Oyama, Natsuko Fuchigami, Yuki Fumoto, Shintaro Sato, Megumu Hagimori, Masayori Shimizu, Kazunori Kawakami, Shigeru
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Drug delivery
We have previously developed an efficient and safe transfection method for the kidney in mice: renal suction-mediated transfection. In this study, we verified the detailed characteristics of transgene expression and plasmid DNA (pDNA) in mice to develop therapeutic strategies and application to gene function analysis in the kidney. After naked pDNA...
Wang, Xiuzhen Zhang, Qing Lv, Lingyan Fu, Junjie Jiang, Yan Xin, Hongliang Yao, Qizheng
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Drug delivery
Drug delivery systems based on nanoparticles (nano-DDS) have aroused attentions for the treatment of glioblastoma (GBM), the most malignant brain cancer with a dismal prognosis. However, there are still numerous unmet challenges for traditional nano-DDS, such as the poor nanoparticle penetration, short retention in the GBM parenchyma and low glioma...
Tian, Cihui Asghar, Sajid Wu, Yifan Kambere Amerigos, Daddy Chen, Zhipeng Zhang, Mei Yin, Lining Huang, Lin Ping, Qineng Xiao, Yanyu
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Drug delivery
The application of orally administered nanoparticles in the circulation system is limited by the secretion and shedding of intestinal tract mucous layer. In order to enhance mucoadhesion and mucus penetration of curcumin (Cur)-loaded nanostructured lipid carrier (NLC) after oral administration, a new multifunctional conjugate, N-acetyl-L-cysteine-p...
Chen, Mei Hou, Jiangping Tan, Guilin Xie, Peng Freeman, William R Beadle, James R Hostetler, Karl Y Cheng, Lingyun
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Drug delivery
Proliferative vitreoretinopathy (PVR) is a blinding eye disease and there is no effective pharmacological measure to prevent PVR development. The difficulty comes from lack of potent antiproliferative agent and lack of sustained delivery to cover high-risk time window for PVR to develop. Lipid prodrug of PMEG, hexadecyloxypropyl 9-[(2-phosphonometh...
Li, Yuling Baiyang, Li Leran, Bu Zhen, Wang Yandong, Xie Baixiang, Du Dandan, Zhu Yufu, Zhu Jun, Liang Rutong, Yu
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Drug delivery
A series of novel reduction-responsive micelles with tailored size were designed and prepared to release doxorubicin (DOX) for treating glioma, which were developed based on amphiphilic block copolymer poly (2-ethyl-2-oxazoline)-b-poly (ε-caprolactone) (PEtOz-SS-PCL) and the micelle size could be regulated by designing the polymer structure. The DO...
Shi, Qiuxiao Tao, Ze Yang, Hao Fan, Qing Wei, Danfeng Wan, Lin Lu, Xiaofeng
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Drug delivery
Vascular-targeted photodynamic therapy (PDT) is an important strategy for cancer therapy. Conventional vascular-targeted PDT has been achieved by passive photosensitizer (PS) delivery, which involves a high risk of adverse effects. Active PS delivery is urgently required for vascular-targeted PDT. Although endothelial cells and pericytes are major ...
Tiash, Snigdha Kamaruzman, Nur Izyani Binti Chowdhury, Ezharul Hoque
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Drug delivery
Cancer cells lose their control on cell cycle by numerous genetic and epigenetic alterations. In a tumor, these cells highly express growth factor receptors (GFRs), eliciting growth, and cell division. Among the GFRs, epidermal growth factor receptor-1 (EGFR1) (Her1/ERBB1) and epidermal growth factor receptor-2 (EGFR2) (Her2/ERBB2) from epidermal g...
Yan, Qinying Liu, Houming Cheng, Zhigang Xue, Yun Cheng, Zhide Dai, Xuyong Shan, Wanshui Chen, Fan
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Drug delivery
Polysaccharide nucleic acid fractions of bacillus Calmette-Guérin, termed BCG-PSN, have traditionally been used as immunomodulators in the treatment of dermatitis and allergic diseases. While the sales of injectable BCG-PSN have shown steady growth in recent years, no reports of using BCG-PSN powder or its immunotherapeutic effects exist. Here, BCG...
Zhou, Jiangtao Tan, Lihua Xie, Jianhui Lai, Zhengquan Huang, Yanfeng Qu, Chang Luo, Dandan Lin, Zhixiu Huang, Ping Su, Ziren
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Drug delivery
Brusatol (BR) is one of the main bioactive components derived from Brucea javanica, a medicinal herb historically used in the treatment of dysenteric disorders (also known as ulcerative colitis(UC)). Due to its poor aqueous solubility, a novel brusatol self-microemulsifying drug delivery system (BR-SMEDDS) nanoformulation with smaller size, higher ...
Gao, Li Xie, Chuanqi Du, Yuzhi Wang, Xiaodong Xuan, Erkang Liu, Xiuxiu Zhao, Yang Xu, Jianjian Luo, Lan
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Drug delivery
Etoposide is widely used in the chemotherapy of a variety of malignancies. But the strong lipophilicity, poor bioavailability, and severe side effects of etoposide limit its clinical application. The aim of this study was to develop sustained-release etoposide-loaded implants and evaluate antitumor activity of the implants after intratumoral implan...