Chang, Xuhong Liu, Fangfang Tian, Minmin Zhao, Hongjun Han, Aijie Sun, Yingbiao
Published in
Environmental toxicology
Nickel oxide nanoparticles (nano NiO) could induce hepatocyte apoptosis, while its potential mechanisms are unclear. This study aimed to explore the role of endoplasmic reticulum (ER) stress pathways in hepatocyte apoptosis induced by nano NiO. Male Wistar rats were administrated with nano NiO (0.015, 0.06, and 0.24 mg/kg b.w.) and micro NiO (0.24 ...
Man, Shuli Chai, Hongyan Cui, Jingxia Yao, Jingwen Ma, Long Gao, Wenyuan
Published in
Environmental toxicology
Lung cancer is one of the most common causes of death in the world. Rhizoma paridis saponins (RPS) have been found to show inhibition of pulmonary adenoma in previous research. However, the detailed mechanisms of RPS from a holistic view have not been established. In this study, Lewis pulmonary adenoma mice were successfully established to analyze ...
Tung, Jia-Chen Huang, Wei-Chien Yang, Juan-Cheng Chen, Guan-Yu Fan, Chi-Chen Chien, Yu-Chuan Lin, Pei-Shan Candice Lung, Shih-Chun Chang, Wei-Chao
Published in
Environmental toxicology
Burning incense to worship deities is a popular religious ritual in large parts of Asia, and is a popular custom affecting more than 1.5 billion adherents. Due to incomplete combustion, burning incense has been well recognized to generate airborne hazards to human health. However, the correlation between burning incense and lung cancer in epidemiol...
Lee, You-Jin Park, Bong-Soo Park, Hae-Ryoun Yu, Su-Bin Kang, Hae-Mi Kim, In-Ryoung
Published in
Environmental toxicology
Embelin is an active ingredient of traditional herbal remedies for cancer and other diseases. Recently, it has been suggested that autophagy may play an important role in cancer therapy. However, little data are available regarding the role of autophagy in oral cancers. Therefore, we conducted this study to examine whether Embelin modulates autopha...
Huang, Chien-Feng Teng, Ying-Hock Lu, Fung-Jou Hsu, Wen-Hung Lin, Chia-Liang Hung, Chia-Chen Tung, Jai-Nien Hsieh, Yi-Hsien Liu, Chung-Jung
Published in
Environmental toxicology
β-mangostin is a dietary xanthone that has been reported to have the anticancer properties in some human cancer cell types. However, the antimetastatic effect and molecular mechanism of β-mangostin action in human hepatocellular carcinoma (HCC) cells remain unknown. In this study, we found that β-mangostin did not induce cytotoxicity in human HCC c...
Wen, Su-Ying Tsai, Cheng-Yen Pai, Pei-Ying Chen, Yi-Wei Yang, Yao-Chih Aneja, Ritu Huang, Chih-Yang Kuo, Wei-Wen
Published in
Environmental toxicology
DATS appears to suppress Dox-induced cardiomyocyte apoptosis by inhibiting NADPH oxidase-related ROS production and the downstream JNK/ERK/NF-κB signaling pathway; DATS may possess clinical therapeutic potential by blocking Dox-induced cardiotoxicity.
Zhang, Chun-Nuan Zhang, Ji-Liang Huang, Yong Ren, Hong-Tao Guan, Su-Hua Zeng, Qing-Hui
Published in
Environmental toxicology
Dibutyltin (DBT) is the degradation products of TBT, which is generally considered higher toxicity than TBT in the immune system. In order to learn more about the mechanisms of immune-toxic of DBT, we exposed zebrafish (Danio rerio) to 0, 1, 10 and 100 ng/L DBT for 8 weeks. At the end of the experiment, we determined the immune parameters and immun...
Møller, Peter Wallin, Håkan Cassee, Flemming R Loft, Steffen
Published in
Environmental toxicology
Yue, Cong Ji, Cheng Zhang, Hang Zhang, Leshuai W Tong, Jian Jiang, Yan Chen, Tao
Published in
Environmental toxicology
Our previous observations indicated that extractable organic matter (EOM) from PM2.5 induced malformations in the heart of zebrafish embryos by activating AhR and inhibiting canonical Wnt/β-catenin signal pathway. As a nutritional factor, folic acid (FA) is reported to prevent cardiac defects during embryo development. Hence, we hypothesize that FA...
Yazdinezhad, Alireza Abbasian, Meysam Hojjat Hosseini, Seyed Naserzadeh, Parvaneh Agh-Atabay, Abdol-Hakim Hosseini, Mir-Jamal
Published in
Environmental toxicology
Chlorpyrifos (CPF) is one of the most widely used organophosphorus, which has spurred renewed interest. This study was conducted to investigate the protective effect of ziziphora tenuior extract against CPF-induced liver and lung toxicity. This study conducted 8-week rat sub-chronic toxicity study and then the effect of ziziphora tenuior extract in...
