Huber, Timo Steininger, Philipp Irrgang, Pascal Korn, Klaus Tenbusch, Matthias Diesch, Katharina Achenbach, Susanne Kremer, Andreas E. Werblow, Marissa Vetter, Marcel
...
Published in
European Journal of Clinical Microbiology & Infectious Diseases
SARS-CoV-2 antibody assays are used for epidemiological studies and for the assessment of vaccine responses in highly vulnerable patients. So far, data on cross-reactivity of SARS-CoV-2 antibody assays is limited. Here, we compared four enzyme-linked immunosorbent assays (ELISAs; Vircell SARS-CoV-2 IgM/IgA and IgG, Euroimmun SARS-CoV-2 IgA and IgG)...
Reiners, Nina Schnurra, Carolin Trawinski, Henning Kannenberg, Judith Hermsdorf, Thomas Aebischer, Andrea Schöneberg, Torsten Reiche, Sven Jassoy, Christian
Published in
European Journal of Clinical Microbiology & Infectious Diseases
SARS CoV-2 antibody assays measure antibodies against the viral nucleoprotein (NP) or spike protein. The study examined if testing of antibodies against both antigens increases the diagnostic sensitivity. Sera (N=98) from infected individuals were tested with ELISAs based on the NP, receptor-binding domain (RBD), or both proteins. The AUROCs were 0...
Di Pietro, Giada Maria Capecchi, Ester Luconi, Ester Lunghi, Giovanna Bosis, Samantha Bertolozzi, Giuseppe Cantoni, Barbara Marano, Giuseppe Boracchi, Patrizia Biganzoli, Elia
...
Published in
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
The tests currently used for the identification of SARS-CoV-2 include specimens taken from the upper and lower respiratory tract. Although recommendations from the World Health Organization prioritise the usage of a nasopharyngeal swab (NS), nasopharyngeal aspirates (NPA) are thought to be superior in identifying SARS-CoV-2 in children. To our know...
Gatti, Milo Raschi, Emanuel De Ponti, Fabrizio
Published in
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
The purpose of this study is to characterize adverse events (AEs) of clinical interest reported with ceftolozane-tazobactam and ceftazidime-avibactam, as an aid in monitoring patients affected by severe multidrug-resistant Gram-negative infections. We queried the worldwide FDA Adverse Event Reporting System (FAERS) and performed disproportionality ...
Hillerdal, Henrik Henningsson, Anna J
Published in
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Interpretation of serological findings in suspected Lyme borreliosis (LB) may be challenging and IgM reactivities in serum are often unspecific (false positive). There is a risk for overdiagnosis of LB, inadequate use of antibiotics, and potential delay of proper diagnosis. In this study, we evaluated the diagnostic value of IgM analysis in serum a...
de la Calle, Cristina Lalueza, Antonio Mancheño-Losa, Mikel Maestro-de la Calle, Guillermo Lora-Tamayo, Jaime Arrieta, Estibaliz García-Reyne, Ana Losada, Irene de Miguel, Borja Díaz-Simón, Raquel
...
Published in
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
The aim of our study was to elucidate if SARS-CoV-2 viral load on admission, measured by real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) cycle threshold (Ct) value on nasopharyngeal samples, was a marker of disease severity. All hospitalized adult patients with a diagnosis of SARS-CoV-2 infection by rRT-PCR performed on a nasoph...
Koeleman, Johannes G. M. Brand, Henk de Man, Stijn J. Ong, David S. Y.
Published in
European Journal of Clinical Microbiology & Infectious Diseases
The RT-qPCR in respiratory specimens is the gold standard for diagnosing acute COVID-19 infections. However, this test takes considerable time before test results become available, thereby delaying patients from being diagnosed, treated, and isolated immediately. Rapid antigen tests could overcome this problem. In the first study, clinical performa...
Plantamura, Julie Bousquet, Aurore Otto, Marie-Pierre Bigaillon, Christine Legland, Anne-Margaux Delacour, Hervé Vest, Philippe Astier, Hélène Valero, Elodie Bylicki, Olivier
...
Published in
European Journal of Clinical Microbiology & Infectious Diseases
Molecular diagnosis on nasopharyngeal swabs (NPS) is the current standard for COVID-19 diagnosis, but saliva may be an alternative specimen to facilitate access to diagnosis. We compared analytic performances, feasibility and acceptability of NPS, saliva, and oral-self sampling swab for the detection of severe acute respiratory syndrome coronavirus...
Guerson-Gil, Arcelia Palaiodimos, Leonidas Assa, Andrei Karamanis, Dimitris Kokkinidis, Damianos Chamorro-Pareja, Natalia Kishore, Preeti Leider, Jason M. Brandt, Lawrence J.
Published in
European Journal of Clinical Microbiology & Infectious Diseases
It has been demonstrated that obesity is an independent risk factor for worse outcomes in patients with COVID-19. Our objectives were to investigate which classes of obesity are associated with higher in-hospital mortality and to assess the association between obesity and systemic inflammation. This was a retrospective study which included consecut...
Kianmehr, Anvarsadat Faraoni, Isabella Kucuk, Omer Mahrooz, Abdolkarim
Published in
European Journal of Clinical Microbiology & Infectious Diseases
Receptor recognition is a crucial step in viral infection and is a critical factor for cell entry and tissue tropism. In several recent studies, angiotensin-converting enzyme 2 (ACE2) has been demonstrated to be the cellular receptor of SARS-CoV-2 as it was previously well known as the receptor of SARS-CoV. SARS-CoV-2 can bind with high affinity to...
