Kuzawa, Christopher W Ryan, Calen P Adair, Linda S Lee, Nanette R Carba, Delia B MacIsaac, Julia L Dever, Kristy Atashzay, Parmida Kobor, Michael S McDade, Thomas W
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Published in
Epigenetics
Epigenetic clocks quantify regular changes in DNA methylation that occur with age, or in relation to biomarkers of ageing, and are strong predictors of morbidity and mortality. Here, we assess whether measures of fetal nutrition and growth that predict adult chronic disease also predict accelerated biological ageing in young adulthood using a suite...
Lucia, Rachel M Huang, Wei-Lin Alvarez, Andrea Masunaka, Irene Ziogas, Argyrios Goodman, Deborah Odegaard, Andrew O Norden-Krichmar, Trina M Park, Hannah Lui
Published in
Epigenetics
Altered DNA methylation may be an intermediate phenotype between breast cancer risk factors and disease. Mammographic density is a strong risk factor for breast cancer. However, no studies to date have identified an epigenetic signature of mammographic density. We performed an epigenome-wide association study of mammographic density. White blood ce...
Infante, Teresa Franzese, Monica Ruocco, Antonio Schiano, Concetta Affinito, Ornella Pane, Katia Memoli, Domenico Rizzo, Francesca Weisz, Alessandro Bontempo, Paola
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Published in
Epigenetics
Acute coronary syndrome (ACS) is the most severe clinical manifestation of coronary heart disease.We performed an epigenome-wide analysis of circulating CD4+ and CD8+ T cells isolated from ACS patients and healthy subjects (HS), enrolled in the DIANA clinical trial, by reduced-representation bisulphite sequencing (RRBS). In CD4+ T cells, we identif...
Pacheco, Mariana Brütt Camilo, Vânia Henrique, Rui Jerónimo, Carmen
Published in
Epigenetics
Epigenome editing consists of fusing a predesigned DNA recognition unit to the catalytic domain of a chromatin modifying enzyme leading to the introduction or removal of an epigenetic mark at a specific locus. These platforms enabled the study of the mechanisms and roles of epigenetic changes in several research domains such as those addressing pat...
Fang, Lei Chen, Danqi Zhang, Jingzi Li, Hongjie Bradford, Beatrix Jin, Chunyuan
Published in
Epigenetics
H3K56 acetylation (H3K56Ac) was first identified in yeast and has recently been reported to play important roles in maintaining genomic stability, chromatin assembly, DNA replication, cell cycle progression and DNA repair. Although H3.1K56Ac has been relatively well studied, the function of H3.3K56Ac remains mostly unknown in mammals. In this study...
Beck, Daniel Ben Maamar, Millissia Skinner, Michael K
Published in
Epigenetics
Genome-wide DNA methylation analysis is one of the most common epigenetic processes analysed for genome characterization and differential DNA methylation assessment. Previous genome-wide analysis has suggested an important variable in DNA methylation methods involves CpG density. The current study was designed to investigate the CpG density in a va...
Voisin, Anne-Sophie Suarez Ulloa, Victoria Stockwell, Peter Chatterjee, Aniruddha Silvestre, Frédéric
Published in
Epigenetics
Organisms exposed to endocrine disruptors in early life can show altered phenotype later in adulthood. Although the mechanisms underlying these long-term effects remain poorly understood, an increasing body of evidence points towards the potential role of epigenetic processes. In the present study, we exposed hatchlings of an isogenic lineage of th...
Supadmanaba, I Gede Putu Mantini, Giulia Randazzo, Ornella Capula, Mjriam Muller, Ittai B Cascioferro, Stella Diana, Patrizia Peters, Godefridus J Giovannetti, Elisa
Published in
Epigenetics
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers because of diagnosis at late stage and inherent/acquired chemoresistance. Recent advances in genomic profiling and biology of this disease have not yet been translated to a relevant improvement in terms of disease management and patient's survival. However, new possibilities ...
Antoun, E Titcombe, P Dalrymple, K Kitaba, N T Barton, S J Flynn, Ac Murray, R Garratt, E S Seed, P T White, S L
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Published in
Epigenetics
Many epidemiological studies have linked low birthweight to an increased risk of non-communicable diseases (NCDs) in later life, with epigenetic proceseses suggested as an underlying mechanism. Here, we sought to identify neonatal methylation changes associated with birthweight, at the individual CpG and genomic regional level, and whether the birt...
Dube, Christabel Thembela Jahan, Fathima Rifkhana Shah Lim, Chin Yan
Published in
Epigenetics
Dynamic shifts in chromatin states occur during embryonic epidermal development to support diverse epigenetic pathways that regulate skin formation and differentiation. However, it is not known whether the epigenomes established during embryonic development are maintained into adulthood or how these epigenetic mechanisms may be altered upon physiol...
