Khan, Adnan Fu, Hongmei Tan, Lee Aun Harper, Jennifer E Beutelspacher, Sven C Larkin, Daniel F P Lombardi, Giovanna McClure, Myra O George, Andrew J T
Published in
European journal of immunology
Dendritic cell (DC) modification is a potential strategy to induce clinical transplantation tolerance. We compared two DC modification strategies to inhibit allogeneic T-cell proliferation. In the first strategy, murine DCs were transduced with a lentiviral vector expressing CTLA4-KDEL, a fusion protein that prevents surface CD80/86 expression by r...
Semple, Fiona MacPherson, Heather Webb, Sheila Cox, Sarah L Mallin, Lucy J Tyrrell, Christine Grimes, Graeme R Semple, Colin A Nix, Matthew A Millhauser, Glenn L
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Published in
European journal of immunology
β-Defensins are cationic host defense peptides that form an amphipathic structure stabilized by three intramolecular disulfide bonds. They are key players in innate and adaptive immunity and have recently been shown to limit the production of pro-inflammatory cytokines in TLR4-stimulated macrophages. In the present study, we investigate the mechani...
Elvire BOURGEOIS Anaïs Levescot Séverine Diem Angélique Chauvineau Hortense Bergès Pierre Milpied Agnès Lehuen Diane Damotte Jean-Marc Gombert Elke Schneider
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Published in
European Journal of Immunology
Activation of invariant natural killer T (iNKT) cells by treatment with their α‐galactosyl ceramide ligand provides therapeutic benefits in several immune inflammatory settings. Given the artificial nature of this stimulation, the natural regulatory functions of iNKT remain uncertain. Addressing this issue in a mouse model of innate‐cell‐driven lun...
Eagle, Robert A Traherne, James A Hair, James R Jafferji, Insiya Trowsdale, John
Published in
European Journal of Immunology
To date five ULBP/RAET (UL16-binding protein, also known as retinoic acid early transcript) genes, encoded on human chromosome 6q24.2-q25.3, have been shown to encode ligands of the activating immunoreceptor NKG2D. Here, we show that a sixth gene, ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript. ULBP6 had a more restrict...
Uhlig, Holm H Powrie, Fiona
Published in
European journal of immunology
Mouse models of intestinal inflammation resemble aspects of inflammatory bowel disease in humans. These models have provided important insights into mechanisms that control intestinal homeostasis and regulation of intestinal inflammation. This viewpoint discusses themes that have emerged from mouse models of intestinal inflammation including bacter...
Rouas, Redouane Fayyad-Kazan, Hussein El Zein, Nabil Lewalle, Philippe Rothé, Françoise Simion, Alexandru Akl, Haidar Mourtada, Mohamad El Rifai, Mohamad Burny, Arsène
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Published in
European journal of immunology
Treg are the main mediators of dominant tolerance. Their mechanisms of action and applications are subjects of considerable debate currently. However, a human microRNA (miR) Treg signature has not been described yet. We investigated human natural Treg and identified a signature composed of five miR (21, 31, 125a, 181c and 374). Among those, two wer...
Elvire BOURGEOIS Linh Van Michel Samson Séverine Diem Anne Barra Stéphane Roga Jean-Marc Gombert Elke Schneider Michel Dy Pierre Gourdy
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Published in
European Journal of Immunology
IL-33 has recently been identified as a cytokine endowed with pro-Th2 functions, raising the question of its effect on invariant natural killer T cell (iNKT), which are potent IL-4 producers. Here, we report a two-fold increase of iNKT-cell counts in spleen and liver after a 7-day treatment of mice with IL-33, which results from a direct effect, gi...
Garcia Casado, Javier Janda, Jozef Wei, Joe Chapatte, Laurence Colombetti, Sara Alves, Pedro Ritter, Gerd Ayyoub, Maha Valmori, Danila Chen, Weisan
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Published in
European journal of immunology
Expression of the cancer/germ-line antigen NY-ESO-1 by tumors elicits spontaneous humoral and cellular immune responses in some cancer patients. Development of vaccines capable of stimulating such comprehensive immune responses is desirable. We have produced recombinant lentivectors directing the intracellular synthesis of NY-ESO-1 (rLV/ESO) and ha...
Rofolovitch, M Amira, M Ginsburg, H
Published in
European Journal of Immunology
Confluent spread of mature nondividing mast cells is obtained after 1 month's growth of lymph node cells taken from mice immunized with horse serum and plated on embryonic fibroblast monolayers. The degranulation capacity of these mast cells and histamine release stimulated by monoclonal IgE antibodies and their antigens were studied. The mast cell...
Abromson-Leeman, S Emanual Maverakis Bronson, R Dorf, Me
Published in
European Journal of Immunology
CD40 ligand-CD40 interactions are important in the development of experimental autoimmune encephalomyelitis (EAE), but it is unclear whether this interaction is critical for de novo recruitment of T cells, entry of T cells into the central nervous system (CNS), or effector function of T cells in vivo. In this report we define the role of CD40 in a ...
