Perez-Cunningham, Jessica Boyer, Scott W Landon, Mark Forsberg, E Camilla
Published in
Experimental hematology
Selective labeling of specific cell types by expression of green fluorescent protein (GFP) within the hematopoietic system would have great utility in identifying, localizing, and tracking different cell populations in flow cytometry, microscopy, lineage tracing, and transplantation assays. In this report, we describe the generation and characteriz...
Published in
Experimental Hematology
DNA methylation is a well-studied epigenetic modification essential for efficient cellular differentiation. Aberrant DNA methylation patterns are a characteristic feature of cancer, including myeloid malignancies such as acute myeloid leukemia. Recurrent mutations in DNA-modifying enzymes were identified in acute myeloid leukemia and linked to dist...
Shouval, Roni Shlush, Liran I Yehudai-Resheff, Shlomit Ali, Shahnaz Pery, Neta Shapiro, Ehud Tzukerman, Maty Rowe, Jacob M Zuckerman, Tsila
Published in
Experimental hematology
FMS-like tyrosine kinase 3 receptor-internal tandem duplication (FLT3-ITD) commonly occurs in acute myeloid leukemia and is considered rare in acute lymphocytic leukemia. Acute leukemia has poor prognosis, mainly due to relapse. Standard FLT3-ITD diagnostic techniques are based on genomic polymerase chain reaction and have recently incorporated Gen...
Sangkhae, Veena Saur, Sebastian Jonas Kaushansky, Alexis Kaushansky, Kenneth Hitchcock, Ian Stuart
Published in
Experimental hematology
Thrombopoietin (TPO) is the primary regulator of platelet production, affecting cell survival, proliferation, and differentiation through binding to and stimulation of the cell surface receptor the cellular myeloproliferative leukemia virus oncogene (c-Mpl). Activating mutations in c-Mpl constitutively stimulate downstream signaling pathways, leadi...
Pourcelot, Emmanuel Trocme, Candice Mondet, Julie Bailly, Sébastien Toussaint, Bertrand Mossuz, Pascal
Published in
Experimental hematology
Studies have shown that the clinical impact of Janus kinase 2 (JAK2) inhibitors in primary myelofibrosis patients is due to the regulation of cytokine levels, suggesting that cytokine profiles might play a critical role in myeloproliferative neoplasms (MPNs) physiopathology. In this study, we compared the plasma cytokine profiles of polycythemia ve...
Pereboom, Tamara C Bondt, Albert Pallaki, Paschalina Klasson, Tim D Goos, Yvonne J Essers, Paul B Groot Koerkamp, Marian J A Gazda, Hanna T Holstege, Frank C P Costa, Lydie Da
...
Published in
Experimental hematology
Diamond-Blackfan anemia (DBA) is a bone marrow failure syndrome linked to mutations in ribosomal protein (RP) genes that result in the impaired proliferation of hematopoietic progenitor cells. The etiology of DBA is not completely understood; however, the ribosomal nature of the genes involved has led to speculation that these mutations may alter t...
Ulyanova, Tatyana Padilla, Steven M Papayannopoulou, Thalia
Published in
Experimental hematology
When the erythroid integrins α5β1 and α4β1 were each deleted previously at the stem cell level, they yielded distinct physiologic responses to stress by affecting erythoid expansion and terminal differentiation or only the latter, respectively. To test at what stage of differentiation the integrin effects were exerted, we created mice with α4- or α...
Ueno, Shikiko Lu, Jiayun He, Jie Li, Ailing Zhang, Xiaoxian Ritz, Jerome Silberstein, Leslie E Chai, Li
Published in
Experimental hematology
Treatment for high-risk pediatric and adult acute B cell lymphoblastic leukemia (B-ALL) remains challenging. Exploring novel pathways in B-ALL could lead to new therapy. Our previous study has shown that stem cell factor SALL4 is aberrantly expressed in B-ALL, but its functional roles and the mechanism that accounts for its upregulation in B-ALL re...
Drouet, Michel
Published in
Experimental hematology
Wallet, Hélène Labussière Sobh, Mohamad Robin, Marie Fegueux, Nathalie Fürst, Sabine Mohty, Mohamad Yakoub-Agha, Ibrahim Marry, Evelyne Rocha, Vanderson Blaise, Didier
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Published in
Experimental hematology
