Published in EMBO reports
The COVID-19 pandemic highlights how our ancient fear response can be exploited for nefarious purposes with social media lending a helping hand. © 2020 The Author.
Published in EMBO reports
Biosafety is a major challenge for developing for synthetic organisms. An early focus on application and their context could assist with the design of appropriate genetic safeguards. © 2020 The Authors. Published under the terms of the CC BY NC ND 4.0 license.
Published in EMBO reports
A long-standing problem in biology is how to dissect traits for which no tractable model exists. Here, we screen for genes like the nude locus (Foxn1)-genes central to mammalian hair and thymus development-using animals that never evolved hair, thymi, or Foxn1. Fruit flies are morphologically disrupted by the FOXN1 transcription factor and rescued ...
Published in EMBO reports
Alternative splicing (AS) leads to transcriptome diversity in eukaryotic cells and is one of the key regulators driving cellular differentiation. Although AS is of crucial importance for normal hematopoiesis and hematopoietic malignancies, its role in early hematopoietic development is still largely unknown. Here, by using high-throughput transcrip...
Published in EMBO reports
Many cancer cells maintain enhanced aerobic glycolysis due to irreversible defective mitochondrial oxidative phosphorylation (OXPHOS). This phenomenon, known as the Warburg effect, is recently challenged because most cancer cells maintain OXPHOS. However, how cancer cells coordinate glycolysis and OXPHOS remains largely unknown. Here, we demonstrat...
Published in EMBO reports
DNA damage tolerance relies on homologous recombination (HR) and translesion synthesis (TLS) mechanisms to fill in the ssDNA gaps generated during passing of the replication fork over DNA lesions in the template. Whereas TLS requires specialized polymerases able to incorporate a dNTP opposite the lesion and is error-prone, HR uses the sister chroma...
Published in EMBO reports
Good manners make a difference-in science and elsewhere. This includes our social media etiquette as researchers. © 2020 The Author.
Published in EMBO reports
Brain imaging and research on bilinguals and patients with speech disorders is helping to unravel semantic processing - the way how the brain interprets and stores sentences and stories. © 2020 The Author.
Published in EMBO reports
This year's Nobel prize for the CRISPR/Cas system is an illustrative example of how scientific breakthroughs rests on preceding work: the discovery of guide RNAs in the 1990s. © 2020 The Author.
Published in EMBO reports
When glucose is available, many organisms repress mitochondrial respiration in favour of aerobic glycolysis, or fermentation in yeast, that suffices for ATP production. Fission yeast cells, however, rely partially on respiration for rapid proliferation under fermentative conditions. Here, we determined the limiting factors that require respiratory ...
