Predicting the efficacy of new coronavirus vaccines - Are neutralising antibodies enough?
Published in EBioMedicine
Predicting the efficacy of new coronavirus vaccines - Are neutralising antibodies enough?
HIV cure trial mergers: Spotlighting the epigenetics of latency reversal.
Published in EBioMedicine
Multi-omic approach to identify risk markers specific to COVID-19.
Published in EBioMedicine
Hepatitis B infection is causally associated with extrahepatic cancers: A Mendelian randomization study.
Published in EBioMedicine
Evidence from observational studies suggests that chronic hepatitis B virus (HBV) infection is associated with extrahepatic cancers. However, the causal association between chronic HBV infection and extrahepatic cancers remains to be determined. We performed two-sample Mendelian randomization (MR) to investigate whether chronic HBV infection is cau...
Multi-omics approaches for biomarker discovery in early ovarian cancer diagnosis.
Published in EBioMedicine
Ovarian cancer (OC) is a heterogeneous disease with the highest mortality rate and the poorest prognosis among gynecological malignancies. Because of the absence of specific early symptoms, most OC patients are often diagnosed at late stages. Thus, improved biomarkers of OC for use in research and clinical practice are urgently needed. The last dec...
Human endogenous retrovirus-H long terminal repeat-associating 2: The next immune checkpoint for antitumour therapy.
Published in EBioMedicine
Human endogenous retrovirus-H long terminal repeat-associating 2 (HHLA2) is a newly emerging immune checkpoint that belongs to B7 family. HHLA2 has a co-stimulatory receptor transmembrane and immunoglobulin domain containing 2 (TMIGD2) and a newly discovered co-inhibitory receptor killer cell Ig-like receptor, three Ig domains, and long cytoplasmic...
Aerobic glycolysis imaging of epileptic foci during the inter-ictal period.
...Published in EBioMedicine
In drug-resistant epilepsy, surgical resection of the epileptic focus can end seizures. However, success is dependent on the ability to identify foci locations and, unfortunately, current methods like electrophysiology and positron emission tomography can give contradictory results. During seizures, glucose is metabolized at epileptic foci through ...
APOLLO: An accurate and independently validated prediction model of lower-grade gliomas overall survival and a comparati...
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Published in EBioMedicine
Virtually few accurate and robust prediction models of lower-grade gliomas (LGG) survival exist that may aid physicians in making clinical decisions. We aimed to develop a prognostic prediction model of LGG by incorporating demographic, clinical and transcriptional biomarkers with either main effects or gene-gene interactions. Based on gene express...
MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in...
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Published in EBioMedicine
Rheumatoid arthritis (RA) is a progressive degenerative disorder that leads to joint destruction. Available treatments only target the inflammatory component with minimal impact on joint repair. We recently uncovered a previously unappreciated family of pro-resolving mediators, the maresin conjugate in tissue regeneration (MCTR), that display both ...
Novel role of UHRF1 in the epigenetic repression of the latent HIV-1.
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Published in EBioMedicine
The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1. Accordingly, all classes of latency-reversing agents (LRAs) have been reported to present variable ex vivo potencies. Here, we investigated the molecular mechanisms und...
