McAlister, Emma Kearney, Mary-Carmel Martin, E Linzi Donnelly, Ryan F
Published in
Drug delivery and translational research
As microneedle (MN) patches progress towards commercialisation, there is a need to address issues surrounding their translation from the laboratory to the end-user. One important aspect of MN patches moving forward is appropriate primary packaging. This research focuses on MN patches containing amoxicillin (AMX) sodium for the potential treatment o...
Rahmati, Majid Ehterami, Arian Saberani, Reza Abbaszadeh-Goudarzi, Ghasem Rezaei Kolarijani, Nariman Khastar, Hossein Garmabi, Behzad Salehi, Majid
Published in
Drug delivery and translational research
Peripheral nerve injuries are the common results of trauma that lead to pain and handicap in patients. Berberine due to its properties like antibiotic, immunostimulant, antitumor, antimotility, and positive effect on neurological disorders can be used to enhance peripheral nerve injuries. In this study, alginate/chitosan hydrogel containing differe...
Gusai, Tejal Dhavalkumar, Mori Soniwala, Moinuddin Dudhat, Kiran Vasoya, Jaydip Chavda, Jayant
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Drug delivery and translational research
The cutaneous penetration of acyclovir from the conventional topical formulations such as cream and ointments is poor due to low water solubility and low octanol buffer partition coefficient of the drug. The present investigation was aimed to prepare acyclovir-loaded microsponge-based emulgel to improve its topical delivery. The microsponges were p...
Abootorabi, Seyedalireza Tripathi, Abhimanyu Yu, Huidan Whitney Dávila, Lilian P
Published in
Drug delivery and translational research
New and efficient drug delivery to the posterior part of the eye is a growing health necessity worldwide. Current treatment of eye diseases, such as age-related macular degeneration (AMD), relies on repeated intravitreal injections of drug-containing solutions. Such a drug delivery has major drawbacks including short drug life, significant medical ...
Monahan, David S Almas, Talal Wyile, Robert Cheema, Faisal H Duffy, Garry P Hameed, Aamir
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Drug delivery and translational research
Cancer therapies have significantly improved cancer survival; however, these therapies can often result in undesired side effects to off target organs. Cardiac disease ranging from mild hypertension to heart failure can occur as a result of cancer therapies. This can warrant the discontinuation of cancer treatment in patients which can be detriment...
Salama, Alaa H AbouSamra, Mona M Awad, Ghada E A Mansy, Soheir S
Published in
Drug delivery and translational research
Our work tackles the combined advantages of both nanotechnology and the bioadhesive gel properties which were utilized to design an ocular drug delivery system that is capable to treat ocular inflammation. Nanoparticles encapsulating an antibiotic drug, ofloxacin, were fabricated using emulsion solvent evaporation technique adopting 23 full factori...
Wang, Xue Liu, Ying Xu, Wanjia Jia, Lirui Chi, Dongxu Yu, Jiang Wang, Jiamei He, Zhonggui Liu, Xiaohong Wang, Yongjun
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Published in
Drug delivery and translational research
Onivyde is the first irinotecan (IRI) nanoliposome that could improve pharmacokinetics and tumor biodistribution of irinotecan. Although FDA approves Onivyde for the treatment of pancreatic cancer patients who are not effective for GEM, the gastrointestinal toxicity caused by Onivyde is still a problem to be solved in clinical application. Berberin...
Darwesh, Alaa Y El-Dahhan, Marwa S Meshali, Mahasen M
Published in
Drug delivery and translational research
Meclizine hydrochloride (MCZ), a first-generation antihistamine of the piperazine class, is antiemetic and intended for the management of nausea and vomiting with few adverse effects. The introduction of orodispersible tablet (ODT) would solve the problems encountered in the administration of this drug to pediatric, geriatric, and psychiatric patie...
Deschamps, Frederic Tselikas, Lambros Tasaki, Masako Motoyama, Shinji Isoardo, Thomas Ducreux, Michel Paunovic, Dragica Moine, Laurence de Baere, Thierry
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Drug delivery and translational research
Hepatic arterial infusion (HAI) of oxaliplatin allows greater liver tumour drug exposure compared to systemic infusion. However, the therapeutic index of HAI oxaliplatin remains poor. Using Pickering emulsion technology, we developed a platform able to provide sustained releases of oxaliplatin. The goal of this study was to evaluate the pharmacokin...
Verco, Shelagh Maulhardt, Holly Baltezor, Michael Williams, Emily Iacobucci, Marc Wendt, Alison Verco, James Marin, Alyson Campbell, Sam Dorman, Paul
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Drug delivery and translational research
This report describes local administration of submicron particle paclitaxel (SPP) (NanoPac®: ~ 800-nm-sized particles with high relative surface area with each particle containing ~ 2 billion molecules of paclitaxel) in preclinical models and clinical trials evaluating treatment of carcinomas. Paclitaxel is active in the treatment of epithelial sol...
