Searching for a traumatic brain injury biomarker to aid clinical decision making in the emergency department.
Published in EBioMedicine
A novel rabies vaccine based on infectious propagating particles derived from hybrid VEEV-Rabies replicon.
Published in EBioMedicine
Live attenuated vaccines (LAVs) can mimic natural infection and have advantages to stimulate a robust and sustained immune response as well as to confer long-term protection. However, safety concerns is one of the major obstacles for LAVs development. In an effort to achieve the optimal balance between immunogenicity and safety, researchers current...
COVID-19 as a STING disorder with delayed over-secretion of interferon-beta.
Published in EBioMedicine
Infectivity of human coronavirus in the brain.
Published in EBioMedicine
A new strain of human coronaviruses (hCoVs), Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been identified to be responsible for the current outbreak of the coronavirus disease 2019 (COVID-19). Though major symptoms are primarily generated from the respiratory system, neurological symptoms are being reported in some of the confi...
A glimpse into the eye of the COVID-19 cytokine storm
Published in EBioMedicine
Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro-Ameri...
...Published in EBioMedicine
Human tuberculosis (TB) is caused by a plethora of Mycobacterium tuberculosis complex (MTBC) strains belonging to seven phylogenetic branches. Lineages 2, 3 and 4 are considered "modern" branches of the MTBC responsible for the majority of worldwide TB. Since the current BCG vaccine confers variable protection against pulmonary TB, new candidates a...
Prognostic and predictive value of a five-molecule panel in resected pancreatic ductal adenocarcinoma: A multicentre stu...
...Published in EBioMedicine
Pancreatic ductal adenocarcinoma (PDAC) has a devastating prognosis. The performance of clinicopathologic parameters and molecules as prognostic factors remains limited and inconsistent. The present study aimed to construct a multi-molecule biomarker panel to more accurately predict post-resectional prognosis of PDAC patients. Firstly, a novel comp...
Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas....
...Published in EBioMedicine
Recurrence after radiation therapy is nearly universal for glioblastomas, the most common form of adult brain cancer. The study aims to define clinically pertinent mechanisms underlying this recurrence. microRNA (miRNA) profiling was performed using matched pre- and post-radiation treatment glioblastoma specimens from the same patients. All specime...
Host transcriptomic signature as alternative test-of-cure in visceral leishmaniasis patients co-infected with HIV.
...Published in EBioMedicine
Visceral leishmaniasis (VL) treatment in HIV patients very often fails and is followed by high relapse and case-fatality rates. Hence, treatment efficacy assessment is imperative but based on invasive organ aspiration for parasite detection. In the search of a less-invasive alternative and because the host immune response is pivotal for treatment o...
Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment.
...Published in EBioMedicine
Studying within-host genetic diversity of Mycobacterium tuberculosis (Mtb) in patients during treatment may identify adaptations to antibiotic and immune pressure. Understanding the significance of genetic heteroresistance, and more specifically heterozygous resistance-associated variants (RAVs), is clinically important given increasing use of rapi...
