"Resistance" to diagnostics: A serious biological challenge for malaria control and elimination.
Published in EBioMedicine
HIV drug resistance testing - The quest for Point-of-Care.
Published in EBioMedicine
Phase I dose-escalation study to determine the safety, tolerability, preliminary efficacy and pharmacokinetics of an int...
Published in EBioMedicine
Tigilanol tiglate, a short-chain diterpene ester, is being developed as intratumoral treatment of a broad range of cancers. We conducted the first-in-human study of intratumoral tigilanol tiglate in patients with solid tumors. Tigilanol tiglate was administered in a multicentre, non randomized, single-arm study, with escalating doses beginning with...
Combined identification of three miRNAs in serum as effective diagnostic biomarkers for HNSCC.
Published in EBioMedicine
Head and neck squamous cell carcinoma (HNSCC) is a disastrous disease with substantial morbidity and mortality. This study aims to explore the effective diagnostic and prognostic biomarkers for HNSCC. MiRNA expression data and corresponding clinical information of HNSCC from The Cancer Genome Atlas (TCGA) database were analyzed comprehensively to i...
Abnormal regulation of glucagon secretion by human islet alpha cells in the absence of beta cells.
Published in EBioMedicine
The understanding of the regulation of glucagon secretion by pancreatic islet α-cells remains elusive. We aimed to develop an in vitro model for investigating the function of human α-cells under direct influence of glucose and other potential regulators. Highly purified human α-cells from islets of deceased donors were re-aggregated in the presence...
CXCR3: Here to stay to enhance cancer immunotherapy?
Published in EBioMedicine
A tale on rabbit ears and pan-handles, the rings that rule all.
Published in EBioMedicine
Oncolytic Newcastle disease virus expressing a checkpoint inhibitor as a radioenhancing agent for murine melanoma.
Published in EBioMedicine
Monoclonal antibodies (mAbs) targeting negative regulators, or checkpoint molecules (e.g. PD1/PD-L1 & CTLA4), of anti-tumoural T cells have demonstrated clinical efficacy in treating several neoplastic diseases. While many patients enjoy remarkable responses to checkpoint inhibitors, a majority show adverse effects. Understanding how checkpoint inh...
Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers wit...
...Published in EBioMedicine
Type 2 diabetes patients and individuals at risk of developing diabetes are characterized by metabolic inflexibility and disturbed glucose homeostasis. Low carnitine availability may contribute to metabolic inflexibility and impaired glucose tolerance. Here, we investigated whether carnitine supplementation improves metabolic flexibility and insuli...
A single faecal microbiota transplantation modulates the microbiome and improves clinical manifestations in a rat model ...
Published in EBioMedicine
Faecal microbiota transplantation (FMT) is a novel potential therapy for inflammatory bowel diseases, but it is poorly characterised. We evaluated the performance of the mouse and rat as a pre-clinical model for human microbiota engraftment. We then characterised the effect of a single human stool transfer (HST) on a humanised model of DSS-induced ...
