Correction: The association of DAT gene methylation with striatal DAT availability in healthy subjects
Published in EJNMMI Research
Correction: The association of DAT gene methylation with striatal DAT availability in healthy subjects
Influence of corticosteroid treatment on CXCR4 expression in DLBCL
Published in EJNMMI Research
Background CXCR4-targeted radioligand therapy (RLT) with [177Lu]Lu/[90Y]Y-PentixaTher has recently evolved as a promising therapeutic option for patients with advanced hematological cancers. Given their advanced disease stage, most patients scheduled for PentixaTher RLT require concomitant or bridging chemotherapy to prevent intermittent tumor prog...
Molecular imaging of fibroblast activation in multiple non-ischemic cardiomyopathies
Published in EJNMMI Research
Background This pilot study is aimed to perform a pilot visualization study to investigate in vivo fibroblast activation in non-ischemic cardiomyopathies by 68Ga-FAPI-04 PET/CT. Methods Twenty-nine consecutive patients with symptomatic non-ischemic cardiomyopathies who underwent 68Ga-FAPI-04 PET/CT were prospectively recruited. Clinical characteris...
Peptide-based PET imaging agent of tumor TIGIT expression
Published in EJNMMI Research
Background Accumulating studies have demonstrated that elevated TIGIT expression in tumor microenvironment correlates with better therapeutic response to TIGIT-based immunotherapy in pre-clinical studies. Therefore, a non-invasive method to detect tumor TIGIT expression is crucial to predict the therapeutic effect. Methods In this study, a peptide-...
Semi-quantitative analysis of visually normal 123I-FP-CIT across three large databases revealed no difference between co...
Published in EJNMMI Research
Background To show the equivalence between the specific binding ratios (SBR) of visually normal 123I-FP-CIT SPECT scans from patients to those from healthy volunteers (Hv) or patients without dopaminergic degeneration to allow their use as a reference database. Methods The SBR values of visually normal SPECT scans from 3 groups were studied: (1) su...
In vitro evaluation of ( S )-2-amino-3-[3-(2- 18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid ( 18F-FIMP) as a po...
Published in EJNMMI Research
Background ( S )-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a promising PET probe for imaging the tumor-specific L-type amino acid transporter (LAT) 1. Our previous study revealed that 18F-FIMP had a higher affinity for LAT1 than for LAT2 abundantly expressed even in normal cells. 18F-FIMP showed high accum...
Glypican-3 targeted positron emission tomography detects sub-centimeter tumors in a xenograft model of hepatocellular ca...
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Published in EJNMMI Research
Background Early intrahepatic recurrence is common after surgical resection of hepatocellular carcinoma (HCC) and leads to increased morbidity and mortality. Insensitive and nonspecific diagnostic imaging contributes to EIR and results in missed treatment opportunities. In addition, novel modalities are needed to identify targets amenable for targe...
Detecting localised prostate cancer using radiomic features in PSMA PET and multiparametric MRI for biologically targete...
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Published in EJNMMI Research
Background Prostate-Specific Membrane Antigen (PSMA) PET/CT and multiparametric MRI (mpMRI) are well-established modalities for identifying intra-prostatic lesions (IPLs) in localised prostate cancer. This study aimed to investigate the use of PSMA PET/CT and mpMRI for biologically targeted radiation therapy treatment planning by: (1) analysing the...
CMR validation of left ventricular volumes and ejection fraction measured by the IQ-SPECT system in patients with small ...
Published in EJNMMI research
The IQ-SPECT system is equipped with multifocal collimators and uses ordered-subset conjugate gradient minimization (OSCGM) as its reconstruction algorithm, achieving a shorter acquisition time than conventional SPECT. Left ventricular ejection fraction (LVEF) is overestimated by conventional SPECT in patients with small heart size. In this study, ...
A tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development of ACE2-selecti...
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Published in EJNMMI Research
Purpose The angiotensin converting enzyme-2 (ACE2)—entry receptor of SARS-CoV-2—and its homologue, the angiotensin-converting enzyme (ACE), play a pivotal role in maintaining cardiovascular homeostasis. Potential changes in ACE2 expression levels and dynamics after SARS-CoV-2 infection have been barely investigated. The aim of this study was to dev...
