Welcome to the 10th volume of Epigenomics.
Published in Epigenomics
Associations between adiposity and repetitive element DNA methylation in healthy postmenopausal women.
Published in Epigenomics
Current and historical adiposity measures are positively associated with long interspersed nuclear element-1 methylation in healthy postmenopausal women.
Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells.
Published in Epigenomics
We identified Kdm6b as a novel regulator of the pro-fibrotic signature of peritoneal foam cells.
DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis.
Published in Epigenomics
DNA methylation at diagnosis is associated with disease-modifying antirheumatic drug treatment response in early RA.
Age-associated DNA methylation changes in naive CD4+ T cells suggest an evolving autoimmune epigenotype in aging T cells...
Published in Epigenomics
Age-associated DNA methylation changes may alter regulatory mechanisms and signaling pathways that predispose to autoimmunity.
Epigenetic variation taking center stage in immunological research.
Published in Epigenomics
DNA methylation in systemic lupus erythematosus.
Published in Epigenomics
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease facilitated by aberrant immune responses directed against cells and tissues, resulting in inflammation and organ damage. In the majority of patients, genetic predisposition is accompanied by additional factors conferring disease expression. While the exact molecular mechanisms rema...
Interplay between genetic and epigenetic mechanisms in rheumatoid arthritis.
Published in Epigenomics
Genetic and environmental factors contribute to the risk for rheumatoid arthritis (RA), with epigenetics serving as a possible interface through which risk factors contribute to RA. High-throughput technologies for interrogating genome and epigenome, and the availability of genetic and epigenetic datasets across a diversity of cell types, enable th...
The neonatal methylome as a gatekeeper in the trajectory to childhood asthma.
Published in Epigenomics
Asthma is a heterogeneous group of conditions that typically begin in early life and result in recurrent, reversible bronchial obstruction. The role played by epigenetic mechanisms in the pathogenesis of childhood asthma is understood only in part. Here we discuss asthma epigenetics within a developmental perspective based on our recent demonstrati...
BET proteins are a key component of immunoglobulin gene expression.
Published in Epigenomics
Our results indicate that BET proteins including Brd4 play a crucial role regulation B-cell-specific gene expression and immunoglobulin production.
