Khan, Adnan Fu, Hongmei Tan, Lee Aun Harper, Jennifer E Beutelspacher, Sven C Larkin, Daniel F P Lombardi, Giovanna McClure, Myra O George, Andrew J T
Published in
European journal of immunology
Dendritic cell (DC) modification is a potential strategy to induce clinical transplantation tolerance. We compared two DC modification strategies to inhibit allogeneic T-cell proliferation. In the first strategy, murine DCs were transduced with a lentiviral vector expressing CTLA4-KDEL, a fusion protein that prevents surface CD80/86 expression by r...
Sridhar, Saranya Begom, Shaima Bermingham, Alison Ziegler, Thedi Roberts, Kim L Barclay, Wendy S Openshaw, Peter Lalvani, Ajit
Published in
European Journal of Immunology
The 2009/10 pandemic (pH1N1) highlighted the need for vaccines conferring heterosubtypic immunity against antigenically shifted influenza strains. Although cross-reactive T cells are strong candidates for mediating heterosubtypic immunity, little is known about the population-level prevalence, frequency, and cytokine-secretion profile of heterosubt...
Eagle, Robert A Traherne, James A Hair, James R Jafferji, Insiya Trowsdale, John
Published in
European Journal of Immunology
To date five ULBP/RAET (UL16-binding protein, also known as retinoic acid early transcript) genes, encoded on human chromosome 6q24.2-q25.3, have been shown to encode ligands of the activating immunoreceptor NKG2D. Here, we show that a sixth gene, ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript. ULBP6 had a more restrict...
Published in
European Journal of Immunology
Mouse models of intestinal inflammation resemble aspects of inflammatory bowel disease in humans. These models have provided important insights into mechanisms that control intestinal homeostasis and regulation of intestinal inflammation. This viewpoint discusses themes that have emerged from mouse models of intestinal inflammation including bacter...
Published in
European Journal of Immunology
Treg are the main mediators of dominant tolerance. Their mechanisms of action and applications are subjects of considerable debate currently. However, a human microRNA (miR) Treg signature has not been described yet. We investigated human natural Treg and identified a signature composed of five miR (21, 31, 125a, 181c and 374). Among those, two wer...
Published in
European Journal of Immunology
Expression of the cancer/germ-line antigen NY-ESO-1 by tumors elicits spontaneous humoral and cellular immune responses in some cancer patients. Development of vaccines capable of stimulating such comprehensive immune responses is desirable. We have produced recombinant lentivectors directing the intracellular synthesis of NY-ESO-1 (rLV/ESO) and ha...
Rofolovitch, M Amira, M Ginsburg, H
Published in
European Journal of Immunology
Confluent spread of mature nondividing mast cells is obtained after 1 month's growth of lymph node cells taken from mice immunized with horse serum and plated on embryonic fibroblast monolayers. The degranulation capacity of these mast cells and histamine release stimulated by monoclonal IgE antibodies and their antigens were studied. The mast cell...
Erkki Ruoslahti Pihko, H Becker, M Mäkelä, O
Published in
European Journal of Immunology
Nanogram quantities of alpha-fetoprotein (AFP), a tumor associated fetal protein, were found in the serum of normal adult rabbits by radioimmunoassay. This AFP was isolated and shown to be immunologically identical to fetal AFP by immunodiffusion. Immunizations of rabbits with unmodified to desialylated AFP in complete Freund s adjuvant did not cau...
Webb, S Cox, Sl Mallin, Lj Tyrrell, C Grimes, Gr Semple, Ca Nix, Ma Glenn Millhauser Dorin, Jr Semple, F
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Published in
European Journal of Immunology
β-Defensins are cationic host defense peptides that form an amphipathic structure stabilized by three intramolecular disulfide bonds. They are key players in innate and adaptive immunity and have recently been shown to limit the production of pro-inflammatory cytokines in TLR4-stimulated macrophages. In the present study, we investigate the mechani...
Abromson-Leeman, S Emanual Maverakis Bronson, R Dorf, Me
Published in
European Journal of Immunology
CD40 ligand-CD40 interactions are important in the development of experimental autoimmune encephalomyelitis (EAE), but it is unclear whether this interaction is critical for de novo recruitment of T cells, entry of T cells into the central nervous system (CNS), or effector function of T cells in vivo. In this report we define the role of CD40 in a ...
