Qin, Yan Dai, Mengyao Chen, Lingyan Zhang, Ting Zhou, Nong Chen, Xianwen
Published in
Epilepsy research
Stigma is a key determinant of mental health among patients with epilepsy (PWE). In prior work, many PWE have been found to exhibit impaired executive function (EF) and to lack sufficient social support. This study was developed to explore factors that may influence stigma in PWE with a focus on the associations among EF, social support, and stigma...
Rainer, L J Granbichler, C A Kobulashvili, T Kuchukhidze, G Rauscher, C Renz, N Langthaler, P B Braun, M Linehan, C Christensen, J
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Published in
Epilepsy research
Epilepsies are severe chronic neurological diseases that impair several domains in life and are often accompanied by various somatic and psychiatric comorbidities. Associations between epilepsy and its comorbidities remain poorly understood. As epidemiological research mainly relies on cross-sectional designs and descriptive results, homogeneities ...
Lüttjohann, Annika van Luijtelaar, Gilles
Published in
Epilepsy research
There is no doubt on the participation of the thalamus in the various types of genetic generalized epilepsies as evidenced by multiple non-invasive imaging studies in humans as well as invasive studies in animal models of GGE. Based on human and mostly animal data gathered in early 2000 a so called 'three compartment model' on seizure generation wa...
Li, Ying-Ying Zhou, Ji-Xiu Fu, Xin-Wei Bao, Yi Xiao, Zheng
Published in
Epilepsy research
Epilepsy is a severe neurological and mental disorder, and not all patients adequately respond to the current treatments. Dynamin 1 plays a key role in synaptic endocytosis and the modulation of neurological function. Cultured hippocampal neurons were used in the study. First, the viability of neurons was determined by the CCK-8 assay after culturi...
Bruzzone, Maria Jose Issa, Naoum P Wu, Shasha Rose, Sandra Esengul, Yasar Taylan Towle, Vernon L Nordli, Douglas Warnke, Peter C Tao, James X
Published in
Epilepsy research
To identify scalp EEG correlates of hippocampal spikes in patients with mesial temporal lobe epilepsy (mTLE). We recorded scalp and intracranial EEG simultaneously in 20 consecutive surgical candidates with mTLE. Hippocampal spikes were identified from depth electrodes during the first hour of sleep on the first night of recording in the epilepsy m...
Middlebrooks, Erik H He, Xiaosong Grewal, Sanjeet S Keller, Simon S
Published in
Epilepsy research
Neuromodulation is an increasingly utilized therapy for the treatment of people with drug-resistant epilepsy. To date, the most common and effective target has been the thalamus, which is known to play a key role in multiple forms of epilepsy. Neuroimaging has facilitated rapid developments in the understanding of functional targets, surgical and p...
Warsi, Nebras M Yan, Han Suresh, Hrishikesh Wong, Simeon M Arski, Olivia N Gorodetsky, Carolina Zhang, Kristina Gouveia, Flavia Venetucci Ibrahim, George M
Published in
Epilepsy research
The thalamus is a densely connected collection of nuclei that play a critical role in gating information flow across the neocortex. Through diffuse reciprocal cortico-thalamo-cortical connectivity, the anterior and centromedian nuclei exert remarkable control over cortically expressed activity. Consequently, mounting evidence implicates these thala...
Küçükali, Cem İsmail Şengül, Büşra Gezen-Ak, Duygu Dursun, Erdinç Erdağ, Ece Akpınar, Gürler Kasap, Murat Karaaslan, Zerrin Şirin, Nermin Görkem Tektürk, Pınar
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Published in
Epilepsy research
Neuronal autoantibodies and favorable response to immunosuppressive treatment have been described in patients with chronic epilepsy of unknown cause, suggesting autoimmune etiology. Our aim was to identify novel epilepsy-specific autoantibodies reactive with neuronal surface antigens. Sera of 172 epilepsy patients with unknown cause and 30 healthy ...
Khoo, Anthony Martin, Lauren Tisi, Jane de O'Keeffe, Aidan G Sander, Josemir W Duncan, John S
Published in
Epilepsy research
To estimate the cost and time taken to evaluate adults with drug-resistant focal epilepsy for potentially curative surgery. We reviewed data on 100 consecutive individuals at a tertiary referral center evaluated for epilepsy surgery in 2017. The time elapsed between referral and either surgery or a definitive decision not to progress was measured. ...
Lee, Cheng-Chia Hung, Sheng-Che Chen, Yi-Hsiu Chen, Hsin-Hung Chen, Chien Chen, Ching-Jen Wu, Hsiu-Mei Lin, Ching-Po Peng, Syu-Jyun
Published in
Epilepsy research
To investigate structural connectivity after total callosotomy. Deterministic fiber tracking (tractography) of whole brain white matter was performed on 13 epilepsy patients pre- and post-callosotomy. The analysis of structural connectivity was based on graph theory and network-based analysis with a focus on the inter- and intrahemispheric networks...
