Schrijver, Irene T Théroude, Charlotte Antonakos, Nikolaos Regina, Jean Le Roy, Didier Bart, Pierre-Alexandre Chiche, Jean-Daniel Perreau, Matthieu Pantaleo, Giuseppe Calandra, Thierry
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Published in
European journal of immunology
We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. B...
Latorre, Daniela
Published in
European journal of immunology
According to the World Health Organization, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already infected more than 400 million people and caused over 5 million deaths globally. The infection is associated with a wide spectrum of clinical manifestations, ranging from no signs of illness to severe pathological complications that ...
Sun, Renren Zhao, Zongzheng Fu, Cong Wang, Yixin Guo, Zhendong Zhang, Chunmao Liu, Lina Zhang, Cheng Shu, Chang He, Jin
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Published in
European Journal of Immunology
We established a humanized mouse model carrying human lung tissue and autologous immune system. We found that these humanized mice are susceptible to infection by SARS‐CoV‐2 and develop disease‐associated lung injury, offering a convenient and useful animal model to investigate COVID‐19 pathogenesis and test anti‐SARS‐CoV‐2 interventions.
Sevilla-Movilla, Silvia Fuentes, Patricia Rodríguez-García, Yaiza Arellano-Sánchez, Nohemi Krenn, Peter W de Val, Soledad Isern Montero-Herradón, Sara García-Ceca, Javier Burdiel-Herencia, Valeria Gardeta, Sofía R
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Published in
European journal of immunology
ICAP-1 regulates β1-integrin activation and cell adhesion. Here, we used ICAP-1-null mice to study ICAP-1 potential involvement during immune cell development and function. Integrin α4β1-dependent adhesion was comparable between ICAP-1-null and control thymocytes, but lack of ICAP-1 caused a defective single-positive (SP) CD8+ cell generation, thus...
Haschka, David Petzer, Verena Burkert, Francesco Robert Fritsche, Gernot Wildner, Sophie Bellmann-Weiler, Rosa Tymoszuk, Piotr Weiss, Guenter
Published in
European journal of immunology
Severe coronavirus disease 19 (COVID-19) manifests with systemic immediate proinflammatory innate immune activation and altered iron turnover. Iron homeostasis, differentiation, and function of myeloid leukocytes are interconnected. Therefore, we characterized the cellularity, surface marker expression, and iron transporter phenotype of neutrophils...
Zhang, Zhili Peng, Haoran Lai, Ju Jiang, Liangliang Wang, Liefu Jin, Shengkai Fan, Kai Zhang, Zimu Zhao, Chuanliang Deng, Dan
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Published in
European journal of immunology
Human nasal mucosa is susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and serves as a reservoir for viral replication before spreading to other organs (e.g. the lung and brain) and transmission to other individuals. Chronic rhinosinusitis (CRS) is a common respiratory tract disease and there is evidence suggest...
L'Imperio, Vincenzo Morello, Gaia Vegliante, Maria Carmela Cancila, Valeria Bertolazzi, Giorgio Mazzara, Saveria Belmonte, Beatrice Mangogna, Alessandro Balzarini, Piera Corral, Lilia
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Published in
European journal of immunology
The GC reaction results in the selection of B cells acquiring effector Ig secreting ability by progressing toward plasmablastic differentiation. This transition is associated with exclusion from the GC microenvironment. The aberrant expansion of plasmablastic elements within the GC fringes configures an atypical condition, the biological characteri...
Amundsen, Sunniva F. Stamnaes, Jorunn du Pré, Marie Fleur Sollid, Ludvig M.
Published in
European Journal of Immunology
Key immunological processes in celiac disease involve interaction between transglutaminase 2 (TG2)‐specific B cells and gluten‐specific T cells. The outcome of these processes is governed by the affinity between different gluten peptides and the enzyme (I) as well as by the presence of secondary TG2 substrates (II).
Mbandi, Stanley Kimbung Painter, Hannah Penn-Nicholson, Adam Toefy, Asma Erasmus, Mzwandile Hanekom, Willem A Scriba, Thomas J Lai, Rachel P J Marais, Suzaan Fletcher, Helen A
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Published in
European journal of immunology
Immune reconstitution inflammatory syndrome (IRIS) can be a complication of antiretroviral therapy (ART) in patients with advanced HIV, but its pathogenesis is uncertain. In tuberculosis (TB) endemic countries, IRIS is often associated with mycobacterial infections or Bacille-Calmette-Guerin (BCG) vaccination in children. With no predictive or conf...
Gritsenko, Anna Díaz-Pino, Rodrigo López-Castejón, Gloria
Published in
European journal of immunology
IL-37 is an anti-inflammatory member of the IL-1 family that dampens inflammation associated with many noncommunicable diseases. However, mechanisms of IL-37 regulation remain understudied. We aimed to investigate the enzymatic cleavage of IL-37 that potentiates extracellular signalling, as well as pathways of IL-37 secretion. In human monocytes, m...