Published in European journal of immunology
Interleukin-31 (IL-31) is a Th2 cell-derived cytokine that has been closely linked to pruritic skin inflammation. More recently, enhanced IL-31 serum levels have also been observed in patients with allergic rhinitis and allergic asthma. Therefore, the main aim of this study was to unravel the contribution of IL-31 to allergen-induced lung inflammat...
Published in European Journal of Immunology
B cells infected with EBV raise antiviral immunity, dependent on HLA class II molecule antigen presentation. The MS associated DRB1*15:01 variant is less apt for immune control of EBV. CD8+ T cells expand, still not effective enough for viral clearance. Molecular mimicry between EBV and CNS targets may drive MS.
Published in European Journal of Immunology
Fibroblastic reticular cells (FRCs) are a subset of lymph node stromal cells that produce the alarmin IL‐33 upon lymphocytic choriomeningitis virus infection. The released IL‐33 triggers the IL‐33 receptor ST2 expressed by CD8+T cells, and this results in increased proliferation and production of IFN‐γ and TNF.
Published in European Journal of Immunology
γδ T cell subsets have opposite roles in cancer immunity: whereas IFN‐γ+ γδ T cells inhibit tumor cell growth, IL‐17+ γδ T cells promote tumor progression and metastasis formation. Furthermore, metabolic sources and pathways can impact on the γδ T cell subset balance in the tumor microenvironment. Manipulating γδ metabolism may pave the way toward ...
Published in European journal of immunology
Although the COVID-19 pandemic peaked in March/April 2020 in France, the prevalence of infection is barely known. Using high-throughput methods, we assessed herein the serological response against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of 1847 participants working in three sites of an institution in Paris conurbation. In M...
Published in European journal of immunology
SARS-CoV-2 infection causes an abrupt response by the host immune system, which is largely responsible for the outcome of COVID-19. We investigated whether the specific immune responses in the peripheral blood of 276 patients associated to severity and progression of COVID-19. At admission, dramatic lymphopenia of T, B and NK cells associated to se...
Published in European Journal of Immunology
The setup of a versatile COVID19 serology ELISA system is described, allowing Yes/No screening with a two‐step method that reduces false‐positives. Accurate antibody titer screening indicates a classic pattern of antibody production, peaking at 3 weeks post‐infection and remaining detectable for at least 6 months in 90% of the subjects tested. The ...
Published in European journal of immunology
Mucosal-associated invariant T (MAIT) cells are innate-like T-cells that recognize bacterial riboflavin metabolites. They are present in human blood but are abundant at barrier sites, including the liver, lungs, and kidneys, where they possess a CD69+ /CD103+/- tissue-resident phenotype. In renal tissue, MAIT cells likely defend against the ascendi...
Published in European Journal of Immunology
Silencing CD73 increases the expression of MHCI and ICAM‐1 on lymphatic endothelial cells (LECs), resulting in elevated MHCII and CD83 levels on DCs. This is also the case for inflammatory genes such as TGFB1 or CD69. In contrast, modulating CD73 expression with antibodies showed no such effect with LECs or blood endothelial cells.
Published in European Journal of Immunology
Tumor cell‐derived MPs (T‐MPs) not only directly stimulate angiogenesis, invasion, and metastasis at primary tumor sites through contained molecules, but also contribute to the premetastatic niche formation by reprogramming macrophages. T‐MPs activate antitumor immunity, thus, conferring a potential role of T‐MPs in tumor immunotherapy and tumor va...
