Published in European journal of immunology
The nature of the immune responses associated with COVID-19 pathogenesis and disease severity, as well as the breadth of vaccine coverage and duration of immunity, is still unclear. Given the unpredictability for developing a severe/complicated disease, there is an urgent need in the field for predictive biomarkers of COVID-19. We have analyzed IgG...
Published in European journal of immunology
COVID-19 vaccines prevent severe forms of the disease, but do not warrant complete protection against breakthrough infections. This could be due to suboptimal mucosal immunity at the site of virus entry, given that all currently approved vaccines are administered via the intramuscular route. In this study, we assessed humoral and cellular immune re...
Published in European Journal of Immunology
Monocyte‐derived antigen presenting cells in the peritoneal cavity are heterogenous, with two discrete populations distinguished by expression of CD11c, dependence upon microbiota, CSF1R, and the transcription factor EGR2, and distinct sex‐dependent contribution to resident CD102+ macrophages. These results help us understand the diverse factors re...
Published in European Journal of Immunology
Graphical Abstract: Epstein–Barr virus and Plasmodium falciparum malaria upregulate activation‐induced cytidine deaminase (AID) and several APOBEC3 enzymes in human B cells, but only AID‐derived driver‐gene mutations are enriched in Burkitt lymphoma tumors. This suggests that oncogenic mutations in Burkitt lymphoma are predominantly caused by AID, ...
Published in European journal of immunology
TRIANNI mice carry an entire set of human immunoglobulin V region gene segments and are a powerful tool to rapidly isolate human monoclonal antibodies. After immunizing these mice with DNA encoding the spike protein of SARS-CoV-2 and boosting with spike protein, we identified 29 hybridoma antibodies that reacted with the SARS-CoV-2 spike protein. N...
Published in European journal of immunology
The emergence of SARS-CoV-2 Omicron variant (B.1.1.529) with major spike protein mutations has raised concern over potential neutralization escape and breakthrough infections among vaccinated and previously SARS-CoV-2-infected subjects. We measured cross-protective antibodies against variants in health care workers (HCW, n = 20) and nursing home re...
Published in European Journal of Immunology
Little is known about the cellular immune response to SARS‐CoV‐2 vaccination in patients after HSCT and B‐NHL with iatrogenic B‐cell aplasia. In nonseroconverted HSCT patients, induction of specific T‐cell responses was assessed. The majority of allogeneic HSCT patients not showing humoral responses to vaccination also fail to mount antigen‐specifi...
Published in European Journal of Immunology
Autoantibodies capable of neutralizing multiple IFN‐α subtypes and IFN‐ω can be found in severe COVID‐19 patients, preferentially males. Anti‐IFN‐I neutralizing antibodies (NAB) positive patients present a defective IFN response and have raised levels of biochemical and hematological parameters predictive of severe COVID‐19.
Published in European Journal of Immunology
Antibodies induced by SARS‐CoV‐2 infection or vaccination mediate NK cell activation, resulting in the release of cytotoxic granules, referred to as ADCC. Highest levels of ADCC were observed when using plasma from BNT162b2‐vaccinated individuals. (Created with BioRender.com)
Published in European Journal of Immunology
