Published in EMBO reports
The correct establishment of DNA methylation patterns is vital for mammalian development and is achieved by the de novo DNA methyltransferases DNMT3A and DNMT3B. DNMT3B localises to H3K36me3 at actively transcribing gene bodies via its PWWP domain. It also functions at heterochromatin through an unknown recruitment mechanism. Here, we find that kno...
Published in EMBO reports
Published in EMBO reports
The pandemic is over, thanks in part to rapid development of vaccines. Why then does it take so long to develop therapies for other major diseases? © 2023 The Author.
Published in EMBO reports
Published in EMBO Reports
Published in EMBO reports
CCCTC-binding factor (CTCF) is an eleven zinc finger (ZF), multivalent transcriptional regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations of its ZFs. The great majority of the ~50,000 genomic locations bound by the CTCF protein in a given cell type is intergenic, and a fraction of these sites overlaps with ...
Published in EMBO reports
The proliferation and differentiation of antigen-specific B cells, including the generation of germinal centers (GC), are prerequisites for long-lasting, antibody-mediated immune protection. Affinity for antigen determines B cell recruitment, proliferation, differentiation, and competitiveness in the response, largely through determining access to ...
Published in EMBO Reports
optoYAP is a new optogenetic tool to manipulate the cellular localisation of YAP and YAP‐dependent gene expression. The efficacy and functionality of this tool is demonstrated in cell culture – including on different substrate stiffnesses – and zebrafish.
Published in EMBO Reports
A study in this issue characterizes two vesicle subpopulations produced by Plasmodium‐infected blood cells having distinct size, content, and membrane characteristics, suggesting that they target different cell types and subcellular locations.
Published in EMBO Reports
Reliable predictions of long‐term ecological and evolutionary processes require more information than the periodicity of the astronomical forces that drive them.
