Neira, Víctor Brito, Bárbara Agüero, Belén Berrios, Felipe Valdés, Valentina Gutierrez, Alberto Ariyama, Naomi Espinoza, Patricio Retamal, Patricio Holmes, Edward C
...
Published in
Emerging microbes & infections
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected in domestic and wild cats. However, little is known about natural viral infections of domestic cats, although their importance for modelling disease spread, informing strategies for managing positive human-animal relationships and disease prevention. Here, we describe th...
Guo, Qinglong Bi, Jing Wang, Honghai Zhang, Xuelian
Published in
Emerging microbes & infections
Proteins secreted by the ESAT-6 secretion system 1 (ESX-1) secretion system are vital for Mycobacterium tuberculosis (Mtb) virulence and pathogenicity. Particularly, EsxA is considered the major ESX-1-related virulence determinant. However, the exact roles of the individual ESX-1 substrates, such as EspC, are still unclear due to their interdepende...
Li, Haibo Ren, Lili Zhang, Lulu Wang, Yeming Guo, Li Wang, Conghui Xiao, Yan Wang, Ying Rao, Jian Wang, Xinming
...
Published in
Emerging microbes & infections
To identify the association between the kinetics of viral load and clinical outcome in severe coronavirus disease 2019 (COVID-19) patients, a retrospective study was performed by involved 188 hospitalized severe COVID-19 patients in the LOTUS China trial. Among the collected 578 paired throat swab (TS) and anal swab (AS) samples, viral RNA was dete...
Chen, Jonathan Hon-Kwan Yip, Cyril Chik-Yan Poon, Rosana Wing-Shan Chan, Kwok-Hung Cheng, Vincent Chi-Chung Hung, Ivan Fan-Ngai Chan, Jasper Fuk-Woo Yuen, Kwok-Yung To, Kelvin Kai-Wang
Published in
Emerging microbes & infections
During the Coronavirus disease 2019 (COVID-19) pandemic, logistic problems associated with specimen collection limited the SARS-CoV-2 testing, especially in the community. In this study, we assessed the use of posterior oropharyngeal saliva as specimens for the detection of SARS-CoV-2 in an automated point-of-care molecular assay. Archived nasophar...
Yang, Chao Jiang, Min Wang, Xiaohui Tang, Xiujuan Fang, Shisong Li, Hao Zuo, Le Jiang, Yixiang Zhong, Yifan Chen, Qiongcheng
...
Published in
Emerging microbes & infections
Managing recovered COVID-19 patients with recurrent-positive SARS-CoV-2 RNA test results is challenging. We performed a population-based observational study to characterize the viral RNA level and serum antibody responses in recurrent-positive patients and evaluate their viral transmission risk. Of 479 recovered COVID-19 patients, 93 (19%) recurren...
Portugal, Raquel Goatley, Lynnette C Husmann, Robert Zuckermann, Federico A Dixon, Linda K
Published in
Emerging microbes & infections
The main target cells for African swine fever virus (ASFV) replication in pigs are of monocyte macrophage lineage and express markers typical of the intermediate to late stages of differentiation. The lack of a porcine cell line, which accurately represents these target cells, limits research on virus host interactions and the development of live-a...
Han, Huan Ma, Qingfeng Li, Cong Liu, Rui Zhao, Li Wang, Wei Zhang, Pingan Liu, Xinghui Gao, Guosheng Liu, Fang
...
Published in
Emerging microbes & infections
Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread across many other countries. While the majority of patients were considered mild, critically ill patients involving respiratory failure and multiple organ dysfunction syndrome are not uncommon, which could result death. We hypothesized that cytokine sto...
Coipan, Claudia E Westrell, Therese van Hoek, Angela H A M Alm, Erik Kotila, Saara Berbers, Bas de Keersmaecker, Sigrid C J Ceyssens, Pieter-Jan Borg, Maria Louise Chattaway, Marie
...
Published in
Emerging microbes & infections
Global dissemination of ciprofloxacin-resistant Salmonella Kentucky has been observed over the past decades. In recent years, there have been reports of extended-spectrum β-lactamase (ESBL) producing S. Kentucky. Routine surveillance at the European Centre for Disease Prevention and Control (ECDC) detected cases with a ciprofloxacin-resistant S. Ke...
Gelman, Ram Bayatra, Areej Kessler, Asa Schwartz, Asaf Ilan, Yaron
Published in
Emerging microbes & infections
The ongoing severe acute respiratory syndrome pandemic caused by the novel coronavirus 2 (SARS-CoV-2) is associated with high morbidity and mortality rates, and it has created a pressing global need for effective antiviral therapies against it. COVID-19 disease pathogenesis is characterized by an initial virus-mediated phase, followed by inappropri...
Li, Zhong Lang, Yuekun Sakamuru, Srilatha Samrat, Subodh Trudeau, Nicole Kuo, Lili Rugenstein, Natasha Tharappel, Anil D'Brant, Lianna Koetzner, Cheri A
...
Published in
Emerging microbes & infections
Many flaviviruses including the Dengue virus (DENV), Zika virus (ZIKV), West Nile virus, Yellow Fever virus, and Japanese encephalitis virus are significant human pathogens, unfortunately without any specific therapy. Here, we demonstrate that methylene blue, an FDA-approved drug, is a broad-spectrum and potent antiviral against Zika virus and Deng...
