Sguizzato, Maddalena Drechsler, Markus Baldisserotto, Anna Cortesi, Rita Esposito, Elisabetta
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Drug delivery and translational research
The present study describes a preliminary study on the use of monoolein aqueous dispersions (MADs) as delivery systems for antioxidant molecules, namely, ascorbyl palmitate (AP) and alpha-tocopherol (AT). MAD, produced by emulsifying monoolein (4.5% w/w) in water and poloxamer 407 (0.5% w/w) as emulsifier, was characterized in terms of size, morpho...
Moore, Thomas L Cook, Alexander B Bellotti, Elena Palomba, Roberto Manghnani, Purnima Spanò, Raffaele Brahmachari, Sayanti Di Francesco, Martina Palange, Anna Lisa Di Mascolo, Daniele
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Drug delivery and translational research
Schlich, Michele Musazzi, Umberto M Campani, Virginia Biondi, Marco Franzé, Silvia Lai, Francesco De Rosa, Giuseppe Sinico, Chiara Cilurzo, Francesco
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Drug delivery and translational research
The skin is the absorption site for drug substances intended to treat loco-regional diseases, although its barrier properties limit the permeation of drug molecules. The growing knowledge of the skin structure and its physiology have supported the design of innovative nanosystems (e.g. liposomal systems) to improve the absorption of poorly skin-per...
Andreana, Ilaria Bincoletto, Valeria Milla, Paola Dosio, Franco Stella, Barbara Arpicco, Silvia
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Drug delivery and translational research
Pentamidine (PTM), which is a diamine that is widely known for its antimicrobial activity, is a very interesting drug whose mechanism of action is not fully understood. In recent years, PTM has been proposed as a novel potential drug candidate for the treatment of mental illnesses, myotonic dystrophy, diabetes, and tumors. Nevertheless, the systemi...
Boffoli, Delia Bellato, Federica Avancini, Greta Gurnani, Pratik Yilmaz, Gokhan Romero, Manuel Robertson, Shaun Moret, Francesca Sandrelli, Federica Caliceti, Paolo
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Drug delivery and translational research
Carbohydrate-based materials are increasingly investigated for a range of applications spanning from healthcare to advanced functional materials. Synthetic glycopolymers are particularly attractive as they possess low toxicity and immunogenicity and can be used as multivalent ligands to target sugar-binding proteins (lectins). Here, we utilised RAF...
Pistone, Monica Racaniello, Giuseppe Francesco Arduino, Ilaria Laquintana, Valentino Lopalco, Antonio Cutrignelli, Annalisa Rizzi, Rosanna Franco, Massimo Lopedota, Angela Denora, Nunzio
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Drug delivery and translational research
Niclosamide (NCS) is a drug that has been used as an anthelmintic and anti-parasitic drug for about 40 years. Recently, some studies have highlighted its potential in treating various tumors, allowing a repositioning of this drug. Despite its potential, NCS is a Biopharmaceutical Classification System (BCS) Class II drug and is consequently charact...
Bellotti, Elena Contarini, Gabriella Geraci, Federica Torrisi, Sebastiano Alfio Piazza, Cateno Drago, Filippo Leggio, Gian Marco Papaleo, Francesco Decuzzi, Paolo
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Drug delivery and translational research
Schizophrenia is a disorder characterized by cognitive impairment and psychotic symptoms that fluctuate over time and can only be mitigated with the chronic administration of antipsychotics. Here, we propose biodegradable microPlates made of PLGA for the sustained release of risperidone over several weeks. Two microPlate configurations - short: 20 ...
Bertoni, Serena Hasa, Dritan Albertini, Beatrice Perissutti, Beatrice Grassi, Mario Voinovich, Dario Passerini, Nadia
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Drug delivery and translational research
In the last decades, Green Chemistry has been gaining widespread attention within the pharmaceutical field. It is thus very important to bring more sustainable approaches into the design and manufacture of effective oral drug delivery systems. This review focuses on spray congealing and mechanochemical activation, two technologies endorsing differe...
Kesserwan, Shereen Mao, Li Sharafieh, Roshanak Kreutzer, Donald L Klueh, Ulrike
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Drug delivery and translational research
Background Extending the lifespan of subcutaneous insulin administration sets and infusion pumps requires overcoming unreliable insulin delivery induced by dermal reactions. All commercially available insulin formulations contain insulin phenolic preservatives (IPP), which stabilize the insulin molecule but result in unwanted cell and tissue toxici...
Aich, Krishanu Singh, Tanya Dang, Shweta
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Drug delivery and translational research
Transdermal drug delivery is a viable and clinically proven route of administration. This route specifically requires overcoming the mechanical barrier provided by the Stratum Corneum of epidermis and vascular and nervous networks within the dermis. First-generation Transdermal patches and second-generation iontophoretic patches have been translate...