional and acce...
Tăbăcaru, Bogdana Stanca, Horia Tudor Pîrvulescu, Ruxandra Angela Stanca, Simona Danielescu, Ciprian Munteanu, Mihnea Roșca, Cosmin Teodoru, Adrian Cosmin
Published in
Experimental and Therapeutic Medicine
The present study evaluated the efficacy, the safety and the predictability of the Femtosecond laser-assisted in situ keratomileusis (Femto-LASIK) procedure for hyperopia and hyperopic astigmatism. We retrospectively analyzed the postoperative 12-month evolution of 593 eyes with hyperopia and hyperopic astigmatism that underwent Femto-LASIK treatme...
Olaru, Octavian Gabriel Constantin, Gianina Ioana Pena, Catalina Monica
Published in
Experimental and Therapeutic Medicine
For women in the postmenopausal period, age-related changes in the hormonal status are associated with a higher risk for type-2 diabetes and its complications. The tissue injury caused by diabetic vascular complications can induce a release of sialic acid (SA) into the general circulation leading to increased levels. The present study is a cross-se...
Jinca, Cristian Serban, Margit Ursu, Emilia Munteanu, Andrei Arghirescu, Smaranda
Published in
Experimental and Therapeutic Medicine
Neutropenia is commonly diagnosed in pediatric clinics. Due to the special vulnerability of neutropenic patients, the assessment of the etiopathogenic background of neutropenia is mandatory. In this retrospective cross-sectional cohort study, we aimed to establish the status of primary autoimmune neutropenia (AIN) from the point of view of its clin...
Zhang, Shurong Cui, Zhe
Published in
Experimental and Therapeutic Medicine
Retinoblastoma (RB) is one of the most common forms of childhood intraocular cancer. While the occurrence of RB is traditionally associated with dysregulation of the RB1 gene, efforts have been made to assess the role of several other pathways that may result in RB. The Notch signaling pathway has been identified as one of the sentinel pathways in ...
Munteanu, Andrei Ioan Manea, Aniko-Maria Jinca, Cristian Marius Boia, Marioara
Published in
Experimental and Therapeutic Medicine
Perinatal hypoxic-ischemic encephalopathy (HIE) represents a major cause of neonatal death or long-term disability. Inflammation plays an important role in mediating brain damage induced by neonatal hypoxic-ischemic encephalopathy. The mechanisms underlying the inflammatory response in hypoxia and ischemia are complex and are still being extensivel...
