Ma, Pengkai Wei, Guijie Chen, Jianhua Jing, Ziqi Wang, Xue Wang, Zhijun
Published in
Drug delivery
Mitochondria are closely correlated with the proliferation and metastasis of tumor for providing suitable micro-environment and energy supply. Herein, we construct a glucose transporter 1 (GLUT1) targeting and hypoxia activating polyprodrug-based micelle (Glu-PEG-Azo-IR808-S-S-PTX) for mitochondria-specific drug delivery and tumor chemo-thermal the...
Ma, Hongyin Jiang, Zhenmin Xu, Jiayun Liu, Junqiu Guo, Zhen-Ni
Published in
Drug delivery
Ischemic stroke is one of the major causes of severe disability and death worldwide. It is mainly caused by a sudden reduction in cerebral blood flow due to obstruction of the supplying vessel by thrombi and subsequent initiation of a complex cascade of pathophysiological changes, which ultimately lead to brain ischemia and even irreversible infarc...
Mao, Liwei Wu, Wei Wang, Miao Guo, Jianmin Li, Hui Zhang, Shihua Xu, Jiake Zou, Jun
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Drug delivery
The management of osteoarthritis (OA) is a clinical challenge due to the particular avascular, dense, and occluded tissue structure. Despite numerous clinical reports and animal studies, the pathogenesis and progression of OA are still not fully understood. On the basis of traditional drugs, a large number of new drugs have been continuously develo...
Pillai, Sindhu C Borah, Ankita Jacob, Eden Mariam Kumar, D Sakthi
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Drug delivery
Atherosclerosis is Caesar's sword, which poses a huge risk to the present generation. Understanding the atherosclerotic disease cycle would allow ensuring improved diagnosis, better care, and treatment. Unfortunately, a highly effective and safe way of treating atherosclerosis in the medical community remains a continuous challenge. Conventional tr...
Wen, Ming Ming Abdelwahab, Ibrahim A Aly, Rania G El-Zahaby, Sally A
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Drug delivery
Burn wound is usually associated by antibiotic-resistant Pseudomonas aeruginosa infection that worsens and complicates its management. An effective approach is to use natural antibiotics such as cinnamon oil as a powerful alternative. This study aims to investigate topical nanostructured lipid carrier (NLC) gel loaded cinnamon oil for Pseudomonas a...
Hosny, Khaled M Alhakamy, Nabil A Al Nahyah, Khalid S
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Drug delivery
Acne Vulgaris is one of the most common chronic inflammatory skin disorders that affect majority of teen-agers worldwide. Isotretinoin (ITT) is the drug of choice in the management of acne, but, it suffers from serious side-effects including hepatotoxicity, and some psychological disturbances following its oral intake. The objective of this study w...
Bertens, Christian J F Gijs, Marlies Dias, Aylvin A J van den Biggelaar, Frank J H M Ghosh, Arkasubhra Sethu, Swaminathan Nuijts, Rudy M M A
Published in
Drug delivery
Eye drops are considered standard practice for the delivery of ocular drugs. However, low patient compliance and low drug levels compromise its effectiveness. Our group developed a ketorolac-loaded ocular coil for sustained drug delivery up to 28 days. The aim of this study was to gain insight into the pharmacokinetics and efficacy of the ocular co...
Han, Xingwen He, Jingjing Wang, Zhan Bai, Zhongtian Qu, Peng Song, Zhengdong Wang, Wenji
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Drug delivery
The present work aims to examine the effect of gelatin on the stabilization of silver nanoparticles (AgNPs) and their use in healing the bone fracture. AgNPs-loaded Gel hydrogels (AgNPs/Gel) were fabricated under sunlight using gelatin (Gel) as stabilizing agent. The characterization of the synthesized hydrogels was performed with the help of techn...
Zhong, Tian Liu, Xingren Li, Hongmin Zhang, Jing
Published in
Drug delivery
To treat various cancers, including lung cancer, chemotherapy requires the systematic administering of chemotherapy. The chemotherapeutic effectiveness of anticancer drugs has been enhanced by polymer nanoparticles (NPs), according to new findings. As an outcome, we have developed biodegradable triblock poly(ethylene glycol)-poly(ε-caprolactone)-po...
Hosny, Khaled M Rizg, Waleed Y Alkhalidi, Hala M Abualsunun, Walaa A Bakhaidar, Rana B Almehmady, Alshaimaa M Alghaith, Adel F Alshehri, Sultan El Sisi, Amani M
Published in
Drug delivery
Natamycin (NT) is a synthetic broad-spectrum antifungal used in eye drops. However, it has low solubility and high molecular weight, limiting its permeation, and generally causes eye discomfort or irritation when administered. Therefore, the present study aimed to develop an ophthalmic in situ gel formulation with NT-loaded cubosomes to enhance ocu...
