Foley, Mary K. Searle, Samuel D. Toloue, Ali Booth, Ryan Falkenham, Alec Falzarano, Darryl Rubino, Salvatore Francis, Magen E. McNeil, Mara Richardson, Christopher
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Published in
EClinicalMedicine
Background The SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) has led to more than 165 million COVID-19 cases and >3.4 million deaths worldwide. Epidemiological analysis has revealed that the risk of developing severe COVID-19 increases with age. Despite a disproportionate number of older individuals and long-term care facilities bein...
Parienti, Jean-Jacques Prazuck, Thierry Peyro-Saint-Paul, Laure Fournier, Anna Valentin, Cécile Brucato, Sylvie Verdon, Renaud Sève, Aymeric Colin, Mathilda Lesne, Fabien
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Published in
EClinicalMedicine
Background Tenofovir and emtricitabine interfere with the SARS CoV-2 ribonucleic acid (RNA)-dependent RNA polymerase (RdRp). Several cohorts reported that people treated by tenofovir disoproxil fumarate and emtricitabine are less likely to develop SARS CoV-2 infection and related severe COVID-19. Methods We conducted a pilot randomized, open-label,...
Blum, Vinicius Fontanesi Cimerman, Sérgio Hunter, James R Tierno, Paulo Lacerda, Acioly Soeiro, Alexandre Cardoso, Florentino Bellei, Nancy Cristina Maricato, Juliana Mantovani, Nathalia
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Published in
EClinicalMedicine
Background The absence of specific antivirals to treat COVID-19 leads to the repositioning of candidates’ drugs. Nitazoxanide (NTZ) has a broad antiviral effect. Methods This was a randomized, double-blind pilot clinical trial comparing NTZ 600 mg BID versus Placebo for seven days among 50 individuals (25 each arm) with SARS-COV-2 RT-PCR+ (PCR) tha...
Hsieh, Szu-Min Liu, Wang-Da Huang, Yu-Shan Lin, Yi-Jiun Hsieh, Erh-Fang Lian, Wei-Cheng Chen, Charles Janssen, Robert Shih, Shin-Ru Huang, Chung-Guei
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Published in
EClinicalMedicine
Background This was a phase 1, dose-escalation open-label trial to evaluate the safety and immunogenicity of MVC—COV1901, a SARS-CoV-2 S-2P protein vaccine adjuvanted with aluminum hydroxide and CpG 1018. Methods Between September 28 and November 13 2020, 77 participants were screened. Of these, 45 healthy adults from 20 to 49 years of age were to ...
Vindrola-Padros, Cecilia Singh, Kelly E Sidhu, Manbinder S Georghiou, Theo Sherlaw-Johnson, Chris Tomini, Sonila M Inada-Kim, Matthew Kirkham, Karen Streetly, Allison Cohen, Nathan
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Published in
EClinicalMedicine
Background the aim of this review was to analyze the implementation and impact of remote home monitoring models (virtual wards) for confirmed or suspected COVID-19 patients, identifying their main components, processes of implementation, target patient populations, impact on outcomes, costs and lessons learnt. Methods we carried out a rapid systema...
Zhang, Min Ni, You Zhou, Qinming He, Lu Meng, Huanyu Gao, Yining Huang, Xinyun Meng, Hongping Li, Peihan Chen, Meidi
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Published in
EClinicalMedicine
Background Amyloid positron emission tomography (PET) can measure in-vivo demyelination in patients with multiple sclerosis (MS). However, the value of 18F-labeled amyloid PET tracer, 18F-florbetapir in the longitudinal study for monitoring myelin loss and recovery has not been confirmed. Methods From March 2019 to September 2020, twenty-three pati...
Townsend, Rosemary Chmielewska, Barbara Barratt, Imogen Kalafat, Erkan van der Meulen, Jan Gurol-Urganci, Ipek O'Brien, Pat Morris, Edward Draycott, Tim Thangaratinam, Shakila
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Published in
EClinicalMedicine
Background The COVID-19 pandemic has had a profound impact on healthcare systems globally, with a worrying increase in adverse maternal and foetal outcomes. We aimed to assess the changes in maternity healthcare provision and healthcare-seeking by pregnant women during the COVID-19 pandemic. Methods We performed a systematic review and meta-analysi...
Duarte, Mariano Pelorosso, Facundo Nicolosi, Liliana N. Victoria Salgado, M. Vetulli, Héctor Aquieri, Analía Azzato, Francisco Castro, Marcela Coyle, Javier Davolos, Ignacio
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Published in
EClinicalMedicine
Background Angiotensin receptor blockers (ARBs), such as telmisartan, have been postulated to treat Covid-19-induced lung inflammation. Methods This is a parallel-group, randomized, two-arm, open-label, adaptive, multicenter superiority trial with 1:1 allocation ratio. Participants included patients from 18 years of age hospitalized with Covid-19 w...
K, Babla O, Akindolie A, Gupta
Published in
EClinicalMedicine
Bhavnani, Supriya Mukherjee, Debarati Bhopal, Sunil Sharma, Kamal Kant Dasgupta, Jayashree Divan, Gauri Soremekun, Seyi Roy, Reetabrata Kirkwood, Betty Patel, Vikram
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Published in
EClinicalMedicine
Background There is an urgent need to fill the gap of scalable cognitive assessment tools for preschool children to enable identification of children at-risk of sub-optimal development and to support their timely referral into interventions. We present the associations between growth in early childhood, a well-established marker of cognitive develo...
