Wang, Fei Wu, Jinsen Wang, Yajuan Wan, Zhimin Shao, Hongxia Qian, Kun Ye, Jianqiang Qin, Aijian
Published in
Emerging microbes & infections
Influenza A H9N2 virus causes economic loss to the poultry industry and has likely contributed to the genesis of H5N1 and H7N9 viruses. The neuraminidase (NA) of H9N2 virus, like haemagglutinin, is under antibody selective pressure and may undergo antigenic change; however, its antigenic structure remains to be elucidated. In this study, we used mo...
Yang, Sisi Zeng, Wanjia Zhang, Jiming Lu, Fengmin Chang, Jinhong Guo, Ju-Tao
Published in
Emerging microbes & infections
AbstractThe prolonged viral antigen stimulation is the driving force for the development of immune tolerance to chronic hepatitis B virus (HBV) infection. The sustained reduction of viral proteins may allow for the recovery and efficient activation of HBV-specific T and B cells by immune stimulating agents, checkpoint blockades and/or therapeutic v...
Shen, Lishuang Bard, Jennifer Dien Triche, Timothy J Judkins, Alexander R Biegel, Jaclyn A Gai, Xiaowu
Published in
Emerging microbes & infections
AbstractThe SARS-CoV-2 B.1.1.7 lineage is highly infectious and as of April 2021 accounted for 92% of COVID-19 cases in Europe and 59% of COVID-19 cases in the U.S. It is defined by the N501Y mutation in the receptor binding domain (RBD) of the Spike (S) protein, and a few other mutations. These include two mutations in the N terminal domain (NTD) ...
Xu, Xingxing Luo, Yuo Chen, Huan Song, Xiaojun Bian, Qiao Wang, Xianjun Liang, Qian Zhao, Jianhong Li, Chunhui Song, Guangzhong
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Published in
Emerging microbes & infections
Clostridioides difficile sequence type (ST) 37 (ribotype 017) is one of the most prevalent genotypes circulating in China. However, its genomic evolution and virulence determinants were rarely explored. Whole-genome sequencing, phylogeographic and phylogenetic analyses were conducted for C. difficile ST37 isolates. The 325 ST37 genomes from six con...
Niikura, Mai Atobe, Satomi Takahashi, Akira Kado, Yukiko Sugimoto, Takuya Tsuji, Hirokazu Shimizu, Kentaro Ogura, Hiroshi Asahara, Takashi
Published in
Emerging microbes & infections
For Pseudomonas aeruginosa (PA), infection control and appropriate antimicrobial treatment have become important issues. Diagnosis is critical in managing PA infection, but conventional methods are not highly accurate or rapid. We developed a new PA quantification system based on 23S rRNA-targeted reverse transcription quantitative PCR (RT-qPCR). W...
Guo, Li Wang, Yeming Kang, Liang Hu, Yongfeng Wang, Linghang Zhong, Jingchuan Chen, Hong Ren, Lili Gu, Xiaoying Wang, Geng
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Published in
Emerging microbes & infections
Seasonal human coronaviruses (HCoVs) including HCoV-229E, -OC43, -NL63 and -HKU1 widely spread in global human populations. However, the relevance of humoral response against seasonal HCoVs to COVID-19 pathogenesis is elusive. In this study, we profiled the temporal changes of IgG antibody against spike proteins (S-IgG) of SARS-CoV-2 and seasonal H...
Neira, Víctor Brito, Bárbara Agüero, Belén Berrios, Felipe Valdés, Valentina Gutierrez, Alberto Ariyama, Naomi Espinoza, Patricio Retamal, Patricio Holmes, Edward C
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Published in
Emerging microbes & infections
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected in domestic and wild cats. However, little is known about natural viral infections of domestic cats, although their importance for modelling disease spread, informing strategies for managing positive human-animal relationships and disease prevention. Here, we describe th...
Guo, Qinglong Bi, Jing Wang, Honghai Zhang, Xuelian
Published in
Emerging microbes & infections
Proteins secreted by the ESAT-6 secretion system 1 (ESX-1) secretion system are vital for Mycobacterium tuberculosis (Mtb) virulence and pathogenicity. Particularly, EsxA is considered the major ESX-1-related virulence determinant. However, the exact roles of the individual ESX-1 substrates, such as EspC, are still unclear due to their interdepende...
Favara, D M Ceron-Gutierrez, M L Carnell, G W Heeney, J L Corrie, P Doffinger, R
Published in
Emerging microbes & infections
A 40-year-old female was found to have strongly neutralizing SARS-CoV-2 breastmilk IgA and IgG antibodies reactive against multiple SARS-CoV-2 antigens at 2.5 months after documented infection with SARS-CoV-2. At 6.5 months following the infection, she remained positive for breastmilk and serum SARS-CoV-2 neutralizing antibodies. Holder breast milk...
Rosenke, Kyle Meade-White, Kimberly Letko, Michael Clancy, Chad Hansen, Frederick Liu, Yanan Okumura, Atsushi Tang-Huau, Tsing-Lee Li, Rong Saturday, Greg
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Published in
Emerging microbes & infections
Following emergence in late 2019, SARS-CoV-2 rapidly became pandemic and is presently responsible for millions of infections and hundreds of thousands of deaths worldwide. There is currently no approved vaccine to halt the spread of SARS-CoV-2 and only very few treatment options are available to manage COVID-19 patients. For development of preclini...
