Tittanegro, Thais China, Louise Forrest, Ewan Kallis, Yiannis Ryder, Stephen D Wright, Gavin Freemantle, Nick O'Brien, Alastair
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EClinicalMedicine
Nonselective B-blockers (NSBBs) are believed to have pleiotropic effects beyond reducing portal pressure. However, studies also report potential harm in patients hospitalized with cirrhosis and ascites. We therefore investigated whether NSBB use at ATTIRE trial entry (Albumin to prevent infection in chronic liver failure, 2016-19) was associated wi...
Ji, Linong Gao, Leili Jiang, Hongwei Yang, Jing Yu, Lei Wen, Jie Cai, Chenghang Deng, Huan Feng, Liqi Song, Baili
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Published in
EClinicalMedicine
Mazdutide (also known as IBI362 or LY3305677), a novel once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist, achieved 12-week body weight loss up to 6.4% at doses up to 6 mg in Chinese adults with overweight or obesity. We further explored the safety and efficacy of mazdutide dosed up to 9 mg and 10 mg. In this randomised,...
Chin, Yip Han Ng, Cheng Han Chew, Nicholas Ws Kong, Gwyneth Lim, Wen Hui Tan, Darren Jun Hao Chan, Kai En Tang, Ansel Huang, Daniel Q Chan, Mark Y
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EClinicalMedicine
There is a growing number of trials examining the effectiveness of pharmacotherapies for obesity, however, little is known about placebo and nocebo effect in these trials. Hence, we sought to examine the effect of placebo in obesity trials, to better understand the potential factors affecting clinical endpoints in them. Medline, Embase, and Cochran...
Shi, Hanxu Li, Siwen Lv, Jin Wang, Harry H X Hou, Qingxiang Jin, Yinzi
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EClinicalMedicine
The risks of a few maternal and/or neonatal morbidities are higher with the trial of labour after caesarean (TOLAC) owing to unplanned caesarean delivery. Thus, it is imperative to consider the trade-off between the risk of side effects and the potential benefits before TOLAC utilisation and whether TOLAC should be provided to women with specific c...
Chen, Yang-Chieh Brian Liang, Chih-Sung Wang, Liang-Jen Hung, Kuo-Chuan Carvalho, Andre F Solmi, Marco Vieta, Eduard Tseng, Ping-Tao Lin, Pao-Yen Tu, Yu-Kang
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EClinicalMedicine
There is a lack of consensus on the optimal serum valproic acid (VPA) concentration for maintenance therapy in bipolar disorder (BD). We aimed to investigate the association between serum VPA levels and risk of mood episode recurrence. We enrolled patients with BD from multiple medical institutions in Taiwan between January 1, 2001 and December 31,...
Fan, K M Rimal, J Zhang, P Johnson, N W
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EClinicalMedicine
GLOBOCAN 2020 and Global Burden of Disease (GBD) 2019 are the two most established global online cancer databases. It is important to examine the differences between the two platforms, to attempt to explain these differences, and to appraise the quality of the data. There are stark differences for lip and oral cancers (LOC) and we attempt to explai...
Zhang, Yuemiao Ma, Xupu Yan, Guanghong Wu, Ying Chen, Yanli Zhou, Zumi Wan, Na Su, Wei Liu, Feng-Wei Dai, Mu-Xian
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Published in
EClinicalMedicine
More effective vaccine candidates against variants of concern as a booster dose are needed in people primed with two-dose inactivated COVID-19 vaccines. This randomised, double-blinded, investigator-initiated phase 2 trial aims to evaluate immunogenicity, durability, and safety of an mRNA vaccine candidate (RQ3013) and three other platform vaccines...
Middleton, Bianca F Fathima, Parveen Snelling, Thomas L Morris, Peter
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EClinicalMedicine
Oral rotavirus vaccines have lower effectiveness in high child mortality settings. We evaluated the impact of additional dose(s) schedules of rotavirus vaccine on vaccine immunogenicity and reduction in episodes of gastroenteritis. We searched Medline (via PubMed), Cochrane databases and ClinicalTrials.gov for randomised controlled trials from 1973...
Arias, Daniel Saxena, Shekhar Verguet, Stéphane
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EClinicalMedicine
Epidemiological and economic estimates suggest that the global burden of mental disorders is considerable, both in its impacts on human health and losses to societal welfare. The availability of additional data and the emergence of new approaches present an opportunity to examine these estimates, which form a critical part in making the investment ...
McMahon, James H Lau, Jillian S Y Coldham, Anna Roney, Janine Hagenauer, Michelle Price, Sally Bryant, Mellissa Garlick, Jill Paterson, Anne Lee, Sue J
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Published in
EClinicalMedicine
Well tolerated antivirals administered early in the course of COVID-19 infection when the viremia is highest could prevent progression to severe disease. Favipiravir inhibits SARS-CoV-2 viral replication in vitro with evidence of clinical benefit in open label trials. Placebo controlled studies of people with early symptomatic COVID-19 with regular...
