Alam, Mohammad Mamun Hannan, Sumaiya Binte Saikat, Tanvir Ahmed Limon, Md Belayet Hasan Topu, Md Raihan Rana, Md Jowel Salauddin, Asma Bosu, Sagar Rahman, Mohammed Ziaur
Published in
Evolutionary bioinformatics online
SARS-CoV-2 has been highly susceptible to mutations since its emergence in Wuhan, China, and its subsequent propagation due to containing an RNA as its genome. The emergence of variants with improved transmissibility still poses a grave threat to global health. The spike protein mutation is mainly responsible for higher transmissibility and risk se...
Durmaz, Arda Scott, Jacob G
Published in
Evolutionary bioinformatics online
Statistical methods developed to address various questions in single-cell datasets show increased variability to different parameter regimes. In order to delineate further the robustness of commonly utilized methods for single-cell RNA-Seq, we aimed to comprehensively review scRNA-Seq analysis workflows in the setting of dimension reduction, cluste...
Ye, Guogang Wang, Yue
Published in
Evolutionary bioinformatics online
Neuroblastoma (NB) is the most common solid malignancy in children. MYCN gene amplification is the most relevant genetic alteration in patients with NB and is associated with poor prognosis. Autophagy plays specific roles in the occurrence, development, and progression of NB. Here, we aimed to identify and assess the prognostic effects of autophagy...
Xiao, Chao Wang, Yao Fan, Yuchao
Published in
Evolutionary bioinformatics online
Intrauterine growth retardation (IUGR) affects approximately 10% to 15% of all pregnancies worldwide. IUGR is not only associated with stillbirth and newborn death, but also the delay of cognition in childhood and the promotion of metabolic and vascular disorders in adulthood. Figuring out the mechanism of IUGR is rather meaningful and valuable. Da...
Pholtaisong, Jatuphol Chaiyaratana, Nachol Aporntewan, Chatchawit Mutirangura, Apiwat
Published in
Evolutionary bioinformatics online
Coding and non-coding short tandem repeats (STRs) facilitate a great diversity of phenotypic traits. The imbalance of mononucleotide A-repeats around transcription start sites (TSSs) was found in 3 mammals: H. sapiens, M. musculus, and R. norvegicus. We found that the imbalance pattern originated in some vertebrates. A similar pattern was observed ...
Zhou, Jieshang Yuan, Yali Xu, Pengli Yi, Bin Chen, Hongju Su, Wei
Published in
Evolutionary bioinformatics online
Gout is a prevalent chronic inflammatory disease that affects the life of tens of millions of people worldwide, and it typically presents as gout arthritis, gout stone, or even kidney damage. Research has revealed its connection with the gut microbiome, although exact mechanism is still unclear. Studies have shown the decline of microbiome diversit...
Luo, Chengchang Zhang, Zunni Su, Qisheng Mo, Wuning
Published in
Evolutionary bioinformatics online
SDF2L1 is a new type of endoplasmic reticulum stress inducible protein, which is related to poor prognosis of various cancer, we initially studied the low expression level of SDF2L1 in NPC, but the molecular mechanism of SDF2L1 in NPC needs further elucidation. To identify phosphorylated proteins regulated by SDF2L1 in nasopharyngeal carcinoma (NPC...
Khan, Abdul Rafay Shah, Sayed Hajan Ajaz, Sadia Firasat, Sadaf Abid, Aiysha Raza, Ali
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Evolutionary bioinformatics online
Pharmacogenomics (PGx), forming the basis of precision medicine, has revolutionized traditional medical practice. Currently, drug responses such as drug efficacy, drug dosage, and drug adverse reactions can be anticipated based on the genetic makeup of the patients. The pharmacogenomic data of Pakistani populations are limited. This study investiga...
Alhindi, Tareq Albdaiwi, Randa
Published in
Evolutionary bioinformatics online
The bacterium Oceanobacillus jordanicus strain GSFE11 is a halotolerant endophyte isolated from sterilized roots of Durum wheat (Triticum turgidum ssp. Durum) growing in hot and arid environments of Ghor Safi area in the Jordan Valley. The draft genome sequence and annotation of this plant growth-promoting endophytic bacterium are reported in this ...
Choi, Tae-June Malik, Adeel An, Hyung-Eun Kim, Jung-Il Dinh Do, Thinh Kim, Chang-Bae
Published in
Evolutionary bioinformatics online
Freshwater ecosystems contain a large diversity of microeukaryotes that play important roles in maintaining their structure. Microeukaryote communities vary in composition and abundance on the basis of temporal and environmental variables and may serve as useful bioindicators of environmental changes. In the present study, 18S rRNA metabarcoding wa...
