Panpradist, Nuttada Wang, Qin Ruth, Parker S. Kotnik, Jack H. Oreskovic, Amy K. Miller, Abraham Stewart, Samuel W.A. Vrana, Justin Han, Peter D. Beck, Ingrid A.
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Published in
EBioMedicine
Background Detection of SARS-CoV-2 infections is important for treatment, isolation of infected and exposed individuals, and contact tracing. RT-qPCR is the “gold-standard” method to sensitively detect SARS-CoV-2 RNA, but most laboratory-developed RT-qPCR assays involve complex steps. Here, we aimed to simplify RT-qPCR assays by streamlining reacti...
Plebani, Mario
Published in
EBioMedicine
Richardson, Tom G Fang, Si Mitchell, Ruth E Holmes, Michael V Davey Smith, George
Published in
EBioMedicine
Background Developing insight into the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of critical importance to overcome the global pandemic caused by coronavirus disease 2019 (covid-19). In this study, we have applied Mendelian randomization (MR) to systematically evaluate the effect of 10 cardiometabolic risk fact...
Low, Joo-Leng Lau, Dawn Pingxi Zhang, Xiaoqian Kwang, Xue-Lin Rohatgi, Neha Chan, Jane Vin Chong, Fui-Teen Wong, Stephen Qi Rong Leong, Hui-Sun Thangavelu, Matan Thangavelu
...
Published in
EBioMedicine
Background Overexpression of epidermal growth factor receptor (EGFR), and downstream pathway activation appears to be a common oncogenic driver in the majority of head and neck squamous cell cancers (HNSCCs); yet targeting EGFR for the treatment of HNSCC has met with limited success. Apart from the anti-EGFR antibody cetuximab, no small molecule EG...
Vibholm, Line K Nielsen, Stine SF Pahus, Marie H Frattari, Giacomo S Olesen, Rikke Andersen, Rebecca Monrad, Ida Andersen, Anna HF Thomsen, Michelle M Konrad, Christina V
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Published in
EBioMedicine
Background Upon SARS-CoV-2 infection, most individuals develop neutralizing antibodies and T-cell immunity. However, some individuals reportedly remain SARS-CoV-2 PCR positive by pharyngeal swabs weeks after recovery. Whether viral RNA in these persistent carriers is contagious and stimulates SARS-CoV-2-specific immune responses is unknown. Methods...
Yan, Dong Dong, Wei He, Qingqing Yang, Meihua Huang, Lifang Kong, Jianqiu Qin, Haide Lin, Tianxin Huang, Jian
Published in
EBioMedicine
Shen, Pei-Xin Li, Xing Deng, Si-Ying Zhao, Li Zhang, Yan-Yan Deng, Xin Han, Bing Yu, Jie Li, Yin Wang, Zhe-Zhi
...
Published in
EBioMedicine
Background Urolithin A (URA) is an intestinal microbiota metabolic product from ellagitannin-containing foods with multiple biological activities. However, its role in autoimmune diseases is largely unknown. Here, for first time, we demonstrate the therapeutic effect of URA in an experimental autoimmune encephalomyelitis (EAE) animal model. Methods...
Withey, Sarah L Willis, Gareth R
Published in
EBioMedicine
Alakpa, Enateri V.
Published in
EBioMedicine
Boccardo, Enrique
Published in
EBioMedicine