Pillai, Sindhu C Borah, Ankita Jacob, Eden Mariam Kumar, D Sakthi
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Drug delivery
Atherosclerosis is Caesar's sword, which poses a huge risk to the present generation. Understanding the atherosclerotic disease cycle would allow ensuring improved diagnosis, better care, and treatment. Unfortunately, a highly effective and safe way of treating atherosclerosis in the medical community remains a continuous challenge. Conventional tr...
Mizuno, Kohei Ikeuchi-Takahashi, Yuri Hattori, Yoshiyuki Onishi, Hiraku
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Drug delivery
Although prednisolone (PD) is used as an anti-arthritis drug due to its rapid and strong anti-inflammatory potential, its frequent and large dosing often brings about adverse effects. Therefore, targeting therapy has attracted increasing attention to overcome such adverse effects. In the present study, nanogels (NGs) composed of macromolecule-PD co...
Li, Jiali Jiang, Xue Shang, Lihuan Li, Zhen Yang, Conglian Luo, Yan Hu, Daoyu Shen, Yaqi Zhang, Zhiping
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Drug delivery
This study aimed to synthesize and characterize L-epigallocatechin gallate (EGCG) complexed Mn2+ nanoparticle (L-EGCG-Mn), a proof-of-concept pH-sensitive manganese core nanoparticle (NP), and compare its magnetic resonance (MR) properties with those of Gd-DTPA, both in vitro and in vivo. Reverse microemulsion was used to obtain the L-EGCG-Mn NPs. ...
Kong, Degang Jiang, Tao Liu, Jian Jiang, Xinyi Liu, Bei Lou, Cheng Zhao, Baobing Carroll, Steven L Feng, Gong
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Drug delivery
Chemoembolization for hepatocellular carcinoma (HCC) is often suboptimal due to multiple involved signaling and lack of effective drugs. Arsenic trioxide (ATO) is a potent chemotherapeutic agent, which can target multiple signaling and have substantial efficacy on HCC. However, its usage is limited due to systemic toxicity. Using ATO-eluting beads/...
Liao, Rongqiang Liu, Ying Lv, Pin Wu, Di Xu, Meiling Zheng, Xiaoyuan
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Drug delivery
A novel β-cyclodextrin pendant polymer (ε-PL-CD), composed of poly(ε-lysine) (ε-PL) main chain and glycine-β-cyclodextrin (Gly-CD) side chains, was prepared by a simple two-step procedure. The ε-PL-CD was investigated as a drug carrier of hydrophobic drug scutellarin (SCU). The characterization and complexation mode of the SCU:ε-PL-CD were research...
Liu, Mengjiao Zhang, Tianyi Zang, Chen Cui, Xiaolan Li, Jianliang Wang, Guohua
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Drug delivery
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive pulmonary disease that can cause fibrotic remodeling of the surrounding lung, thus leading to respiratory failure. Although IPF is the most common form of idiopathic interstitial pneumonia, the precise mechanisms underlying this condition remain unknown. In this study, we used total s...
Qiu, Renna Sun, Denghua Bai, Yuzhuo Li, Jiannan Wang, Lizhe
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Drug delivery
Osteosarcoma is the most common primary malignant bone tumor in childhood and adolescence. Currently, surgery combined with chemotherapy is the main treatment for osteosarcoma. However, the long-term survival of patients with metastatic osteosarcoma is unsatisfactory. Therefore, new treatment methods to improve the prognosis of patients with osteos...
Gundogdu, Evren Atlihan Demir, Emine Selin Ekinci, Meliha Ozgenc, Emre Ilem Ozdemir, Derya Senyigit, Zeynep Asikoglu, Makbule
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Drug delivery
The aim of current study is to develop new nanostructured lipid carrier systems (NLCSs) containing imatinib mesylate (IMT) and evaluate their targeting efficiency on NIH-3T3 as fibroblast cells and CRL-1739 as gastric adenocarcinoma cells with radiolabeled formulations. Three formulations (F1-IMT, F2-IMT and F3-IMT) were prepared and radiolabeled w...
Molotkov, Andrei Doubrovin, Mikhail Bhatt, Nikunj Hsu, Fang-Chi Beserra, Amanda Chopra, Rajiv Mintz, Akiva
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Drug delivery
Multimodality 3D Optical Imaging (OI)/CT has the potential to play a major role in drug development for glioblastomas (GBM), as it is an accessible preclinical method. To demonstrate the potential of 3D OI/CT to visualize orthotopic GBM implantation, we labeled GBM cells with Cy7 and imaged their location using 3D OI/CT. To confirm the accuracy of ...
Zeng, Huahui Zhu, Xin Tian, Qikang Yan, Yinyin Zhang, Lan Yan, Min Li, Ruiqin Li, Xiaofang Wang, Guoqiang Ma, Jinlian
...
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Drug delivery
The purpose of this study is to evaluate in vitro and in vivo antitumor efficacy and subacute toxicity of triptolide (TP) prodrug, a conjugate between TP and carboxymethyl chitosan (CC). The CCTP conjugate contained 4∼ wt % TP and displayed excellent aqueous solubility (5 mg/mL) as compared to the native TP (17 μg/mL). In vitro cytotoxicity of CCTP...
