Das, Supratim Kaur, Sukhbir Rai, Vineet Kumar
Published in
Drug delivery and translational research
Gastro-retentive drug delivery systems are some of the best technologies delivered through oral route. These mainly came into picture for their effective local action in the GI region, specifically for the drugs with narrow absorption window. In the recent decades, several technologies have evolved showing different mechanisms for retaining the dru...
Ferreira, Natália N Granja, Sara Boni, Fernanda I Prezotti, Fabíola G Ferreira, Leonardo M B Cury, Beatriz S F Reis, Rui M Baltazar, Fátima Gremião, Maria Palmira D
Published in
Drug delivery and translational research
Nose-to-brain delivery is a promising approach to target drugs into the brain, avoiding the blood-brain barrier and other drawbacks related to systemic absorption, and enabling an effective and safer treatment of diseases such as glioblastoma (GBM). Innovative materials and technologies that improve residence time in the nasal cavity and modulate b...
Rodrigues, Susana Cunha, Ludmylla Rico, João Rosa da Costa, Ana M Almeida, António J Faleiro, M Leonor Buttini, Francesca Grenha, Ana
Published in
Drug delivery and translational research
Macrophages have unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms, including in the bacterial cell wall. Benefiting from a similar composition regarding the referred moieties, polysaccharides might be good candidates to compose the matrix of drug carriers aimed at macrophage...
Campos, Patrícia Mazureki Praça, Fabíola Garcia Mussi, Samuel Vidal Figueiredo, Sônia Aparecida Fantini, Márcia Carvalho de Abreu Fonseca, Maria José Vieira Torchilin, Vladimir P Bentley, Maria Vitória Lopes Badra
Published in
Drug delivery and translational research
In this study, the development and the performance of a new targeted liquid crystalline nanodispersion (LCN) by the attachment of cell-penetrating peptides (CPP) onto their surfaces to improve skin delivery of lipoic acid (LA) were evaluated. For that, the synthesis and characterization of this new platform as well as its spatiotemporal analysis fr...
Carvalho, Suzana Gonçalves Cipriano, Daniel Fernandes de Freitas, Jair Carlos Checon Junior, Miguel Ângelo Schettino Ocaris, Enrique Ronald Yapuchura Teles, Carolina Bioni Garcia de Jesus Gouveia, Aurileya Rodrigues, Ricardo Pereira Zanini, Marcos Santos Villanova, Janaína Cecília Oliveira
...
Published in
Drug delivery and translational research
The discovery of new drugs and dosage forms for the treatment of neglected tropical diseases, such as human and animal leishmaniasis, is gaining interest in the chemical, biological, pharmaceutical, and medical fields. Many pharmaceutical companies are exploring the use of old drugs to establishing new drug dosage forms and drug delivery systems, i...
Kaur, Atinderpal Nigam, Kuldeep Bhatnagar, Ishita Sukhpal, Himanshu Awasthy, Stuti Shankar, Shivanika Tyagi, Amit Dang, Shweta
Published in
Drug delivery and translational research
Alzheimer disease (AD) is very common among the older people. There are few medications available as oral and suspension dosage forms for the management of AD. Due to the rising cases of AD and the associated risks of the existing line of treatment, oil in water (o/w) nanoemulsion (NE) loaded with donepezil was prepared to explore intranasal route ...
de Assis, Karoll Moangella Andrade da Silva Leite, Joandra Maísa de Melo, Demis Ferreira Borges, Joyce Cordeiro Santana, Lucas Matheus Barreto Dos Reis, Malu Maria Lucas Moreira, Vandiara Martins da Rocha, Wilma Rainny Vieira Catão, Raïssa Mayer Ramalho Dos Santos, Sócrates Golzio
...
Published in
Drug delivery and translational research
The Melaleuca alternifolia essential oil (MEO) has been widely used due to its healing and antimicrobial action. Its incorporation into drug delivery systems is a reality, and numerous studies have already been developed for this purpose. In this regard, the aim of this work was to develop, characterize, and evaluate the in vivo pharmacological act...
Han, Yunho Park, Ji-Ho
Published in
Drug delivery and translational research
The blood-brain barrier (BBB) impedes the efficient delivery of systemically administered drugs to brain tumors, thus reducing the therapeutic efficacy. To overcome the limitations of intravascular delivery, convention-enhanced delivery (CED) was introduced to infuse drugs directly into the brain tumor using a catheter with a continuous positive pr...
Gazzi, R P Frank, L A Onzi, G Pohlmann, A R Guterres, Silvia S
Published in
Drug delivery and translational research
We developed a pectin-based hydrogel containing nanocapsules as a new strategy for melanoma treatment. Our first objective was to evaluate the nanoencapsulation effect of imiquimod on melanoma. Imiquimod-loaded polymeric nanocapsules (NCimiq) showed significant time-dependent decrease in cell viability after treatment at 3 μmol L-1 (79% viable cell...
Sweeney, Corinne Dudhipala, Narendar Thakkar, Ruchi Mehraj, Tabish Marathe, Sushrut Gul, Waseem ElSohly, Mahmoud A Murphy, Brian Majumdar, Soumyajit
Published in
Drug delivery and translational research
The use of Δ9-tetrahydrocannabinol (THC) and Δ9-tetrahydrocannabinol-valine-hemisuccinate (THC-VHS; NB1111) has recently been investigated in the management of intraocular pressure (IOP). The current study was undertaken to develop an optimized THC-VHS-loaded nanoemulsion formulation (NE; THC-VHS-NE) that could improve the drug load and duration of...
