Quiros-Fernandez, Isaac Poorebrahim, Mansour Fakhr, Elham Cid-Arregui, Angel
Published in
EBioMedicine
Background Recent studies have provided evidence of T cell reactivity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in significant numbers of non-infected individuals, which has been attributed to cross-reactive CD4 memory T cells from previous exposure to seasonal coronaviruses. Less evidence of cross-reactive memory CD8 T cells ...
Lan, Jiaming Yao, Yanfeng Deng, Yao Chen, Hong Lu, Guangwen Wang, Wen Bao, Linlin Deng, Wei Wei, Qiang Gao, George F.
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Published in
EBioMedicine
Hoppstädter, Jessica Dembek, Anna Höring, Marcus Schymik, Hanna S. Dahlem, Charlotte Sultan, Afnan Wirth, Natalie Al-Fityan, Salma Diesel, Britta Gasparoni, Gilles
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Published in
EBioMedicine
Background Based on reports on elevated cholesterol levels in cancer cells, strategies to lower cholesterol synthesis have been suggested as an antitumour strategy. However, cholesterol depletion has also been shown to induce tumour-promoting actions in tumour-associated macrophages (TAMs). Methods We performed lipidomic and transcriptomic analyses...
Morton, Ben Burr, Sarah Chikaonda, Tarsizio Nsomba, Edna Manda-Taylor, Lucinda Henrion, Marc Y.R. Banda, Ndaziona Peter Rylance, Jamie Ferreira, Daniela M. Jambo, Kondwani
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Published in
EBioMedicine
Background Persistent carriage of pneumococcal vaccine serotypes has occurred after introduction of PCV13 vaccination in Africa but the mechanisms are unclear. We tested the feasibility of using a human pneumococcal challenge model in Malawi to understand immune correlates of protection against carriage and to trial alternative vaccine candidates. ...
Uphaus, Timo Steffen, Falk Muthuraman, Muthuraman Ripfel, Nina Fleischer, Vinzenz Groppa, Sergiu Ruck, Tobias Meuth, Sven G. Pul, Refik Kleinschnitz, Christoph
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Published in
EBioMedicine
Background Easily accessible biomarkers enabling the identification of those patients with multiple sclerosis (MS) who will accumulate irreversible disability in the long term are essential to guide early therapeutic decisions. We here examine the utility of serum neurofilament light chain (sNfL) for forecasting relapse-free disability progression ...
Koko, Mahmoud Krause, Roland Sander, Thomas Bobbili, Dheeraj Reddy Nothnagel, Michael May, Patrick Lerche, Holger
Published in
EBioMedicine
Background Analyses of few gene-sets in epilepsy showed a potential to unravel key disease associations. We set out to investigate the burden of ultra-rare variants (URVs) in a comprehensive range of biologically informed gene-sets presumed to be implicated in epileptogenesis. Methods The burden of 12 URV types in 92 gene-sets was compared between ...
Balduzzi, Adriana
Published in
EBioMedicine
Abdelnabi, Rana Foo, Caroline S. Kaptein, Suzanne J.F. Zhang, Xin Do, Thuc Nguyen Dan Langendries, Lana Vangeel, Laura Breuer, Judith Pang, Juanita Williams, Rachel
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Published in
EBioMedicine
Background Favipiravir and Molnupiravir, orally available antivirals, have been reported to exert antiviral activity against SARS-CoV-2. First efficacy data have been recently reported in COVID-19 patients. Methods We here report on the combined antiviral effect of both drugs in a SARS-CoV-2 Syrian hamster infection model. The infected hamsters wer...
Appelman, Brent van der Straten, Karlijn Lavell, A.H. Ayesha Schinkel, Michiel Slim, Marleen A. Poniman, Meliawati Burger, Judith A. Oomen, Melissa Tejjani, Khadija Vlaar, Alexander P.J.
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Published in
EBioMedicine
Background To optimise the use of available SARS-CoV-2 vaccines, some advocate delaying second vaccination for individuals infected within six months. We studied whether post-vaccination immune response is equally potent in individuals infected over six months prior to vaccination. Methods We tested serum IgG binding to SARS-CoV-2 spike protein and...
Grönwall, Caroline Malmström, Vivianne
Published in
EBioMedicine
