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Fractional flow reserve in clinical practice: from wire-based invasive measurement to image-based computation.

Published in European heart journal

Fractional flow reserve (FFR) and instantaneous wave-free ratio are the present standard diagnostic methods for invasive assessment of the functional significance of epicardial coronary stenosis. Despite the overall trend towards more physiology-guided revascularization, there remains a gap between guideline recommendations and the clinical adoptio...

Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis.

Published in European heart journal

Inflammation is a hallmark and potent driver of pathological vascular remodelling in atherosclerosis. However, current anti-inflammatory therapeutic strategies have shown mixed results. As an alternative perspective on the conundrum of chronic inflammation emerging evidence points towards a small subset of senescent cells as a critical player and c...

Spontaneous transcardiac migration of a ventriculoperitoneal shunt.

Published in European heart journal

2019 vs. 2016 ESC/EAS statin guidelines for primary prevention of atherosclerotic cardiovascular disease.

Published in European heart journal

The 2019 vs. 2016 European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) dyslipidaemia guidelines contains new recommendations for primary prevention with statins; however, the potential impact of these changes is unclear. We compared the 2019 and 2016 guidelines regarding statin eligibility and potential impact on prevention of ...

Comparison of interleukin-6, C-reactive protein, and low-density lipoprotein cholesterol as biomarkers of residual risk ...

Published in European heart journal

In epidemiologic cohorts initiated >30 years ago, inflammatory biomarkers, such as interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) were shown to independently predict future cardiovascular events with a magnitude of effect comparable to that of low-density lipoprotein cholesterol (LDLC). Whether aggressive contemporary therapy ...

Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease.

Published in European heart journal

The ongoing worldwide increase in life expectancy portends a rising prevalence of age-related cardiovascular (CV) diseases in the coming decades that demands a deeper understanding of their molecular mechanisms. Inflammation has recently emerged as an important contributor for CV disease development. Indeed, a state of chronic sterile low-grade inf...

With our powers combined: Does the pooled analysis of existing randomized data regarding treatment of atrial fibrillatio...

Published in European heart journal

Rhythm control for patients with atrial fibrillation complicated with heart failure in the contemporary era of catheter ...

Published in European heart journal

The optimal treatment for patients with atrial fibrillation (AF) and heart failure (HF) has been a subject of debate for years. We aimed to evaluate the efficacy and safety of rhythm control strategy in patients with AF complicated with HF regarding hard clinical endpoints. Up-to-date randomized data comparing rhythm control using antiarrhythmic dr...

Thrombosis of a mechanical mitral valve: a sticky situation.

Published in European heart journal

Conduction disturbances following trancatheter aortic valve implantation: increasing the 'pace' towards prospective evid...

Published in European heart journal