Suah, Jing Lian Tng, Boon Hwa Tok, Peter Seah Keng Husin, Masliyana Thevananthan, Thevesh Peariasamy, Kalaiarasu M Sivasampu, Sheamini
Published in
Emerging microbes & infections
Given emerging evidence of immune escape in the SARS-CoV-2 Omicron viral variant, and its dominance, effectiveness of heterologous and homologous boosting schedules commonly used in low-to-middle income countries needs to be re-evaluated. We conducted a test-negative design using consolidated national administrative data in Malaysia to compare the ...
Ji, Ningfei Zhang, Mingshun Ren, Liang Wang, Yunyun Hu, Bicheng Xiang, Jie Gong, Yingyun Wu, Chaojie Qu, Guoqiang Ding, Wenqiu
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Published in
Emerging microbes & infections
Diabetes mellitus (DM) is one of the most common underlying diseases that may aggravates COVID-19. In the present study, we explored islet function, the presence of SARS-CoV-2 and pathological changes in the pancreas of patients with COVID-19. Oral glucose tolerance tests (OGTTs) and the C-peptide release test demonstrated a decrease in glucose-sti...
Zhao, Na Cheng, Danhong Yang, Ziyu Liu, Yao Wang, Yanan Jian, Ying Wang, Hua Li, Min Bae, Taeok Liu, Qian
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Published in
Emerging microbes & infections
Staphylococcus aureus is an important human commensal bacteria colonizing the human body, especially the nasal cavity. The nasal carriage can be a source of S. aureus bacteremia. However, the bacterial factors contributing to nasal colonization are not completely understood. By analysing S. aureus strains from the nasal cavity of the children, youn...
Wang, Dongshu Chen, Gang Lyu, Yufei Feng, Erling Zhu, Li Pan, Chao Zhang, Weicai Liu, Xiankai Wang, Hengliang
Published in
Emerging microbes & infections
As next-generation pathogen detection methods, CRISPR-Cas-based detection methods can perform single-nucleotide polymorphism (SNP) level detection with high sensitivity and good specificity. They do not require any particular equipment, which opens up new possibilities for the accurate detection and identification of Bacillus anthracis. In this stu...
Wang, Xin Yin, Xiaochen Zhang, Boya Liu, Chenfeng Lin, Yahua Huang, Xiaofen Li, Yufang Shen, Chenguang Zheng, Weibin Fu, Guofeng
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Published in
Emerging microbes & infections
Infection caused by respiratory viruses can lead to a severe respiratory disease and even death. Vaccination is the most effective way to prevent the disease, but it cannot be quickly applied when facing an emerging infectious disease. Here, we demonstrated that immunization with an aluminium-zinc hybrid particulate adjuvant (FH-001) alone, bearing...
Yu, Su-Yeon Koh, Dae-Hyup Choi, Miyoung Ryoo, Seungeun Huh, Kyungmin Yeom, Joon Sup Yoon, Young Kyung
Published in
Emerging microbes & infections
This study investigated the efficacy and safety of interleukin-6 (IL-6) receptor antagonists with standard care treatment in patients with coronavirus disease 2019 (COVID-19). The randomized controlled trials were identified through systematic searches of electronic databases through February 10, 2022. In total, 17 trials comprising 8,614 patients ...
Chen, Yiyi Ji, Shujuan Sun, Lu Wang, Haiping Zhu, Feiteng Chen, Mengzhen Zhuang, Hemu Wang, Zhengan Jiang, Shengnan Yu, Yunsong
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Published in
Emerging microbes & infections
Fosfomycin has gained attention as a combination therapy for methicillin-resistant Staphylococcus aureus infections. Hence, the detection of novel fosfomycin-resistance mechanisms in S. aureus is important. Here, the minimal inhibitory concentrations (MICs) of fosfomycin in CC1 methicillin-resistant S. aureus were determined. The pangenome analysis...
Shi, Chenjuan Tian, Li Zheng, Wenwen Zhu, Yelei Sun, Peilu Liu, Lele Liu, Wenkai Song, Yanyan Xia, Xianzhu Xue, Xianghong
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Published in
Emerging microbes & infections
Three or four intramuscular doses of the inactivated human rabies virus vaccines are needed for pre- or post-exposure prophylaxis in humans. This procedure has made a great contribution to prevent human rabies deaths, which bring huge economic burdens in developing countries. Herein, a recombinant adeno-associated virus serotype 9, AAV9-RABVG, harb...
Zhang, Xi Chu, Hin Chik, Kenn Ka-Heng Wen, Lei Shuai, Huiping Yang, Dong Wang, Yixin Hou, Yuxin Yuen, Terrence Tsz-Tai Cai, Jian-Piao
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Published in
Emerging microbes & infections
ABSTRACTHost circular RNAs (circRNAs) play critical roles in the pathogenesis of viral infections. However, how viruses modulate the biogenesis of host proviral circRNAs to facilitate their replication remains unclear. We have recently shown that Middle East respiratory syndrome coronavirus (MERS-CoV) infection increases co-expression of circRNAs a...
Zhou, Yun-Qi Wang, Ke Wang, Xue-Yan Cui, Hong-Yong Zhao, Yongxiang Zhu, Ping Chen, Zhi-Nan
Published in
Emerging microbes & infections
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants is threatening public health around the world. Endocytosis functions as an important way for viral infection, and SARS-CoV-2 bears no exception. However, the specific endocytic mechanism of SARS-CoV-2 remains unknown. In this study, we used endocytic inhibit...
