Published in EMBO reports
Leasing instead of purchasing scientific instruments is an economic option for academic core facilities to stay technologically ahead and competitive with predictable, consistent costs. © 2020 The Authors.
Published in EMBO reports
Bacterial secretory preproteins are translocated across the inner membrane post-translationally by the SecYEG-SecA translocase. Mature domain features and signal peptides maintain preproteins in kinetically trapped, largely soluble, folding intermediates. Some aggregation-prone preproteins require chaperones, like trigger factor (TF) and SecB, for ...
Published in EMBO reports
Replication across oxidative DNA lesions can give rise to mutations that pose a threat to genome integrity. How such lesions, which escape base excision repair, get removed without error during replication remains unknown. Our PCNA-based screen to uncover changes in replisome composition under different replication stress conditions had revealed a ...
Published in EMBO reports
University accountants and administrators should support scientists going to meetings, not further burden them with bureaucratic hurdles, expense claims or unnecessary auditing. © 2020 The Authors.
Published in EMBO reports
Mitochondria are cellular organelles that orchestrate a vast range of biological processes, from energy production and metabolism to cell death and inflammation. Despite this seemingly symbiotic relationship, mitochondria harbour within them a potent agonist of innate immunity: their own genome. Release of mitochondrial DNA into the cytoplasm and o...
Published in EMBO reports
Synthetic biology and artificial intelligence naturally converge in the biofoundry. Navigating the ethical and societal issues of the biofoundry's potential remains a major challenge. © 2020 The Authors.
Published in EMBO reports
SAMHD1 possesses multiple functions, but whether cellular factors regulate SAMHD1 expression or its function remains not well characterized. Here, by investigating why cultured RD and HEK293T cells show different sensitivity to enterovirus 71 (EV71) infection, we demonstrate that SAMHD1 is a restriction factor for EV71. Importantly, we identify TRI...
Published in EMBO reports
Published in EMBO reports
Comment on "A microRNA cluster in the Fragile-X region expressed during spermatogenesis targets FMR1" by Ramaiah et al. © 2019 The Authors.
Published in EMBO reports
The type VI secretion system (T6SS) is used by many bacteria to engage in social behavior and can affect the health of its host plant or animal. Because activities associated with T6SSs are often costly, T6SSs must be tightly regulated. However, our knowledge regarding how T6SS assembly and contraction are regulated remains limited. Using the plant...
