Yang, Bei Wang, Xinlu Ma, Yilin Yan, Lei Ren, Yuan Yu, Dainan Qiao, Bo Shen, Xin Liu, Hui Zhang, Dalei
...
Published in
Environmental toxicology
Tri-ortho-cresyl phosphate (TOCP) has been widely used as plasticizers, and reported causing reproductive toxicity in mammals. However, little is known about the toxic effect on the placenta. In this study, dams were orally administered different doses of TOCP to explore the effect of TOCP on placental development. Results showed that TOCP exposure...
Kim, Cho-Won Go, Ryeo-Eun Ko, Eul Bee Jeung, Eui-Bae Kim, Min-Seok Choi, Kyung-Chul
Published in
Environmental toxicology
The heart is the first organ formed in the developing fetus, and abnormal development of the heart is a major cause of fetal death. The adverse effects of cigarette smoke on the heart have been well established, but it is not well understood how cigarette smoke components regulate signaling molecules and cardiac specific functions during the early ...
Ramos, Alice A Castro-Carvalho, Bruno Prata-Sena, Maria Malhão, Fernanda Buttachon, Suradet Dethoup, Tida Kijjoa, Anake Rocha, Eduardo
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Environmental toxicology
Doxorubicin (Dox) is one of the most successful anticancer drugs in use. However, chemoresistance is one of the main limitations that patients face. Therefore, development of new strategies to improve the efficacy of Dox is needed. Marine-derived fungi are especially promising sources of new anticancer compounds. In this work, antitumor activity of...
Romualdo, Guilherme R Silva, Elizangela Dos Anjos Da Silva, Tereza C Aloia, Thiago P A Nogueira, Marina S De Castro, Inar A Vinken, Mathieu Barbisan, Luís F Cogliati, Bruno
Published in
Environmental toxicology
Nonalcoholic steatohepatitis (NASH) is considered growing risk factor for hepatocellular carcinoma development in high-income countries. Diet- and chemically induced rodent models have been applied for the translational study of NASH-associated hepatocarcinogenesis due to their morphological and molecular similarities to the corresponding human dis...
He, Shuangjiang Zhuo, Liling Cao, Ying Liu, Gang Zhao, Hongyan Song, Ruilong Liu, Zongping
Published in
Environmental toxicology
Cadmium (Cd) is a toxic heavy metal that represents an occupational hazard and environmental pollutant toxic heavy metal, which can cause osteoporosis following accumulation in the body. The purpose of this study was to investigate the effect of Cd on bone tissue osteoclast differentiation in vivo. Female BALB/c mice were randomly divided into thre...
Lu, Chieh-Hsiang Ou, Hsiu-Chung Day, Cecilia-Hsuan Chen, Hsiu-I Pai, Pei-Ying Lee, Cheng-Yu Chen, Ray-Jade Chang, Ruey-Lin PadmaViswanadha, Vijaya Hsieh, Dennis Jine-Yuan
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Published in
Environmental toxicology
It has been well-documented that the consumption of deep sea water (DSW) has beneficial effects on myocardial hypertrophy and cardiac apoptosis induced by hypercholesterolemia. However, the molecular mechanisms for the anti-inflammatory effects of DSW on diabetic cardiomyopathy are still largely unclear. The main purpose of this present study was t...
Wu, Shijin Wu, Mei Tian, Dongcan Qiu, Lequan Li, Tongtong
Published in
Environmental toxicology
Microplastics (MPs) pollution is a global paradigm that raises concern in relation to environment and human health. In order to investigate the molecular toxicity mechanisms of MPs, transcriptomic analyses were performed on in vitro Caco-2 cell model. After observing that polystyrene microplastics (PS-MPs) decreased cell viability in a dose-depende...
Liao, Nien-Chieh Shih, Yung-Luen Ho, Ming-Tak Lu, Tai-Jung Lee, Ching-Hsiao Peng, Shu-Fen Leu, Sy-Jye Chung, Jing-Gung
Published in
Environmental toxicology
Cardamonin, a monomeric alkaloid, is isolated from Alpinia conchigera Griff and other natural plants. Recently, it has been focused on its anticancer activities, and no information showing its immune effects on leukemia mice was reported. In this study, we investigated the immune effects of cardamonin on WEHI-3 cell-generated leukemia mice. Forty B...
Yang, Si Shao, Shuxin Huang, Boshu Yang, Dan Zeng, Lin Gan, Yu Long, Dingxin Chen, Jiaxiang Wang, Jinglei
Published in
Environmental toxicology
Tri-ortho-cresyl phosphate (TOCP), a widely used plasticizer in industry, can cause female reproductive damage. Tea polyphenols (TPs) have multiple health effects via inhibiting oxidative stress. However, the reproductive protection of TPs in TOCP-induced female reproductive system damage is yet to be elucidated. In the study, TOCP inhibited cell v...
Abdel-Magied, Nadia Shedid, Shereen M
Published in
Environmental toxicology
Nanoparticle is a microscopic particle that has been existed in a wide range of biotechnological purposes. Zinc oxide nanoparticles (ZnO-NPs) have fewer environmental hazards and have shown positive impacts in the medical field. This work aimed to observe the effects of low and high doses of ZnO-NPs on heart injury induced by ionizing radiation (IR...
