Three-dimensional reconstruction system in pulmonary broncho vascular surgery using AI.
Published in EBioMedicine
Three-dimensional reconstruction system in pulmonary broncho vascular surgery using AI.
Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune dise...
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Published in EBioMedicine
To explore the associations of genetically proxied TYK2 inhibition with a wide range of disease outcomes and biomarkers to identify therapeutic repurposing opportunities, adverse effects, and biomarkers of efficacy. The loss-of-function missense variant rs34536443 in TYK2 gene was used as a genetic instrument to proxy the effect of TYK2 inhibition....
Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of ...
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Published in EBioMedicine
Sleep phenotypes have been reported to be associated with cognitive ageing outcomes. However, there is limited research using genetic variants as proxies for sleep traits to study their associations. We estimated associations between Polygenic Risk Scores (PRSs) for sleep duration, insomnia, daytime sleepiness, and obstructive sleep apnoea (OSA) an...
Inherited rare variants in homologous recombination and neurodevelopmental genes are associated with increased risk of n...
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Published in EBioMedicine
Neuroblastoma (NB) is the most common solid extracranial paediatric tumour. Genome-wide association studies have driven the discovery of common risk variants, but no large study has investigated the contribution of rare variants to NB susceptibility. Here, we conducted a whole-exome sequencing (WES) of 664 NB cases and 822 controls and used indepen...
Equitable endotyping is essential to achieve a global standard of precise, effective, and locally-relevant sepsis care.
Published in EBioMedicine
Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis.
Published in EBioMedicine
Physiological shifts during pregnancy predispose women to a higher risk of developing sepsis resulting from a maladapted host-response to infection. Insightful studies have delineated subtle point-changes to the immune system during pregnancy. Here, we present an overlay of these point-changes, asking what changes and when, at a physiological, cell...
Current sepsis therapeutics.
Published in EBioMedicine
Management of the patient with sepsis comprises three key branches: control of the underlying infection, haemodynamic stabilization, and modulation of the host response. Each aspect should be considered in all patients and, when relevant, managed at the same time. Infection control is applicable to all patients with sepsis and will include antibiot...
Sepsis biomarkers and diagnostic tools with a focus on machine learning.
Published in EBioMedicine
Over the last years, there have been advances in the use of data-driven techniques to improve the definition, early recognition, subtypes characterisation, prognostication and treatment personalisation of sepsis. Some of those involve the discovery or evaluation of biomarkers or digital signatures of sepsis or sepsis sub-phenotypes. It is hoped tha...
Host-targeted approaches to sepsis due to community-acquired pneumonia.
Published in EBioMedicine
Immunopathophysiology of human sepsis.
Published in EBioMedicine
Sepsis is an ill-defined syndrome yet is a leading cause of morbidity and mortality worldwide. The most recent consensus defines sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection. However, this definition belies the complexity and breadth of immune mechanisms involved in sepsis, which are characterized...
