Afzal, Shekh Mohammad Vafa, Abul Rashid, Summya Barnwal, Preeti Shahid, Ayaz Shree, Alpa Islam, Johirul Ali, Nemat Sultana, Sarwat
Published in
Environmental toxicology
Hesperidin (HD), a citrus bioflavonoid possesses a variety of biological activities including antioxidant, anti-inflammatory, anti-apoptotic and anti-carcinogenic properties. In the present study, we investigated the effect of HD treatment on N,N'-dimethylhydrazine (DMH) induced oxidative stress, inflammation, apoptosis and goblet cell disintegrati...
Chang, Xuhong Tian, Minmin Zhang, Qiong Gao, Jinxia Li, Sheng Sun, Yingbiao
Published in
Environmental toxicology
Our previous study demonstrated that nano nickel oxide (NiO) induce pulmonary fibrosis in rats and collagen excessive formation in A549 cells, which mechanism was related with the increasing transforming growth factor β1 (TGF-β1) secretion. However, it remains unclear understanding the role of TGF-β1 in collagen excessive formation. Here, we found ...
Shi, Junxia Liu, Chenyu Chen, Mingyue Yan, Jinhui Wang, Chonggang Zuo, Zhenghong He, Chengyong
Published in
Environmental toxicology
Numerous studies have shown that endocrine-disrupting chemicals are one of the important pathogenic factors in women with polycystic ovary syndrome. Our previous study has revealed that bisphenol A (BPA) can cause steroid hormone imbalance, polycystic ovary, and estrus cycle disorder. In this study, we aimed to explore the effect of BPA, a typical ...
Zhao, Qi Sun, Peng Qin, Songbing Liu, Jisheng
Published in
Environmental toxicology
Recent evidences show that acylglycerol kinase (AGK) expression is related to the occurrence and development of various human cancers. However, its roles in nasopharyngeal carcinoma (NPC) progression are still unclear. This work aims to explore the roles of AGK in NPC cell stemness. It was shown that AGK expression was higher in NPC tissues compare...
Xu, Zhixiang Zhao, Dimeng Zheng, Xianyao Huang, Bin Xia, Xueshan Pan, Xuejun
Published in
Environmental toxicology
Tamoxifen was widely applied in the therapy of estrogen receptor (ER)-positive breast cancer. With the purpose of determining the potential impacts of quercetin on its effectiveness, MCF-7 cells were selected as the in vitro model and several cellular biological behaviors (ie, cell proliferation, migration, invasion, cycle, apoptosis, and oxidative...
Chen, Ling Xia, Jing-Sheng Wu, Jin-Hu Chen, Yong-Gang Qiu, Chao-Jun
Published in
Environmental toxicology
As a natural compound, resveratrol (Res) is confirmed to be promising drug for the treatment of malignant tumors. Therefore, our study aimed to observe the impacts of Res on the proliferation and apoptosis of oral squamous cell carcinoma cells (HSC-3 cells) as well as the mechanism involving chromobox protein homolog 7 (CBX7) signal transduction. H...
Meng, Shunlong Chen, Xi Gyimah, Eric Xu, Hai Chen, Jiazhang
Published in
Environmental toxicology
Polybrominated diphenyl ethers (PBDEs) are ubiquitous and prolific contaminant in both the abiotic and biotic environment because of the wide industrial applications of these chemicals. In the present study, the effects of 2,2',4,4'-tetrabrominateddiphenyl ether (BDE-47) and 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE-153) exposure on the induction...
El-Sonbaty, Sawsan M Moawed, Fatma S M Elbakry, Mustafa M M
Published in
Environmental toxicology
d-Galactosamine (d-GalN) is a well-known toxin that causes many metabolic and morphological abnormalities resulting in advanced renal failure and liver damage. Occupational exposure to low-level ionizing radiation (
Chen, Po-Chun Liu, Shan-Chi Lin, Tien-Huang Lin, Liang-Wei Wu, Hsi-Chin Tai, Huai-Ching Wang, Shih-Wei Tang, Chih-Hsin
Published in
Environmental toxicology
Prostate cancer osteoblastic bone metastases are incurable and associated with chronic bone pain and a high mortality rate. Osteoclast-targeting drugs intended to prevent skeletal-related events associated with prostate cancer bone metastases do not prolong overall survival. Improved understanding of the bone-derived factors that contribute to pros...
Wu, Qianqian Fang, Lijun Yang, Youjing Wang, Aiqing Chen, Xiaoyu Sun, Jiaojiao Wan, Jianmei Hong, Chengjiao Tong, Jian Tao, Shasha
...
Published in
Environmental toxicology
Radon is one of the major pathogenic factors worldwide. Recently, epidemiological studies have suggested that radon exposure plays an important role in lung injury, which could further cause cancer. However, the toxic effects and underlying mechanism on lung injury are still not clear. Here, we identified the detailed toxic effects of long-term rad...
