Grit, Jamie L. Johnson, Benjamin K. Dischinger, Patrick S. J. Essenburg, Curt Adams, Marie Campbell, Stacy Pollard, Kai Pratilas, Christine A. Triche, Tim J. Jr. Graveel, Carrie R.
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Published in
Epigenetics & Chromatin
Benign peripheral nerve sheath tumors are the clinical hallmark of Neurofibromatosis Type 1. They account for substantial morbidity and mortality in NF1. Cutaneous (CNF) and plexiform neurofibromas (PNF) share nearly identical histology, but maintain different growth rates and risk of malignant conversion. The reasons for this disparate clinical be...
Beck, Daniel Ben Maamar, Millissia Skinner, Michael K.
Published in
Epigenetics & Chromatin
BackgroundEnvironmentally induced epigenetic transgenerational inheritance of pathology and phenotypic variation has been demonstrated in all organisms investigated from plants to humans. This non-genetic form of inheritance is mediated through epigenetic alterations in the sperm and/or egg to subsequent generations. Although the combined regulatio...
Marr, Luke T. Ocampo, Josefina Clark, David J. Hayes, Jeffrey J.
Published in
Epigenetics & Chromatin
BackgroundThe vast majority of methods available to characterize genome-wide chromatin structure exploit differences in DNA accessibility to nucleases or chemical crosslinking. We developed a novel method to gauge genome-wide accessibility of histone protein surfaces within nucleosomes by assessing reactivity of engineered cysteine residues with a ...
Tinarelli, Federico Ivanova, Elena Colombi, Ilaria Barini, Erica Balzani, Edoardo Garcia, Celina Garcia Gasparini, Laura Chiappalone, Michela Kelsey, Gavin Tucci, Valter
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Published in
Epigenetics & Chromatin
BackgroundDNA methylation has emerged as an important epigenetic regulator of brain processes, including circadian rhythms. However, how DNA methylation intervenes between environmental signals, such as light entrainment, and the transcriptional and translational molecular mechanisms of the cellular clock is currently unknown. Here, we studied the ...
Shalini, Vasantha Bhaduri, Utsa Ravikkumar, Anjhana C. Rengarajan, Anusha Satyanarayana, Rao M. R.
Published in
Epigenetics & Chromatin
BackgroundH1T2/H1FNT is a germ cell-specific linker histone variant expressed during spermiogenesis specifically in round and elongating spermatids. Infertile phenotype of homozygous H1T2 mutant male mice revealed the essential function of H1T2 for the DNA condensation and histone-to-protamine replacement in spermiogenesis. However, the mechanism b...
Hearn, Jack Plenderleith, Fiona Little, Tom J.
Published in
Epigenetics & Chromatin
BackgroundPatterns of methylation influence lifespan, but methylation and lifespan may also depend on diet, or differ between genotypes. Prior to this study, interactions between diet and genotype have not been explored together to determine their influence on methylation. The invertebrate Daphnia magna is an excellent choice for testing the epigen...
Martin, Eric W. Krietsch, Jana Reggiardo, Roman E. Sousae, Rebekah Kim, Daniel H. Forsberg, E. Camilla
Published in
Epigenetics & Chromatin
Hematopoietic stem cells (HSCs) have the capacity to differentiate into vastly different types of mature blood cells. The epigenetic mechanisms regulating the multilineage ability, or multipotency, of HSCs are not well understood. To test the hypothesis that cis-regulatory elements that control fate decisions for all lineages are primed in HSCs, we...
Nohara, Keiko Nakabayashi, Kazuhiko Okamura, Kazuyuki Suzuki, Takehiro Suzuki, Shigekatsu Hata, Kenichiro
Published in
Epigenetics & Chromatin
BackgroundEnvironmental impacts on a fetus can disrupt germ cell development leading to epimutations in mature germ cells. Paternal inheritance of adverse health effects through sperm epigenomes, including DNA methylomes, has been recognized in human and animal studies. However, the impacts of gestational exposure to a variety of environmental fact...
Tsusaka, Takeshi Fukuda, Kei Shimura, Chikako Kato, Masaki Shinkai, Yoichi
Published in
Epigenetics & Chromatin
BackgroundThe histone methyltransferase SETDB1 (also known as ESET) represses genes and various types of transposable elements, such as endogenous retroviruses (ERVs) and integrated exogenous retroviruses, through a deposition of trimethylation on lysine 9 of histone H3 (H3K9me3) in mouse embryonic stem cells (mESCs). ATF7IP (also known as MCAF1 or...
Tang, Jingyi Chisholm, Scott A. Yeoh, Lee M. Gilson, Paul R. Papenfuss, Anthony T. Day, Karen P. Petter, Michaela Duffy, Michael F.
Published in
Epigenetics & Chromatin
BackgroundThe malaria parasite Plasmodium falciparum has an unusually euchromatic genome with poorly conserved positioning of nucleosomes in intergenic sequences and poorly understood mechanisms of gene regulation. Variant histones and histone modifications determine nucleosome stability and recruit trans factors, but their combinatorial contributi...
